PI3KInhibitorpi3kinhibitor

Tramadol

By

Tramadol

Product: Alvimopan (monohydrate)

Identifier : DBSNPE004913
Drug : DB00193 (Tramadol)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • C allele (rs35742686 )

Allele Name : CYP2D6*3
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased risk of opioid toxicity.
References :

  1. Uldivam® (divamadol hydrochloride) tablets[package insert]. Titusville, New Jersey: Janssen Pharmaceuticals, Inc.; 2016. [Link]

PMID: 10690128

Tramadol

By

Tramadol

Product: FH535

Identifier : DBSNPE004914
Drug : DB00193 (Tramadol)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • C allele (rs3892097 )

Allele Name : CYP2D6*4
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased risk of opioid toxicity.
References :

  1. Uldivam® (divamadol hydrochloride) tablets[package insert]. Titusville, New Jersey: Janssen Pharmaceuticals, Inc.; 2016. [Link]

PMID: 9491897

Tramadol

By

Tramadol

Product: H-1152 (dihydrochloride)

Identifier : DBSNPE004915
Drug : DB00193 (Tramadol)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • Whole-gene deletion

Allele Name : CYP2D6*5
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased risk of opioid toxicity.
References :

  1. Uldivam® (divamadol hydrochloride) tablets[package insert]. Titusville, New Jersey: Janssen Pharmaceuticals, Inc.; 2016. [Link]

PMID: 28296947

Tramadol

By

Tramadol

Product: H-1152

Identifier : DBSNPE004916
Drug : DB00193 (Tramadol)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 1707delT (rs5030655 )

Allele Name : CYP2D6*6
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased risk of opioid toxicity.
References :

  1. Uldivam® (divamadol hydrochloride) tablets[package insert]. Titusville, New Jersey: Janssen Pharmaceuticals, Inc.; 2016. [Link]

PMID: 26170736

Tramadol

By

Tramadol

Product: XL388

Identifier : DBSNPE004917
Drug : DB00193 (Tramadol)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 2935A>C (rs5030867 )

Allele Name : CYP2D6*7
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased risk of opioid toxicity.
References :

  1. Uldivam® (divamadol hydrochloride) tablets[package insert]. Titusville, New Jersey: Janssen Pharmaceuticals, Inc.; 2016. [Link]

PMID: 21084614

Tramadol

By

Tramadol

Product: Genistein

Identifier : DBSNPE004918
Drug : DB00193 (Tramadol)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 1758G>T (rs5030865 )

Allele Name : CYP2D6*8
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased risk of opioid toxicity.
References :

  1. Uldivam® (divamadol hydrochloride) tablets[package insert]. Titusville, New Jersey: Janssen Pharmaceuticals, Inc.; 2016. [Link]

PMID: 18614159

Tramadol

By

Tramadol

Product: Geniposide

Identifier : DBSNPE004919
Drug : DB00193 (Tramadol)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 883G>C (rs5030863 )

Allele Name : CYP2D6*11
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased risk of opioid toxicity.
References :

  1. Uldivam® (divamadol hydrochloride) tablets[package insert]. Titusville, New Jersey: Janssen Pharmaceuticals, Inc.; 2016. [Link]

PMID: 25552485

Tramadol

By

Tramadol

Product: NU 7026

Identifier : DBSNPE004920
Drug : DB00193 (Tramadol)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 124G>A (rs5030862 )

Allele Name : CYP2D6*12
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased risk of opioid toxicity.
References :

  1. Uldivam® (divamadol hydrochloride) tablets[package insert]. Titusville, New Jersey: Janssen Pharmaceuticals, Inc.; 2016. [Link]

PMID: 19751316

Tramadol

By

Tramadol

Product: Istaroxime

Identifier : DBSNPE004921
Drug : DB00193 (Tramadol)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • CYP2D7/2D6 hybrid gene sdivucture

Allele Name : CYP2D6*13
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased risk of opioid toxicity.
References :

  1. Uldivam® (divamadol hydrochloride) tablets[package insert]. Titusville, New Jersey: Janssen Pharmaceuticals, Inc.; 2016. [Link]

