PI3KInhibitorpi3kinhibitor

Propafenone

By

Propafenone

Product: WEHI-539 (hydrochloride)

Identifier : DBSNPE004763
Drug : DB01182 (Propafenone)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • C allele (rs35742686 )

Allele Name : CYP2D6*3
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased exposure may lead to cardiac arrhythmias and exaggerated beta-adrenergic blocking activity.
References :

  1. Rythmol SR (propafenone hydrochloride)[package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2013. [Link]

PMID: 15537880

Propafenone

By

Propafenone

Product: Verapamil (hydrochloride)

Identifier : DBSNPE004764
Drug : DB01182 (Propafenone)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • C allele (rs3892097 )

Allele Name : CYP2D6*4
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased exposure may lead to cardiac arrhythmias and exaggerated beta-adrenergic blocking activity.
References :

  1. Rythmol SR (propafenone hydrochloride)[package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2013. [Link]

PMID: 9191956

Propafenone

By

Propafenone

Product: Alvelestat

Identifier : DBSNPE004765
Drug : DB01182 (Propafenone)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • Whole-gene deletion

Allele Name : CYP2D6*5
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased exposure may lead to cardiac arrhythmias and exaggerated beta-adrenergic blocking activity.
References :

  1. Rythmol SR (propafenone hydrochloride)[package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2013. [Link]

PMID: 9351503

Propafenone

By

Propafenone

Product: ETP-46464

Identifier : DBSNPE004766
Drug : DB01182 (Propafenone)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 1707delT (rs5030655 )

Allele Name : CYP2D6*6
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased exposure may lead to cardiac arrhythmias and exaggerated beta-adrenergic blocking activity.
References :

  1. Rythmol SR (propafenone hydrochloride)[package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2013. [Link]

PMID: 20804497

Propafenone

By

Propafenone

Product: Levalbuterol (tartrate)

Identifier : DBSNPE004767
Drug : DB01182 (Propafenone)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 2935A>C (rs5030867 )

Allele Name : CYP2D6*7
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased exposure may lead to cardiac arrhythmias and exaggerated beta-adrenergic blocking activity.
References :

  1. Rythmol SR (propafenone hydrochloride)[package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2013. [Link]

PMID: 10992004

Propafenone

By

Propafenone

Product: SRPIN340

Identifier : DBSNPE004768
Drug : DB01182 (Propafenone)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 1758G>T (rs5030865 )

Allele Name : CYP2D6*8
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased exposure may lead to cardiac arrhythmias and exaggerated beta-adrenergic blocking activity.
References :

  1. Rythmol SR (propafenone hydrochloride)[package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2013. [Link]

PMID: 20375616

Propafenone

By

Propafenone

Product: Vilanterol

Identifier : DBSNPE004769
Drug : DB01182 (Propafenone)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 883G>C (rs5030863 )

Allele Name : CYP2D6*11
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased exposure may lead to cardiac arrhythmias and exaggerated beta-adrenergic blocking activity.
References :

  1. Rythmol SR (propafenone hydrochloride)[package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2013. [Link]

PMID: 18822303

Propafenone

By

Propafenone

Product: Vilanterol (trifenatate)

Identifier : DBSNPE004770
Drug : DB01182 (Propafenone)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 124G>A (rs5030862 )

Allele Name : CYP2D6*12
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased exposure may lead to cardiac arrhythmias and exaggerated beta-adrenergic blocking activity.
References :

  1. Rythmol SR (propafenone hydrochloride)[package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2013. [Link]

PMID: 11226387

Propafenone

By

Propafenone

Product: Ro 31-8220

Identifier : DBSNPE004771
Drug : DB01182 (Propafenone)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • CYP2D7/2D6 hybrid gene sdivucture

Allele Name : CYP2D6*13
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased exposure may lead to cardiac arrhythmias and exaggerated beta-adrenergic blocking activity.
References :

  1. Rythmol SR (propafenone hydrochloride)[package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2013. [Link]

PMID: 9190866

Propafenone

By

Propafenone

Product: Ro 31-8220 (mesylate)

Identifier : DBSNPE004772
Drug : DB01182 (Propafenone)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 1758G>A (rs5030865 )

Allele Name : CYP2D6*14A
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased exposure may lead to cardiac arrhythmias and exaggerated beta-adrenergic blocking activity.
References :

  1. Rythmol SR (propafenone hydrochloride)[package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2013. [Link]

PMID: 12056557

Propafenone

By

Propafenone

Product: CID 2011756

Identifier : DBSNPE004773
Drug : DB01182 (Propafenone)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 137insT, 137_138insT

Allele Name : CYP2D6*15
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased exposure may lead to cardiac arrhythmias and exaggerated beta-adrenergic blocking activity.
References :

  1. Rythmol SR (propafenone hydrochloride)[package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2013. [Link]

PMID: 19125610

Propafenone

By

Propafenone

Product: Erastin

Identifier : DBSNPE004774
Drug : DB01182 (Propafenone)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 2539_2542delAACT (rs72549353 )

Allele Name : CYP2D6*19
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased exposure may lead to cardiac arrhythmias and exaggerated beta-adrenergic blocking activity.
References :

  1. Rythmol SR (propafenone hydrochloride)[package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2013. [Link]

PMID: 18319566

Propafenone

By

Propafenone

Product: Valdecoxib

Identifier : DBSNPE004775
Drug : DB01182 (Propafenone)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 1973_1974insG (rs72549354 )

Allele Name : CYP2D6*20
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased exposure may lead to cardiac arrhythmias and exaggerated beta-adrenergic blocking activity.
References :

  1. Rythmol SR (propafenone hydrochloride)[package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2013. [Link]

PMID: 11053209

Propafenone

By

Propafenone

Product: Ro3280

Identifier : DBSNPE004776
Drug : DB01182 (Propafenone)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 2573insC

Allele Name : CYP2D6*21
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased exposure may lead to cardiac arrhythmias and exaggerated beta-adrenergic blocking activity.
References :

  1. Rythmol SR (propafenone hydrochloride)[package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2013. [Link]

PMID: 24188792

Propafenone

By

Propafenone

Product: AZD2858

Identifier : DBSNPE004777
Drug : DB01182 (Propafenone)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • -1770G>A
  • -1584C>G
  • -1235A>G
  • -740C>T
  • -678G>A
  • CYP2D7 gene conversion in indivon 1
  • 310G>T
  • 746C>G
  • 843T>G
  • 1661G>C
  • 2850C>T
  • 3384A>C
  • 3584G>A
  • 3790C>T
  • 4042G>A
  • 4180G>C
  • 4481G>A

