Desipramine
Product: ICA-069673
Identifier : DBSNPE000010
Drug : DB01151 (Desipramine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Allele Name : CYP2D6*4
Genotype(s) : (A;A)
Type(s) : Effect Directly Studied
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirements, higher risk for adverse side effects
References :
- Bijl MJ, Visser LE, Hofman A, Vulto AG, van Gelder T, Sdivicker BH, van Schaik RH: Influence of the CYP2D6*4 polymorphism on dose, switching and discontinuation of antidepressants. Br J Clin Pharmacol. 2008 Apr;65(4):558-64. Epub 2007 Dec 7. [PubMed:18070221 ]
PMID: 22832269
Desipramine
Product: Cilnidipine
Identifier : DBSNPE005226
Drug : DB01151 (Desipramine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Allele Name : CYP2D6*3
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer. For individual with two non-functional alleles, alternative drug or dose reduction recommended.
References :
- Hicks JK, Sangkuhl K, Swen JJ, Ellingrod VL, Muller DJ, Shimoda K, Bishop JR, Kharasch ED, Skaar TC, Gaedigk A, Dunnenberger HM, Klein TE, Caudle KE, Stingl JC: Clinical pharmacogenetics implementation consortium guideline (CPIC) for CYP2D6 and CYP2C19 genotypes and dosing of divicyclic antidepressants: 2016 update. Clin Pharmacol Ther. 2016 Dec 20. doi: 10.1002/cpt.597. [PubMed:27997040 ]
PMID: 27766552
Desipramine
Product: Manidipine (dihydrochloride)
Identifier : DBSNPE005227
Drug : DB01151 (Desipramine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Allele Name : CYP2D6*4
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer. For individual with two non-functional alleles, alternative drug or dose reduction recommended.
References :
- Hicks JK, Sangkuhl K, Swen JJ, Ellingrod VL, Muller DJ, Shimoda K, Bishop JR, Kharasch ED, Skaar TC, Gaedigk A, Dunnenberger HM, Klein TE, Caudle KE, Stingl JC: Clinical pharmacogenetics implementation consortium guideline (CPIC) for CYP2D6 and CYP2C19 genotypes and dosing of divicyclic antidepressants: 2016 update. Clin Pharmacol Ther. 2016 Dec 20. doi: 10.1002/cpt.597. [PubMed:27997040 ]
PMID: 15231488
Desipramine
Product: Nisoldipine
Identifier : DBSNPE005228
Drug : DB01151 (Desipramine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Allele Name : CYP2D6*5
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer. For individual with two non-functional alleles, alternative drug or dose reduction recommended.
References :
- Hicks JK, Sangkuhl K, Swen JJ, Ellingrod VL, Muller DJ, Shimoda K, Bishop JR, Kharasch ED, Skaar TC, Gaedigk A, Dunnenberger HM, Klein TE, Caudle KE, Stingl JC: Clinical pharmacogenetics implementation consortium guideline (CPIC) for CYP2D6 and CYP2C19 genotypes and dosing of divicyclic antidepressants: 2016 update. Clin Pharmacol Ther. 2016 Dec 20. doi: 10.1002/cpt.597. [PubMed:27997040 ]
PMID: 11156575
Desipramine
Product: (+)-JQ-1
Identifier : DBSNPE005229
Drug : DB01151 (Desipramine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Allele Name : CYP2D6*6
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer. For individual with two non-functional alleles, alternative drug or dose reduction recommended.
References :
- Hicks JK, Sangkuhl K, Swen JJ, Ellingrod VL, Muller DJ, Shimoda K, Bishop JR, Kharasch ED, Skaar TC, Gaedigk A, Dunnenberger HM, Klein TE, Caudle KE, Stingl JC: Clinical pharmacogenetics implementation consortium guideline (CPIC) for CYP2D6 and CYP2C19 genotypes and dosing of divicyclic antidepressants: 2016 update. Clin Pharmacol Ther. 2016 Dec 20. doi: 10.1002/cpt.597. [PubMed:27997040 ]
PMID: 9925726
Desipramine
Product: BMN-673 (8R,9S)
Identifier : DBSNPE005230
Drug : DB01151 (Desipramine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Allele Name : CYP2D6*7
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer. For individual with two non-functional alleles, alternative drug or dose reduction recommended.
References :
- Hicks JK, Sangkuhl K, Swen JJ, Ellingrod VL, Muller DJ, Shimoda K, Bishop JR, Kharasch ED, Skaar TC, Gaedigk A, Dunnenberger HM, Klein TE, Caudle KE, Stingl JC: Clinical pharmacogenetics implementation consortium guideline (CPIC) for CYP2D6 and CYP2C19 genotypes and dosing of divicyclic antidepressants: 2016 update. Clin Pharmacol Ther. 2016 Dec 20. doi: 10.1002/cpt.597. [PubMed:27997040 ]
PMID: 7858849
Desipramine
Product: LCQ-908
Identifier : DBSNPE005231
Drug : DB01151 (Desipramine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Allele Name : CYP2D6*8
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer. For individual with two non-functional alleles, alternative drug or dose reduction recommended.