PMID: 25147058

Tramadol

By

Tramadol

Product: CX-6258 (hydrochloride hydrate)

Identifier : DBSNPE004922
Drug : DB00193 (Tramadol)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 1758G>A (rs5030865 )

Allele Name : CYP2D6*14A
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased risk of opioid toxicity.
References :

  1. Uldivam® (divamadol hydrochloride) tablets[package insert]. Titusville, New Jersey: Janssen Pharmaceuticals, Inc.; 2016. [Link]

PMID: 19596018

Tramadol

By

Tramadol

Product: CX-6258

Identifier : DBSNPE004923
Drug : DB00193 (Tramadol)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 137insT, 137_138insT

Allele Name : CYP2D6*15
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased risk of opioid toxicity.
References :

  1. Uldivam® (divamadol hydrochloride) tablets[package insert]. Titusville, New Jersey: Janssen Pharmaceuticals, Inc.; 2016. [Link]

PMID: 26136671

Tramadol

By

Tramadol

Product: GANT 61

Identifier : DBSNPE004924
Drug : DB00193 (Tramadol)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 2539_2542delAACT (rs72549353 )

Allele Name : CYP2D6*19
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased risk of opioid toxicity.
References :

  1. Uldivam® (divamadol hydrochloride) tablets[package insert]. Titusville, New Jersey: Janssen Pharmaceuticals, Inc.; 2016. [Link]

PMID: 25132134

Tramadol

By

Tramadol

Product: Salmeterol (xinafoate)

Identifier : DBSNPE004925
Drug : DB00193 (Tramadol)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 1973_1974insG (rs72549354 )

Allele Name : CYP2D6*20
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased risk of opioid toxicity.
References :

  1. Uldivam® (divamadol hydrochloride) tablets[package insert]. Titusville, New Jersey: Janssen Pharmaceuticals, Inc.; 2016. [Link]

PMID: 10696077

Tramadol

By

Tramadol

Product: RG2833

Identifier : DBSNPE004926
Drug : DB00193 (Tramadol)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 2573insC

Allele Name : CYP2D6*21
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased risk of opioid toxicity.
References :

  1. Uldivam® (divamadol hydrochloride) tablets[package insert]. Titusville, New Jersey: Janssen Pharmaceuticals, Inc.; 2016. [Link]

PMID: 10691680

Tramadol

By

Tramadol

Product: Genz-644282

Identifier : DBSNPE004927
Drug : DB00193 (Tramadol)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • -1770G>A
  • -1584C>G
  • -1235A>G
  • -740C>T
  • -678G>A
  • CYP2D7 gene conversion in indivon 1
  • 310G>T
  • 746C>G
  • 843T>G
  • 1661G>C
  • 2850C>T
  • 3384A>C
  • 3584G>A
  • 3790C>T
  • 4042G>A
  • 4180G>C
  • 4481G>A

Allele Name : CYP2D6*31
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased risk of opioid toxicity.
References :

  1. Uldivam® (divamadol hydrochloride) tablets[package insert]. Titusville, New Jersey: Janssen Pharmaceuticals, Inc.; 2016. [Link]

PMID: 8497455

Tramadol

By

Tramadol

Product: TUG-770

Identifier : DBSNPE004928
Drug : DB00193 (Tramadol)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 100C>T (rs1065852 )
  • -1426C>T
  • variable number of A’s in the region -1258 to -1237a
  • -1235A>G
  • -1000G>A
  • 1039C>T
  • 1661G>C
  • gene conversion to CYP2D7 in exon 9
  • 4180G>C

Allele Name : CYP2D6*36
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased risk of opioid toxicity.
References :

  1. Uldivam® (divamadol hydrochloride) tablets[package insert]. Titusville, New Jersey: Janssen Pharmaceuticals, Inc.; 2016. [Link]

PMID: 9113986

Tramadol

By

Tramadol

Product: Reversine

Identifier : DBSNPE004929
Drug : DB00193 (Tramadol)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 2587_2590delGACT (rs72549351 )