Allele Name : CYP2D6*31
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased exposure may lead to cardiac arrhythmias and exaggerated beta-adrenergic blocking activity.
References :

  1. Rythmol SR (propafenone hydrochloride)[package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2013. [Link]

PMID: 10998526

Propafenone

By

Propafenone

Product: TDZD-8

Identifier : DBSNPE004778
Drug : DB01182 (Propafenone)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 100C>T (rs1065852 )
  • -1426C>T
  • variable number of A’s in the region -1258 to -1237a
  • -1235A>G
  • -1000G>A
  • 1039C>T
  • 1661G>C
  • gene conversion to CYP2D7 in exon 9
  • 4180G>C

Allele Name : CYP2D6*36
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased exposure may lead to cardiac arrhythmias and exaggerated beta-adrenergic blocking activity.
References :

  1. Rythmol SR (propafenone hydrochloride)[package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2013. [Link]

PMID: 9277133

Propafenone

By

Propafenone

Product: Sunitinib

Identifier : DBSNPE004779
Drug : DB01182 (Propafenone)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 2587_2590delGACT (rs72549351 )

Allele Name : CYP2D6*38
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased exposure may lead to cardiac arrhythmias and exaggerated beta-adrenergic blocking activity.
References :

  1. Rythmol SR (propafenone hydrochloride)[package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2013. [Link]

PMID: 7566152

Propafenone

By

Propafenone

Product: Cidofovir

Identifier : DBSNPE004780
Drug : DB01182 (Propafenone)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 1863_1864ins(TTT CGC CCC)2 (rs72549356 )

Allele Name : CYP2D6*40
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased exposure may lead to cardiac arrhythmias and exaggerated beta-adrenergic blocking activity.
References :

  1. Rythmol SR (propafenone hydrochloride)[package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2013. [Link]

PMID: 7481766

Propafenone

By

Propafenone

Product: AZD1208

Identifier : DBSNPE004781
Drug : DB01182 (Propafenone)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 3259_3260insGT (rs72549346 )

Allele Name : CYP2D6*42
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased exposure may lead to cardiac arrhythmias and exaggerated beta-adrenergic blocking activity.
References :

  1. Rythmol SR (propafenone hydrochloride)[package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2013. [Link]

PMID: 26017846

Propafenone

By

Propafenone

Product: DHEA

Identifier : DBSNPE004782
Drug : DB01182 (Propafenone)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 2950G>C

Allele Name : CYP2D6*44
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased exposure may lead to cardiac arrhythmias and exaggerated beta-adrenergic blocking activity.
References :

  1. Rythmol SR (propafenone hydrochloride)[package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2013. [Link]

PMID: 25276817

Propafenone

By

Propafenone

Product: Necrostatin-1

Identifier : DBSNPE004783
Drug : DB01182 (Propafenone)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 100C>T (rs1065852 )
  • -1426C>T
  • -1235A>G
  • -1000G>A
  • 73C<T
  • 1039C>T
  • 1661G>C
  • 4180G>C

Allele Name : CYP2D6*47
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased exposure may lead to cardiac arrhythmias and exaggerated beta-adrenergic blocking activity.
References :

  1. Rythmol SR (propafenone hydrochloride)[package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2013. [Link]

PMID: 23439216

Propafenone

By

Propafenone

Product: Necrostatin 2 (S enantiomer)

Identifier : DBSNPE004784
Drug : DB01182 (Propafenone)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • -1584C>G
  • -1235A>G
  • -740C>T
  • -678G>A
  • CYP2D7 gene conversion in indivon 1
  • 1661G>C
  • 2850C>T
  • 3172A>C
  • 4180G>C

Allele Name : CYP2D6*51
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased exposure may lead to cardiac arrhythmias and exaggerated beta-adrenergic blocking activity.
References :

  1. Rythmol SR (propafenone hydrochloride)[package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2013. [Link]

PMID: 14662736

Propafenone

By

Propafenone

Product: Necrostatin 2 (racemate)

Identifier : DBSNPE004785
Drug : DB01182 (Propafenone)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 3201C>T (rs72549347 )

Allele Name : CYP2D6*56
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased exposure may lead to cardiac arrhythmias and exaggerated beta-adrenergic blocking activity.
References :

  1. Rythmol SR (propafenone hydrochloride)[package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2013. [Link]

PMID: 11250866

Propafenone

By

Propafenone

Product: PP2

Identifier : DBSNPE004786
Drug : DB01182 (Propafenone)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 100C>T
  • 310G>T
  • 843T>G
  • 887C>T
  • 1039C>T
  • 1661G>C
  • 3384A>C
  • 3582A>G
  • gene conversion to CYP2D7 in exon 9
  • 4180G>C

Allele Name : CYP2D6*57
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased exposure may lead to cardiac arrhythmias and exaggerated beta-adrenergic blocking activity.
References :

  1. Rythmol SR (propafenone hydrochloride)[package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2013. [Link]

PMID: 8842416

Propafenone

By

Propafenone

Product: PP1

Identifier : DBSNPE004787
Drug : DB01182 (Propafenone)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 4044C>T

Allele Name : CYP2D6*62
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased exposure may lead to cardiac arrhythmias and exaggerated beta-adrenergic blocking activity.
References :

  1. Rythmol SR (propafenone hydrochloride)[package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2013. [Link]

PMID: 10742280

Propafenone

By

Propafenone

Product: Delavirdine (mesylate)

Identifier : DBSNPE004788
Drug : DB01182 (Propafenone)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • -1426C>T
  • -1235A>G
  • -1000G>A
  • 100C>T
  • 310G>T
  • CYP2D7 sequence from indivon 1 onwards

Allele Name : CYP2D6*68A
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased exposure may lead to cardiac arrhythmias and exaggerated beta-adrenergic blocking activity.
References :

  1. Rythmol SR (propafenone hydrochloride)[package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2013. [Link]

PMID: 9884077

Propafenone

By

Propafenone

Product: Delavirdine

Identifier : DBSNPE004789
Drug : DB01182 (Propafenone)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • Similar but not identical switch region compared to CYP2D6*68A. Found in tandem arrangement with CYP2D6*4.

