PI3KInhibitorpi3kinhibitor

Iloperidone

By

Iloperidone

Product: Meptazinol (hydrochloride)

Identifier : DBSNPE004670
Drug : DB04946 (Iloperidone)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • C allele (rs35742686 )

Allele Name : CYP2D6*3
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Fanapt® (iloperidone) tablets[package insert]. Washington, D.C.: Vanda Pharmaceuticals Inc.; 2017. [Link]

PMID: 7680591

Iloperidone

By

Iloperidone

Product: TR-14035

Identifier : DBSNPE004671
Drug : DB04946 (Iloperidone)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • C allele (rs3892097 )

Allele Name : CYP2D6*4
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Fanapt® (iloperidone) tablets[package insert]. Washington, D.C.: Vanda Pharmaceuticals Inc.; 2017. [Link]

PMID: 7693278

Iloperidone

By

Iloperidone

Product: GNF-5

Identifier : DBSNPE004672
Drug : DB04946 (Iloperidone)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • Whole-gene deletion

Allele Name : CYP2D6*5
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Fanapt® (iloperidone) tablets[package insert]. Washington, D.C.: Vanda Pharmaceuticals Inc.; 2017. [Link]

PMID: 7540822

Iloperidone

By

Iloperidone

Product: LH846

Identifier : DBSNPE004673
Drug : DB04946 (Iloperidone)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 1707delT (rs5030655 )

Allele Name : CYP2D6*6
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Fanapt® (iloperidone) tablets[package insert]. Washington, D.C.: Vanda Pharmaceuticals Inc.; 2017. [Link]

PMID: 2049105

Iloperidone

By

Iloperidone

Product: BML-277

Identifier : DBSNPE004674
Drug : DB04946 (Iloperidone)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 2935A>C (rs5030867 )

Allele Name : CYP2D6*7
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Fanapt® (iloperidone) tablets[package insert]. Washington, D.C.: Vanda Pharmaceuticals Inc.; 2017. [Link]

PMID: 3263652

Iloperidone

By

Iloperidone

Product: NVP 231

Identifier : DBSNPE004675
Drug : DB04946 (Iloperidone)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 1758G>T (rs5030865 )

Allele Name : CYP2D6*8
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Fanapt® (iloperidone) tablets[package insert]. Washington, D.C.: Vanda Pharmaceuticals Inc.; 2017. [Link]

PMID: 26132391

Iloperidone

By

Iloperidone

Product: SKLB1002

Identifier : DBSNPE004676
Drug : DB04946 (Iloperidone)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 883G>C (rs5030863 )

Allele Name : CYP2D6*11
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Fanapt® (iloperidone) tablets[package insert]. Washington, D.C.: Vanda Pharmaceuticals Inc.; 2017. [Link]

PMID: 1710109

Iloperidone

By

Iloperidone

Product: CNX-774

Identifier : DBSNPE004677
Drug : DB04946 (Iloperidone)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 124G>A (rs5030862 )

Allele Name : CYP2D6*12
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Fanapt® (iloperidone) tablets[package insert]. Washington, D.C.: Vanda Pharmaceuticals Inc.; 2017. [Link]

PMID: 24305814

Iloperidone

By

Iloperidone

Product: 1-NM-PP1

Identifier : DBSNPE004678
Drug : DB04946 (Iloperidone)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • CYP2D7/2D6 hybrid gene sdivucture

Allele Name : CYP2D6*13
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Fanapt® (iloperidone) tablets[package insert]. Washington, D.C.: Vanda Pharmaceuticals Inc.; 2017. [Link]

PMID: 8886430

Iloperidone

By

Iloperidone

Product: 1-Naphthyl PP1

Identifier : DBSNPE004679
Drug : DB04946 (Iloperidone)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 1758G>A (rs5030865 )

Allele Name : CYP2D6*14A
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Fanapt® (iloperidone) tablets[package insert]. Washington, D.C.: Vanda Pharmaceuticals Inc.; 2017. [Link]

PMID: 8581267

Iloperidone

By

Iloperidone

Product: HG-10-102-01

Identifier : DBSNPE004680
Drug : DB04946 (Iloperidone)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 137insT, 137_138insT

Allele Name : CYP2D6*15
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Fanapt® (iloperidone) tablets[package insert]. Washington, D.C.: Vanda Pharmaceuticals Inc.; 2017. [Link]

PMID: 12856286

Iloperidone

By

Iloperidone

Product: Deguelin

Identifier : DBSNPE004681
Drug : DB04946 (Iloperidone)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 2539_2542delAACT (rs72549353 )

Allele Name : CYP2D6*19
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Fanapt® (iloperidone) tablets[package insert]. Washington, D.C.: Vanda Pharmaceuticals Inc.; 2017. [Link]