Allele Name : CYP2D6*38
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased risk of opioid toxicity.
References :

  1. Uldivam® (divamadol hydrochloride) tablets[package insert]. Titusville, New Jersey: Janssen Pharmaceuticals, Inc.; 2016. [Link]

PMID: 19220285

Tramadol

By

Tramadol

Product: AZD1080

Identifier : DBSNPE004930
Drug : DB00193 (Tramadol)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 1863_1864ins(TTT CGC CCC)2 (rs72549356 )

Allele Name : CYP2D6*40
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased risk of opioid toxicity.
References :

  1. Uldivam® (divamadol hydrochloride) tablets[package insert]. Titusville, New Jersey: Janssen Pharmaceuticals, Inc.; 2016. [Link]

PMID: 12672231

Tramadol

By

Tramadol

Product: Resminostat (hydrochloride)

Identifier : DBSNPE004931
Drug : DB00193 (Tramadol)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 3259_3260insGT (rs72549346 )

Allele Name : CYP2D6*42
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased risk of opioid toxicity.
References :

  1. Uldivam® (divamadol hydrochloride) tablets[package insert]. Titusville, New Jersey: Janssen Pharmaceuticals, Inc.; 2016. [Link]

PMID: 12401884

Tramadol

By

Tramadol

Product: Resminostat

Identifier : DBSNPE004932
Drug : DB00193 (Tramadol)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 2950G>C

Allele Name : CYP2D6*44
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased risk of opioid toxicity.
References :

  1. Uldivam® (divamadol hydrochloride) tablets[package insert]. Titusville, New Jersey: Janssen Pharmaceuticals, Inc.; 2016. [Link]

PMID: 11587644

Tramadol

By

Tramadol

Product: LY2795050

Identifier : DBSNPE004933
Drug : DB00193 (Tramadol)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 100C>T (rs1065852 )
  • -1426C>T
  • -1235A>G
  • -1000G>A
  • 73C<T
  • 1039C>T
  • 1661G>C
  • 4180G>C

Allele Name : CYP2D6*47
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased risk of opioid toxicity.
References :

  1. Uldivam® (divamadol hydrochloride) tablets[package insert]. Titusville, New Jersey: Janssen Pharmaceuticals, Inc.; 2016. [Link]

PMID: 21043485

Tramadol

By

Tramadol

Product: Capsaicin

Identifier : DBSNPE004934
Drug : DB00193 (Tramadol)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • -1584C>G
  • -1235A>G
  • -740C>T
  • -678G>A
  • CYP2D7 gene conversion in indivon 1
  • 1661G>C
  • 2850C>T
  • 3172A>C
  • 4180G>C

Allele Name : CYP2D6*51
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased risk of opioid toxicity.
References :

  1. Uldivam® (divamadol hydrochloride) tablets[package insert]. Titusville, New Jersey: Janssen Pharmaceuticals, Inc.; 2016. [Link]

PMID: 22633688

Tramadol

By

Tramadol

Product: Bilobalide

Identifier : DBSNPE004935
Drug : DB00193 (Tramadol)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 3201C>T (rs72549347 )

Allele Name : CYP2D6*56
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased risk of opioid toxicity.
References :

  1. Uldivam® (divamadol hydrochloride) tablets[package insert]. Titusville, New Jersey: Janssen Pharmaceuticals, Inc.; 2016. [Link]

PMID: 22460951

Tramadol

By

Tramadol

Product: Ascomycin

Identifier : DBSNPE004936
Drug : DB00193 (Tramadol)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 100C>T
  • 310G>T
  • 843T>G
  • 887C>T
  • 1039C>T
  • 1661G>C
  • 3384A>C
  • 3582A>G
  • gene conversion to CYP2D7 in exon 9
  • 4180G>C

Allele Name : CYP2D6*57
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased risk of opioid toxicity.
References :

  1. Uldivam® (divamadol hydrochloride) tablets[package insert]. Titusville, New Jersey: Janssen Pharmaceuticals, Inc.; 2016. [Link]

