PI3KInhibitorpi3kinhibitor

Perphenazine

By

Perphenazine

Product: HG-9-91-01

Identifier : DBSNPE004701
Drug : DB00850 (Perphenazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • C allele (rs35742686 )

Allele Name : CYP2D6*3
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, more side effects.
References :

  1. Trilafon® (perphenazine) tablets[package insert]. Kenilworth, New Jersey: Schering Corporation; 2002. [Link]

PMID: 23953843

Perphenazine

By

Perphenazine

Product: Deltarasin (hydrochloride)

Identifier : DBSNPE004702
Drug : DB00850 (Perphenazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • C allele (rs3892097 )

Allele Name : CYP2D6*4
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, more side effects.
References :

  1. Trilafon® (perphenazine) tablets[package insert]. Kenilworth, New Jersey: Schering Corporation; 2002. [Link]

PMID: 7531648

Perphenazine

By

Perphenazine

Product: Napabucasin

Identifier : DBSNPE004703
Drug : DB00850 (Perphenazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • Whole-gene deletion

Allele Name : CYP2D6*5
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, more side effects.
References :

  1. Trilafon® (perphenazine) tablets[package insert]. Kenilworth, New Jersey: Schering Corporation; 2002. [Link]

PMID: 7686493

Perphenazine

By

Perphenazine

Product: Flupirtine

Identifier : DBSNPE004704
Drug : DB00850 (Perphenazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 1707delT (rs5030655 )

Allele Name : CYP2D6*6
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, more side effects.
References :

  1. Trilafon® (perphenazine) tablets[package insert]. Kenilworth, New Jersey: Schering Corporation; 2002. [Link]

PMID: 1282073

Perphenazine

By

Perphenazine

Product: Isoliquiritigenin

Identifier : DBSNPE004705
Drug : DB00850 (Perphenazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 2935A>C (rs5030867 )

Allele Name : CYP2D6*7
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, more side effects.
References :

  1. Trilafon® (perphenazine) tablets[package insert]. Kenilworth, New Jersey: Schering Corporation; 2002. [Link]

PMID: 8566116

Perphenazine

By

Perphenazine

Product: IOWH-032

Identifier : DBSNPE004706
Drug : DB00850 (Perphenazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 1758G>T (rs5030865 )

Allele Name : CYP2D6*8
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, more side effects.
References :

  1. Trilafon® (perphenazine) tablets[package insert]. Kenilworth, New Jersey: Schering Corporation; 2002. [Link]

PMID: 1335533

Perphenazine

By

Perphenazine

Product: SKLB610

Identifier : DBSNPE004707
Drug : DB00850 (Perphenazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 883G>C (rs5030863 )

Allele Name : CYP2D6*11
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, more side effects.
References :

  1. Trilafon® (perphenazine) tablets[package insert]. Kenilworth, New Jersey: Schering Corporation; 2002. [Link]

PMID: 11708932

Perphenazine

By

Perphenazine

Product: Cortisone (acetate)

Identifier : DBSNPE004708
Drug : DB00850 (Perphenazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 124G>A (rs5030862 )

Allele Name : CYP2D6*12
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, more side effects.
References :

  1. Trilafon® (perphenazine) tablets[package insert]. Kenilworth, New Jersey: Schering Corporation; 2002. [Link]

PMID: 9831906

Perphenazine

By

Perphenazine

Product: Pacritinib

Identifier : DBSNPE004709
Drug : DB00850 (Perphenazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • CYP2D7/2D6 hybrid gene sdivucture

Allele Name : CYP2D6*13
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, more side effects.
References :

  1. Trilafon® (perphenazine) tablets[package insert]. Kenilworth, New Jersey: Schering Corporation; 2002. [Link]

PMID: 7509807

Perphenazine

By

Perphenazine

Product: AZD7545

Identifier : DBSNPE004710
Drug : DB00850 (Perphenazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 1758G>A (rs5030865 )

Allele Name : CYP2D6*14A
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, more side effects.
References :

  1. Trilafon® (perphenazine) tablets[package insert]. Kenilworth, New Jersey: Schering Corporation; 2002. [Link]

PMID: 7513763

Perphenazine

By

Perphenazine

Product: PF-4708671

Identifier : DBSNPE004711
Drug : DB00850 (Perphenazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 137insT, 137_138insT

Allele Name : CYP2D6*15
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, more side effects.
References :

  1. Trilafon® (perphenazine) tablets[package insert]. Kenilworth, New Jersey: Schering Corporation; 2002. [Link]

PMID: 8393115

Perphenazine

By

Perphenazine

Product: TIC10 isomer

Identifier : DBSNPE004712
Drug : DB00850 (Perphenazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 2539_2542delAACT (rs72549353 )

Allele Name : CYP2D6*19
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, more side effects.
References :

  1. Trilafon® (perphenazine) tablets[package insert]. Kenilworth, New Jersey: Schering Corporation; 2002. [Link]

PMID: 23345604

Perphenazine

By

Perphenazine

Product: CBB1007

Identifier : DBSNPE004713
Drug : DB00850 (Perphenazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 1973_1974insG (rs72549354 )

