PI3KInhibitorpi3kinhibitor

Eliglustat

By

Eliglustat

Product: Gatifloxacin

Identifier : DBSNPE004606
Drug : DB09039 (Eliglustat)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • C allele (rs35742686 )

Allele Name : CYP2D6*3
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Cerdelga™ (eliglustat) capsules[package insert]. Waterford, Ireland: Genzyme Ireland, Lspan.; 2014. [Link]

PMID: 18348680

Eliglustat

By

Eliglustat

Product: Fluvoxamine

Identifier : DBSNPE004607
Drug : DB09039 (Eliglustat)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • C allele (rs3892097 )

Allele Name : CYP2D6*4
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Cerdelga™ (eliglustat) capsules[package insert]. Waterford, Ireland: Genzyme Ireland, Lspan.; 2014. [Link]

PMID: 18077569

Eliglustat

By

Eliglustat

Product: Fluvoxamine (maleate)

Identifier : DBSNPE004608
Drug : DB09039 (Eliglustat)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • Whole-gene deletion

Allele Name : CYP2D6*5
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Cerdelga™ (eliglustat) capsules[package insert]. Waterford, Ireland: Genzyme Ireland, Lspan.; 2014. [Link]

PMID: 24347167

Eliglustat

By

Eliglustat

Product: Fluoxetine (hydrochloride)

Identifier : DBSNPE004609
Drug : DB09039 (Eliglustat)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 1707delT (rs5030655 )

Allele Name : CYP2D6*6
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Cerdelga™ (eliglustat) capsules[package insert]. Waterford, Ireland: Genzyme Ireland, Lspan.; 2014. [Link]

PMID: 23446639

Eliglustat

By

Eliglustat

Product: Fluconazole (mesylate)

Identifier : DBSNPE004610
Drug : DB09039 (Eliglustat)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 2935A>C (rs5030867 )

Allele Name : CYP2D6*7
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Cerdelga™ (eliglustat) capsules[package insert]. Waterford, Ireland: Genzyme Ireland, Lspan.; 2014. [Link]

PMID: 21136519

Eliglustat

By

Eliglustat

Product: Fluconazole (hydrate)

Identifier : DBSNPE004611
Drug : DB09039 (Eliglustat)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 1758G>T (rs5030865 )

Allele Name : CYP2D6*8
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Cerdelga™ (eliglustat) capsules[package insert]. Waterford, Ireland: Genzyme Ireland, Lspan.; 2014. [Link]

PMID: 26404256

Eliglustat

By

Eliglustat

Product: Fluconazole

Identifier : DBSNPE004612
Drug : DB09039 (Eliglustat)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 883G>C (rs5030863 )

Allele Name : CYP2D6*11
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Cerdelga™ (eliglustat) capsules[package insert]. Waterford, Ireland: Genzyme Ireland, Lspan.; 2014. [Link]

PMID: 24356881

Eliglustat

By

Eliglustat

Product: Etomidate (hydrochloride)

Identifier : DBSNPE004613
Drug : DB09039 (Eliglustat)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 124G>A (rs5030862 )

Allele Name : CYP2D6*12
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Cerdelga™ (eliglustat) capsules[package insert]. Waterford, Ireland: Genzyme Ireland, Lspan.; 2014. [Link]

PMID: 24583017

Eliglustat

By

Eliglustat

Product: Etomidate

Identifier : DBSNPE004614
Drug : DB09039 (Eliglustat)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • CYP2D7/2D6 hybrid gene sdivucture

Allele Name : CYP2D6*13
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Cerdelga™ (eliglustat) capsules[package insert]. Waterford, Ireland: Genzyme Ireland, Lspan.; 2014. [Link]

PMID: 23748647

Eliglustat

By

Eliglustat

Product: Edaravone

Identifier : DBSNPE004615
Drug : DB09039 (Eliglustat)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 1758G>A (rs5030865 )

Allele Name : CYP2D6*14A
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Cerdelga™ (eliglustat) capsules[package insert]. Waterford, Ireland: Genzyme Ireland, Lspan.; 2014. [Link]