Allele Name : CYP2D6*68B
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased exposure may lead to cardiac arrhythmias and exaggerated beta-adrenergic blocking activity.
References :

  1. Rythmol SR (propafenone hydrochloride)[package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2013. [Link]

PMID: 11906488

Propafenone

By

Propafenone

Product: BIX 02565

Identifier : DBSNPE004790
Drug : DB01182 (Propafenone)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 2988G>A (rs28371725 )
  • -1426C>T
  • -1235A>G
  • -1000G>A
  • 100C>T
  • 310G>T
  • 746C>G
  • 843T>G
  • 1062A>G
  • 1661G>C
  • 2850C>T
  • 3384A>C
  • 3584G>A
  • 3790C>T
  • 4180G>C
  • 4401C>T
  • 4481G>A

Allele Name : CYP2D6*69
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased exposure may lead to cardiac arrhythmias and exaggerated beta-adrenergic blocking activity.
References :

  1. Rythmol SR (propafenone hydrochloride)[package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2013. [Link]

PMID: 11752097

Propafenone

By

Propafenone

Product: UNC1999

Identifier : DBSNPE004791
Drug : DB01182 (Propafenone)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 1995delC

Allele Name : CYP2D6*92
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased exposure may lead to cardiac arrhythmias and exaggerated beta-adrenergic blocking activity.
References :

  1. Rythmol SR (propafenone hydrochloride)[package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2013. [Link]

PMID: 11097863

Propafenone

By

Propafenone

Product: MLN2238

Identifier : DBSNPE004792
Drug : DB01182 (Propafenone)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • -1426C>T
  • -1235A>G
  • -1109C>T
  • -1000G>A
  • 100C>T
  • 310G>T
  • 843T>G
  • 1039C>T
  • 1661G>C
  • 2097A>G
  • 2828delC
  • 3384A>C
  • 3582A>G
  • 4180G>C
  • 4401C>T

Allele Name : CYP2D6*100
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased exposure may lead to cardiac arrhythmias and exaggerated beta-adrenergic blocking activity.
References :

  1. Rythmol SR (propafenone hydrochloride)[package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2013. [Link]

PMID: 12070757

Propafenone

By

Propafenone

Product: Batimastat (sodium salt)

Identifier : DBSNPE004793
Drug : DB01182 (Propafenone)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • -1426C>T
  • -1235A>G
  • -1000G>A
  • 100C>T
  • 310G>T
  • 843T>G
  • 1039C>T
  • 1661G>C
  • 2097A>G
  • 2927_2945delGATCCTACATCCGGATGTG
  • 3384A>C
  • 3582A>G
  • 4180G>C
  • 4401C>T

Allele Name : CYP2D6*101
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased exposure may lead to cardiac arrhythmias and exaggerated beta-adrenergic blocking activity.
References :

  1. Rythmol SR (propafenone hydrochloride)[package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2013. [Link]

PMID: 12070758

Propafenone

By

Propafenone

Product: Batimastat

Identifier : DBSNPE004794
Drug : DB01182 (Propafenone)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 2615-2617delAAG (rs5030656 )

Allele Name : CYP2D6*9
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Decreased CYP2D6
Description : Poor drug metabolizer, increased exposure may lead to cardiac arrhythmias and exaggerated beta-adrenergic blocking activity.
References :

  1. Rythmol SR (propafenone hydrochloride)[package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2013. [Link]

PMID: 11689082

Propafenone

By

Propafenone

Product: EI1

Identifier : DBSNPE004795
Drug : DB01182 (Propafenone)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 100C>T (rs1065852 )
  • 1661G>C
  • 4180G>C

Allele Name : CYP2D6*10
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Decreased CYP2D6
Description : Poor drug metabolizer, increased exposure may lead to cardiac arrhythmias and exaggerated beta-adrenergic blocking activity.
References :

  1. Rythmol SR (propafenone hydrochloride)[package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2013. [Link]

PMID: 10369464

Propafenone

By

Propafenone

Product: CUDC-907

Identifier : DBSNPE004796
Drug : DB01182 (Propafenone)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 1758G>A (rs5030865 )

Allele Name : CYP2D6*14B
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Decreased CYP2D6
Description : Poor drug metabolizer, increased exposure may lead to cardiac arrhythmias and exaggerated beta-adrenergic blocking activity.
References :

  1. Rythmol SR (propafenone hydrochloride)[package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2013. [Link]

PMID: 9489602

Propafenone

By

Propafenone

Product: Ledipasvir

Identifier : DBSNPE004797
Drug : DB01182 (Propafenone)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 1023C>T (rs28371706 )
  • 2850C>T (rs16947 )

Allele Name : CYP2D6*17
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Decreased CYP2D6
Description : Poor drug metabolizer, increased exposure may lead to cardiac arrhythmias and exaggerated beta-adrenergic blocking activity.
References :

  1. Rythmol SR (propafenone hydrochloride)[package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2013. [Link]

PMID: 9682833

Propafenone

By

Propafenone

Product: Delavirdine (mesylate)

Identifier : DBSNPE004788
Drug : DB01182 (Propafenone)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • -1426C>T
  • -1235A>G
  • -1000G>A
  • 100C>T
  • 310G>T
  • CYP2D7 sequence from indivon 1 onwards

Allele Name : CYP2D6*68A
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased exposure may lead to cardiac arrhythmias and exaggerated beta-adrenergic blocking activity.
References :

  1. Rythmol SR (propafenone hydrochloride)[package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2013. [Link]

PMID: 9884077

Propafenone

By

Propafenone

Product: Delavirdine

Identifier : DBSNPE004789
Drug : DB01182 (Propafenone)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • Similar but not identical switch region compared to CYP2D6*68A. Found in tandem arrangement with CYP2D6*4.

Allele Name : CYP2D6*68B
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased exposure may lead to cardiac arrhythmias and exaggerated beta-adrenergic blocking activity.
References :

  1. Rythmol SR (propafenone hydrochloride)[package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2013. [Link]

PMID: 11906488

Propafenone

By

Propafenone

Product: BIX 02565

Identifier : DBSNPE004790
Drug : DB01182 (Propafenone)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 2988G>A (rs28371725 )
  • -1426C>T
  • -1235A>G
  • -1000G>A
  • 100C>T
  • 310G>T
  • 746C>G
  • 843T>G
  • 1062A>G
  • 1661G>C
  • 2850C>T
  • 3384A>C
  • 3584G>A
  • 3790C>T
  • 4180G>C
  • 4401C>T
  • 4481G>A

Allele Name : CYP2D6*69
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased exposure may lead to cardiac arrhythmias and exaggerated beta-adrenergic blocking activity.
References :

  1. Rythmol SR (propafenone hydrochloride)[package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2013. [Link]

PMID: 11752097

Propafenone

By

Propafenone

Product: UNC1999

Identifier : DBSNPE004791
Drug : DB01182 (Propafenone)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 1995delC

Allele Name : CYP2D6*92
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased exposure may lead to cardiac arrhythmias and exaggerated beta-adrenergic blocking activity.
References :