Allele Name : CYP2D6*20
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, more side effects.
References :

  1. Trilafon® (perphenazine) tablets[package insert]. Kenilworth, New Jersey: Schering Corporation; 2002. [Link]

PMID: 24030979

Perphenazine

By

Perphenazine

Product: Arginase inhibitor 1

Identifier : DBSNPE004714
Drug : DB00850 (Perphenazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 2573insC

Allele Name : CYP2D6*21
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, more side effects.
References :

  1. Trilafon® (perphenazine) tablets[package insert]. Kenilworth, New Jersey: Schering Corporation; 2002. [Link]

PMID: 12225694

Perphenazine

By

Perphenazine

Product: AZ505

Identifier : DBSNPE004715
Drug : DB00850 (Perphenazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • -1770G>A
  • -1584C>G
  • -1235A>G
  • -740C>T
  • -678G>A
  • CYP2D7 gene conversion in indivon 1
  • 310G>T
  • 746C>G
  • 843T>G
  • 1661G>C
  • 2850C>T
  • 3384A>C
  • 3584G>A
  • 3790C>T
  • 4042G>A
  • 4180G>C
  • 4481G>A

Allele Name : CYP2D6*31
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, more side effects.
References :

  1. Trilafon® (perphenazine) tablets[package insert]. Kenilworth, New Jersey: Schering Corporation; 2002. [Link]

PMID: 9733503

Perphenazine

By

Perphenazine

Product: AZ505 (ditrifluoroacetate)

Identifier : DBSNPE004716
Drug : DB00850 (Perphenazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 100C>T (rs1065852 )
  • -1426C>T
  • variable number of A’s in the region -1258 to -1237a
  • -1235A>G
  • -1000G>A
  • 1039C>T
  • 1661G>C
  • gene conversion to CYP2D7 in exon 9
  • 4180G>C

Allele Name : CYP2D6*36
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, more side effects.
References :

  1. Trilafon® (perphenazine) tablets[package insert]. Kenilworth, New Jersey: Schering Corporation; 2002. [Link]

PMID: 8982729

Perphenazine

By

Perphenazine

Product: AWD 131-138

Identifier : DBSNPE004717
Drug : DB00850 (Perphenazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 2587_2590delGACT (rs72549351 )

Allele Name : CYP2D6*38
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, more side effects.
References :

  1. Trilafon® (perphenazine) tablets[package insert]. Kenilworth, New Jersey: Schering Corporation; 2002. [Link]

PMID: 26114632

Perphenazine

By

Perphenazine

Product: Methotrexate

Identifier : DBSNPE004718
Drug : DB00850 (Perphenazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 1863_1864ins(TTT CGC CCC)2 (rs72549356 )

Allele Name : CYP2D6*40
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, more side effects.
References :

  1. Trilafon® (perphenazine) tablets[package insert]. Kenilworth, New Jersey: Schering Corporation; 2002. [Link]

PMID: 23996004

Perphenazine

By

Perphenazine

Product: ZCL278

Identifier : DBSNPE004719
Drug : DB00850 (Perphenazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 3259_3260insGT (rs72549346 )

Allele Name : CYP2D6*42
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, more side effects.
References :

  1. Trilafon® (perphenazine) tablets[package insert]. Kenilworth, New Jersey: Schering Corporation; 2002. [Link]

PMID: 22905134

Perphenazine

By

Perphenazine

Product: GSK1324726A

Identifier : DBSNPE004720
Drug : DB00850 (Perphenazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 2950G>C

Allele Name : CYP2D6*44
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, more side effects.
References :

  1. Trilafon® (perphenazine) tablets[package insert]. Kenilworth, New Jersey: Schering Corporation; 2002. [Link]

PMID: 18337316

Perphenazine

By

Perphenazine

Product: MS436

Identifier : DBSNPE004721
Drug : DB00850 (Perphenazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 100C>T (rs1065852 )
  • -1426C>T
  • -1235A>G
  • -1000G>A
  • 73C<T
  • 1039C>T
  • 1661G>C
  • 4180G>C

Allele Name : CYP2D6*47
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, more side effects.
References :

  1. Trilafon® (perphenazine) tablets[package insert]. Kenilworth, New Jersey: Schering Corporation; 2002. [Link]

PMID: 18945947

Perphenazine

By

Perphenazine

Product: GNF-5837

Identifier : DBSNPE004722
Drug : DB00850 (Perphenazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • -1584C>G
  • -1235A>G
  • -740C>T
  • -678G>A
  • CYP2D7 gene conversion in indivon 1
  • 1661G>C
  • 2850C>T
  • 3172A>C
  • 4180G>C

Allele Name : CYP2D6*51
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, more side effects.
References :