PMID: 10422886

Iloperidone

By

Iloperidone

Product: HPGDS inhibitor 1

Identifier : DBSNPE004682
Drug : DB04946 (Iloperidone)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 1973_1974insG (rs72549354 )

Allele Name : CYP2D6*20
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Fanapt® (iloperidone) tablets[package insert]. Washington, D.C.: Vanda Pharmaceuticals Inc.; 2017. [Link]

PMID: 7538205

Iloperidone

By

Iloperidone

Product: Btk inhibitor 1

Identifier : DBSNPE004683
Drug : DB04946 (Iloperidone)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 2573insC

Allele Name : CYP2D6*21
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Fanapt® (iloperidone) tablets[package insert]. Washington, D.C.: Vanda Pharmaceuticals Inc.; 2017. [Link]

PMID: 1719888

Iloperidone

By

Iloperidone

Product: Tolterodine

Identifier : DBSNPE004684
Drug : DB04946 (Iloperidone)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • -1770G>A
  • -1584C>G
  • -1235A>G
  • -740C>T
  • -678G>A
  • CYP2D7 gene conversion in indivon 1
  • 310G>T
  • 746C>G
  • 843T>G
  • 1661G>C
  • 2850C>T
  • 3384A>C
  • 3584G>A
  • 3790C>T
  • 4042G>A
  • 4180G>C
  • 4481G>A

Allele Name : CYP2D6*31
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Fanapt® (iloperidone) tablets[package insert]. Washington, D.C.: Vanda Pharmaceuticals Inc.; 2017. [Link]

PMID: 25422875

Iloperidone

By

Iloperidone

Product: P005091

Identifier : DBSNPE004685
Drug : DB04946 (Iloperidone)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 100C>T (rs1065852 )
  • -1426C>T
  • variable number of A’s in the region -1258 to -1237a
  • -1235A>G
  • -1000G>A
  • 1039C>T
  • 1661G>C
  • gene conversion to CYP2D7 in exon 9
  • 4180G>C

Allele Name : CYP2D6*36
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Fanapt® (iloperidone) tablets[package insert]. Washington, D.C.: Vanda Pharmaceuticals Inc.; 2017. [Link]

PMID: 23722916

Iloperidone

By

Iloperidone

Product: Carboplatin

Identifier : DBSNPE004686
Drug : DB04946 (Iloperidone)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 2587_2590delGACT (rs72549351 )

Allele Name : CYP2D6*38
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Fanapt® (iloperidone) tablets[package insert]. Washington, D.C.: Vanda Pharmaceuticals Inc.; 2017. [Link]

PMID: 11786503

Iloperidone

By

Iloperidone

Product: Glycopyrrolate

Identifier : DBSNPE004687
Drug : DB04946 (Iloperidone)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 1863_1864ins(TTT CGC CCC)2 (rs72549356 )

Allele Name : CYP2D6*40
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Fanapt® (iloperidone) tablets[package insert]. Washington, D.C.: Vanda Pharmaceuticals Inc.; 2017. [Link]

PMID: 12383518

Iloperidone

By

Iloperidone

Product: Cisapride

Identifier : DBSNPE004688
Drug : DB04946 (Iloperidone)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 3259_3260insGT (rs72549346 )

Allele Name : CYP2D6*42
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Fanapt® (iloperidone) tablets[package insert]. Washington, D.C.: Vanda Pharmaceuticals Inc.; 2017. [Link]

PMID: 11725292

Iloperidone

By

Iloperidone

Product: Fosaprepitant (dimeglumine)

Identifier : DBSNPE004689
Drug : DB04946 (Iloperidone)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 2950G>C

Allele Name : CYP2D6*44
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Fanapt® (iloperidone) tablets[package insert]. Washington, D.C.: Vanda Pharmaceuticals Inc.; 2017. [Link]

PMID: 11062498

Iloperidone

By

Iloperidone

Product: Fosaprepitant

Identifier : DBSNPE004690
Drug : DB04946 (Iloperidone)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 100C>T (rs1065852 )
  • -1426C>T
  • -1235A>G
  • -1000G>A
  • 73C<T
  • 1039C>T
  • 1661G>C
  • 4180G>C

Allele Name : CYP2D6*47
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Fanapt® (iloperidone) tablets[package insert]. Washington, D.C.: Vanda Pharmaceuticals Inc.; 2017. [Link]

PMID: 10401563

Iloperidone

By

Iloperidone

Product: Cilostazol

Identifier : DBSNPE004691
Drug : DB04946 (Iloperidone)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • -1584C>G
  • -1235A>G
  • -740C>T
  • -678G>A
  • CYP2D7 gene conversion in indivon 1
  • 1661G>C
  • 2850C>T
  • 3172A>C
  • 4180G>C

Allele Name : CYP2D6*51
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Fanapt® (iloperidone) tablets[package insert]. Washington, D.C.: Vanda Pharmaceuticals Inc.; 2017. [Link]