  1. Rythmol SR (propafenone hydrochloride)[package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2013. [Link]

PMID: 11097863

Propafenone

By

Propafenone

Product: MLN2238

Identifier : DBSNPE004792
Drug : DB01182 (Propafenone)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • -1426C>T
  • -1235A>G
  • -1109C>T
  • -1000G>A
  • 100C>T
  • 310G>T
  • 843T>G
  • 1039C>T
  • 1661G>C
  • 2097A>G
  • 2828delC
  • 3384A>C
  • 3582A>G
  • 4180G>C
  • 4401C>T

Allele Name : CYP2D6*100
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased exposure may lead to cardiac arrhythmias and exaggerated beta-adrenergic blocking activity.
References :

  1. Rythmol SR (propafenone hydrochloride)[package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2013. [Link]

PMID: 12070757

Propafenone

By

Propafenone

Product: Batimastat (sodium salt)

Identifier : DBSNPE004793
Drug : DB01182 (Propafenone)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • -1426C>T
  • -1235A>G
  • -1000G>A
  • 100C>T
  • 310G>T
  • 843T>G
  • 1039C>T
  • 1661G>C
  • 2097A>G
  • 2927_2945delGATCCTACATCCGGATGTG
  • 3384A>C
  • 3582A>G
  • 4180G>C
  • 4401C>T

Allele Name : CYP2D6*101
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, increased exposure may lead to cardiac arrhythmias and exaggerated beta-adrenergic blocking activity.
References :

  1. Rythmol SR (propafenone hydrochloride)[package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2013. [Link]

PMID: 12070758

Propafenone

By

Propafenone

Product: Batimastat

Identifier : DBSNPE004794
Drug : DB01182 (Propafenone)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 2615-2617delAAG (rs5030656 )

Allele Name : CYP2D6*9
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Decreased CYP2D6
Description : Poor drug metabolizer, increased exposure may lead to cardiac arrhythmias and exaggerated beta-adrenergic blocking activity.
References :

  1. Rythmol SR (propafenone hydrochloride)[package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2013. [Link]

PMID: 11689082

Propafenone

By

Propafenone

Product: EI1

Identifier : DBSNPE004795
Drug : DB01182 (Propafenone)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 100C>T (rs1065852 )
  • 1661G>C
  • 4180G>C

Allele Name : CYP2D6*10
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Decreased CYP2D6
Description : Poor drug metabolizer, increased exposure may lead to cardiac arrhythmias and exaggerated beta-adrenergic blocking activity.
References :

  1. Rythmol SR (propafenone hydrochloride)[package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2013. [Link]

PMID: 10369464

Propafenone

By

Propafenone

Product: CUDC-907

Identifier : DBSNPE004796
Drug : DB01182 (Propafenone)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 1758G>A (rs5030865 )

Allele Name : CYP2D6*14B
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Decreased CYP2D6
Description : Poor drug metabolizer, increased exposure may lead to cardiac arrhythmias and exaggerated beta-adrenergic blocking activity.
References :

  1. Rythmol SR (propafenone hydrochloride)[package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2013. [Link]

PMID: 9489602

Propafenone

By

Propafenone

Product: Ledipasvir

Identifier : DBSNPE004797
Drug : DB01182 (Propafenone)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 1023C>T (rs28371706 )
  • 2850C>T (rs16947 )

Allele Name : CYP2D6*17
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Decreased CYP2D6
Description : Poor drug metabolizer, increased exposure may lead to cardiac arrhythmias and exaggerated beta-adrenergic blocking activity.
References :

  1. Rythmol SR (propafenone hydrochloride)[package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2013. [Link]

PMID: 9682833

Propafenone

By

Propafenone

Product: 3,3-Diindolylmethane

Identifier : DBSNPE004798
Drug : DB01182 (Propafenone)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 4133dupGTGCCCACT

Allele Name : CYP2D6*18
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Decreased CYP2D6
Description : Poor drug metabolizer, increased exposure may lead to cardiac arrhythmias and exaggerated beta-adrenergic blocking activity.
References :

  1. Rythmol SR (propafenone hydrochloride)[package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2013. [Link]

PMID: 9191955

Propafenone

By

Propafenone

Product: Solasodine

Identifier : DBSNPE004799
Drug : DB01182 (Propafenone)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 1659G>A
  • 1661G>C
  • 2850C>T
  • 3183G>A
  • 4180G>C

Allele Name : CYP2D6*29
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Decreased CYP2D6
Description : Poor drug metabolizer, increased exposure may lead to cardiac arrhythmias and exaggerated beta-adrenergic blocking activity.
References :

  1. Rythmol SR (propafenone hydrochloride)[package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2013. [Link]

PMID: 9593974

Propafenone

By

Propafenone

Product: SJB2-043

Identifier : DBSNPE004800
Drug : DB01182 (Propafenone)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 2988G>A (rs28371725 )

Allele Name : CYP2D6*41
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Decreased CYP2D6
Description : Poor drug metabolizer, increased exposure may lead to cardiac arrhythmias and exaggerated beta-adrenergic blocking activity.
References :

  1. Rythmol SR (propafenone hydrochloride)[package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2013. [Link]

PMID: 9262352

Propafenone

By

Propafenone

Product: SJB3-019A

Identifier : DBSNPE004801
Drug : DB01182 (Propafenone)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 100C>T (rs1065852 )
  • -1426C>T
  • -1235A>G
  • -1000G>A
  • 1039C>T
  • 1611T>A
  • 1661G>C
  • 4180G>C

Allele Name : CYP2D6*49
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Decreased CYP2D6
Description : Poor drug metabolizer, increased exposure may lead to cardiac arrhythmias and exaggerated beta-adrenergic blocking activity.
References :

  1. Rythmol SR (propafenone hydrochloride)[package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2013. [Link]

PMID: 8662940

Propafenone

By

Propafenone

Product: XL228

Identifier : DBSNPE004802
Drug : DB01182 (Propafenone)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 1720A>C

Allele Name : CYP2D6*50
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Decreased CYP2D6
Description : Poor drug metabolizer, increased exposure may lead to cardiac arrhythmias and exaggerated beta-adrenergic blocking activity.
References :

  1. Rythmol SR (propafenone hydrochloride)[package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2013. [Link]

PMID: 10991930

Propafenone

By

Propafenone

Product: SB-222200

Identifier : DBSNPE004803
Drug : DB01182 (Propafenone)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 100C>T
  • 1039C>T
  • 1661G>C
  • 2556C>T
  • 4180G>C

Allele Name : CYP2D6*54
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Decreased CYP2D6
Description : Poor drug metabolizer, increased exposure may lead to cardiac arrhythmias and exaggerated beta-adrenergic blocking activity.
References :

  1. Rythmol SR (propafenone hydrochloride)[package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2013. [Link]

PMID: 9353393

Propafenone

By

Propafenone

Product: UNC1215

Identifier : DBSNPE004804
Drug : DB01182 (Propafenone)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 1661G>C
  • 2850C>T
  • 3790C>T
  • 3835A>C
  • 4180G>C