  1. Trilafon® (perphenazine) tablets[package insert]. Kenilworth, New Jersey: Schering Corporation; 2002. [Link]

PMID: 17295025

Perphenazine

By

Perphenazine

Product: VU0152100

Identifier : DBSNPE004723
Drug : DB00850 (Perphenazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 3201C>T (rs72549347 )

Allele Name : CYP2D6*56
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, more side effects.
References :

  1. Trilafon® (perphenazine) tablets[package insert]. Kenilworth, New Jersey: Schering Corporation; 2002. [Link]

PMID: 14617692

Perphenazine

By

Perphenazine

Product: SR-3677

Identifier : DBSNPE004724
Drug : DB00850 (Perphenazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 100C>T
  • 310G>T
  • 843T>G
  • 887C>T
  • 1039C>T
  • 1661G>C
  • 3384A>C
  • 3582A>G
  • gene conversion to CYP2D7 in exon 9
  • 4180G>C

Allele Name : CYP2D6*57
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, more side effects.
References :

  1. Trilafon® (perphenazine) tablets[package insert]. Kenilworth, New Jersey: Schering Corporation; 2002. [Link]

PMID: 7682138

Perphenazine

By

Perphenazine

Product: PYZD-4409

Identifier : DBSNPE004725
Drug : DB00850 (Perphenazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 4044C>T

Allele Name : CYP2D6*62
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, more side effects.
References :

  1. Trilafon® (perphenazine) tablets[package insert]. Kenilworth, New Jersey: Schering Corporation; 2002. [Link]

PMID: 8306108

Perphenazine

By

Perphenazine

Product: PYR-41

Identifier : DBSNPE004726
Drug : DB00850 (Perphenazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • -1426C>T
  • -1235A>G
  • -1000G>A
  • 100C>T
  • 310G>T
  • CYP2D7 sequence from indivon 1 onwards

Allele Name : CYP2D6*68A
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, more side effects.
References :

  1. Trilafon® (perphenazine) tablets[package insert]. Kenilworth, New Jersey: Schering Corporation; 2002. [Link]

PMID: 1281470

Perphenazine

By

Perphenazine

Product: FAAH inhibitor 1

Identifier : DBSNPE004727
Drug : DB00850 (Perphenazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • Similar but not identical switch region compared to CYP2D6*68A. Found in tandem arrangement with CYP2D6*4.

Allele Name : CYP2D6*68B
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, more side effects.
References :

  1. Trilafon® (perphenazine) tablets[package insert]. Kenilworth, New Jersey: Schering Corporation; 2002. [Link]

PMID: 1719549

Perphenazine

By

Perphenazine

Product: Palosuran

Identifier : DBSNPE004728
Drug : DB00850 (Perphenazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 2988G>A (rs28371725 )
  • -1426C>T
  • -1235A>G
  • -1000G>A
  • 100C>T
  • 310G>T
  • 746C>G
  • 843T>G
  • 1062A>G
  • 1661G>C
  • 2850C>T
  • 3384A>C
  • 3584G>A
  • 3790C>T
  • 4180G>C
  • 4401C>T
  • 4481G>A

Allele Name : CYP2D6*69
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, more side effects.
References :

  1. Trilafon® (perphenazine) tablets[package insert]. Kenilworth, New Jersey: Schering Corporation; 2002. [Link]

PMID: 22849826

Perphenazine

By

Perphenazine

Product: LXR-623

Identifier : DBSNPE004729
Drug : DB00850 (Perphenazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 1995delC

Allele Name : CYP2D6*92
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, more side effects.
References :

  1. Trilafon® (perphenazine) tablets[package insert]. Kenilworth, New Jersey: Schering Corporation; 2002. [Link]

PMID: 19812353

Perphenazine

By

Perphenazine

Product: MLN9708

Identifier : DBSNPE004730
Drug : DB00850 (Perphenazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • -1426C>T
  • -1235A>G
  • -1109C>T
  • -1000G>A
  • 100C>T
  • 310G>T
  • 843T>G
  • 1039C>T
  • 1661G>C
  • 2097A>G
  • 2828delC
  • 3384A>C
  • 3582A>G
  • 4180G>C
  • 4401C>T

Allele Name : CYP2D6*100
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, more side effects.
References :

  1. Trilafon® (perphenazine) tablets[package insert]. Kenilworth, New Jersey: Schering Corporation; 2002. [Link]

PMID: 9758219

Perphenazine

By

Perphenazine

Product: Pyrimethamine

Identifier : DBSNPE004731
Drug : DB00850 (Perphenazine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • -1426C>T
  • -1235A>G
  • -1000G>A
  • 100C>T
  • 310G>T
  • 843T>G
  • 1039C>T
  • 1661G>C
  • 2097A>G
  • 2927_2945delGATCCTACATCCGGATGTG
  • 3384A>C
  • 3582A>G
  • 4180G>C
  • 4401C>T

Allele Name : CYP2D6*101
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, more side effects.
References :

  1. Trilafon® (perphenazine) tablets[package insert]. Kenilworth, New Jersey: Schering Corporation; 2002. [Link]

PMID: 9630347

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