References :
- Hicks JK, Sangkuhl K, Swen JJ, Ellingrod VL, Muller DJ, Shimoda K, Bishop JR, Kharasch ED, Skaar TC, Gaedigk A, Dunnenberger HM, Klein TE, Caudle KE, Stingl JC: Clinical pharmacogenetics implementation consortium guideline (CPIC) for CYP2D6 and CYP2C19 genotypes and dosing of divicyclic antidepressants: 2016 update. Clin Pharmacol Ther. 2016 Dec 20. doi: 10.1002/cpt.597. [PubMed:27997040 ]
PMID: 24119131
Desipramine
Product: CP-809101 (hydrochloride)
Identifier : DBSNPE005232
Drug : DB01151 (Desipramine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Allele Name : CYP2D6*11
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer. For individual with two non-functional alleles, alternative drug or dose reduction recommended.
References :
- Hicks JK, Sangkuhl K, Swen JJ, Ellingrod VL, Muller DJ, Shimoda K, Bishop JR, Kharasch ED, Skaar TC, Gaedigk A, Dunnenberger HM, Klein TE, Caudle KE, Stingl JC: Clinical pharmacogenetics implementation consortium guideline (CPIC) for CYP2D6 and CYP2C19 genotypes and dosing of divicyclic antidepressants: 2016 update. Clin Pharmacol Ther. 2016 Dec 20. doi: 10.1002/cpt.597. [PubMed:27997040 ]
PMID: 19346255
Desipramine
Product: CAL-130 (Racemate)
Identifier : DBSNPE005233
Drug : DB01151 (Desipramine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Allele Name : CYP2D6*12
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer. For individual with two non-functional alleles, alternative drug or dose reduction recommended.
References :
- Hicks JK, Sangkuhl K, Swen JJ, Ellingrod VL, Muller DJ, Shimoda K, Bishop JR, Kharasch ED, Skaar TC, Gaedigk A, Dunnenberger HM, Klein TE, Caudle KE, Stingl JC: Clinical pharmacogenetics implementation consortium guideline (CPIC) for CYP2D6 and CYP2C19 genotypes and dosing of divicyclic antidepressants: 2016 update. Clin Pharmacol Ther. 2016 Dec 20. doi: 10.1002/cpt.597. [PubMed:27997040 ]
PMID: 11046080
Desipramine
Product: CAL-130
Identifier : DBSNPE005234
Drug : DB01151 (Desipramine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :
- CYP2D7/2D6 hybrid gene sdivucture
Allele Name : CYP2D6*13
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer. For individual with two non-functional alleles, alternative drug or dose reduction recommended.
References :
- Hicks JK, Sangkuhl K, Swen JJ, Ellingrod VL, Muller DJ, Shimoda K, Bishop JR, Kharasch ED, Skaar TC, Gaedigk A, Dunnenberger HM, Klein TE, Caudle KE, Stingl JC: Clinical pharmacogenetics implementation consortium guideline (CPIC) for CYP2D6 and CYP2C19 genotypes and dosing of divicyclic antidepressants: 2016 update. Clin Pharmacol Ther. 2016 Dec 20. doi: 10.1002/cpt.597. [PubMed:27997040 ]
PMID: 24670650
Desipramine
Product: Mibefradil
Identifier : DBSNPE005235
Drug : DB01151 (Desipramine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Allele Name : CYP2D6*14A
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer. For individual with two non-functional alleles, alternative drug or dose reduction recommended.
References :
- Hicks JK, Sangkuhl K, Swen JJ, Ellingrod VL, Muller DJ, Shimoda K, Bishop JR, Kharasch ED, Skaar TC, Gaedigk A, Dunnenberger HM, Klein TE, Caudle KE, Stingl JC: Clinical pharmacogenetics implementation consortium guideline (CPIC) for CYP2D6 and CYP2C19 genotypes and dosing of divicyclic antidepressants: 2016 update. Clin Pharmacol Ther. 2016 Dec 20. doi: 10.1002/cpt.597. [PubMed:27997040 ]
PMID: 23899349
Desipramine
Product: Betulinic acid
Identifier : DBSNPE005236
Drug : DB01151 (Desipramine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Allele Name : CYP2D6*15
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer. For individual with two non-functional alleles, alternative drug or dose reduction recommended.
