N=Embase n=223 Duplicates, n=Total publications for assessment n=Excluded, n=201 Not human, n=10 Not low BMD or osteoporosis, n=8 Not raloxifene, n=17 No relevant outcomes, n=19 Case reports, n=9 Narrative testimonials, n=135 Not Japan, n=Publications for full-text evaluation n=Excluded, n=11 Systematic critiques, n=2 Multicountry study with no country-level analysis, n=1 Antiresorptive therapy study with no drug-level analysis, n=1 Participants with osteoporosis/osteoarthritis with no disease-level analysis, n=1 Conference abstract, n=1 Participants on dialysis, n=3 Published in non-peer-reviewed journal, n=Included publications n=Figure 1 Flow diagram of literature-search outcomes. Databases had been Medline by means of PubMed and embase. Searches had been restricted to human species and publications from 1980 onwards. Abbreviation: BMD, bone mineral density.Inside the eight publications24,29,32,33,36?9 that reported findings for BMD inside the femoral neck, total hip, total neck, or other regions of your hip, BMD elevated, remained exactly the same, or decreased; handful of with the increases in BMD have been statistically substantial.Fracture incidenceFracture incidence (vertebral or nonvertebral) was reported in three on the 15 publications, like publications from two randomized controlled trials31,35 and a single observational study.40 Even so, only the observational study, which was asubmit your manuscript | dovepressClinical Interventions in Aging 2014:DovepressTable 1 Study and participant characteristicsTherapy and dose, n 52 L-BMD #2.5 SD of YAM and KGF/FGF-7 Protein custom synthesis Japanese diagnostic criteriac Japanese diagnostic criteriad Mean (SD) age, years Study period, weeks NOTCH1 Protein MedChemExpress Illness definition ObjectiveDovepressAuthorsEnrolled, nRandomized controlled trials Morii et al35 302aAssess security and efficacy of RLX (double-blind, placebo-controlled)Iwamoto et al31 52 52Clinical Interventions in Aging 2014:9 52 L-BMD #2.5 SD of YAM and Japanese diagnostic criteriad L-BMD #2.5 SD of YAM (osteoporosis) or 2.five SD ,L-BMD #2.0 SD of YAM (osteopenia)d L-BMD #2.0 SD of YAM 104 RLX 60 mg/day, 92a RLX 120 mg/day, 95a Placebo, 97a RLX 60 mg/day, 61 ALN 5 mg/day, 61 RLX 60 mg/day, 32 RLX 60 mg + ALF 1 g/day, 28 RLX 60 mg/day, 45 ALF 1 g/day, 44 RLX 60 mg + ALF 1 g/day, 48 RLX 60 mg/day, 16 HRT, 16 Control, 14f RLX 60 mg/day, 42g ALF 1 g/day, 46g RLX 60 mg + ALF 1 g/day, 45g RLX 60 mg/day am, 20 RLX 60 mg/day pm, 19 52 L-BMD #2.5 SD of YAM (osteoporosis) or two.5 SD ,L-BMD #2.0 SD of YAM (osteopenia)d Japanese Guidelines for the Prevention and Therapy of Osteoporosisi 65 (6)b 65 (six)b 64 (7) 69 (7) 70 (8) 72 (9)e 70 (11)e 64 (7) 65 (7) 65 (eight) 71 (3) 72 (three) 73 (three) 64 (7) 65 (7) 65 (7) 77 (ten)h 78 (7)h RLX 60 mg/day, 50 RLX 60 mg/day, 68 70 (9)j 52 72 (10) 52 L-BMD #2.five SD of YAM and Japanese diagnostic criteriad L-BMD #2.five SD of YAM and Japanese diagnostic criteriad RLX 60 mg/day, 73 RLX 60 mg/day, 6,970l RLX 60 mg/day, 198 63 (eight) 70 (9)m 52n 104 156 52 71 (9)bMajima et alGorai et alCompare effects of RLX and ALN on L-BMD, bone turnover, and lipid metabolism Assess efficacy of RLX + ALF on BMD and bone turnover Assess adherence to RLX, ALF, and RLX + ALFHayashi et alGorai et alAndo et alCompare atheroprotective and osteoprotective effects of RLX and HRT when switching from HRT to RLX (age-matched controlsf) Assess efficacy of RLX + ALF on BMD and bone turnover and impact of RLX on serum PTH Assess effects of RLX dosing time on coagulation, fibrinolysis, and bone turnoverObservational research Majima et al36Majima et alMajima et al38 70 (.