PI3KInhibitorpi3kinhibitor

Vortioxetine

By

Vortioxetine

Product: MK-0773

Identifier : DBSNPE004944
Drug : DB09068 (Vortioxetine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • C allele (rs35742686 )

Allele Name : CYP2D6*3
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower maximum dose.
References :

  1. Trintellix (vortioxetine) tablets[package insert]. Deerfield, Illinois: Takeda Pharmaceuticals America, Inc. 2017. [Link]

PMID: 11459658

Vortioxetine

By

Vortioxetine

Product: Tacrolimus

Identifier : DBSNPE004945
Drug : DB09068 (Vortioxetine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • C allele (rs3892097 )

Allele Name : CYP2D6*4
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower maximum dose.
References :

  1. Trintellix (vortioxetine) tablets[package insert]. Deerfield, Illinois: Takeda Pharmaceuticals America, Inc. 2017. [Link]

PMID: 11250867

Vortioxetine

By

Vortioxetine

Product: SMIP004

Identifier : DBSNPE004946
Drug : DB09068 (Vortioxetine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • Whole-gene deletion

Allele Name : CYP2D6*5
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower maximum dose.
References :

  1. Trintellix (vortioxetine) tablets[package insert]. Deerfield, Illinois: Takeda Pharmaceuticals America, Inc. 2017. [Link]

PMID: 11102651

Vortioxetine

By

Vortioxetine

Product: Dexamethasone

Identifier : DBSNPE004947
Drug : DB09068 (Vortioxetine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 1707delT (rs5030655 )

Allele Name : CYP2D6*6
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower maximum dose.
References :

  1. Trintellix (vortioxetine) tablets[package insert]. Deerfield, Illinois: Takeda Pharmaceuticals America, Inc. 2017. [Link]

PMID: 25993564

Vortioxetine

By

Vortioxetine

Product: Micafungin (sodium)

Identifier : DBSNPE004948
Drug : DB09068 (Vortioxetine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 2935A>C (rs5030867 )

Allele Name : CYP2D6*7
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower maximum dose.
References :

  1. Trintellix (vortioxetine) tablets[package insert]. Deerfield, Illinois: Takeda Pharmaceuticals America, Inc. 2017. [Link]

PMID: 25695914

Vortioxetine

By

Vortioxetine

Product: Beclometasone dipropionate

Identifier : DBSNPE004949
Drug : DB09068 (Vortioxetine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 1758G>T (rs5030865 )

Allele Name : CYP2D6*8
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower maximum dose.
References :

  1. Trintellix (vortioxetine) tablets[package insert]. Deerfield, Illinois: Takeda Pharmaceuticals America, Inc. 2017. [Link]

PMID: 26536818

Vortioxetine

By

Vortioxetine

Product: N3PT

Identifier : DBSNPE004950
Drug : DB09068 (Vortioxetine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 883G>C (rs5030863 )

Allele Name : CYP2D6*11
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower maximum dose.
References :

  1. Trintellix (vortioxetine) tablets[package insert]. Deerfield, Illinois: Takeda Pharmaceuticals America, Inc. 2017. [Link]

PMID: 25114294

Vortioxetine

By

Vortioxetine

Product: Pitolisant (hydrochloride)

Identifier : DBSNPE004951
Drug : DB09068 (Vortioxetine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 124G>A (rs5030862 )

Allele Name : CYP2D6*12
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower maximum dose.
References :

  1. Trintellix (vortioxetine) tablets[package insert]. Deerfield, Illinois: Takeda Pharmaceuticals America, Inc. 2017. [Link]

PMID: 24382962

Vortioxetine

By

Vortioxetine

Product: Mitotane

Identifier : DBSNPE004952
Drug : DB09068 (Vortioxetine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • CYP2D7/2D6 hybrid gene sdivucture

Allele Name : CYP2D6*13
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower maximum dose.
References :

  1. Trintellix (vortioxetine) tablets[package insert]. Deerfield, Illinois: Takeda Pharmaceuticals America, Inc. 2017. [Link]