PMID: 24171924

Tramadol

By

Tramadol

Product: QNZ

Identifier : DBSNPE004937
Drug : DB00193 (Tramadol)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 4044C>T

Allele Name : CYP2D6*62
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased risk of opioid toxicity.
References :

  1. Uldivam® (divamadol hydrochloride) tablets[package insert]. Titusville, New Jersey: Janssen Pharmaceuticals, Inc.; 2016. [Link]

PMID: 24785407

Tramadol

By

Tramadol

Product: PluriSln 1

Identifier : DBSNPE004938
Drug : DB00193 (Tramadol)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • -1426C>T
  • -1235A>G
  • -1000G>A
  • 100C>T
  • 310G>T
  • CYP2D7 sequence from indivon 1 onwards

Allele Name : CYP2D6*68A
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased risk of opioid toxicity.
References :

  1. Uldivam® (divamadol hydrochloride) tablets[package insert]. Titusville, New Jersey: Janssen Pharmaceuticals, Inc.; 2016. [Link]

PMID: 20033049

Tramadol

By

Tramadol

Product: PR-619

Identifier : DBSNPE004939
Drug : DB00193 (Tramadol)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • Similar but not identical switch region compared to CYP2D6*68A. Found in tandem arrangement with CYP2D6*4.

Allele Name : CYP2D6*68B
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased risk of opioid toxicity.
References :

  1. Uldivam® (divamadol hydrochloride) tablets[package insert]. Titusville, New Jersey: Janssen Pharmaceuticals, Inc.; 2016. [Link]

PMID: 24707347

Tramadol

By

Tramadol

Product: Tenovin-1

Identifier : DBSNPE004940
Drug : DB00193 (Tramadol)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 2988G>A (rs28371725 )
  • -1426C>T
  • -1235A>G
  • -1000G>A
  • 100C>T
  • 310G>T
  • 746C>G
  • 843T>G
  • 1062A>G
  • 1661G>C
  • 2850C>T
  • 3384A>C
  • 3584G>A
  • 3790C>T
  • 4180G>C
  • 4401C>T
  • 4481G>A

Allele Name : CYP2D6*69
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased risk of opioid toxicity.
References :

  1. Uldivam® (divamadol hydrochloride) tablets[package insert]. Titusville, New Jersey: Janssen Pharmaceuticals, Inc.; 2016. [Link]

PMID: 11266181

Tramadol

By

Tramadol

Product: Necrostatin 2

Identifier : DBSNPE004941
Drug : DB00193 (Tramadol)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 1995delC

Allele Name : CYP2D6*92
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased risk of opioid toxicity.
References :

  1. Uldivam® (divamadol hydrochloride) tablets[package insert]. Titusville, New Jersey: Janssen Pharmaceuticals, Inc.; 2016. [Link]

PMID: 23173601

Tramadol

By

Tramadol

Product: Granisetron (Hydrochloride)

Identifier : DBSNPE004942
Drug : DB00193 (Tramadol)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • -1426C>T
  • -1235A>G
  • -1109C>T
  • -1000G>A
  • 100C>T
  • 310G>T
  • 843T>G
  • 1039C>T
  • 1661G>C
  • 2097A>G
  • 2828delC
  • 3384A>C
  • 3582A>G
  • 4180G>C
  • 4401C>T

Allele Name : CYP2D6*100
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased risk of opioid toxicity.
References :

  1. Uldivam® (divamadol hydrochloride) tablets[package insert]. Titusville, New Jersey: Janssen Pharmaceuticals, Inc.; 2016. [Link]

PMID: 23589487

Tramadol

By

Tramadol

Product: Granisetron

Identifier : DBSNPE004943
Drug : DB00193 (Tramadol)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • -1426C>T
  • -1235A>G
  • -1000G>A
  • 100C>T
  • 310G>T
  • 843T>G
  • 1039C>T
  • 1661G>C
  • 2097A>G
  • 2927_2945delGATCCTACATCCGGATGTG
  • 3384A>C
  • 3582A>G
  • 4180G>C
  • 4401C>T

