PI3KInhibitorpi3kinhibitor

Tetrabenazine

By

Tetrabenazine

Product: StemRegenin 1

Identifier : DBSNPE004807
Drug : DB04844 (Tedivabenazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • C allele (rs35742686 )

Allele Name : CYP2D6*3
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Xenazine® (tedivabenazine) tablets[package insert]. Deerfield, Illinois: Lundbeck; 2015. [Link]

PMID: 19445927

Tetrabenazine

By

Tetrabenazine

Product: Firategrast

Identifier : DBSNPE004808
Drug : DB04844 (Tedivabenazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • C allele (rs3892097 )

Allele Name : CYP2D6*4
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Xenazine® (tedivabenazine) tablets[package insert]. Deerfield, Illinois: Lundbeck; 2015. [Link]

PMID: 19374842

Tetrabenazine

By

Tetrabenazine

Product: Dabrafenib (Mesylate)

Identifier : DBSNPE004809
Drug : DB04844 (Tedivabenazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • Whole-gene deletion

Allele Name : CYP2D6*5
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Xenazine® (tedivabenazine) tablets[package insert]. Deerfield, Illinois: Lundbeck; 2015. [Link]

PMID: 16451050

Tetrabenazine

By

Tetrabenazine

Product: CPPHA

Identifier : DBSNPE004810
Drug : DB04844 (Tedivabenazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 1707delT (rs5030655 )

Allele Name : CYP2D6*6
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Xenazine® (tedivabenazine) tablets[package insert]. Deerfield, Illinois: Lundbeck; 2015. [Link]

PMID: 24428821

Tetrabenazine

By

Tetrabenazine

Product: Talnetant (hydrochloride)

Identifier : DBSNPE004811
Drug : DB04844 (Tedivabenazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 2935A>C (rs5030867 )

Allele Name : CYP2D6*7
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Xenazine® (tedivabenazine) tablets[package insert]. Deerfield, Illinois: Lundbeck; 2015. [Link]

PMID: 17287504

Tetrabenazine

By

Tetrabenazine

Product: Talnetant

Identifier : DBSNPE004812
Drug : DB04844 (Tedivabenazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 1758G>T (rs5030865 )

Allele Name : CYP2D6*8
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Xenazine® (tedivabenazine) tablets[package insert]. Deerfield, Illinois: Lundbeck; 2015. [Link]

PMID: 10940356

Tetrabenazine

By

Tetrabenazine

Product: Troglitazone

Identifier : DBSNPE004813
Drug : DB04844 (Tedivabenazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 883G>C (rs5030863 )

Allele Name : CYP2D6*11
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Xenazine® (tedivabenazine) tablets[package insert]. Deerfield, Illinois: Lundbeck; 2015. [Link]

PMID: 10602690

Tetrabenazine

By

Tetrabenazine

Product: LY2090314

Identifier : DBSNPE004814
Drug : DB04844 (Tedivabenazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 124G>A (rs5030862 )

Allele Name : CYP2D6*12
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Xenazine® (tedivabenazine) tablets[package insert]. Deerfield, Illinois: Lundbeck; 2015. [Link]

PMID: 21863064

Tetrabenazine

By

Tetrabenazine

Product: RKI-1447

Identifier : DBSNPE004815
Drug : DB04844 (Tedivabenazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • CYP2D7/2D6 hybrid gene sdivucture

Allele Name : CYP2D6*13
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Xenazine® (tedivabenazine) tablets[package insert]. Deerfield, Illinois: Lundbeck; 2015. [Link]

PMID: 15763246

Tetrabenazine

By

Tetrabenazine

Product: CO-1686

Identifier : DBSNPE004816
Drug : DB04844 (Tedivabenazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 1758G>A (rs5030865 )

Allele Name : CYP2D6*14A
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Xenazine® (tedivabenazine) tablets[package insert]. Deerfield, Illinois: Lundbeck; 2015. [Link]

PMID: 11815367

Tetrabenazine

By

Tetrabenazine

Product: NVP-BSK805

Identifier : DBSNPE004817
Drug : DB04844 (Tedivabenazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 137insT, 137_138insT

Allele Name : CYP2D6*15
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Xenazine® (tedivabenazine) tablets[package insert]. Deerfield, Illinois: Lundbeck; 2015. [Link]

PMID: 11101358

Tetrabenazine

By

Tetrabenazine

Product: R1530

Identifier : DBSNPE004818
Drug : DB04844 (Tedivabenazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 2539_2542delAACT (rs72549353 )

Allele Name : CYP2D6*19
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Xenazine® (tedivabenazine) tablets[package insert]. Deerfield, Illinois: Lundbeck; 2015. [Link]