PMID: 24813431

Vortioxetine

By

Vortioxetine

Product: 6-Mercaptopurine

Identifier : DBSNPE004953
Drug : DB09068 (Vortioxetine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 1758G>A (rs5030865 )

Allele Name : CYP2D6*14A
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower maximum dose.
References :

  1. Trintellix (vortioxetine) tablets[package insert]. Deerfield, Illinois: Takeda Pharmaceuticals America, Inc. 2017. [Link]

PMID: 24727338

Vortioxetine

By

Vortioxetine

Product: Topotecan (Hydrochloride)

Identifier : DBSNPE004954
Drug : DB09068 (Vortioxetine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 137insT, 137_138insT

Allele Name : CYP2D6*15
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower maximum dose.
References :

  1. Trintellix (vortioxetine) tablets[package insert]. Deerfield, Illinois: Takeda Pharmaceuticals America, Inc. 2017. [Link]

PMID: 24930888

Vortioxetine

By

Vortioxetine

Product: 6-Thioguanine

Identifier : DBSNPE004955
Drug : DB09068 (Vortioxetine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 2539_2542delAACT (rs72549353 )

Allele Name : CYP2D6*19
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower maximum dose.
References :

  1. Trintellix (vortioxetine) tablets[package insert]. Deerfield, Illinois: Takeda Pharmaceuticals America, Inc. 2017. [Link]

PMID: 24759941

Vortioxetine

By

Vortioxetine

Product: INCB 024360

Identifier : DBSNPE004956
Drug : DB09068 (Vortioxetine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 1973_1974insG (rs72549354 )

Allele Name : CYP2D6*20
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower maximum dose.
References :

  1. Trintellix (vortioxetine) tablets[package insert]. Deerfield, Illinois: Takeda Pharmaceuticals America, Inc. 2017. [Link]

PMID: 24915296

Vortioxetine

By

Vortioxetine

Product: IDO5L

Identifier : DBSNPE004957
Drug : DB09068 (Vortioxetine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 2573insC

Allele Name : CYP2D6*21
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower maximum dose.
References :

  1. Trintellix (vortioxetine) tablets[package insert]. Deerfield, Illinois: Takeda Pharmaceuticals America, Inc. 2017. [Link]

PMID: 24466352

Vortioxetine

By

Vortioxetine

Product: AVL-292 (benzenesulfonate)

Identifier : DBSNPE004958
Drug : DB09068 (Vortioxetine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • -1770G>A
  • -1584C>G
  • -1235A>G
  • -740C>T
  • -678G>A
  • CYP2D7 gene conversion in indivon 1
  • 310G>T
  • 746C>G
  • 843T>G
  • 1661G>C
  • 2850C>T
  • 3384A>C
  • 3584G>A
  • 3790C>T
  • 4042G>A
  • 4180G>C
  • 4481G>A

Allele Name : CYP2D6*31
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower maximum dose.
References :

  1. Trintellix (vortioxetine) tablets[package insert]. Deerfield, Illinois: Takeda Pharmaceuticals America, Inc. 2017. [Link]

PMID: 23518606

Vortioxetine

By

Vortioxetine

Product: Fosbretabulin (disodium)

Identifier : DBSNPE004959
Drug : DB09068 (Vortioxetine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 100C>T (rs1065852 )
  • -1426C>T
  • variable number of A’s in the region -1258 to -1237a
  • -1235A>G
  • -1000G>A
  • 1039C>T
  • 1661G>C
  • gene conversion to CYP2D7 in exon 9
  • 4180G>C

Allele Name : CYP2D6*36
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower maximum dose.
References :

  1. Trintellix (vortioxetine) tablets[package insert]. Deerfield, Illinois: Takeda Pharmaceuticals America, Inc. 2017. [Link]

PMID: 22453138

Vortioxetine

By

Vortioxetine

Product: Salinomycin (sodium salt)

Identifier : DBSNPE004960
Drug : DB09068 (Vortioxetine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 2587_2590delGACT (rs72549351 )

Allele Name : CYP2D6*38
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower maximum dose.
References :