Allele Name : CYP2D6*55
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Decreased CYP2D6
Description : Poor drug metabolizer, increased exposure may lead to cardiac arrhythmias and exaggerated beta-adrenergic blocking activity.
References :

  1. Rythmol SR (propafenone hydrochloride)[package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2013. [Link]

PMID: 19332374

Propafenone

By

Propafenone

Product: SB-269970

Identifier : DBSNPE004805
Drug : DB01182 (Propafenone)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 1661G>C
  • 2291G>A
  • 2850C>T
  • 2939G>A
  • 4180G>C

Allele Name : CYP2D6*59
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Decreased CYP2D6
Description : Poor drug metabolizer, increased exposure may lead to cardiac arrhythmias and exaggerated beta-adrenergic blocking activity.
References :

  1. Rythmol SR (propafenone hydrochloride)[package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2013. [Link]

PMID: 18670432

Propafenone

By

Propafenone

Product: SB-269970 (hydrochloride)

Identifier : DBSNPE004806
Drug : DB01182 (Propafenone)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • -1426C>T
  • -1235A>G
  • -1000G>A
  • 100C>T
  • 310G>T
  • 843T>G
  • 1039C>T
  • 1661G>C
  • 2097A>G
  • 3318G>A
  • 3384A>C
  • 3582A>G
  • 4180G>C
  • 4401C>T

Allele Name : CYP2D6*72
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Decreased CYP2D6
Description : Poor drug metabolizer, increased exposure may lead to cardiac arrhythmias and exaggerated beta-adrenergic blocking activity.
References :

  1. Rythmol SR (propafenone hydrochloride)[package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2013. [Link]

PMID: 18492950

Propafenone

By

Propafenone

Product: Sodium phenylbutyrate

Identifier : DBSNPE005043
Drug : DB01182 (Propafenone)
Interacting Gene/Enzyme : Cytochrome P450 3A4
Gene Name : CYP3A4
UniProt ID : P08684
Defining Change(s) :

  • 1461_1462insA (rs67666821 )

Allele Name : CYP3A4*20
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP3A4
Description : Poor drug metabolizer, increased exposure may lead to cardiac arrhythmias and exaggerated beta-adrenergic blocking activity.
References :

  1. Rythmol SR (propafenone hydrochloride)[package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2013. [Link]

PMID: 2581174

Propafenone

By

Propafenone

Product: Azilsartan

Identifier : DBSNPE005044
Drug : DB01182 (Propafenone)
Interacting Gene/Enzyme : Cytochrome P450 3A4
Gene Name : CYP3A4
UniProt ID : P08684
Defining Change(s) :

  • 802C>T (rs138105638 )

Allele Name : CYP3A4*26
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP3A4
Description : Poor drug metabolizer, increased exposure may lead to cardiac arrhythmias and exaggerated beta-adrenergic blocking activity.
References :

  1. Rythmol SR (propafenone hydrochloride)[package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2013. [Link]

PMID: 2581167

Propafenone

By

Propafenone

Product: Tripelennamine (hydrochloride)

Identifier : DBSNPE005045
Drug : DB01182 (Propafenone)
Interacting Gene/Enzyme : Cytochrome P450 3A4
Gene Name : CYP3A4
UniProt ID : P08684
Defining Change(s) :

  • 13908G>A (rs72552799 )

Allele Name : CYP3A4*8
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Decreased CYP3A4
Description : Poor drug metabolizer, increased exposure may lead to cardiac arrhythmias and exaggerated beta-adrenergic blocking activity.
References :

  1. Rythmol SR (propafenone hydrochloride)[package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2013. [Link]

PMID: 6194840

Propafenone

By

Propafenone

Product: (R)-(-)-Ibuprofen

Identifier : DBSNPE005046
Drug : DB01182 (Propafenone)
Interacting Gene/Enzyme : Cytochrome P450 3A4
Gene Name : CYP3A4
UniProt ID : P08684
Defining Change(s) :

  • 1088C>T (rs67784355 )

Allele Name : CYP3A4*11
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Decreased CYP3A4
Description : Poor drug metabolizer, increased exposure may lead to cardiac arrhythmias and exaggerated beta-adrenergic blocking activity.
References :

  1. Rythmol SR (propafenone hydrochloride)[package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2013. [Link]

PMID: 11897392

Propafenone

By

Propafenone

Product: (S)-(+)-Ibuprofen

Identifier : DBSNPE005047
Drug : DB01182 (Propafenone)
Interacting Gene/Enzyme : Cytochrome P450 3A4
Gene Name : CYP3A4
UniProt ID : P08684
Defining Change(s) :

  • 1117C>T (rs12721629 )

Allele Name : CYP3A4*12
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Decreased CYP3A4
Description : Poor drug metabolizer, increased exposure may lead to cardiac arrhythmias and exaggerated beta-adrenergic blocking activity.
References :

  1. Rythmol SR (propafenone hydrochloride)[package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2013. [Link]

PMID: 10800964

Propafenone

By

Propafenone

Product: AG 18

Identifier : DBSNPE005048
Drug : DB01182 (Propafenone)
Interacting Gene/Enzyme : Cytochrome P450 3A4
Gene Name : CYP3A4
UniProt ID : P08684
Defining Change(s) :

  • 1247C>T (rs4986909 )

Allele Name : CYP3A4*13
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Decreased CYP3A4
Description : Poor drug metabolizer, increased exposure may lead to cardiac arrhythmias and exaggerated beta-adrenergic blocking activity.
References :

  1. Rythmol SR (propafenone hydrochloride)[package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2013. [Link]

PMID: 25445788

Propafenone

By

Propafenone

Product: LY 303511

Identifier : DBSNPE005049
Drug : DB01182 (Propafenone)
Interacting Gene/Enzyme : Cytochrome P450 3A4
Gene Name : CYP3A4
UniProt ID : P08684
Defining Change(s) :

  • 554C>G (rs12721627 )

Allele Name : CYP3A4*16A
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Decreased CYP3A4
Description : Poor drug metabolizer, increased exposure may lead to cardiac arrhythmias and exaggerated beta-adrenergic blocking activity.
References :

  1. Rythmol SR (propafenone hydrochloride)[package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2013. [Link]

PMID: 16300398

Propafenone

By

Propafenone

Product: Zaltidine

Identifier : DBSNPE005050
Drug : DB01182 (Propafenone)
Interacting Gene/Enzyme : Cytochrome P450 3A4
Gene Name : CYP3A4
UniProt ID : P08684
Defining Change(s) :

  • 554C>G (rs12721627 )