PMID: 24666365

Tetrabenazine

By

Tetrabenazine

Product: GSK343

Identifier : DBSNPE004819
Drug : DB04844 (Tedivabenazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 1973_1974insG (rs72549354 )

Allele Name : CYP2D6*20
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Xenazine® (tedivabenazine) tablets[package insert]. Deerfield, Illinois: Lundbeck; 2015. [Link]

PMID: 20159949

Tetrabenazine

By

Tetrabenazine

Product: Istaroxime (hydrochloride)

Identifier : DBSNPE004820
Drug : DB04844 (Tedivabenazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 2573insC

Allele Name : CYP2D6*21
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Xenazine® (tedivabenazine) tablets[package insert]. Deerfield, Illinois: Lundbeck; 2015. [Link]

PMID: 10725267

Tetrabenazine

By

Tetrabenazine

Product: Tulathromycin A

Identifier : DBSNPE004821
Drug : DB04844 (Tedivabenazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • -1770G>A
  • -1584C>G
  • -1235A>G
  • -740C>T
  • -678G>A
  • CYP2D7 gene conversion in indivon 1
  • 310G>T
  • 746C>G
  • 843T>G
  • 1661G>C
  • 2850C>T
  • 3384A>C
  • 3584G>A
  • 3790C>T
  • 4042G>A
  • 4180G>C
  • 4481G>A

Allele Name : CYP2D6*31
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Xenazine® (tedivabenazine) tablets[package insert]. Deerfield, Illinois: Lundbeck; 2015. [Link]

PMID: 10643813

Tetrabenazine

By

Tetrabenazine

Product: XL019

Identifier : DBSNPE004822
Drug : DB04844 (Tedivabenazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 100C>T (rs1065852 )
  • -1426C>T
  • variable number of A’s in the region -1258 to -1237a
  • -1235A>G
  • -1000G>A
  • 1039C>T
  • 1661G>C
  • gene conversion to CYP2D7 in exon 9
  • 4180G>C

Allele Name : CYP2D6*36
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Xenazine® (tedivabenazine) tablets[package insert]. Deerfield, Illinois: Lundbeck; 2015. [Link]

PMID: 10844138

Tetrabenazine

By

Tetrabenazine

Product: Risperidone

Identifier : DBSNPE004823
Drug : DB04844 (Tedivabenazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 2587_2590delGACT (rs72549351 )

Allele Name : CYP2D6*38
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Xenazine® (tedivabenazine) tablets[package insert]. Deerfield, Illinois: Lundbeck; 2015. [Link]

PMID: 17618307

Tetrabenazine

By

Tetrabenazine

Product: Alogliptin

Identifier : DBSNPE004824
Drug : DB04844 (Tedivabenazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 1863_1864ins(TTT CGC CCC)2 (rs72549356 )

Allele Name : CYP2D6*40
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Xenazine® (tedivabenazine) tablets[package insert]. Deerfield, Illinois: Lundbeck; 2015. [Link]

PMID: 10218885

Tetrabenazine

By

Tetrabenazine

Product: Cys-mcMMAD

Identifier : DBSNPE004825
Drug : DB04844 (Tedivabenazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 3259_3260insGT (rs72549346 )

Allele Name : CYP2D6*42
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Xenazine® (tedivabenazine) tablets[package insert]. Deerfield, Illinois: Lundbeck; 2015. [Link]

PMID: 9774260

Tetrabenazine

By

Tetrabenazine

Product: Mc-MMAD

Identifier : DBSNPE004826
Drug : DB04844 (Tedivabenazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 2950G>C

Allele Name : CYP2D6*44
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Xenazine® (tedivabenazine) tablets[package insert]. Deerfield, Illinois: Lundbeck; 2015. [Link]

PMID: 9521323

Tetrabenazine

By

Tetrabenazine

Product: Vc-MMAD

Identifier : DBSNPE004827
Drug : DB04844 (Tedivabenazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 100C>T (rs1065852 )
  • -1426C>T
  • -1235A>G
  • -1000G>A
  • 73C<T
  • 1039C>T
  • 1661G>C
  • 4180G>C

Allele Name : CYP2D6*47
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Xenazine® (tedivabenazine) tablets[package insert]. Deerfield, Illinois: Lundbeck; 2015. [Link]

PMID: 10998544

Tetrabenazine

By

Tetrabenazine

Product: MMAD

Identifier : DBSNPE004828
Drug : DB04844 (Tedivabenazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • -1584C>G
  • -1235A>G
  • -740C>T
  • -678G>A
  • CYP2D7 gene conversion in indivon 1
  • 1661G>C
  • 2850C>T
  • 3172A>C
  • 4180G>C

Allele Name : CYP2D6*51
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Xenazine® (tedivabenazine) tablets[package insert]. Deerfield, Illinois: Lundbeck; 2015. [Link]

