PI3KInhibitorpi3kinhibitor

Thioridazine

By

Thioridazine

Product: Impurity B of Calcitriol

Identifier : DBSNPE004838
Drug : DB00679 (Thioridazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • C allele (rs35742686 )

Allele Name : CYP2D6*3
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Reduced CYP2D6 activity associated with Torsades de pointes and/or sudden death.
References :

  1. Thioridazine Hydrochloride[package insert]. Morgantown, West Virginia: MYLAN PHARMACEUTICALS INC.; 2016. [Link]

PMID: 10188961

Thioridazine

By

Thioridazine

Product: Org 27569

Identifier : DBSNPE004839
Drug : DB00679 (Thioridazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • C allele (rs3892097 )

Allele Name : CYP2D6*4
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Reduced CYP2D6 activity associated with Torsades de pointes and/or sudden death.
References :

  1. Thioridazine Hydrochloride[package insert]. Morgantown, West Virginia: MYLAN PHARMACEUTICALS INC.; 2016. [Link]

PMID: 10998548

Thioridazine

By

Thioridazine

Product: Ki16425

Identifier : DBSNPE004840
Drug : DB00679 (Thioridazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • Whole-gene deletion

Allele Name : CYP2D6*5
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Reduced CYP2D6 activity associated with Torsades de pointes and/or sudden death.
References :

  1. Thioridazine Hydrochloride[package insert]. Morgantown, West Virginia: MYLAN PHARMACEUTICALS INC.; 2016. [Link]

PMID: 10556929

Thioridazine

By

Thioridazine

Product: MK-6892

Identifier : DBSNPE004841
Drug : DB00679 (Thioridazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 1707delT (rs5030655 )

Allele Name : CYP2D6*6
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Reduced CYP2D6 activity associated with Torsades de pointes and/or sudden death.
References :

  1. Thioridazine Hydrochloride[package insert]. Morgantown, West Virginia: MYLAN PHARMACEUTICALS INC.; 2016. [Link]

PMID: 8978746

Thioridazine

By

Thioridazine

Product: Asenapine

Identifier : DBSNPE004842
Drug : DB00679 (Thioridazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 2935A>C (rs5030867 )

Allele Name : CYP2D6*7
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Reduced CYP2D6 activity associated with Torsades de pointes and/or sudden death.
References :

  1. Thioridazine Hydrochloride[package insert]. Morgantown, West Virginia: MYLAN PHARMACEUTICALS INC.; 2016. [Link]

PMID: 10622282

Thioridazine

By

Thioridazine

Product: Tipiracil (hydrochloride)

Identifier : DBSNPE004843
Drug : DB00679 (Thioridazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 1758G>T (rs5030865 )

Allele Name : CYP2D6*8
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Reduced CYP2D6 activity associated with Torsades de pointes and/or sudden death.
References :

  1. Thioridazine Hydrochloride[package insert]. Morgantown, West Virginia: MYLAN PHARMACEUTICALS INC.; 2016. [Link]

PMID: 9106751

Thioridazine

By

Thioridazine

Product: Gabapentin (hydrochloride)

Identifier : DBSNPE004844
Drug : DB00679 (Thioridazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 883G>C (rs5030863 )

Allele Name : CYP2D6*11
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Reduced CYP2D6 activity associated with Torsades de pointes and/or sudden death.
References :

  1. Thioridazine Hydrochloride[package insert]. Morgantown, West Virginia: MYLAN PHARMACEUTICALS INC.; 2016. [Link]

PMID: 22308478

Thioridazine

By

Thioridazine

Product: Nifuratel

Identifier : DBSNPE004845
Drug : DB00679 (Thioridazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 124G>A (rs5030862 )

Allele Name : CYP2D6*12
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Reduced CYP2D6 activity associated with Torsades de pointes and/or sudden death.
References :

  1. Thioridazine Hydrochloride[package insert]. Morgantown, West Virginia: MYLAN PHARMACEUTICALS INC.; 2016. [Link]

PMID: 8700116

Thioridazine

By

Thioridazine

Product: LCL161

Identifier : DBSNPE004846
Drug : DB00679 (Thioridazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • CYP2D7/2D6 hybrid gene sdivucture

