Oned3 cycles, 10 min day for 1 dayAt the exact same time as reperfusionBilateral femoral arteriesp38MAPK signal pathway(80)(Continued)Frontiers in Neurology | www.frontiersin.org 7 February 2018 | Volume 9 | ArticleChen et al.TABLe 1 | Continued Animal Sex, age, body weight Male, 9 weeks old, 29020 g ischemic organ Heart Anesthetic made use of prior to Ceforanide Inhibitor ischemia Pentobarbital 60 mgkg Anesthetic applied throughout RiC Not described RiC protocolday when RiC was began RiC organ Most important pathway investigated pioid receptors ReferenceSD rats1 cycle, 10 min ischemia, five min reperfusionday for 1 dayTwo hind limbs At 15 min right after left coronary artery ligation, and limb blood supply was restored 5 min prior to loosening the left coronary artery ligation for myocardial reperfusion. At 24 h following hypoxia ischemia. Heart ischemia was induced right away immediately after LRIpreC At 24 h before ischemia Brain ischemia was induced instantly following LRIpreC Brain ischemia was induced at 1 h right after LRIpreC Hind limb(81)SD ratsUnsexed Brain pups, ten days Male, ten days old Heart3 Isoflurane and maintained with 1.5 3 Isoflurane and maintained with 1.5 Pentobarbital 70 mgkg 5 Isoflurane and maintained with two four Isoflurane and maintained with 21.5 Isoflurane4 cycles, 10 min day for 1 day 4 cycles, 5 minday for 1 dayNo precise pathway mentioned By systemic releasing of microRNA(66)Limb remote ischemic preconditioning (LRIpreC)C57BL6 micePentobarbital 60 mgkgHind limb(82)C57BL6 mice SD ratsMale, 92 weeks Male, 25050 g Male, 280Heart BrainNot described two Isoflurane 2 Isoflurane3 cycles, 5 minday for 1 day three cycles, 15 min day for 1 day three cycles, 5 minday for 1 dayLeft femoral artery Left hind limbBy upregulating IL10 No precise pathway mentioned Rely on the activation of adenosine A1 receptors and by reduction in oxidative strain, inflammation and endogenous antioxidant preservation No certain pathway talked about(83) (84)SD ratsBrainRight hind limb(85)Wistar ratsMale, 25080 gBrain10 Chloral HydrateNot mentioned3 cycles 5 min; three sessionsday for 3 days 2 cycles, five or 15 min (2 cycles, 5 min; 3 cycles, 5 min; two cycles 15 min, three cycles 15 min)day for 1 day 3 cycles, five minday for three daysBrain ischemia was induced instantly immediately after the last LRIpreC operationLeft prevalent carotid artery(86)SD ratsMale, 27030 gBrain5 Isoflurane and maintained with 11 IsofluraneBrain ischemia was Left hind limb induced immediately or 12 h, 2 d after LRIpreCNo specific pathway described(41) Remote Ischemic ConditioningWistar ratsMale, 24060 gHeartUrethane 1 gkgChloral Hydrate 0.3 gkgAt dayLeft hind limbDecreased leakage of myocardial Choline (bitartrate) Autophagy enzymes(87) (Continued)TABLe 1 | Continued Animal Sex, age, body weight Male, 28020 g Unsexed pups, 15000 g Male, 80 weeks ischemic organ Brain Anesthetic utilised prior to ischemia five Isoflurane and maintained with two.five Thiopental 35 mgkg Pentobarbital 60 mgkg Anesthetic applied during RiC 2.five Isoflurane RiC protocolday when RiC was began At 1 h ahead of middle cerebral artery occlusion (MCAO) At 10 min ahead of the heart ischemia Collected blood sample at 5 min (LRIpreC5) or ten min (LRIpreC10) right after limb ischemia RiC organ Principal pathway investigated Important alterations in peripheral immune responses TRPV1 channels ReferenceFrontiers in Neurology | www.frontiersin.org 8 February 2018 | Volume 9 | ArticleChen et al.SD rats4 cycles, five minday for 1 day 4 cycles, 5 minday for 1 day 10 min limb ischemia followed by 5 min (LRIpreC5) or 10 min (LRIpreC10) reperfusionday for 1 day 3 cycles, 15.