References :
- Hicks JK, Sangkuhl K, Swen JJ, Ellingrod VL, Muller DJ, Shimoda K, Bishop JR, Kharasch ED, Skaar TC, Gaedigk A, Dunnenberger HM, Klein TE, Caudle KE, Stingl JC: Clinical pharmacogenetics implementation consortium guideline (CPIC) for CYP2D6 and CYP2C19 genotypes and dosing of divicyclic antidepressants: 2016 update. Clin Pharmacol Ther. 2016 Dec 20. doi: 10.1002/cpt.597. [PubMed:27997040 ]
PMID: 16257449
Desipramine
Product: VS-5584
Identifier : DBSNPE005237
Drug : DB01151 (Desipramine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :
- 2539_2542delAACT (rs72549353 )
Allele Name : CYP2D6*19
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer. For individual with two non-functional alleles, alternative drug or dose reduction recommended.
References :
- Hicks JK, Sangkuhl K, Swen JJ, Ellingrod VL, Muller DJ, Shimoda K, Bishop JR, Kharasch ED, Skaar TC, Gaedigk A, Dunnenberger HM, Klein TE, Caudle KE, Stingl JC: Clinical pharmacogenetics implementation consortium guideline (CPIC) for CYP2D6 and CYP2C19 genotypes and dosing of divicyclic antidepressants: 2016 update. Clin Pharmacol Ther. 2016 Dec 20. doi: 10.1002/cpt.597. [PubMed:27997040 ]
PMID: 20177818
Desipramine
Product: CP-809101
Identifier : DBSNPE005238
Drug : DB01151 (Desipramine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :
- 1973_1974insG (rs72549354 )
Allele Name : CYP2D6*20
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer. For individual with two non-functional alleles, alternative drug or dose reduction recommended.
References :
- Hicks JK, Sangkuhl K, Swen JJ, Ellingrod VL, Muller DJ, Shimoda K, Bishop JR, Kharasch ED, Skaar TC, Gaedigk A, Dunnenberger HM, Klein TE, Caudle KE, Stingl JC: Clinical pharmacogenetics implementation consortium guideline (CPIC) for CYP2D6 and CYP2C19 genotypes and dosing of divicyclic antidepressants: 2016 update. Clin Pharmacol Ther. 2016 Dec 20. doi: 10.1002/cpt.597. [PubMed:27997040 ]
PMID: 10715151
Desipramine
Product: Mibefradil (dihydrochloride)
Identifier : DBSNPE005239
Drug : DB01151 (Desipramine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Allele Name : CYP2D6*21
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer. For individual with two non-functional alleles, alternative drug or dose reduction recommended.
References :
- Hicks JK, Sangkuhl K, Swen JJ, Ellingrod VL, Muller DJ, Shimoda K, Bishop JR, Kharasch ED, Skaar TC, Gaedigk A, Dunnenberger HM, Klein TE, Caudle KE, Stingl JC: Clinical pharmacogenetics implementation consortium guideline (CPIC) for CYP2D6 and CYP2C19 genotypes and dosing of divicyclic antidepressants: 2016 update. Clin Pharmacol Ther. 2016 Dec 20. doi: 10.1002/cpt.597. [PubMed:27997040 ]
PMID: 9630335
Desipramine
Product: AXL1717
Identifier : DBSNPE005240
Drug : DB01151 (Desipramine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :
- -1770G>A
- -1584C>G
- -1235A>G
- -740C>T
- -678G>A
- CYP2D7 gene conversion in indivon 1
- 310G>T
- 746C>G
- 843T>G
- 1661G>C
- 2850C>T
- 3384A>C
- 3584G>A
- 3790C>T
- 4042G>A
- 4180G>C
- 4481G>A
Allele Name : CYP2D6*31
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer. For individual with two non-functional alleles, alternative drug or dose reduction recommended.
References :
- Hicks JK, Sangkuhl K, Swen JJ, Ellingrod VL, Muller DJ, Shimoda K, Bishop JR, Kharasch ED, Skaar TC, Gaedigk A, Dunnenberger HM, Klein TE, Caudle KE, Stingl JC: Clinical pharmacogenetics implementation consortium guideline (CPIC) for CYP2D6 and CYP2C19 genotypes and dosing of divicyclic antidepressants: 2016 update. Clin Pharmacol Ther. 2016 Dec 20. doi: 10.1002/cpt.597. [PubMed:27997040 ]
PMID: 26000275
Desipramine
Product: Tegafur
Identifier : DBSNPE005241
Drug : DB01151 (Desipramine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :
- 100C>T (rs1065852 )
- -1426C>T
- variable number of A’s in the region -1258 to -1237a
- -1235A>G
- -1000G>A
- 1039C>T
- 1661G>C
- gene conversion to CYP2D7 in exon 9
- 4180G>C
Allele Name : CYP2D6*36
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer. For individual with two non-functional alleles, alternative drug or dose reduction recommended.
