Min day for 1 dayBilateral hind limb(88)Wistar ratsHeartNot mentionedHind limb(89)Wistar ratsLimbNot mentionedRight femoral arteryEffect on plasma proteome(90)SD ratsMale, 27030 gBrain5 Isoflurane and maintained with 1 Thiopental 35 mgkg1 IsofluraneAt 1.5 h before dMCAOLeft femoral arteryExtrinsic apoptotic pathway and TNF-related apoptosis-inducing ligand receptors expression Activation of mechanosensitive TRP and specially TRPV channels Circulating elements released by visceral organs(40)Wistar ratsMale, 15000 gHeartNot mentioned5 cycles, 5 minday for 1 dayHeart ischemia was induced straight away right after LRIpreC Heart ischemia was induced instantly after LRIpreCHind limb(91)SD ratsMale, 28020 gHeartPentobarbital 60 mgkgPentobarbital, 105 mgkg15 min occlusion followed by 10 min reperfusionday for 1 day 4 cycles, 10 min day for 1 dayBoth hind limbs(92)Limb remote ischemic perconditioning (LRIperC)C57BL6J Female, mice, 20 2 weeks ovariectomized C57BL6J mice SD rats Male, 20 1 weeks Male, Postnatal dayBrainMild Isoflurane; dose not described three.5 isoflurane and maintained with 1.five two.0 Ketamine Hydrochloride 8000 mg kg and ACE-2 Inhibitors Related Products Acepromazine Maleate 5 mgkg ten Chloral HydrateNot mentionedAt 2 h poststrokeLimbNo precise pathway described(53)BrainNot mentioned5 cycles, 5 minday for 1 day 4 cycles, 5 minday for 1 dayAt 2 h right after embolic MCAO At 40 min prior to MCAOLeft limbNo distinct pathway mentioned(93)BrainNot mentionedLeft hind limb(94) Remote Ischemic ConditioningSD ratsMale, 25080 gBrainNot mentioned4 cycles, five minday for 1 dayAt 40 min before reperfusionLeft hind limbInhibits autophagy to attenuate plasma higher mobility group box 1 and induce neuroprotection(51)(Continued)Chen et al.Remote Ischemic ConditioningTABLe 1 | ContinuedWistar 25 aromatase Inhibitors targets ratsAnimalSD ratsFor LRIperC, Costa et al. made use of combined LRIperC and regional postconditioning in rats that underwent 60 min of liver ischemia (104). The procedure consisted of 4 cycles of 5-min hind limb ischemia and 5-min perfusion; neighborhood postconditioning consisted of 4 cycles of 5-min liver ischemia followed by 5-min perfusion. Results showed that the mixture of LRIperC and neighborhood postconditioning was capable to decrease hepatic tissue MDA levels and additional attenuate IR injury (104). For LRIP, Li et al. made use of CD1 mice to prove that LRIP could drastically lessen the IR injury through upregulation and expression of Nrf2 in addition to heme oxygenase 1 (HO1), quinone oxidoreductase 1 (NQO1), and superoxide dismutase (SOD), all cytoprotective enzymes downstream of Nrf2 (52). Their group employed mice to conduct three cycles of 5-min ischemia and subsequent 5-min reperfusion of bilateral femoral arteries to show that LRIP considerably improved neurological outcomes likely by reducing oxidative pressure and initiating the Nrf2-ARE pathway. Zhang et al., Zhou et al., and Kadkhodaee et al. all investigated the effect of LRIP against IR injury in rats; all groups showed a significant decrease within the degree of MDA following LRIP (64, 105, 106). We performed research in rats to understand the part of nitrotyrosine, mRNA of P22phox, and xanthine oxidase and how they contribute to oxidative harm. Throughout three cycles of 15-min occlusion and subsequent 15-min reperfusion with the left femoral artery, the levels of these three oxidants had been decreased by LRIP. Additional experimentation proved that LRIP could reverse the eNOS uncoupling to decrease the IR injury brought on by the aforementioned oxidants (43). Other researchers also proved.