Allele Name : CYP3A4*16B
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Decreased CYP3A4
Description : Poor drug metabolizer, increased exposure may lead to cardiac arrhythmias and exaggerated beta-adrenergic blocking activity.
References :

  1. Rythmol SR (propafenone hydrochloride)[package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2013. [Link]

PMID: 18927296

Propafenone

By

Propafenone

Product: Ebrotidine

Identifier : DBSNPE005051
Drug : DB01182 (Propafenone)
Interacting Gene/Enzyme : Cytochrome P450 3A4
Gene Name : CYP3A4
UniProt ID : P08684
Defining Change(s) :

  • 566T>C (rs4987161 )

Allele Name : CYP3A4*17
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Decreased CYP3A4
Description : Poor drug metabolizer, increased exposure may lead to cardiac arrhythmias and exaggerated beta-adrenergic blocking activity.
References :

  1. Rythmol SR (propafenone hydrochloride)[package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2013. [Link]

PMID: 16330545

Propafenone

By

Propafenone

Product: Tilbroquinol

Identifier : DBSNPE005052
Drug : DB01182 (Propafenone)
Interacting Gene/Enzyme : Cytochrome P450 1A2
Gene Name : CYP1A2
UniProt ID : P05177
Defining Change(s) :

  • 5090C>T (rs28399424 )

Allele Name : CYP1A2*6
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP1A2
Description : Poor drug metabolizer, increased exposure may lead to cardiac arrhythmias and exaggerated beta-adrenergic blocking activity.
References :

  1. Rythmol SR (propafenone hydrochloride)[package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2013. [Link]

PMID: 23329341

Propafenone

By

Propafenone

Product: Lesinurad

Identifier : DBSNPE005053
Drug : DB01182 (Propafenone)
Interacting Gene/Enzyme : Cytochrome P450 1A2
Gene Name : CYP1A2
UniProt ID : P05177
Defining Change(s) :

  • -3860G>A (rs2069514 )

Allele Name : CYP1A2*1C
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Decreased CYP1A2
Description : Poor drug metabolizer, increased exposure may lead to cardiac arrhythmias and exaggerated beta-adrenergic blocking activity.
References :

  1. Rythmol SR (propafenone hydrochloride)[package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2013. [Link]

PMID: 22513931

Propafenone

By

Propafenone

Product: SC-514

Identifier : DBSNPE005054
Drug : DB01182 (Propafenone)
Interacting Gene/Enzyme : Cytochrome P450 1A2
Gene Name : CYP1A2
UniProt ID : P05177
Defining Change(s) :

  • -739T>G (rs12720461 )
  • -729C>T (rs762551 )
  • -163C>A

Allele Name : CYP1A2*1K
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Decreased CYP1A2
Description : Poor drug metabolizer, increased exposure may lead to cardiac arrhythmias and exaggerated beta-adrenergic blocking activity.
References :

  1. Rythmol SR (propafenone hydrochloride)[package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2013. [Link]

PMID: 10074787

Propafenone

By

Propafenone

Product: PQ401

Identifier : DBSNPE005055
Drug : DB01182 (Propafenone)
Interacting Gene/Enzyme : Cytochrome P450 1A2
Gene Name : CYP1A2
UniProt ID : P05177
Defining Change(s) :

  • 2116G>A (rs56276455 )
  • 5347T>C

Allele Name : CYP1A2*3
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Decreased CYP1A2
Description : Poor drug metabolizer, increased exposure may lead to cardiac arrhythmias and exaggerated beta-adrenergic blocking activity.
References :

  1. Rythmol SR (propafenone hydrochloride)[package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2013. [Link]

PMID: 8853957

Propafenone

By

Propafenone

Product: Lomeguatrib

Identifier : DBSNPE005056
Drug : DB01182 (Propafenone)
Interacting Gene/Enzyme : Cytochrome P450 1A2
Gene Name : CYP1A2
UniProt ID : P05177
Defining Change(s) :

  • 2499A>T (rs72547516 )

Allele Name : CYP1A2*4
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Decreased CYP1A2
Description : Poor drug metabolizer, increased exposure may lead to cardiac arrhythmias and exaggerated beta-adrenergic blocking activity.
References :

  1. Rythmol SR (propafenone hydrochloride)[package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2013. [Link]

PMID: 20104850

Propafenone

By

Propafenone

Product: mTOR-IN-1

Identifier : DBSNPE005057
Drug : DB01182 (Propafenone)
Interacting Gene/Enzyme : Cytochrome P450 1A2
Gene Name : CYP1A2
UniProt ID : P05177
Defining Change(s) :

  • 3533G>A (rs56107638 )

Allele Name : CYP1A2*7
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Decreased CYP1A2
Description : Poor drug metabolizer, increased exposure may lead to cardiac arrhythmias and exaggerated beta-adrenergic blocking activity.
References :

  1. Rythmol SR (propafenone hydrochloride)[package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2013. [Link]

PMID: 15357997

Propafenone

By

Propafenone

Product: AZD-3463

Identifier : DBSNPE005058
Drug : DB01182 (Propafenone)
Interacting Gene/Enzyme : Cytochrome P450 1A2
Gene Name : CYP1A2
UniProt ID : P05177
Defining Change(s) :

  • 5166G>A (rs72547517 )
  • 5347T>C

Allele Name : CYP1A2*8
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Decreased CYP1A2
Description : Poor drug metabolizer, increased exposure may lead to cardiac arrhythmias and exaggerated beta-adrenergic blocking activity.
References :

  1. Rythmol SR (propafenone hydrochloride)[package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2013. [Link]

PMID: 19615387

Propafenone

By

Propafenone

Product: BMS-564929

Identifier : DBSNPE005059
Drug : DB01182 (Propafenone)
Interacting Gene/Enzyme : Cytochrome P450 1A2
Gene Name : CYP1A2
UniProt ID : P05177
Defining Change(s) :

  • 558C>A (rs72547513 )

Allele Name : CYP1A2*11
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Decreased CYP1A2
Description : Poor drug metabolizer, increased exposure may lead to cardiac arrhythmias and exaggerated beta-adrenergic blocking activity.
References :

  1. Rythmol SR (propafenone hydrochloride)[package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2013. [Link]

PMID: 20550119

Propafenone

By

Propafenone

Product: Amineptine

Identifier : DBSNPE005060
Drug : DB01182 (Propafenone)
Interacting Gene/Enzyme : Cytochrome P450 1A2
Gene Name : CYP1A2
UniProt ID : P05177
Defining Change(s) :

  • 125C>G (rs72547511 )
  • 5347T>C

Allele Name : CYP1A2*15
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Decreased CYP1A2
Description : Poor drug metabolizer, increased exposure may lead to cardiac arrhythmias and exaggerated beta-adrenergic blocking activity.
References :