  1. Trintellix (vortioxetine) tablets[package insert]. Deerfield, Illinois: Takeda Pharmaceuticals America, Inc. 2017. [Link]

PMID: 21951179

Vortioxetine

By

Vortioxetine

Product: Omadacycline (mesylate)

Identifier : DBSNPE004961
Drug : DB09068 (Vortioxetine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 1863_1864ins(TTT CGC CCC)2 (rs72549356 )

Allele Name : CYP2D6*40
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower maximum dose.
References :

  1. Trintellix (vortioxetine) tablets[package insert]. Deerfield, Illinois: Takeda Pharmaceuticals America, Inc. 2017. [Link]

PMID: 21971160

Vortioxetine

By

Vortioxetine

Product: Lck inhibitor 2

Identifier : DBSNPE004962
Drug : DB09068 (Vortioxetine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 3259_3260insGT (rs72549346 )

Allele Name : CYP2D6*42
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower maximum dose.
References :

  1. Trintellix (vortioxetine) tablets[package insert]. Deerfield, Illinois: Takeda Pharmaceuticals America, Inc. 2017. [Link]

PMID: 21596094

Vortioxetine

By

Vortioxetine

Product: Curcumin

Identifier : DBSNPE004963
Drug : DB09068 (Vortioxetine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 2950G>C

Allele Name : CYP2D6*44
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower maximum dose.
References :

  1. Trintellix (vortioxetine) tablets[package insert]. Deerfield, Illinois: Takeda Pharmaceuticals America, Inc. 2017. [Link]

PMID: 21054340

Vortioxetine

By

Vortioxetine

Product: Clemizole (hydrochloride)

Identifier : DBSNPE004964
Drug : DB09068 (Vortioxetine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 100C>T (rs1065852 )
  • -1426C>T
  • -1235A>G
  • -1000G>A
  • 73C<T
  • 1039C>T
  • 1661G>C
  • 4180G>C

Allele Name : CYP2D6*47
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower maximum dose.
References :

  1. Trintellix (vortioxetine) tablets[package insert]. Deerfield, Illinois: Takeda Pharmaceuticals America, Inc. 2017. [Link]

PMID: 19033203

Vortioxetine

By

Vortioxetine

Product: PRT062607 (Hydrochloride)

Identifier : DBSNPE004965
Drug : DB09068 (Vortioxetine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • -1584C>G
  • -1235A>G
  • -740C>T
  • -678G>A
  • CYP2D7 gene conversion in indivon 1
  • 1661G>C
  • 2850C>T
  • 3172A>C
  • 4180G>C

Allele Name : CYP2D6*51
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower maximum dose.
References :

  1. Trintellix (vortioxetine) tablets[package insert]. Deerfield, Illinois: Takeda Pharmaceuticals America, Inc. 2017. [Link]

PMID: 17192702

Vortioxetine

By

Vortioxetine

Product: Costunolide

Identifier : DBSNPE004966
Drug : DB09068 (Vortioxetine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 3201C>T (rs72549347 )

Allele Name : CYP2D6*56
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower maximum dose.
References :

  1. Trintellix (vortioxetine) tablets[package insert]. Deerfield, Illinois: Takeda Pharmaceuticals America, Inc. 2017. [Link]

PMID: 14691055

Vortioxetine

By

Vortioxetine

Product: Brassinolide

Identifier : DBSNPE004967
Drug : DB09068 (Vortioxetine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 100C>T
  • 310G>T
  • 843T>G
  • 887C>T
  • 1039C>T
  • 1661G>C
  • 3384A>C
  • 3582A>G
  • gene conversion to CYP2D7 in exon 9
  • 4180G>C

Allele Name : CYP2D6*57
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower maximum dose.
References :

  1. Trintellix (vortioxetine) tablets[package insert]. Deerfield, Illinois: Takeda Pharmaceuticals America, Inc. 2017. [Link]

PMID: 21547533

Vortioxetine

By

Vortioxetine

Product: AZ20

Identifier : DBSNPE004968
Drug : DB09068 (Vortioxetine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 4044C>T