PMID: 22952960

Eliglustat

By

Eliglustat

Product: Doxazosin

Identifier : DBSNPE004616
Drug : DB09039 (Eliglustat)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 137insT, 137_138insT

Allele Name : CYP2D6*15
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Cerdelga™ (eliglustat) capsules[package insert]. Waterford, Ireland: Genzyme Ireland, Lspan.; 2014. [Link]

PMID: 22246885

Eliglustat

By

Eliglustat

Product: Doxazosin (mesylate)

Identifier : DBSNPE004617
Drug : DB09039 (Eliglustat)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 2539_2542delAACT (rs72549353 )

Allele Name : CYP2D6*19
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Cerdelga™ (eliglustat) capsules[package insert]. Waterford, Ireland: Genzyme Ireland, Lspan.; 2014. [Link]

PMID: 26028783

Eliglustat

By

Eliglustat

Product: Zoledronic Acid

Identifier : DBSNPE004618
Drug : DB09039 (Eliglustat)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 1973_1974insG (rs72549354 )

Allele Name : CYP2D6*20
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Cerdelga™ (eliglustat) capsules[package insert]. Waterford, Ireland: Genzyme Ireland, Lspan.; 2014. [Link]

PMID: 22331903

Eliglustat

By

Eliglustat

Product: Streptozocin

Identifier : DBSNPE004619
Drug : DB09039 (Eliglustat)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 2573insC

Allele Name : CYP2D6*21
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Cerdelga™ (eliglustat) capsules[package insert]. Waterford, Ireland: Genzyme Ireland, Lspan.; 2014. [Link]

PMID: 22302819

Eliglustat

By

Eliglustat

Product: Floxuridine

Identifier : DBSNPE004620
Drug : DB09039 (Eliglustat)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • -1770G>A
  • -1584C>G
  • -1235A>G
  • -740C>T
  • -678G>A
  • CYP2D7 gene conversion in indivon 1
  • 310G>T
  • 746C>G
  • 843T>G
  • 1661G>C
  • 2850C>T
  • 3384A>C
  • 3584G>A
  • 3790C>T
  • 4042G>A
  • 4180G>C
  • 4481G>A

Allele Name : CYP2D6*31
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Cerdelga™ (eliglustat) capsules[package insert]. Waterford, Ireland: Genzyme Ireland, Lspan.; 2014. [Link]

PMID: 20407211

Eliglustat

By

Eliglustat

Product: Flumatinib (mesylate)

Identifier : DBSNPE004621
Drug : DB09039 (Eliglustat)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 100C>T (rs1065852 )
  • -1426C>T
  • variable number of A’s in the region -1258 to -1237a
  • -1235A>G
  • -1000G>A
  • 1039C>T
  • 1661G>C
  • gene conversion to CYP2D7 in exon 9
  • 4180G>C

Allele Name : CYP2D6*36
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Cerdelga™ (eliglustat) capsules[package insert]. Waterford, Ireland: Genzyme Ireland, Lspan.; 2014. [Link]

PMID: 21505263

Eliglustat

By

Eliglustat

Product: Dolastatin 10

Identifier : DBSNPE004622
Drug : DB09039 (Eliglustat)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 2587_2590delGACT (rs72549351 )

Allele Name : CYP2D6*38
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Cerdelga™ (eliglustat) capsules[package insert]. Waterford, Ireland: Genzyme Ireland, Lspan.; 2014. [Link]

PMID: 26594153

Eliglustat

By

Eliglustat

Product: Anidulafungin

Identifier : DBSNPE004623
Drug : DB09039 (Eliglustat)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 1863_1864ins(TTT CGC CCC)2 (rs72549356 )

Allele Name : CYP2D6*40
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Cerdelga™ (eliglustat) capsules[package insert]. Waterford, Ireland: Genzyme Ireland, Lspan.; 2014. [Link]

PMID: 22560237

Eliglustat

By

Eliglustat

Product: Mizoribine

Identifier : DBSNPE004624
Drug : DB09039 (Eliglustat)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 3259_3260insGT (rs72549346 )