  1. Rythmol SR (propafenone hydrochloride)[package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2013. [Link]

PMID: 16302826

Propafenone

By

Propafenone

Product: Reparixin (L-lysine salt)

Identifier : DBSNPE005061
Drug : DB01182 (Propafenone)
Interacting Gene/Enzyme : Cytochrome P450 1A2
Gene Name : CYP1A2
UniProt ID : P05177
Defining Change(s) :

  • 2473G>A (rs72547515 )
  • 5347T>C

Allele Name : CYP1A2*16
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Decreased CYP1A2
Description : Poor drug metabolizer, increased exposure may lead to cardiac arrhythmias and exaggerated beta-adrenergic blocking activity.
References :

  1. Rythmol SR (propafenone hydrochloride)[package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2013. [Link]

PMID: 14550509

Propafenone

By

Propafenone

Product: Sodium phenylbutyrate

Identifier : DBSNPE005043
Drug : DB01182 (Propafenone)
Interacting Gene/Enzyme : Cytochrome P450 3A4
Gene Name : CYP3A4
UniProt ID : P08684
Defining Change(s) :

  • 1461_1462insA (rs67666821 )

Allele Name : CYP3A4*20
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP3A4
Description : Poor drug metabolizer, increased exposure may lead to cardiac arrhythmias and exaggerated beta-adrenergic blocking activity.
References :

  1. Rythmol SR (propafenone hydrochloride)[package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2013. [Link]

PMID: 2581174

Propafenone

By

Propafenone

Product: Azilsartan

Identifier : DBSNPE005044
Drug : DB01182 (Propafenone)
Interacting Gene/Enzyme : Cytochrome P450 3A4
Gene Name : CYP3A4
UniProt ID : P08684
Defining Change(s) :

  • 802C>T (rs138105638 )

Allele Name : CYP3A4*26
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP3A4
Description : Poor drug metabolizer, increased exposure may lead to cardiac arrhythmias and exaggerated beta-adrenergic blocking activity.
References :

  1. Rythmol SR (propafenone hydrochloride)[package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2013. [Link]

PMID: 2581167

Propafenone

By

Propafenone

Product: Tripelennamine (hydrochloride)

Identifier : DBSNPE005045
Drug : DB01182 (Propafenone)
Interacting Gene/Enzyme : Cytochrome P450 3A4
Gene Name : CYP3A4
UniProt ID : P08684
Defining Change(s) :

  • 13908G>A (rs72552799 )

Allele Name : CYP3A4*8
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Decreased CYP3A4
Description : Poor drug metabolizer, increased exposure may lead to cardiac arrhythmias and exaggerated beta-adrenergic blocking activity.
References :

  1. Rythmol SR (propafenone hydrochloride)[package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2013. [Link]

PMID: 6194840

Propafenone

By

Propafenone

Product: (R)-(-)-Ibuprofen

Identifier : DBSNPE005046
Drug : DB01182 (Propafenone)
Interacting Gene/Enzyme : Cytochrome P450 3A4
Gene Name : CYP3A4
UniProt ID : P08684
Defining Change(s) :

  • 1088C>T (rs67784355 )

Allele Name : CYP3A4*11
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Decreased CYP3A4
Description : Poor drug metabolizer, increased exposure may lead to cardiac arrhythmias and exaggerated beta-adrenergic blocking activity.
References :

  1. Rythmol SR (propafenone hydrochloride)[package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2013. [Link]

PMID: 11897392

Propafenone

By

Propafenone

Product: (S)-(+)-Ibuprofen

Identifier : DBSNPE005047
Drug : DB01182 (Propafenone)
Interacting Gene/Enzyme : Cytochrome P450 3A4
Gene Name : CYP3A4
UniProt ID : P08684
Defining Change(s) :

  • 1117C>T (rs12721629 )

Allele Name : CYP3A4*12
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Decreased CYP3A4
Description : Poor drug metabolizer, increased exposure may lead to cardiac arrhythmias and exaggerated beta-adrenergic blocking activity.
References :

  1. Rythmol SR (propafenone hydrochloride)[package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2013. [Link]

PMID: 10800964

Propafenone

By

Propafenone

Product: AG 18

Identifier : DBSNPE005048
Drug : DB01182 (Propafenone)
Interacting Gene/Enzyme : Cytochrome P450 3A4
Gene Name : CYP3A4
UniProt ID : P08684
Defining Change(s) :

  • 1247C>T (rs4986909 )

Allele Name : CYP3A4*13
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Decreased CYP3A4
Description : Poor drug metabolizer, increased exposure may lead to cardiac arrhythmias and exaggerated beta-adrenergic blocking activity.
References :

  1. Rythmol SR (propafenone hydrochloride)[package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2013. [Link]

PMID: 25445788

Propafenone

By

Propafenone

Product: LY 303511

Identifier : DBSNPE005049
Drug : DB01182 (Propafenone)
Interacting Gene/Enzyme : Cytochrome P450 3A4
Gene Name : CYP3A4
UniProt ID : P08684
Defining Change(s) :

  • 554C>G (rs12721627 )

Allele Name : CYP3A4*16A
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Decreased CYP3A4
Description : Poor drug metabolizer, increased exposure may lead to cardiac arrhythmias and exaggerated beta-adrenergic blocking activity.
References :

  1. Rythmol SR (propafenone hydrochloride)[package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2013. [Link]

PMID: 16300398

Propafenone

By

Propafenone

Product: Zaltidine

Identifier : DBSNPE005050
Drug : DB01182 (Propafenone)
Interacting Gene/Enzyme : Cytochrome P450 3A4
Gene Name : CYP3A4
UniProt ID : P08684
Defining Change(s) :

  • 554C>G (rs12721627 )

Allele Name : CYP3A4*16B
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Decreased CYP3A4
Description : Poor drug metabolizer, increased exposure may lead to cardiac arrhythmias and exaggerated beta-adrenergic blocking activity.
References :

  1. Rythmol SR (propafenone hydrochloride)[package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2013. [Link]

PMID: 18927296

Propafenone

By

Propafenone

Product: Ebrotidine

Identifier : DBSNPE005051
Drug : DB01182 (Propafenone)
Interacting Gene/Enzyme : Cytochrome P450 3A4
Gene Name : CYP3A4
UniProt ID : P08684
Defining Change(s) :

  • 566T>C (rs4987161 )

Allele Name : CYP3A4*17
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Decreased CYP3A4
Description : Poor drug metabolizer, increased exposure may lead to cardiac arrhythmias and exaggerated beta-adrenergic blocking activity.
References :