Allele Name : CYP2D6*62
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower maximum dose.
References :

  1. Trintellix (vortioxetine) tablets[package insert]. Deerfield, Illinois: Takeda Pharmaceuticals America, Inc. 2017. [Link]

PMID: 17015451

Vortioxetine

By

Vortioxetine

Product: AVL-292

Identifier : DBSNPE004969
Drug : DB09068 (Vortioxetine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • -1426C>T
  • -1235A>G
  • -1000G>A
  • 100C>T
  • 310G>T
  • CYP2D7 sequence from indivon 1 onwards

Allele Name : CYP2D6*68A
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower maximum dose.
References :

  1. Trintellix (vortioxetine) tablets[package insert]. Deerfield, Illinois: Takeda Pharmaceuticals America, Inc. 2017. [Link]

PMID: 12467628

Vortioxetine

By

Vortioxetine

Product: Clemizole

Identifier : DBSNPE004970
Drug : DB09068 (Vortioxetine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • Similar but not identical switch region compared to CYP2D6*68A. Found in tandem arrangement with CYP2D6*4.

Allele Name : CYP2D6*68B
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower maximum dose.
References :

  1. Trintellix (vortioxetine) tablets[package insert]. Deerfield, Illinois: Takeda Pharmaceuticals America, Inc. 2017. [Link]

PMID: 24929062

Vortioxetine

By

Vortioxetine

Product: Phloretin

Identifier : DBSNPE004971
Drug : DB09068 (Vortioxetine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 2988G>A (rs28371725 )
  • -1426C>T
  • -1235A>G
  • -1000G>A
  • 100C>T
  • 310G>T
  • 746C>G
  • 843T>G
  • 1062A>G
  • 1661G>C
  • 2850C>T
  • 3384A>C
  • 3584G>A
  • 3790C>T
  • 4180G>C
  • 4401C>T
  • 4481G>A

Allele Name : CYP2D6*69
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower maximum dose.
References :

  1. Trintellix (vortioxetine) tablets[package insert]. Deerfield, Illinois: Takeda Pharmaceuticals America, Inc. 2017. [Link]

PMID: 21368172

Vortioxetine

By

Vortioxetine

Product: SDZ 220-581 (Ammonium salt)

Identifier : DBSNPE004972
Drug : DB09068 (Vortioxetine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 1995delC

Allele Name : CYP2D6*92
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower maximum dose.
References :

  1. Trintellix (vortioxetine) tablets[package insert]. Deerfield, Illinois: Takeda Pharmaceuticals America, Inc. 2017. [Link]

PMID: 20404073

Vortioxetine

By

Vortioxetine

Product: SDZ 220-581

Identifier : DBSNPE004973
Drug : DB09068 (Vortioxetine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • -1426C>T
  • -1235A>G
  • -1109C>T
  • -1000G>A
  • 100C>T
  • 310G>T
  • 843T>G
  • 1039C>T
  • 1661G>C
  • 2097A>G
  • 2828delC
  • 3384A>C
  • 3582A>G
  • 4180G>C
  • 4401C>T

Allele Name : CYP2D6*100
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower maximum dose.
References :

  1. Trintellix (vortioxetine) tablets[package insert]. Deerfield, Illinois: Takeda Pharmaceuticals America, Inc. 2017. [Link]

PMID: 23964859

Vortioxetine

By

Vortioxetine

Product: Azathramycin

Identifier : DBSNPE004974
Drug : DB09068 (Vortioxetine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • -1426C>T
  • -1235A>G
  • -1000G>A
  • 100C>T
  • 310G>T
  • 843T>G
  • 1039C>T
  • 1661G>C
  • 2097A>G
  • 2927_2945delGATCCTACATCCGGATGTG
  • 3384A>C
  • 3582A>G
  • 4180G>C
  • 4401C>T

Allele Name : CYP2D6*101
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower maximum dose.
References :

  1. Trintellix (vortioxetine) tablets[package insert]. Deerfield, Illinois: Takeda Pharmaceuticals America, Inc. 2017. [Link]

