Oned3 cycles, 10 min day for 1 dayAt exactly the same time as reperfusionBilateral femoral arteriesp38MAPK signal pathway(80)(Continued)Frontiers in Neurology | www.frontiersin.org 7 February 2018 | Volume 9 | ArticleChen et al.TABLe 1 | Continued Animal Sex, age, physique weight Male, 9 weeks old, 29020 g ischemic organ Heart Anesthetic utilized prior to ischemia Pentobarbital 60 mgkg Anesthetic utilised throughout RiC Not described RiC protocolday when RiC was started RiC organ Main Algo bio Inhibitors products pathway investigated pioid receptors ReferenceSD rats1 cycle, 10 min ischemia, 5 min reperfusionday for 1 dayTwo hind limbs At 15 min soon after left coronary artery ligation, and limb blood provide was restored five min just before loosening the left coronary artery ligation for Ritanserin GPCR/G Protein myocardial reperfusion. At 24 h immediately after hypoxia ischemia. Heart ischemia was induced promptly after LRIpreC At 24 h before ischemia Brain ischemia was induced instantly after LRIpreC Brain ischemia was induced at 1 h right after LRIpreC Hind limb(81)SD ratsUnsexed Brain pups, ten days Male, ten days old Heart3 Isoflurane and maintained with 1.5 three Isoflurane and maintained with 1.5 Pentobarbital 70 mgkg 5 Isoflurane and maintained with two 4 Isoflurane and maintained with 21.5 Isoflurane4 cycles, 10 min day for 1 day four cycles, 5 minday for 1 dayNo distinct pathway pointed out By systemic releasing of microRNA(66)Limb remote ischemic preconditioning (LRIpreC)C57BL6 micePentobarbital 60 mgkgHind limb(82)C57BL6 mice SD ratsMale, 92 weeks Male, 25050 g Male, 280Heart BrainNot mentioned 2 Isoflurane two Isoflurane3 cycles, 5 minday for 1 day three cycles, 15 min day for 1 day 3 cycles, five minday for 1 dayLeft femoral artery Left hind limbBy upregulating IL10 No precise pathway talked about Rely on the activation of adenosine A1 receptors and by reduction in oxidative stress, inflammation and endogenous antioxidant preservation No certain pathway mentioned(83) (84)SD ratsBrainRight hind limb(85)Wistar ratsMale, 25080 gBrain10 Chloral HydrateNot mentioned3 cycles five min; 3 sessionsday for 3 days two cycles, 5 or 15 min (two cycles, 5 min; 3 cycles, 5 min; 2 cycles 15 min, three cycles 15 min)day for 1 day 3 cycles, five minday for three daysBrain ischemia was induced quickly following the last LRIpreC operationLeft prevalent carotid artery(86)SD ratsMale, 27030 gBrain5 Isoflurane and maintained with 11 IsofluraneBrain ischemia was Left hind limb induced straight away or 12 h, two d following LRIpreCNo specific pathway mentioned(41) Remote Ischemic ConditioningWistar ratsMale, 24060 gHeartUrethane 1 gkgChloral Hydrate 0.3 gkgAt dayLeft hind limbDecreased leakage of myocardial enzymes(87) (Continued)TABLe 1 | Continued Animal Sex, age, body weight Male, 28020 g Unsexed pups, 15000 g Male, 80 weeks ischemic organ Brain Anesthetic made use of prior to ischemia 5 Isoflurane and maintained with two.5 Thiopental 35 mgkg Pentobarbital 60 mgkg Anesthetic used throughout RiC 2.5 Isoflurane RiC protocolday when RiC was started At 1 h just before middle cerebral artery occlusion (MCAO) At 10 min just before the heart ischemia Collected blood sample at five min (LRIpreC5) or 10 min (LRIpreC10) after limb ischemia RiC organ Principal pathway investigated Substantial alterations in peripheral immune responses TRPV1 channels ReferenceFrontiers in Neurology | www.frontiersin.org 8 February 2018 | Volume 9 | ArticleChen et al.SD rats4 cycles, 5 minday for 1 day four cycles, 5 minday for 1 day 10 min limb ischemia followed by 5 min (LRIpreC5) or 10 min (LRIpreC10) reperfusionday for 1 day three cycles, 15.