Allele Name : CYP2D6*101
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased risk of opioid toxicity.
References :

  1. Uldivam® (divamadol hydrochloride) tablets[package insert]. Titusville, New Jersey: Janssen Pharmaceuticals, Inc.; 2016. [Link]

PMID: 11205420

Tramadol

By

Tramadol

Product: CX-6258

Identifier : DBSNPE004923
Drug : DB00193 (Tramadol)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 137insT, 137_138insT

Allele Name : CYP2D6*15
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased risk of opioid toxicity.
References :

  1. Uldivam® (divamadol hydrochloride) tablets[package insert]. Titusville, New Jersey: Janssen Pharmaceuticals, Inc.; 2016. [Link]

PMID: 26136671

Tramadol

By

Tramadol

Product: GANT 61

Identifier : DBSNPE004924
Drug : DB00193 (Tramadol)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 2539_2542delAACT (rs72549353 )

Allele Name : CYP2D6*19
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased risk of opioid toxicity.
References :

  1. Uldivam® (divamadol hydrochloride) tablets[package insert]. Titusville, New Jersey: Janssen Pharmaceuticals, Inc.; 2016. [Link]

PMID: 25132134

Tramadol

By

Tramadol

Product: Salmeterol (xinafoate)

Identifier : DBSNPE004925
Drug : DB00193 (Tramadol)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 1973_1974insG (rs72549354 )

Allele Name : CYP2D6*20
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased risk of opioid toxicity.
References :

  1. Uldivam® (divamadol hydrochloride) tablets[package insert]. Titusville, New Jersey: Janssen Pharmaceuticals, Inc.; 2016. [Link]

PMID: 10696077

Tramadol

By

Tramadol

Product: RG2833

Identifier : DBSNPE004926
Drug : DB00193 (Tramadol)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 2573insC

Allele Name : CYP2D6*21
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased risk of opioid toxicity.
References :

  1. Uldivam® (divamadol hydrochloride) tablets[package insert]. Titusville, New Jersey: Janssen Pharmaceuticals, Inc.; 2016. [Link]

PMID: 10691680

Tramadol

By

Tramadol

Product: Genz-644282

Identifier : DBSNPE004927
Drug : DB00193 (Tramadol)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • -1770G>A
  • -1584C>G
  • -1235A>G
  • -740C>T
  • -678G>A
  • CYP2D7 gene conversion in indivon 1
  • 310G>T
  • 746C>G
  • 843T>G
  • 1661G>C
  • 2850C>T
  • 3384A>C
  • 3584G>A
  • 3790C>T
  • 4042G>A
  • 4180G>C
  • 4481G>A

Allele Name : CYP2D6*31
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased risk of opioid toxicity.
References :

  1. Uldivam® (divamadol hydrochloride) tablets[package insert]. Titusville, New Jersey: Janssen Pharmaceuticals, Inc.; 2016. [Link]

PMID: 8497455

Tramadol

By

Tramadol

Product: TUG-770

Identifier : DBSNPE004928
Drug : DB00193 (Tramadol)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 100C>T (rs1065852 )
  • -1426C>T
  • variable number of A’s in the region -1258 to -1237a
  • -1235A>G
  • -1000G>A
  • 1039C>T
  • 1661G>C
  • gene conversion to CYP2D7 in exon 9
  • 4180G>C

Allele Name : CYP2D6*36
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased risk of opioid toxicity.
References :

  1. Uldivam® (divamadol hydrochloride) tablets[package insert]. Titusville, New Jersey: Janssen Pharmaceuticals, Inc.; 2016. [Link]

PMID: 9113986

Tramadol

By

Tramadol

Product: Reversine

Identifier : DBSNPE004929
Drug : DB00193 (Tramadol)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 2587_2590delGACT (rs72549351 )

Allele Name : CYP2D6*38
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased risk of opioid toxicity.
References :

  1. Uldivam® (divamadol hydrochloride) tablets[package insert]. Titusville, New Jersey: Janssen Pharmaceuticals, Inc.; 2016. [Link]