PMID: 24376396

Vortioxetine

By

Vortioxetine

Product: MK-0773

Identifier : DBSNPE004944
Drug : DB09068 (Vortioxetine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • C allele (rs35742686 )

Allele Name : CYP2D6*3
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower maximum dose.
References :

  1. Trintellix (vortioxetine) tablets[package insert]. Deerfield, Illinois: Takeda Pharmaceuticals America, Inc. 2017. [Link]

PMID: 11459658

Vortioxetine

By

Vortioxetine

Product: Tacrolimus

Identifier : DBSNPE004945
Drug : DB09068 (Vortioxetine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • C allele (rs3892097 )

Allele Name : CYP2D6*4
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower maximum dose.
References :

  1. Trintellix (vortioxetine) tablets[package insert]. Deerfield, Illinois: Takeda Pharmaceuticals America, Inc. 2017. [Link]

PMID: 11250867

Vortioxetine

By

Vortioxetine

Product: SMIP004

Identifier : DBSNPE004946
Drug : DB09068 (Vortioxetine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • Whole-gene deletion

Allele Name : CYP2D6*5
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower maximum dose.
References :

  1. Trintellix (vortioxetine) tablets[package insert]. Deerfield, Illinois: Takeda Pharmaceuticals America, Inc. 2017. [Link]

PMID: 11102651

Vortioxetine

By

Vortioxetine

Product: Dexamethasone

Identifier : DBSNPE004947
Drug : DB09068 (Vortioxetine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 1707delT (rs5030655 )

Allele Name : CYP2D6*6
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower maximum dose.
References :

  1. Trintellix (vortioxetine) tablets[package insert]. Deerfield, Illinois: Takeda Pharmaceuticals America, Inc. 2017. [Link]

PMID: 25993564

Vortioxetine

By

Vortioxetine

Product: Micafungin (sodium)

Identifier : DBSNPE004948
Drug : DB09068 (Vortioxetine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 2935A>C (rs5030867 )

Allele Name : CYP2D6*7
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower maximum dose.
References :

  1. Trintellix (vortioxetine) tablets[package insert]. Deerfield, Illinois: Takeda Pharmaceuticals America, Inc. 2017. [Link]

PMID: 25695914

Vortioxetine

By

Vortioxetine

Product: Beclometasone dipropionate

Identifier : DBSNPE004949
Drug : DB09068 (Vortioxetine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 1758G>T (rs5030865 )

Allele Name : CYP2D6*8
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower maximum dose.
References :

  1. Trintellix (vortioxetine) tablets[package insert]. Deerfield, Illinois: Takeda Pharmaceuticals America, Inc. 2017. [Link]

PMID: 26536818

Vortioxetine

By

Vortioxetine

Product: N3PT

Identifier : DBSNPE004950
Drug : DB09068 (Vortioxetine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 883G>C (rs5030863 )

Allele Name : CYP2D6*11
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower maximum dose.
References :

  1. Trintellix (vortioxetine) tablets[package insert]. Deerfield, Illinois: Takeda Pharmaceuticals America, Inc. 2017. [Link]

PMID: 25114294

Vortioxetine

By

Vortioxetine

Product: Pitolisant (hydrochloride)

Identifier : DBSNPE004951
Drug : DB09068 (Vortioxetine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 124G>A (rs5030862 )

Allele Name : CYP2D6*12
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower maximum dose.
References :

  1. Trintellix (vortioxetine) tablets[package insert]. Deerfield, Illinois: Takeda Pharmaceuticals America, Inc. 2017. [Link]

PMID: 24382962

Vortioxetine

By

Vortioxetine

Product: Mitotane

Identifier : DBSNPE004952
Drug : DB09068 (Vortioxetine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • CYP2D7/2D6 hybrid gene sdivucture

Allele Name : CYP2D6*13
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower maximum dose.
References :

  1. Trintellix (vortioxetine) tablets[package insert]. Deerfield, Illinois: Takeda Pharmaceuticals America, Inc. 2017. [Link]