Allele Name : CYP2D6*42
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Cerdelga™ (eliglustat) capsules[package insert]. Waterford, Ireland: Genzyme Ireland, Lspan.; 2014. [Link]

PMID: 20333308

Eliglustat

By

Eliglustat

Product: Gimeracil

Identifier : DBSNPE004625
Drug : DB09039 (Eliglustat)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 2950G>C

Allele Name : CYP2D6*44
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Cerdelga™ (eliglustat) capsules[package insert]. Waterford, Ireland: Genzyme Ireland, Lspan.; 2014. [Link]

PMID: 15013000

Eliglustat

By

Eliglustat

Product: Bumetanide

Identifier : DBSNPE004626
Drug : DB09039 (Eliglustat)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 100C>T (rs1065852 )
  • -1426C>T
  • -1235A>G
  • -1000G>A
  • 73C<T
  • 1039C>T
  • 1661G>C
  • 4180G>C

Allele Name : CYP2D6*47
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Cerdelga™ (eliglustat) capsules[package insert]. Waterford, Ireland: Genzyme Ireland, Lspan.; 2014. [Link]

PMID: 25538243

Eliglustat

By

Eliglustat

Product: L-Thyroxine (sodium salt pentahydrate)

Identifier : DBSNPE004627
Drug : DB09039 (Eliglustat)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • -1584C>G
  • -1235A>G
  • -740C>T
  • -678G>A
  • CYP2D7 gene conversion in indivon 1
  • 1661G>C
  • 2850C>T
  • 3172A>C
  • 4180G>C

Allele Name : CYP2D6*51
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Cerdelga™ (eliglustat) capsules[package insert]. Waterford, Ireland: Genzyme Ireland, Lspan.; 2014. [Link]

PMID: 21771732

Eliglustat

By

Eliglustat

Product: L-Thyroxine

Identifier : DBSNPE004628
Drug : DB09039 (Eliglustat)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 3201C>T (rs72549347 )

Allele Name : CYP2D6*56
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Cerdelga™ (eliglustat) capsules[package insert]. Waterford, Ireland: Genzyme Ireland, Lspan.; 2014. [Link]

PMID: 27766865

Eliglustat

By

Eliglustat

Product: Refametinib

Identifier : DBSNPE004629
Drug : DB09039 (Eliglustat)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 100C>T
  • 310G>T
  • 843T>G
  • 887C>T
  • 1039C>T
  • 1661G>C
  • 3384A>C
  • 3582A>G
  • gene conversion to CYP2D7 in exon 9
  • 4180G>C

Allele Name : CYP2D6*57
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Cerdelga™ (eliglustat) capsules[package insert]. Waterford, Ireland: Genzyme Ireland, Lspan.; 2014. [Link]

PMID: 9350985

Eliglustat

By

Eliglustat

Product: Mc-Val-Cit-PABC-PNP

Identifier : DBSNPE004630
Drug : DB09039 (Eliglustat)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 4044C>T

Allele Name : CYP2D6*62
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Cerdelga™ (eliglustat) capsules[package insert]. Waterford, Ireland: Genzyme Ireland, Lspan.; 2014. [Link]

PMID: 23103525

Eliglustat

By

Eliglustat

Product: Cetirizine (dihydrochloride)

Identifier : DBSNPE004631
Drug : DB09039 (Eliglustat)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • -1426C>T
  • -1235A>G
  • -1000G>A
  • 100C>T
  • 310G>T
  • CYP2D7 sequence from indivon 1 onwards

Allele Name : CYP2D6*68A
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Cerdelga™ (eliglustat) capsules[package insert]. Waterford, Ireland: Genzyme Ireland, Lspan.; 2014. [Link]

PMID: 18289033

Eliglustat

By

Eliglustat

Product: Biperiden

Identifier : DBSNPE004632
Drug : DB09039 (Eliglustat)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • Similar but not identical switch region compared to CYP2D6*68A. Found in tandem arrangement with CYP2D6*4.