PMID: 19220285

Tramadol

By

Tramadol

Product: AZD1080

Identifier : DBSNPE004930
Drug : DB00193 (Tramadol)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 1863_1864ins(TTT CGC CCC)2 (rs72549356 )

Allele Name : CYP2D6*40
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased risk of opioid toxicity.
References :

  1. Uldivam® (divamadol hydrochloride) tablets[package insert]. Titusville, New Jersey: Janssen Pharmaceuticals, Inc.; 2016. [Link]

PMID: 12672231

Tramadol

By

Tramadol

Product: Resminostat (hydrochloride)

Identifier : DBSNPE004931
Drug : DB00193 (Tramadol)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 3259_3260insGT (rs72549346 )

Allele Name : CYP2D6*42
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased risk of opioid toxicity.
References :

  1. Uldivam® (divamadol hydrochloride) tablets[package insert]. Titusville, New Jersey: Janssen Pharmaceuticals, Inc.; 2016. [Link]

PMID: 12401884

Tramadol

By

Tramadol

Product: Resminostat

Identifier : DBSNPE004932
Drug : DB00193 (Tramadol)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 2950G>C

Allele Name : CYP2D6*44
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased risk of opioid toxicity.
References :

  1. Uldivam® (divamadol hydrochloride) tablets[package insert]. Titusville, New Jersey: Janssen Pharmaceuticals, Inc.; 2016. [Link]

PMID: 11587644

Tramadol

By

Tramadol

Product: LY2795050

Identifier : DBSNPE004933
Drug : DB00193 (Tramadol)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 100C>T (rs1065852 )
  • -1426C>T
  • -1235A>G
  • -1000G>A
  • 73C<T
  • 1039C>T
  • 1661G>C
  • 4180G>C

Allele Name : CYP2D6*47
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased risk of opioid toxicity.
References :

  1. Uldivam® (divamadol hydrochloride) tablets[package insert]. Titusville, New Jersey: Janssen Pharmaceuticals, Inc.; 2016. [Link]

PMID: 21043485

Tramadol

By

Tramadol

Product: Capsaicin

Identifier : DBSNPE004934
Drug : DB00193 (Tramadol)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • -1584C>G
  • -1235A>G
  • -740C>T
  • -678G>A
  • CYP2D7 gene conversion in indivon 1
  • 1661G>C
  • 2850C>T
  • 3172A>C
  • 4180G>C

Allele Name : CYP2D6*51
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased risk of opioid toxicity.
References :

  1. Uldivam® (divamadol hydrochloride) tablets[package insert]. Titusville, New Jersey: Janssen Pharmaceuticals, Inc.; 2016. [Link]

PMID: 22633688

Tramadol

By

Tramadol

Product: Bilobalide

Identifier : DBSNPE004935
Drug : DB00193 (Tramadol)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 3201C>T (rs72549347 )

Allele Name : CYP2D6*56
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased risk of opioid toxicity.
References :

  1. Uldivam® (divamadol hydrochloride) tablets[package insert]. Titusville, New Jersey: Janssen Pharmaceuticals, Inc.; 2016. [Link]

PMID: 22460951

Tramadol

By

Tramadol

Product: Ascomycin

Identifier : DBSNPE004936
Drug : DB00193 (Tramadol)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 100C>T
  • 310G>T
  • 843T>G
  • 887C>T
  • 1039C>T
  • 1661G>C
  • 3384A>C
  • 3582A>G
  • gene conversion to CYP2D7 in exon 9
  • 4180G>C

Allele Name : CYP2D6*57
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased risk of opioid toxicity.
References :

  1. Uldivam® (divamadol hydrochloride) tablets[package insert]. Titusville, New Jersey: Janssen Pharmaceuticals, Inc.; 2016. [Link]

PMID: 24171924

Tramadol

By

Tramadol

Product: QNZ

Identifier : DBSNPE004937
Drug : DB00193 (Tramadol)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 4044C>T

Allele Name : CYP2D6*62
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased risk of opioid toxicity.
References :