PMID: 24813431

Vortioxetine

By

Vortioxetine

Product: 6-Mercaptopurine

Identifier : DBSNPE004953
Drug : DB09068 (Vortioxetine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 1758G>A (rs5030865 )

Allele Name : CYP2D6*14A
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower maximum dose.
References :

  1. Trintellix (vortioxetine) tablets[package insert]. Deerfield, Illinois: Takeda Pharmaceuticals America, Inc. 2017. [Link]

PMID: 24727338

Vortioxetine

By

Vortioxetine

Product: Topotecan (Hydrochloride)

Identifier : DBSNPE004954
Drug : DB09068 (Vortioxetine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 137insT, 137_138insT

Allele Name : CYP2D6*15
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower maximum dose.
References :

  1. Trintellix (vortioxetine) tablets[package insert]. Deerfield, Illinois: Takeda Pharmaceuticals America, Inc. 2017. [Link]

PMID: 24930888

Vortioxetine

By

Vortioxetine

Product: 6-Thioguanine

Identifier : DBSNPE004955
Drug : DB09068 (Vortioxetine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 2539_2542delAACT (rs72549353 )

Allele Name : CYP2D6*19
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower maximum dose.
References :

  1. Trintellix (vortioxetine) tablets[package insert]. Deerfield, Illinois: Takeda Pharmaceuticals America, Inc. 2017. [Link]

PMID: 24759941

Vortioxetine

By

Vortioxetine

Product: INCB 024360

Identifier : DBSNPE004956
Drug : DB09068 (Vortioxetine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 1973_1974insG (rs72549354 )

Allele Name : CYP2D6*20
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower maximum dose.
References :

  1. Trintellix (vortioxetine) tablets[package insert]. Deerfield, Illinois: Takeda Pharmaceuticals America, Inc. 2017. [Link]

PMID: 24915296

Vortioxetine

By

Vortioxetine

Product: IDO5L

Identifier : DBSNPE004957
Drug : DB09068 (Vortioxetine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 2573insC

Allele Name : CYP2D6*21
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower maximum dose.
References :

  1. Trintellix (vortioxetine) tablets[package insert]. Deerfield, Illinois: Takeda Pharmaceuticals America, Inc. 2017. [Link]

PMID: 24466352

Vortioxetine

By

Vortioxetine

Product: AVL-292 (benzenesulfonate)

Identifier : DBSNPE004958
Drug : DB09068 (Vortioxetine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • -1770G>A
  • -1584C>G
  • -1235A>G
  • -740C>T
  • -678G>A
  • CYP2D7 gene conversion in indivon 1
  • 310G>T
  • 746C>G
  • 843T>G
  • 1661G>C
  • 2850C>T
  • 3384A>C
  • 3584G>A
  • 3790C>T
  • 4042G>A
  • 4180G>C
  • 4481G>A

Allele Name : CYP2D6*31
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower maximum dose.
References :

  1. Trintellix (vortioxetine) tablets[package insert]. Deerfield, Illinois: Takeda Pharmaceuticals America, Inc. 2017. [Link]

PMID: 23518606

Vortioxetine

By

Vortioxetine

Product: Fosbretabulin (disodium)

Identifier : DBSNPE004959
Drug : DB09068 (Vortioxetine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 100C>T (rs1065852 )
  • -1426C>T
  • variable number of A’s in the region -1258 to -1237a
  • -1235A>G
  • -1000G>A
  • 1039C>T
  • 1661G>C
  • gene conversion to CYP2D7 in exon 9
  • 4180G>C

Allele Name : CYP2D6*36
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower maximum dose.
References :

  1. Trintellix (vortioxetine) tablets[package insert]. Deerfield, Illinois: Takeda Pharmaceuticals America, Inc. 2017. [Link]

PMID: 22453138

Vortioxetine

By

Vortioxetine

Product: Salinomycin (sodium salt)

Identifier : DBSNPE004960
Drug : DB09068 (Vortioxetine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 2587_2590delGACT (rs72549351 )

Allele Name : CYP2D6*38
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower maximum dose.
References :

