Topic dermatitis Duration of symptoms (years) Median SMS on 15th March initially treatment yearan.a.: not accessible; afirst day on which SMS information was collectedComparator birch pollen depot preparation n = 27 13/14 37.70 9.83 220 21.28 39.76 0.768.Reference group n = 34 10/24 38.38 11.58 239 n.a.10/14 41.00 12.28 203 21.79 24.96 0.601.n ( ) n ( ) n ( ) n ( ) n ( ) Mean SD Range24 (100 ) 24 (100 ) 6 (25 ) 9 (38 ) 1 (4 ) 11.75 ten.86 13 3.27 (one hundred ) 26 (96 ) three (11 ) 11 (41 ) 0 (0 ) 12.52 9.34 13 three.34 (one hundred ) 34 (100 ) 20 (59 ) 15 (44 ) four (12 ) 14.09 six.45 26 5.Klimek et al. Clinical and Translational Allergy (2015) 5:Web page 4 ofTable 2 Median AUC in the symptom scores, medication scores and combined SMS for the 21 day observation period during key birch pollen exposure in each with the two seasonsrBet v 1-FV median (IQR) Initially remedy year Symptom score Medication score SMS Second remedy year Symptom score Medication score SMS 2.81 (4.02) 0.29 (1.36) 3.00 (6.50) 1.67 (two.41) 1.05 (3.50) two.93 (4.86) 0.393 0.730 0.812 three.10 (9.36) 1.43 (three.ten) 5.86 (14.02) 5.69 (four.71) 2.83 (five.75) 12.40 (9.32) 0.400 0.285 0.330 Comparator median (IQR) Wilcoxon ann hitney U-Test p-valuesFig. two Course of every day median SMS and median pollen counts through the 21-day observational periods within the birch pollen season just after a single (above) and two courses (under) of SCIT, respectivelyKlimek et al. Clinical and Translational Allergy (2015) 5:Web page five ofFindingsApplication of study medication265 rBet v 1-FV injections have been administered in the course of the first therapy year, 228 during 2nd year (median 11 and 12 per patient); comparator 349 and 353 (median 14 and 18). The maximum dose of 80 g rBet v 1-FV was achieved in 22/24 subjects in the 1st year, 1 accomplished 20 g, one four g (2nd year: 17 (80 g), two (2 g)). Only 7/27 subjects accomplished the recommended dose of five,000 TU together with the comparator, equivalent to 16 g organic Bet v 1, 4/27 attaining 4,000 TU, 7/27 3,000 TU, 4/27 two,000 TU and 5/27 1,000 TU or significantly less (2nd year: 18 (five,000 TU), 3 (4,000/3,000/40 TU).Symptom medication score (SMS)With a peak pollen count of 834 grains/m3 during the very first pollen season the median AUC of SMS for the rBet v 1-FV group was 5.CD28 Protein Species 86 (IQR: 14.FGF-21, Human (HEK293, mFc-Avi) 02), substantially decrease than the 12.PMID:23522542 40 (IQR: 9.32) recorded for the comparator group (p = 0.330), reference group 14.67 (IQR: 13.64) (Table 2 Fig. 2). Substantial cross-reacting tree pollen counts occurred during the handful of weeks prior to the 21 day observation period, and possibly accounted for the variations in SMS at the starting of your 21 day observation period (7th April) (Fig. two). The median SMS values for the 3 groups on 15th March, the first day on which data was collected, were three.0, three.0 and five.five respectively. In the second year (peak pollen count 827 grains/m3) the median SMS for the rBet v 1-FV and comparator groups had been 3.00 (IQR: 6.50) and 2.93 (IQR: 4.86) respectively (Table 2).Certain antibody responsesBaseline birch pollen-specific IgE levels too as levels through remedy have been equivalent for rBet v 1-FV and the comparator groups; IgG1 and IgG4 levels were comparable at baseline, showed considerable increases with marginally stronger responses within the rBet v 1-FV group (Fig. three) and additional increases within the second year.Nasal provocation testFig. three Birch pollen-specific IgE, IgG1 and IgG4 concentrations. Median values with 25th/75th and 10th/90th percentiles represented by boxes and error bars respectively, outliers by points. Time points: 1, scre.