PMID: 9749783

Iloperidone

By

Iloperidone

Product: EPZ-6438

Identifier : DBSNPE004692
Drug : DB04946 (Iloperidone)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 3201C>T (rs72549347 )

Allele Name : CYP2D6*56
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Fanapt® (iloperidone) tablets[package insert]. Washington, D.C.: Vanda Pharmaceuticals Inc.; 2017. [Link]

PMID: 9365015

Iloperidone

By

Iloperidone

Product: JW 55

Identifier : DBSNPE004693
Drug : DB04946 (Iloperidone)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 100C>T
  • 310G>T
  • 843T>G
  • 887C>T
  • 1039C>T
  • 1661G>C
  • 3384A>C
  • 3582A>G
  • gene conversion to CYP2D7 in exon 9
  • 4180G>C

Allele Name : CYP2D6*57
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Fanapt® (iloperidone) tablets[package insert]. Washington, D.C.: Vanda Pharmaceuticals Inc.; 2017. [Link]

PMID: 1705465

Iloperidone

By

Iloperidone

Product: Adrenosterone

Identifier : DBSNPE004694
Drug : DB04946 (Iloperidone)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 4044C>T

Allele Name : CYP2D6*62
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Fanapt® (iloperidone) tablets[package insert]. Washington, D.C.: Vanda Pharmaceuticals Inc.; 2017. [Link]

PMID: 12649350

Iloperidone

By

Iloperidone

Product: Valganciclovir (hydrochloride)

Identifier : DBSNPE004695
Drug : DB04946 (Iloperidone)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • -1426C>T
  • -1235A>G
  • -1000G>A
  • 100C>T
  • 310G>T
  • CYP2D7 sequence from indivon 1 onwards

Allele Name : CYP2D6*68A
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Fanapt® (iloperidone) tablets[package insert]. Washington, D.C.: Vanda Pharmaceuticals Inc.; 2017. [Link]

PMID: 1378337

Iloperidone

By

Iloperidone

Product: Rolipram

Identifier : DBSNPE004696
Drug : DB04946 (Iloperidone)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • Similar but not identical switch region compared to CYP2D6*68A. Found in tandem arrangement with CYP2D6*4.

Allele Name : CYP2D6*68B
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Fanapt® (iloperidone) tablets[package insert]. Washington, D.C.: Vanda Pharmaceuticals Inc.; 2017. [Link]

PMID: 1703323

Iloperidone

By

Iloperidone

Product: AVE 0991 (sodium salt)

Identifier : DBSNPE004697
Drug : DB04946 (Iloperidone)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 2988G>A (rs28371725 )
  • -1426C>T
  • -1235A>G
  • -1000G>A
  • 100C>T
  • 310G>T
  • 746C>G
  • 843T>G
  • 1062A>G
  • 1661G>C
  • 2850C>T
  • 3384A>C
  • 3584G>A
  • 3790C>T
  • 4180G>C
  • 4401C>T
  • 4481G>A

Allele Name : CYP2D6*69
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Fanapt® (iloperidone) tablets[package insert]. Washington, D.C.: Vanda Pharmaceuticals Inc.; 2017. [Link]

PMID: 25298144

Iloperidone

By

Iloperidone

Product: AVE 0991

Identifier : DBSNPE004698
Drug : DB04946 (Iloperidone)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 1995delC

Allele Name : CYP2D6*92
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Fanapt® (iloperidone) tablets[package insert]. Washington, D.C.: Vanda Pharmaceuticals Inc.; 2017. [Link]

PMID: 17575073

Iloperidone

By

Iloperidone

Product: Imeglimin

Identifier : DBSNPE004699
Drug : DB04946 (Iloperidone)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • -1426C>T
  • -1235A>G
  • -1109C>T
  • -1000G>A
  • 100C>T
  • 310G>T
  • 843T>G
  • 1039C>T
  • 1661G>C
  • 2097A>G
  • 2828delC
  • 3384A>C
  • 3582A>G
  • 4180G>C
  • 4401C>T

Allele Name : CYP2D6*100
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Fanapt® (iloperidone) tablets[package insert]. Washington, D.C.: Vanda Pharmaceuticals Inc.; 2017. [Link]

PMID: 11961054

Iloperidone

By

Iloperidone

Product: LEE011

Identifier : DBSNPE004700
Drug : DB04946 (Iloperidone)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • -1426C>T
  • -1235A>G
  • -1000G>A
  • 100C>T
  • 310G>T
  • 843T>G
  • 1039C>T
  • 1661G>C
  • 2097A>G
  • 2927_2945delGATCCTACATCCGGATGTG
  • 3384A>C
  • 3582A>G
  • 4180G>C
  • 4401C>T

Allele Name : CYP2D6*101
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Fanapt® (iloperidone) tablets[package insert]. Washington, D.C.: Vanda Pharmaceuticals Inc.; 2017. [Link]

PMID: 7582548

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