Allele Name : CYP2D6*13
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Reduced CYP2D6 activity associated with Torsades de pointes and/or sudden death.
References :

  1. Thioridazine Hydrochloride[package insert]. Morgantown, West Virginia: MYLAN PHARMACEUTICALS INC.; 2016. [Link]

PMID: 1321958

Thioridazine

By

Thioridazine

Product: RGFP966

Identifier : DBSNPE004847
Drug : DB00679 (Thioridazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 1758G>A (rs5030865 )

Allele Name : CYP2D6*14A
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Reduced CYP2D6 activity associated with Torsades de pointes and/or sudden death.
References :

  1. Thioridazine Hydrochloride[package insert]. Morgantown, West Virginia: MYLAN PHARMACEUTICALS INC.; 2016. [Link]

PMID: 8133899

Thioridazine

By

Thioridazine

Product: ONX-0914

Identifier : DBSNPE004848
Drug : DB00679 (Thioridazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 137insT, 137_138insT

Allele Name : CYP2D6*15
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Reduced CYP2D6 activity associated with Torsades de pointes and/or sudden death.
References :

  1. Thioridazine Hydrochloride[package insert]. Morgantown, West Virginia: MYLAN PHARMACEUTICALS INC.; 2016. [Link]

PMID: 2234096

Thioridazine

By

Thioridazine

Product: Delanzomib

Identifier : DBSNPE004849
Drug : DB00679 (Thioridazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 2539_2542delAACT (rs72549353 )

Allele Name : CYP2D6*19
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Reduced CYP2D6 activity associated with Torsades de pointes and/or sudden death.
References :

  1. Thioridazine Hydrochloride[package insert]. Morgantown, West Virginia: MYLAN PHARMACEUTICALS INC.; 2016. [Link]

PMID: 3698092

Thioridazine

By

Thioridazine

Product: Clozapine (N-oxide)

Identifier : DBSNPE004850
Drug : DB00679 (Thioridazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 1973_1974insG (rs72549354 )

Allele Name : CYP2D6*20
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Reduced CYP2D6 activity associated with Torsades de pointes and/or sudden death.
References :

  1. Thioridazine Hydrochloride[package insert]. Morgantown, West Virginia: MYLAN PHARMACEUTICALS INC.; 2016. [Link]

PMID: 10457188

Thioridazine

By

Thioridazine

Product: Azaphen (dihydrochloride monohydrate)

Identifier : DBSNPE004851
Drug : DB00679 (Thioridazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 2573insC

Allele Name : CYP2D6*21
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Reduced CYP2D6 activity associated with Torsades de pointes and/or sudden death.
References :

  1. Thioridazine Hydrochloride[package insert]. Morgantown, West Virginia: MYLAN PHARMACEUTICALS INC.; 2016. [Link]

PMID: 3663239

Thioridazine

By

Thioridazine

Product: AG-1478

Identifier : DBSNPE004852
Drug : DB00679 (Thioridazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • -1770G>A
  • -1584C>G
  • -1235A>G
  • -740C>T
  • -678G>A
  • CYP2D7 gene conversion in indivon 1
  • 310G>T
  • 746C>G
  • 843T>G
  • 1661G>C
  • 2850C>T
  • 3384A>C
  • 3584G>A
  • 3790C>T
  • 4042G>A
  • 4180G>C
  • 4481G>A

Allele Name : CYP2D6*31
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Reduced CYP2D6 activity associated with Torsades de pointes and/or sudden death.
References :

  1. Thioridazine Hydrochloride[package insert]. Morgantown, West Virginia: MYLAN PHARMACEUTICALS INC.; 2016. [Link]

PMID: 10781694

Thioridazine

By

Thioridazine

Product: Trifluorothymidine

Identifier : DBSNPE004853
Drug : DB00679 (Thioridazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 100C>T (rs1065852 )
  • -1426C>T
  • variable number of A’s in the region -1258 to -1237a
  • -1235A>G
  • -1000G>A
  • 1039C>T
  • 1661G>C
  • gene conversion to CYP2D7 in exon 9
  • 4180G>C

Allele Name : CYP2D6*36
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Reduced CYP2D6 activity associated with Torsades de pointes and/or sudden death.
References :

