; readily available in PMC 2016 September 01.Loy et al.Pageintakes from day to day could have led to misclassification of women in line with feeding patterns. In conclusion, predominantly night-time feeding was related with greater FG concentration in lean but not in overweight pregnant girls. This suggests that the impact of feeding patterns on glucose tolerance through pregnancy may very well be adiposity-dependent. Additional investigation is required to determine the underlying mechanism of such variations. Nonetheless, our findings are critical to serve as a basis on building novel nutritional methods to enhance glucose tolerance in the course of pregnancy. As a result, intervention study targeting pregnant females at danger of glucose intolerance and examination of changes in metabolic profile needs to be performed to far better elucidate the effectiveness of making use of this time-related dietary method. It’ll also be exciting to examine the adjustments in feeding patterns across different trimesters of pregnancy. On top of that, the prospective long term overall health benefits of consuming larger calories for the duration of the day for both mother and offspring will have to be assessed. Undoubtedly, future investigation will shed more light on the interaction among the circadian timing program, nutrition and metabolism to enhance human well being, calling for far more interest around the role of chrono-nutrition.Europe PMC Funders Author Manuscripts Europe PMC Funders Author ManuscriptsSupplementary MaterialRefer to Net version on PubMed Central for supplementary material.AcknowledgementsWe would prefer to thank the study subjects and their families for their participation. We also thank the GUSTO study group, which involves Pratibha Agarwal, Arijit Biswas, Choon Looi Bong, Birit F.P. Broekman, Shirong Cai, Yiong Huak Chan, Cornelia Yin Ing Chee, Helen Chen, Amutha Chinnadurai, Chai Kiat Chng, Shang Chee Chong, Mei Chien Chua, Doris Fok, Marielle V. Fortier, Anne Eng Neo Goh, Yam Thiam Daniel Goh, Joshua J. Gooley, Wee Meng Han, Mark Hanson, Christiani Jeyakumar Henry, Joanna D. Holbrook, Chin-Ying Hsu, Neerja Karnani, Jeevesh Kapur, Ivy Yee-Man Lau, Bee Wah Lee, Yung Seng Lee, Sok Bee Lim, Iliana Magiati, Lourdes Mary Daniel, Michael Meaney, Cheryl Ngo, Krishnamoorthy Niduvaje, Wei Wei Pang, Anqi Qiu, Boon Extended Quah, Victor Samuel Rajadurai, Mary Rauff, Salome A. Rebello, Jenny L. Richmond, Anne Rifkin-Graboi, Lynette PeiChi Shek, Allan Sheppard, Borys Shuter, Leher Singh, Shu-E Soh, Walter Stunkel, Lin Lin Su, Kok Hian Tan, Oon Hoe Teoh, Mya Thway Tint, Hugo P S van Bever, Rob M. van Dam, Inez Bik Yun Wong, P. C. Wong and George Seow Heong Yeo. Economic Support This study was supported by the Singapore National Research Foundation below its Translational and Clinical Analysis (TCR) Flagship Programme and administered by the Singapore Ministry of Health’s National Medical Research Council (NMRC), Singapore- NMRC/TCR/004-NUS/2008; NMRC/TCR/012-NUHS/2014.CDKN1B Protein Formulation Added funding is supplied by the Singapore Institute for Clinical Sciences, Agency for Science Technologies and Investigation (ASTAR), Singapore.MCP-4/CCL13 Protein Storage & Stability K.PMID:32261617 M. G. is supported by the National Institute for Health Investigation through the NIHR Southampton Biomedical Research Centre and by the European Union’s Seventh Framework Programme (FP7/2007sirtuininhibitor013), project EarlyNutrition beneath grant agreement nsirtuininhibitor89346. J. K. Y. C. received salary support from the Ministry of Health’s National Healthcare Research Council, Singapore (NMRC/CSA/043/2012).
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