  1. Rythmol SR (propafenone hydrochloride)[package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2013. [Link]

PMID: 16330545

Propafenone

By

Propafenone

Product: Tilbroquinol

Identifier : DBSNPE005052
Drug : DB01182 (Propafenone)
Interacting Gene/Enzyme : Cytochrome P450 1A2
Gene Name : CYP1A2
UniProt ID : P05177
Defining Change(s) :

  • 5090C>T (rs28399424 )

Allele Name : CYP1A2*6
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP1A2
Description : Poor drug metabolizer, increased exposure may lead to cardiac arrhythmias and exaggerated beta-adrenergic blocking activity.
References :

  1. Rythmol SR (propafenone hydrochloride)[package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2013. [Link]

PMID: 23329341

Propafenone

By

Propafenone

Product: Lesinurad

Identifier : DBSNPE005053
Drug : DB01182 (Propafenone)
Interacting Gene/Enzyme : Cytochrome P450 1A2
Gene Name : CYP1A2
UniProt ID : P05177
Defining Change(s) :

  • -3860G>A (rs2069514 )

Allele Name : CYP1A2*1C
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Decreased CYP1A2
Description : Poor drug metabolizer, increased exposure may lead to cardiac arrhythmias and exaggerated beta-adrenergic blocking activity.
References :

  1. Rythmol SR (propafenone hydrochloride)[package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2013. [Link]

PMID: 22513931

Propafenone

By

Propafenone

Product: SC-514

Identifier : DBSNPE005054
Drug : DB01182 (Propafenone)
Interacting Gene/Enzyme : Cytochrome P450 1A2
Gene Name : CYP1A2
UniProt ID : P05177
Defining Change(s) :

  • -739T>G (rs12720461 )
  • -729C>T (rs762551 )
  • -163C>A

Allele Name : CYP1A2*1K
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Decreased CYP1A2
Description : Poor drug metabolizer, increased exposure may lead to cardiac arrhythmias and exaggerated beta-adrenergic blocking activity.
References :

  1. Rythmol SR (propafenone hydrochloride)[package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2013. [Link]

PMID: 10074787

Propafenone

By

Propafenone

Product: PQ401

Identifier : DBSNPE005055
Drug : DB01182 (Propafenone)
Interacting Gene/Enzyme : Cytochrome P450 1A2
Gene Name : CYP1A2
UniProt ID : P05177
Defining Change(s) :

  • 2116G>A (rs56276455 )
  • 5347T>C

Allele Name : CYP1A2*3
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Decreased CYP1A2
Description : Poor drug metabolizer, increased exposure may lead to cardiac arrhythmias and exaggerated beta-adrenergic blocking activity.
References :

  1. Rythmol SR (propafenone hydrochloride)[package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2013. [Link]

PMID: 8853957

Propafenone

By

Propafenone

Product: Lomeguatrib

Identifier : DBSNPE005056
Drug : DB01182 (Propafenone)
Interacting Gene/Enzyme : Cytochrome P450 1A2
Gene Name : CYP1A2
UniProt ID : P05177
Defining Change(s) :

  • 2499A>T (rs72547516 )

Allele Name : CYP1A2*4
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Decreased CYP1A2
Description : Poor drug metabolizer, increased exposure may lead to cardiac arrhythmias and exaggerated beta-adrenergic blocking activity.
References :

  1. Rythmol SR (propafenone hydrochloride)[package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2013. [Link]

PMID: 20104850

Propafenone

By

Propafenone

Product: mTOR-IN-1

Identifier : DBSNPE005057
Drug : DB01182 (Propafenone)
Interacting Gene/Enzyme : Cytochrome P450 1A2
Gene Name : CYP1A2
UniProt ID : P05177
Defining Change(s) :

  • 3533G>A (rs56107638 )

Allele Name : CYP1A2*7
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Decreased CYP1A2
Description : Poor drug metabolizer, increased exposure may lead to cardiac arrhythmias and exaggerated beta-adrenergic blocking activity.
References :

  1. Rythmol SR (propafenone hydrochloride)[package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2013. [Link]

PMID: 15357997

Propafenone

By

Propafenone

Product: AZD-3463

Identifier : DBSNPE005058
Drug : DB01182 (Propafenone)
Interacting Gene/Enzyme : Cytochrome P450 1A2
Gene Name : CYP1A2
UniProt ID : P05177
Defining Change(s) :

  • 5166G>A (rs72547517 )
  • 5347T>C

Allele Name : CYP1A2*8
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Decreased CYP1A2
Description : Poor drug metabolizer, increased exposure may lead to cardiac arrhythmias and exaggerated beta-adrenergic blocking activity.
References :

  1. Rythmol SR (propafenone hydrochloride)[package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2013. [Link]

PMID: 19615387

Propafenone

By

Propafenone

Product: BMS-564929

Identifier : DBSNPE005059
Drug : DB01182 (Propafenone)
Interacting Gene/Enzyme : Cytochrome P450 1A2
Gene Name : CYP1A2
UniProt ID : P05177
Defining Change(s) :

  • 558C>A (rs72547513 )

Allele Name : CYP1A2*11
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Decreased CYP1A2
Description : Poor drug metabolizer, increased exposure may lead to cardiac arrhythmias and exaggerated beta-adrenergic blocking activity.
References :

  1. Rythmol SR (propafenone hydrochloride)[package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2013. [Link]

PMID: 20550119

Propafenone

By

Propafenone

Product: Amineptine

Identifier : DBSNPE005060
Drug : DB01182 (Propafenone)
Interacting Gene/Enzyme : Cytochrome P450 1A2
Gene Name : CYP1A2
UniProt ID : P05177
Defining Change(s) :

  • 125C>G (rs72547511 )
  • 5347T>C

Allele Name : CYP1A2*15
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Decreased CYP1A2
Description : Poor drug metabolizer, increased exposure may lead to cardiac arrhythmias and exaggerated beta-adrenergic blocking activity.
References :

  1. Rythmol SR (propafenone hydrochloride)[package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2013. [Link]

PMID: 16302826

Propafenone

By

Propafenone

Product: Reparixin (L-lysine salt)

Identifier : DBSNPE005061
Drug : DB01182 (Propafenone)
Interacting Gene/Enzyme : Cytochrome P450 1A2
Gene Name : CYP1A2
UniProt ID : P05177
Defining Change(s) :

  • 2473G>A (rs72547515 )
  • 5347T>C

Allele Name : CYP1A2*16
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Decreased CYP1A2
Description : Poor drug metabolizer, increased exposure may lead to cardiac arrhythmias and exaggerated beta-adrenergic blocking activity.
References :

  1. Rythmol SR (propafenone hydrochloride)[package insert]. Research Triangle Park, North Carolina: GlaxoSmithKline; 2013. [Link]

PMID: 14550509

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