  1. Thioridazine Hydrochloride[package insert]. Morgantown, West Virginia: MYLAN PHARMACEUTICALS INC.; 2016. [Link]

PMID: 1407003

Thioridazine

By

Thioridazine

Product: Hydroxyfasudil (hydrochloride)

Identifier : DBSNPE004854
Drug : DB00679 (Thioridazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 2587_2590delGACT (rs72549351 )

Allele Name : CYP2D6*38
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Reduced CYP2D6 activity associated with Torsades de pointes and/or sudden death.
References :

  1. Thioridazine Hydrochloride[package insert]. Morgantown, West Virginia: MYLAN PHARMACEUTICALS INC.; 2016. [Link]

PMID: 1732528

Thioridazine

By

Thioridazine

Product: Hydroxyfasudil

Identifier : DBSNPE004855
Drug : DB00679 (Thioridazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 1863_1864ins(TTT CGC CCC)2 (rs72549356 )

Allele Name : CYP2D6*40
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Reduced CYP2D6 activity associated with Torsades de pointes and/or sudden death.
References :

  1. Thioridazine Hydrochloride[package insert]. Morgantown, West Virginia: MYLAN PHARMACEUTICALS INC.; 2016. [Link]

PMID: 2412048

Thioridazine

By

Thioridazine

Product: Docetaxel (Trihydrate)

Identifier : DBSNPE004856
Drug : DB00679 (Thioridazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 3259_3260insGT (rs72549346 )

Allele Name : CYP2D6*42
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Reduced CYP2D6 activity associated with Torsades de pointes and/or sudden death.
References :

  1. Thioridazine Hydrochloride[package insert]. Morgantown, West Virginia: MYLAN PHARMACEUTICALS INC.; 2016. [Link]

PMID: 2860558

Thioridazine

By

Thioridazine

Product: Ivacaftor (hydrate)

Identifier : DBSNPE004857
Drug : DB00679 (Thioridazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 2950G>C

Allele Name : CYP2D6*44
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Reduced CYP2D6 activity associated with Torsades de pointes and/or sudden death.
References :

  1. Thioridazine Hydrochloride[package insert]. Morgantown, West Virginia: MYLAN PHARMACEUTICALS INC.; 2016. [Link]

PMID: 9178649

Thioridazine

By

Thioridazine

Product: Ivacaftor (benzenesulfonate)

Identifier : DBSNPE004858
Drug : DB00679 (Thioridazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 100C>T (rs1065852 )
  • -1426C>T
  • -1235A>G
  • -1000G>A
  • 73C<T
  • 1039C>T
  • 1661G>C
  • 4180G>C

Allele Name : CYP2D6*47
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Reduced CYP2D6 activity associated with Torsades de pointes and/or sudden death.
References :

  1. Thioridazine Hydrochloride[package insert]. Morgantown, West Virginia: MYLAN PHARMACEUTICALS INC.; 2016. [Link]

PMID: 9439826

Thioridazine

By

Thioridazine

Product: Malotilate

Identifier : DBSNPE004859
Drug : DB00679 (Thioridazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • -1584C>G
  • -1235A>G
  • -740C>T
  • -678G>A
  • CYP2D7 gene conversion in indivon 1
  • 1661G>C
  • 2850C>T
  • 3172A>C
  • 4180G>C

Allele Name : CYP2D6*51
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Reduced CYP2D6 activity associated with Torsades de pointes and/or sudden death.
References :

  1. Thioridazine Hydrochloride[package insert]. Morgantown, West Virginia: MYLAN PHARMACEUTICALS INC.; 2016. [Link]

PMID: 8735640

Thioridazine

By

Thioridazine

Product: Masitinib (mesylate)

Identifier : DBSNPE004860
Drug : DB00679 (Thioridazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 3201C>T (rs72549347 )

Allele Name : CYP2D6*56
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Reduced CYP2D6 activity associated with Torsades de pointes and/or sudden death.
References :

  1. Thioridazine Hydrochloride[package insert]. Morgantown, West Virginia: MYLAN PHARMACEUTICALS INC.; 2016. [Link]

PMID: 11526979

Thioridazine

By

Thioridazine

Product: Vandetanib (hydrochloride)

Identifier : DBSNPE004861
Drug : DB00679 (Thioridazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 100C>T
  • 310G>T
  • 843T>G
  • 887C>T
  • 1039C>T
  • 1661G>C
  • 3384A>C
  • 3582A>G
  • gene conversion to CYP2D7 in exon 9
  • 4180G>C

