Kg/m2 Physical activity, metabolic equivalent 18.5 six 22.eight 18.0 6 22.five task-h/wk Household history of diabetes, n ( ) 43,178 (31.three) 33,565 (31.three) Menopausal status, n ( ) Premenopausal 66,226 (48.0) 52,865 (49.3) Postmenopausal, no RSK2 site hormone use 14,295 (10.four) 11,043 (10.3) Postmenopausal, previous hormone use 19,162 (13.9) 14,658 (13.7) Postmenopausal, current hormone use 29,442 (21.three) 21,798 (20.3) Missing value 8831 (six.four) 6969 (six.5) History of hypertension, n ( ) 33,470 (24.three) 26,189 (24.four) History of hypercholesterolemia, n ( ) 52,174 (37.8) 40,347 (37.six) Current smoker, n ( ) 13,332 (9.7) 10,910 (10.2) White, n ( ) 133,828 (97.0) 104,104 (97.0) Multivitamin use, n ( ) 67,124 (48.7) 51,650 (48.1) Alcohol consumption, g/d 4.five 6 8.2 four.5 six 8.two Total energy intake, kcal/d 1790 6 558 1730 6 540 Whole grain intake, g/d 27.five six 18.two 27.three six 18.four Red/processed meat intake, g/d 60.six six 45.4 59.7 6 44.6 Fish intake, g/d 18.9 six 19.0 17.eight six 18.three Poultry intake, g/d 58.5 six 45.1 57.8 6 44.eight Vegetable intake, g/d 245 six 153 232 6 145 Fruit intake, g/d 161 six 124 152 six 121 Coffee, g/d 389 6 372 389 6 372 Sugar-sweetened beverage, g/d 158 six 302 162 six 310 Fiber, g/d 19.7 six 6.0 19.four 6 5.9 Glycemic load 122 six 24 123 six 24 Total fats, g/d 57.three six 14.two 56.6 six 14.two PUFA to SFA ratio 0.58 six 0.20 0.58 6 0.20 a-Linolenic acid, g/d 1.00 6 0.36 0.93 six 0.31 Magnesium, mg/d 348 six 97 345 6 98 Arginine, g/d 4.04 6 0.85 4.03 six 0.86 Walnut intake, g/d 0.56 6 2.24 060 Peanut intake, g/d 1.40 6 3.92 1.12 six three.36 Other nut intake, g/d 1.12 6 3.64 0.84 six 3.36 Total nut intake, g/d 3.36 six 3.92 1.96 6 5.,0.001 48.1 ,0.001 0.56 ,0.001 0.10 ,0.001 ,0.001 0.01 ,0.001 ,0.001 ,0.001 ,0.001 0.79 ,0.001 ,0.001 ,0.001 ,0.001 ,0.001 ,0.001 ,0.001 ,0.001 ,0.001 ,0.001 ,0.001 ,0.Data are mean six SD or n ( ) as specified. 1 serving of Monoamine Transporter medchemexpress walnuts = 28 g.respectively (P-trend = 0.002). Every single 2-servings/wk increment of walnut intake was linked with 21 (13?9 ) and 15 (six?23 ) decrease threat of incident type 2 diabetes before and after adjustment for BMI, respectively. The associations had been related to adjustments for saturated fat, trans fat, glycemic load, and cereal fiber as an alternative of adjustment for food variables, and further adjustment for PUFAs, a-linolenic acid, total fiber, magnesium, and arginine did not modify the results (data not shown). We did not discover any interaction involving walnut consumption and obesity status, physical activity, dietary high quality, and loved ones history of diabetes inside the risk of sort two diabetes (data not shown). For other tree nuts, we also identified an inverse association with risk of variety 2 diabetes. Within the multivariable-adjusted model without BMI, the pooled HRs (95 CIs) for participants consuming 1? servings/mo, 1 serving/wk, and 2 servings/wk of other tree nuts were 0.99 (0.94?.06), 0.93 (0.83?.04), and 0.88 (0.77?.99) compared with ladies who never/rarely514 Pan et al.consumed other tree nuts (P-trend = 0.03). However, the association was attenuated to null soon after further adjustment for BMI. We further examined the relation of total nut (which includes peanut, walnut, along with other nuts) and peanut intakes with threat of type 2 diabetes (Table 3). Total nut consumption was connected using a lower risk of incident variety two diabetes prior to adjustment for BMI in both cohorts. Inside the pooled evaluation, the HRs (95 CIs) for participants consuming 1? servings/mo, 1 serving/wk, two? servings/wk, and 5 servings/wk of total nuts were 0.96 (0.92?.01), 0.95 (0.89?.02), 0.89 (0.80?.98), and 0.84 (0.75?.93), re.