PMID: 9720768

Tetrabenazine

By

Tetrabenazine

Product: Deltarasin

Identifier : DBSNPE004829
Drug : DB04844 (Tedivabenazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 3201C>T (rs72549347 )

Allele Name : CYP2D6*56
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Xenazine® (tedivabenazine) tablets[package insert]. Deerfield, Illinois: Lundbeck; 2015. [Link]

PMID: 11181645

Tetrabenazine

By

Tetrabenazine

Product: Tenofovir

Identifier : DBSNPE004830
Drug : DB04844 (Tedivabenazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 100C>T
  • 310G>T
  • 843T>G
  • 887C>T
  • 1039C>T
  • 1661G>C
  • 3384A>C
  • 3582A>G
  • gene conversion to CYP2D7 in exon 9
  • 4180G>C

Allele Name : CYP2D6*57
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Xenazine® (tedivabenazine) tablets[package insert]. Deerfield, Illinois: Lundbeck; 2015. [Link]

PMID: 17329551

Tetrabenazine

By

Tetrabenazine

Product: Trabectedin

Identifier : DBSNPE004831
Drug : DB04844 (Tedivabenazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 4044C>T

Allele Name : CYP2D6*62
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Xenazine® (tedivabenazine) tablets[package insert]. Deerfield, Illinois: Lundbeck; 2015. [Link]

PMID: 14593080

Tetrabenazine

By

Tetrabenazine

Product: Nelarabine

Identifier : DBSNPE004832
Drug : DB04844 (Tedivabenazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • -1426C>T
  • -1235A>G
  • -1000G>A
  • 100C>T
  • 310G>T
  • CYP2D7 sequence from indivon 1 onwards

Allele Name : CYP2D6*68A
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Xenazine® (tedivabenazine) tablets[package insert]. Deerfield, Illinois: Lundbeck; 2015. [Link]

PMID: 19014386

Tetrabenazine

By

Tetrabenazine

Product: WHI-P154

Identifier : DBSNPE004833
Drug : DB04844 (Tedivabenazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • Similar but not identical switch region compared to CYP2D6*68A. Found in tandem arrangement with CYP2D6*4.

Allele Name : CYP2D6*68B
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Xenazine® (tedivabenazine) tablets[package insert]. Deerfield, Illinois: Lundbeck; 2015. [Link]

PMID: 16202610

Tetrabenazine

By

Tetrabenazine

Product: JANEX-1

Identifier : DBSNPE004834
Drug : DB04844 (Tedivabenazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 2988G>A (rs28371725 )
  • -1426C>T
  • -1235A>G
  • -1000G>A
  • 100C>T
  • 310G>T
  • 746C>G
  • 843T>G
  • 1062A>G
  • 1661G>C
  • 2850C>T
  • 3384A>C
  • 3584G>A
  • 3790C>T
  • 4180G>C
  • 4401C>T
  • 4481G>A

Allele Name : CYP2D6*69
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Xenazine® (tedivabenazine) tablets[package insert]. Deerfield, Illinois: Lundbeck; 2015. [Link]

PMID: 12752799

Tetrabenazine

By

Tetrabenazine

Product: EBE-A22

Identifier : DBSNPE004835
Drug : DB04844 (Tedivabenazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 1995delC

Allele Name : CYP2D6*92
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Xenazine® (tedivabenazine) tablets[package insert]. Deerfield, Illinois: Lundbeck; 2015. [Link]

PMID: 12522077

Tetrabenazine

By

Tetrabenazine

Product: Matrine

Identifier : DBSNPE004836
Drug : DB04844 (Tedivabenazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • -1426C>T
  • -1235A>G
  • -1109C>T
  • -1000G>A
  • 100C>T
  • 310G>T
  • 843T>G
  • 1039C>T
  • 1661G>C
  • 2097A>G
  • 2828delC
  • 3384A>C
  • 3582A>G
  • 4180G>C
  • 4401C>T

Allele Name : CYP2D6*100
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Xenazine® (tedivabenazine) tablets[package insert]. Deerfield, Illinois: Lundbeck; 2015. [Link]

PMID: 12595960

Tetrabenazine

By

Tetrabenazine

Product: OTX-015

Identifier : DBSNPE004837
Drug : DB04844 (Tedivabenazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • -1426C>T
  • -1235A>G
  • -1000G>A
  • 100C>T
  • 310G>T
  • 843T>G
  • 1039C>T
  • 1661G>C
  • 2097A>G
  • 2927_2945delGATCCTACATCCGGATGTG
  • 3384A>C
  • 3582A>G
  • 4180G>C
  • 4401C>T

Allele Name : CYP2D6*101
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Xenazine® (tedivabenazine) tablets[package insert]. Deerfield, Illinois: Lundbeck; 2015. [Link]

PMID: 12010780

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