Allele Name : CYP2D6*57
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Reduced CYP2D6 activity associated with Torsades de pointes and/or sudden death.
References :

  1. Thioridazine Hydrochloride[package insert]. Morgantown, West Virginia: MYLAN PHARMACEUTICALS INC.; 2016. [Link]

PMID: 7260485

Thioridazine

By

Thioridazine

Product: Vandetanib (trifluoroacetate)

Identifier : DBSNPE004862
Drug : DB00679 (Thioridazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 4044C>T

Allele Name : CYP2D6*62
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Reduced CYP2D6 activity associated with Torsades de pointes and/or sudden death.
References :

  1. Thioridazine Hydrochloride[package insert]. Morgantown, West Virginia: MYLAN PHARMACEUTICALS INC.; 2016. [Link]

PMID: 25262373

Thioridazine

By

Thioridazine

Product: Sorafenib

Identifier : DBSNPE004863
Drug : DB00679 (Thioridazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • -1426C>T
  • -1235A>G
  • -1000G>A
  • 100C>T
  • 310G>T
  • CYP2D7 sequence from indivon 1 onwards

Allele Name : CYP2D6*68A
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Reduced CYP2D6 activity associated with Torsades de pointes and/or sudden death.
References :

  1. Thioridazine Hydrochloride[package insert]. Morgantown, West Virginia: MYLAN PHARMACEUTICALS INC.; 2016. [Link]

PMID: 25066302

Thioridazine

By

Thioridazine

Product: Lenalidomide (hydrochloride)

Identifier : DBSNPE004864
Drug : DB00679 (Thioridazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • Similar but not identical switch region compared to CYP2D6*68A. Found in tandem arrangement with CYP2D6*4.

Allele Name : CYP2D6*68B
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Reduced CYP2D6 activity associated with Torsades de pointes and/or sudden death.
References :

  1. Thioridazine Hydrochloride[package insert]. Morgantown, West Virginia: MYLAN PHARMACEUTICALS INC.; 2016. [Link]

PMID: 20179192

Thioridazine

By

Thioridazine

Product: Gefitinib (hydrochloride)

Identifier : DBSNPE004865
Drug : DB00679 (Thioridazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 2988G>A (rs28371725 )
  • -1426C>T
  • -1235A>G
  • -1000G>A
  • 100C>T
  • 310G>T
  • 746C>G
  • 843T>G
  • 1062A>G
  • 1661G>C
  • 2850C>T
  • 3384A>C
  • 3584G>A
  • 3790C>T
  • 4180G>C
  • 4401C>T
  • 4481G>A

Allele Name : CYP2D6*69
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Reduced CYP2D6 activity associated with Torsades de pointes and/or sudden death.
References :

  1. Thioridazine Hydrochloride[package insert]. Morgantown, West Virginia: MYLAN PHARMACEUTICALS INC.; 2016. [Link]

PMID: 18387175

Thioridazine

By

Thioridazine

Product: Erlotinib (mesylate)

Identifier : DBSNPE004866
Drug : DB00679 (Thioridazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 1995delC

Allele Name : CYP2D6*92
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Reduced CYP2D6 activity associated with Torsades de pointes and/or sudden death.
References :

  1. Thioridazine Hydrochloride[package insert]. Morgantown, West Virginia: MYLAN PHARMACEUTICALS INC.; 2016. [Link]

PMID: 15095008

Thioridazine

By

Thioridazine

Product: Dasatinib (hydrochloride)

Identifier : DBSNPE004867
Drug : DB00679 (Thioridazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • -1426C>T
  • -1235A>G
  • -1109C>T
  • -1000G>A
  • 100C>T
  • 310G>T
  • 843T>G
  • 1039C>T
  • 1661G>C
  • 2097A>G
  • 2828delC
  • 3384A>C
  • 3582A>G
  • 4180G>C
  • 4401C>T

Allele Name : CYP2D6*100
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Reduced CYP2D6 activity associated with Torsades de pointes and/or sudden death.
References :