  1. Trintellix (vortioxetine) tablets[package insert]. Deerfield, Illinois: Takeda Pharmaceuticals America, Inc. 2017. [Link]

PMID: 21951179

Vortioxetine

By

Vortioxetine

Product: Omadacycline (mesylate)

Identifier : DBSNPE004961
Drug : DB09068 (Vortioxetine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 1863_1864ins(TTT CGC CCC)2 (rs72549356 )

Allele Name : CYP2D6*40
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower maximum dose.
References :

  1. Trintellix (vortioxetine) tablets[package insert]. Deerfield, Illinois: Takeda Pharmaceuticals America, Inc. 2017. [Link]

PMID: 21971160

Vortioxetine

By

Vortioxetine

Product: Lck inhibitor 2

Identifier : DBSNPE004962
Drug : DB09068 (Vortioxetine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 3259_3260insGT (rs72549346 )

Allele Name : CYP2D6*42
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower maximum dose.
References :

  1. Trintellix (vortioxetine) tablets[package insert]. Deerfield, Illinois: Takeda Pharmaceuticals America, Inc. 2017. [Link]

PMID: 21596094

Vortioxetine

By

Vortioxetine

Product: Curcumin

Identifier : DBSNPE004963
Drug : DB09068 (Vortioxetine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 2950G>C

Allele Name : CYP2D6*44
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower maximum dose.
References :

  1. Trintellix (vortioxetine) tablets[package insert]. Deerfield, Illinois: Takeda Pharmaceuticals America, Inc. 2017. [Link]

PMID: 21054340

Vortioxetine

By

Vortioxetine

Product: Clemizole (hydrochloride)

Identifier : DBSNPE004964
Drug : DB09068 (Vortioxetine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 100C>T (rs1065852 )
  • -1426C>T
  • -1235A>G
  • -1000G>A
  • 73C<T
  • 1039C>T
  • 1661G>C
  • 4180G>C

Allele Name : CYP2D6*47
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower maximum dose.
References :

  1. Trintellix (vortioxetine) tablets[package insert]. Deerfield, Illinois: Takeda Pharmaceuticals America, Inc. 2017. [Link]

PMID: 19033203

Vortioxetine

By

Vortioxetine

Product: PRT062607 (Hydrochloride)

Identifier : DBSNPE004965
Drug : DB09068 (Vortioxetine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • -1584C>G
  • -1235A>G
  • -740C>T
  • -678G>A
  • CYP2D7 gene conversion in indivon 1
  • 1661G>C
  • 2850C>T
  • 3172A>C
  • 4180G>C

Allele Name : CYP2D6*51
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower maximum dose.
References :

  1. Trintellix (vortioxetine) tablets[package insert]. Deerfield, Illinois: Takeda Pharmaceuticals America, Inc. 2017. [Link]

PMID: 17192702

Vortioxetine

By

Vortioxetine

Product: Costunolide

Identifier : DBSNPE004966
Drug : DB09068 (Vortioxetine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 3201C>T (rs72549347 )

Allele Name : CYP2D6*56
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower maximum dose.
References :

  1. Trintellix (vortioxetine) tablets[package insert]. Deerfield, Illinois: Takeda Pharmaceuticals America, Inc. 2017. [Link]

PMID: 14691055

Vortioxetine

By

Vortioxetine

Product: Brassinolide

Identifier : DBSNPE004967
Drug : DB09068 (Vortioxetine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 100C>T
  • 310G>T
  • 843T>G
  • 887C>T
  • 1039C>T
  • 1661G>C
  • 3384A>C
  • 3582A>G
  • gene conversion to CYP2D7 in exon 9
  • 4180G>C

Allele Name : CYP2D6*57
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower maximum dose.
References :

  1. Trintellix (vortioxetine) tablets[package insert]. Deerfield, Illinois: Takeda Pharmaceuticals America, Inc. 2017. [Link]

PMID: 21547533

Vortioxetine

By

Vortioxetine

Product: AZ20

Identifier : DBSNPE004968
Drug : DB09068 (Vortioxetine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 4044C>T