  1. Uldivam® (divamadol hydrochloride) tablets[package insert]. Titusville, New Jersey: Janssen Pharmaceuticals, Inc.; 2016. [Link]

PMID: 24785407

Tramadol

By

Tramadol

Product: PluriSln 1

Identifier : DBSNPE004938
Drug : DB00193 (Tramadol)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • -1426C>T
  • -1235A>G
  • -1000G>A
  • 100C>T
  • 310G>T
  • CYP2D7 sequence from indivon 1 onwards

Allele Name : CYP2D6*68A
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased risk of opioid toxicity.
References :

  1. Uldivam® (divamadol hydrochloride) tablets[package insert]. Titusville, New Jersey: Janssen Pharmaceuticals, Inc.; 2016. [Link]

PMID: 20033049

Tramadol

By

Tramadol

Product: PR-619

Identifier : DBSNPE004939
Drug : DB00193 (Tramadol)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • Similar but not identical switch region compared to CYP2D6*68A. Found in tandem arrangement with CYP2D6*4.

Allele Name : CYP2D6*68B
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased risk of opioid toxicity.
References :

  1. Uldivam® (divamadol hydrochloride) tablets[package insert]. Titusville, New Jersey: Janssen Pharmaceuticals, Inc.; 2016. [Link]

PMID: 24707347

Tramadol

By

Tramadol

Product: Tenovin-1

Identifier : DBSNPE004940
Drug : DB00193 (Tramadol)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 2988G>A (rs28371725 )
  • -1426C>T
  • -1235A>G
  • -1000G>A
  • 100C>T
  • 310G>T
  • 746C>G
  • 843T>G
  • 1062A>G
  • 1661G>C
  • 2850C>T
  • 3384A>C
  • 3584G>A
  • 3790C>T
  • 4180G>C
  • 4401C>T
  • 4481G>A

Allele Name : CYP2D6*69
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased risk of opioid toxicity.
References :

  1. Uldivam® (divamadol hydrochloride) tablets[package insert]. Titusville, New Jersey: Janssen Pharmaceuticals, Inc.; 2016. [Link]

PMID: 11266181

Tramadol

By

Tramadol

Product: Necrostatin 2

Identifier : DBSNPE004941
Drug : DB00193 (Tramadol)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 1995delC

Allele Name : CYP2D6*92
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased risk of opioid toxicity.
References :

  1. Uldivam® (divamadol hydrochloride) tablets[package insert]. Titusville, New Jersey: Janssen Pharmaceuticals, Inc.; 2016. [Link]

PMID: 23173601

Tramadol

By

Tramadol

Product: Granisetron (Hydrochloride)

Identifier : DBSNPE004942
Drug : DB00193 (Tramadol)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • -1426C>T
  • -1235A>G
  • -1109C>T
  • -1000G>A
  • 100C>T
  • 310G>T
  • 843T>G
  • 1039C>T
  • 1661G>C
  • 2097A>G
  • 2828delC
  • 3384A>C
  • 3582A>G
  • 4180G>C
  • 4401C>T

Allele Name : CYP2D6*100
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased risk of opioid toxicity.
References :

  1. Uldivam® (divamadol hydrochloride) tablets[package insert]. Titusville, New Jersey: Janssen Pharmaceuticals, Inc.; 2016. [Link]

PMID: 23589487

Tramadol

By

Tramadol

Product: Granisetron

Identifier : DBSNPE004943
Drug : DB00193 (Tramadol)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • -1426C>T
  • -1235A>G
  • -1000G>A
  • 100C>T
  • 310G>T
  • 843T>G
  • 1039C>T
  • 1661G>C
  • 2097A>G
  • 2927_2945delGATCCTACATCCGGATGTG
  • 3384A>C
  • 3582A>G
  • 4180G>C
  • 4401C>T

Allele Name : CYP2D6*101
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased risk of opioid toxicity.
References :

  1. Uldivam® (divamadol hydrochloride) tablets[package insert]. Titusville, New Jersey: Janssen Pharmaceuticals, Inc.; 2016. [Link]

PMID: 11205420

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