  1. Thioridazine Hydrochloride[package insert]. Morgantown, West Virginia: MYLAN PHARMACEUTICALS INC.; 2016. [Link]

PMID: 1356551

Thioridazine

By

Thioridazine

Product: PND-1186

Identifier : DBSNPE004868
Drug : DB00679 (Thioridazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • -1426C>T
  • -1235A>G
  • -1000G>A
  • 100C>T
  • 310G>T
  • 843T>G
  • 1039C>T
  • 1661G>C
  • 2097A>G
  • 2927_2945delGATCCTACATCCGGATGTG
  • 3384A>C
  • 3582A>G
  • 4180G>C
  • 4401C>T

Allele Name : CYP2D6*101
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Reduced CYP2D6 activity associated with Torsades de pointes and/or sudden death.
References :

  1. Thioridazine Hydrochloride[package insert]. Morgantown, West Virginia: MYLAN PHARMACEUTICALS INC.; 2016. [Link]

PMID: 15685201

Thioridazine

By

Thioridazine

Product: SB-505124 (hydrochloride)

Identifier : DBSNPE004869
Drug : DB00679 (Thioridazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 2615-2617delAAG (rs5030656 )

Allele Name : CYP2D6*9
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Decreased CYP2D6
Description : Reduced CYP2D6 activity associated with Torsades de pointes and/or sudden death.
References :

  1. Thioridazine Hydrochloride[package insert]. Morgantown, West Virginia: MYLAN PHARMACEUTICALS INC.; 2016. [Link]

PMID: 3656113

Thioridazine

By

Thioridazine

Product: SB-505124

Identifier : DBSNPE004870
Drug : DB00679 (Thioridazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 100C>T (rs1065852 )
  • 1661G>C
  • 4180G>C

Allele Name : CYP2D6*10
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Decreased CYP2D6
Description : Reduced CYP2D6 activity associated with Torsades de pointes and/or sudden death.
References :

  1. Thioridazine Hydrochloride[package insert]. Morgantown, West Virginia: MYLAN PHARMACEUTICALS INC.; 2016. [Link]

PMID: 2883298

Thioridazine

By

Thioridazine

Product: Vinorelbine (ditartrate)

Identifier : DBSNPE004871
Drug : DB00679 (Thioridazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 1758G>A (rs5030865 )

Allele Name : CYP2D6*14B
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Decreased CYP2D6
Description : Reduced CYP2D6 activity associated with Torsades de pointes and/or sudden death.
References :

  1. Thioridazine Hydrochloride[package insert]. Morgantown, West Virginia: MYLAN PHARMACEUTICALS INC.; 2016. [Link]

PMID: 10073321

Thioridazine

By

Thioridazine

Product: Etimizol

Identifier : DBSNPE004872
Drug : DB00679 (Thioridazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 1023C>T (rs28371706 )
  • 2850C>T (rs16947 )

Allele Name : CYP2D6*17
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Decreased CYP2D6
Description : Reduced CYP2D6 activity associated with Torsades de pointes and/or sudden death.
References :

  1. Thioridazine Hydrochloride[package insert]. Morgantown, West Virginia: MYLAN PHARMACEUTICALS INC.; 2016. [Link]

PMID: 11784301

Thioridazine

By

Thioridazine

Product: SN-38

Identifier : DBSNPE004873
Drug : DB00679 (Thioridazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 4133dupGTGCCCACT

Allele Name : CYP2D6*18
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Decreased CYP2D6
Description : Reduced CYP2D6 activity associated with Torsades de pointes and/or sudden death.
References :

  1. Thioridazine Hydrochloride[package insert]. Morgantown, West Virginia: MYLAN PHARMACEUTICALS INC.; 2016. [Link]

PMID: 8025903

Thioridazine

By

Thioridazine

Product: IWP-2

Identifier : DBSNPE004874
Drug : DB00679 (Thioridazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 1659G>A
  • 1661G>C
  • 2850C>T
  • 3183G>A
  • 4180G>C

Allele Name : CYP2D6*29
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Decreased CYP2D6
Description : Reduced CYP2D6 activity associated with Torsades de pointes and/or sudden death.
References :

  1. Thioridazine Hydrochloride[package insert]. Morgantown, West Virginia: MYLAN PHARMACEUTICALS INC.; 2016. [Link]

PMID: 2779359

Thioridazine

By

Thioridazine

Product: Sildenafil

Identifier : DBSNPE004875
Drug : DB00679 (Thioridazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 2988G>A (rs28371725 )