Allele Name : CYP2D6*62
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower maximum dose.
References :

  1. Trintellix (vortioxetine) tablets[package insert]. Deerfield, Illinois: Takeda Pharmaceuticals America, Inc. 2017. [Link]

PMID: 17015451

Vortioxetine

By

Vortioxetine

Product: AVL-292

Identifier : DBSNPE004969
Drug : DB09068 (Vortioxetine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • -1426C>T
  • -1235A>G
  • -1000G>A
  • 100C>T
  • 310G>T
  • CYP2D7 sequence from indivon 1 onwards

Allele Name : CYP2D6*68A
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower maximum dose.
References :

  1. Trintellix (vortioxetine) tablets[package insert]. Deerfield, Illinois: Takeda Pharmaceuticals America, Inc. 2017. [Link]

PMID: 12467628

Vortioxetine

By

Vortioxetine

Product: Clemizole

Identifier : DBSNPE004970
Drug : DB09068 (Vortioxetine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • Similar but not identical switch region compared to CYP2D6*68A. Found in tandem arrangement with CYP2D6*4.

Allele Name : CYP2D6*68B
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower maximum dose.
References :

  1. Trintellix (vortioxetine) tablets[package insert]. Deerfield, Illinois: Takeda Pharmaceuticals America, Inc. 2017. [Link]

PMID: 24929062

Vortioxetine

By

Vortioxetine

Product: Phloretin

Identifier : DBSNPE004971
Drug : DB09068 (Vortioxetine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 2988G>A (rs28371725 )
  • -1426C>T
  • -1235A>G
  • -1000G>A
  • 100C>T
  • 310G>T
  • 746C>G
  • 843T>G
  • 1062A>G
  • 1661G>C
  • 2850C>T
  • 3384A>C
  • 3584G>A
  • 3790C>T
  • 4180G>C
  • 4401C>T
  • 4481G>A

Allele Name : CYP2D6*69
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower maximum dose.
References :

  1. Trintellix (vortioxetine) tablets[package insert]. Deerfield, Illinois: Takeda Pharmaceuticals America, Inc. 2017. [Link]

PMID: 21368172

Vortioxetine

By

Vortioxetine

Product: SDZ 220-581 (Ammonium salt)

Identifier : DBSNPE004972
Drug : DB09068 (Vortioxetine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 1995delC

Allele Name : CYP2D6*92
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower maximum dose.
References :

  1. Trintellix (vortioxetine) tablets[package insert]. Deerfield, Illinois: Takeda Pharmaceuticals America, Inc. 2017. [Link]

PMID: 20404073

Vortioxetine

By

Vortioxetine

Product: SDZ 220-581

Identifier : DBSNPE004973
Drug : DB09068 (Vortioxetine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • -1426C>T
  • -1235A>G
  • -1109C>T
  • -1000G>A
  • 100C>T
  • 310G>T
  • 843T>G
  • 1039C>T
  • 1661G>C
  • 2097A>G
  • 2828delC
  • 3384A>C
  • 3582A>G
  • 4180G>C
  • 4401C>T

Allele Name : CYP2D6*100
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower maximum dose.
References :

  1. Trintellix (vortioxetine) tablets[package insert]. Deerfield, Illinois: Takeda Pharmaceuticals America, Inc. 2017. [Link]

PMID: 23964859

Vortioxetine

By

Vortioxetine

Product: Azathramycin

Identifier : DBSNPE004974
Drug : DB09068 (Vortioxetine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • -1426C>T
  • -1235A>G
  • -1000G>A
  • 100C>T
  • 310G>T
  • 843T>G
  • 1039C>T
  • 1661G>C
  • 2097A>G
  • 2927_2945delGATCCTACATCCGGATGTG
  • 3384A>C
  • 3582A>G
  • 4180G>C
  • 4401C>T

Allele Name : CYP2D6*101
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower maximum dose.
References :

  1. Trintellix (vortioxetine) tablets[package insert]. Deerfield, Illinois: Takeda Pharmaceuticals America, Inc. 2017. [Link]

PMID: 24376396

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