Allele Name : CYP2D6*68B
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Cerdelga™ (eliglustat) capsules[package insert]. Waterford, Ireland: Genzyme Ireland, Lspan.; 2014. [Link]

PMID: 15051797

Eliglustat

By

Eliglustat

Product: Benazepril (hydrochloride)

Identifier : DBSNPE004633
Drug : DB09039 (Eliglustat)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 2988G>A (rs28371725 )
  • -1426C>T
  • -1235A>G
  • -1000G>A
  • 100C>T
  • 310G>T
  • 746C>G
  • 843T>G
  • 1062A>G
  • 1661G>C
  • 2850C>T
  • 3384A>C
  • 3584G>A
  • 3790C>T
  • 4180G>C
  • 4401C>T
  • 4481G>A

Allele Name : CYP2D6*69
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Cerdelga™ (eliglustat) capsules[package insert]. Waterford, Ireland: Genzyme Ireland, Lspan.; 2014. [Link]

PMID: 15060526

Eliglustat

By

Eliglustat

Product: Benazepril

Identifier : DBSNPE004634
Drug : DB09039 (Eliglustat)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 1995delC

Allele Name : CYP2D6*92
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Cerdelga™ (eliglustat) capsules[package insert]. Waterford, Ireland: Genzyme Ireland, Lspan.; 2014. [Link]

PMID: 10900073

Eliglustat

By

Eliglustat

Product: Artemisinin

Identifier : DBSNPE004635
Drug : DB09039 (Eliglustat)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • -1426C>T
  • -1235A>G
  • -1109C>T
  • -1000G>A
  • 100C>T
  • 310G>T
  • 843T>G
  • 1039C>T
  • 1661G>C
  • 2097A>G
  • 2828delC
  • 3384A>C
  • 3582A>G
  • 4180G>C
  • 4401C>T

Allele Name : CYP2D6*100
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Cerdelga™ (eliglustat) capsules[package insert]. Waterford, Ireland: Genzyme Ireland, Lspan.; 2014. [Link]

PMID: 20631193

Eliglustat

By

Eliglustat

Product: Aniracetam

Identifier : DBSNPE004636
Drug : DB09039 (Eliglustat)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • -1426C>T
  • -1235A>G
  • -1000G>A
  • 100C>T
  • 310G>T
  • 843T>G
  • 1039C>T
  • 1661G>C
  • 2097A>G
  • 2927_2945delGATCCTACATCCGGATGTG
  • 3384A>C
  • 3582A>G
  • 4180G>C
  • 4401C>T

Allele Name : CYP2D6*101
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Cerdelga™ (eliglustat) capsules[package insert]. Waterford, Ireland: Genzyme Ireland, Lspan.; 2014. [Link]

PMID: 10497131

Eliglustat

By

Eliglustat

Product: Amisulpride (hydrochloride)

Identifier : DBSNPE004637
Drug : DB09039 (Eliglustat)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • Normal allele duplicated.

Allele Name : CYP2D6*1XN
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Uldiva-rapid metabolizer CYP2D6
Description : Reduced efficacy.
References :

  1. Cerdelga™ (eliglustat) capsules[package insert]. Waterford, Ireland: Genzyme Ireland, Lspan.; 2014. [Link]

PMID: 22479554

Eliglustat

By

Eliglustat

Product: Amisulpride

Identifier : DBSNPE004638
Drug : DB09039 (Eliglustat)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 2850C>T (rs16947 )
  • 4180G>C (rs1135840 )
  • 1661G>C duplicated

Allele Name : CYP2D6*2XN
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Uldiva-rapid metabolizer CYP2D6
Description : Reduced efficacy.
References :

  1. Cerdelga™ (eliglustat) capsules[package insert]. Waterford, Ireland: Genzyme Ireland, Lspan.; 2014. [Link]

PMID: 14770176

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anti-ALOX12 antibody, Singh

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proteasome (prosome, macropain) subunit, beta type, 1

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PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae)

Uncategorized

anti-PD-1 antibody, Beijing Biocytogen