Allele Name : CYP2D6*41
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Decreased CYP2D6
Description : Reduced CYP2D6 activity associated with Torsades de pointes and/or sudden death.
References :

  1. Thioridazine Hydrochloride[package insert]. Morgantown, West Virginia: MYLAN PHARMACEUTICALS INC.; 2016. [Link]

PMID: 26056314

Thioridazine

By

Thioridazine

Product: Sildenafil (citrate)

Identifier : DBSNPE004876
Drug : DB00679 (Thioridazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 100C>T (rs1065852 )
  • -1426C>T
  • -1235A>G
  • -1000G>A
  • 1039C>T
  • 1611T>A
  • 1661G>C
  • 4180G>C

Allele Name : CYP2D6*49
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Decreased CYP2D6
Description : Reduced CYP2D6 activity associated with Torsades de pointes and/or sudden death.
References :

  1. Thioridazine Hydrochloride[package insert]. Morgantown, West Virginia: MYLAN PHARMACEUTICALS INC.; 2016. [Link]

PMID: 10758091

Thioridazine

By

Thioridazine

Product: Noopept

Identifier : DBSNPE004877
Drug : DB00679 (Thioridazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 1720A>C

Allele Name : CYP2D6*50
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Decreased CYP2D6
Description : Reduced CYP2D6 activity associated with Torsades de pointes and/or sudden death.
References :

  1. Thioridazine Hydrochloride[package insert]. Morgantown, West Virginia: MYLAN PHARMACEUTICALS INC.; 2016. [Link]

PMID: 2257444

Thioridazine

By

Thioridazine

Product: Phenylpiracetam

Identifier : DBSNPE004878
Drug : DB00679 (Thioridazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 100C>T
  • 1039C>T
  • 1661G>C
  • 2556C>T
  • 4180G>C

Allele Name : CYP2D6*54
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Decreased CYP2D6
Description : Reduced CYP2D6 activity associated with Torsades de pointes and/or sudden death.
References :

  1. Thioridazine Hydrochloride[package insert]. Morgantown, West Virginia: MYLAN PHARMACEUTICALS INC.; 2016. [Link]

PMID: 2713675

Thioridazine

By

Thioridazine

Product: Pramiracetam

Identifier : DBSNPE004879
Drug : DB00679 (Thioridazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 1661G>C
  • 2850C>T
  • 3790C>T
  • 3835A>C
  • 4180G>C

Allele Name : CYP2D6*55
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Decreased CYP2D6
Description : Reduced CYP2D6 activity associated with Torsades de pointes and/or sudden death.
References :

  1. Thioridazine Hydrochloride[package insert]. Morgantown, West Virginia: MYLAN PHARMACEUTICALS INC.; 2016. [Link]

PMID: 2289527

Thioridazine

By

Thioridazine

Product: Capsazepine

Identifier : DBSNPE004880
Drug : DB00679 (Thioridazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 1661G>C
  • 2291G>A
  • 2850C>T
  • 2939G>A
  • 4180G>C

Allele Name : CYP2D6*59
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Decreased CYP2D6
Description : Reduced CYP2D6 activity associated with Torsades de pointes and/or sudden death.
References :

  1. Thioridazine Hydrochloride[package insert]. Morgantown, West Virginia: MYLAN PHARMACEUTICALS INC.; 2016. [Link]

PMID: 3427281

Thioridazine

By

Thioridazine

Product: Letermovir

Identifier : DBSNPE004881
Drug : DB00679 (Thioridazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • -1426C>T
  • -1235A>G
  • -1000G>A
  • 100C>T
  • 310G>T
  • 843T>G
  • 1039C>T
  • 1661G>C
  • 2097A>G
  • 3318G>A
  • 3384A>C
  • 3582A>G
  • 4180G>C
  • 4401C>T

Allele Name : CYP2D6*72
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Decreased CYP2D6
Description : Reduced CYP2D6 activity associated with Torsades de pointes and/or sudden death.
References :

  1. Thioridazine Hydrochloride[package insert]. Morgantown, West Virginia: MYLAN PHARMACEUTICALS INC.; 2016. [Link]

PMID: 10525104

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