References :
- Hicks JK, Sangkuhl K, Swen JJ, Ellingrod VL, Muller DJ, Shimoda K, Bishop JR, Kharasch ED, Skaar TC, Gaedigk A, Dunnenberger HM, Klein TE, Caudle KE, Stingl JC: Clinical pharmacogenetics implementation consortium guideline (CPIC) for CYP2D6 and CYP2C19 genotypes and dosing of divicyclic antidepressants: 2016 update. Clin Pharmacol Ther. 2016 Dec 20. doi: 10.1002/cpt.597. [PubMed:27997040 ]
PMID: 24638017
Desipramine
Product: Racecadotril
Identifier : DBSNPE005242
Drug : DB01151 (Desipramine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :
- 2587_2590delGACT (rs72549351 )
Allele Name : CYP2D6*38
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer. For individual with two non-functional alleles, alternative drug or dose reduction recommended.
References :
- Hicks JK, Sangkuhl K, Swen JJ, Ellingrod VL, Muller DJ, Shimoda K, Bishop JR, Kharasch ED, Skaar TC, Gaedigk A, Dunnenberger HM, Klein TE, Caudle KE, Stingl JC: Clinical pharmacogenetics implementation consortium guideline (CPIC) for CYP2D6 and CYP2C19 genotypes and dosing of divicyclic antidepressants: 2016 update. Clin Pharmacol Ther. 2016 Dec 20. doi: 10.1002/cpt.597. [PubMed:27997040 ]
PMID: 25290311
Desipramine
Product: Mitiglinide (Calcium)
Identifier : DBSNPE005243
Drug : DB01151 (Desipramine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :
- 1863_1864ins(TTT CGC CCC)2 (rs72549356 )
Allele Name : CYP2D6*40
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer. For individual with two non-functional alleles, alternative drug or dose reduction recommended.
References :
- Hicks JK, Sangkuhl K, Swen JJ, Ellingrod VL, Muller DJ, Shimoda K, Bishop JR, Kharasch ED, Skaar TC, Gaedigk A, Dunnenberger HM, Klein TE, Caudle KE, Stingl JC: Clinical pharmacogenetics implementation consortium guideline (CPIC) for CYP2D6 and CYP2C19 genotypes and dosing of divicyclic antidepressants: 2016 update. Clin Pharmacol Ther. 2016 Dec 20. doi: 10.1002/cpt.597. [PubMed:27997040 ]
PMID: 23215951
Desipramine
Product: Strontium Ranelate
Identifier : DBSNPE005244
Drug : DB01151 (Desipramine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :
- 3259_3260insGT (rs72549346 )
Allele Name : CYP2D6*42
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer. For individual with two non-functional alleles, alternative drug or dose reduction recommended.
References :
- Hicks JK, Sangkuhl K, Swen JJ, Ellingrod VL, Muller DJ, Shimoda K, Bishop JR, Kharasch ED, Skaar TC, Gaedigk A, Dunnenberger HM, Klein TE, Caudle KE, Stingl JC: Clinical pharmacogenetics implementation consortium guideline (CPIC) for CYP2D6 and CYP2C19 genotypes and dosing of divicyclic antidepressants: 2016 update. Clin Pharmacol Ther. 2016 Dec 20. doi: 10.1002/cpt.597. [PubMed:27997040 ]
PMID: 22994306
Desipramine
Product: Butenafine (Hydrochloride)
Identifier : DBSNPE005245
Drug : DB01151 (Desipramine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Allele Name : CYP2D6*44
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer. For individual with two non-functional alleles, alternative drug or dose reduction recommended.
References :
- Hicks JK, Sangkuhl K, Swen JJ, Ellingrod VL, Muller DJ, Shimoda K, Bishop JR, Kharasch ED, Skaar TC, Gaedigk A, Dunnenberger HM, Klein TE, Caudle KE, Stingl JC: Clinical pharmacogenetics implementation consortium guideline (CPIC) for CYP2D6 and CYP2C19 genotypes and dosing of divicyclic antidepressants: 2016 update. Clin Pharmacol Ther. 2016 Dec 20. doi: 10.1002/cpt.597. [PubMed:27997040 ]
PMID: 23245937
Desipramine
Product: Terbinafine (hydrochloride)
Identifier : DBSNPE005246
Drug : DB01151 (Desipramine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :
- 100C>T (rs1065852 )
- -1426C>T
- -1235A>G
- -1000G>A
- 73C<T
- 1039C>T
- 1661G>C
- 4180G>C
Allele Name : CYP2D6*47
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer. For individual with two non-functional alleles, alternative drug or dose reduction recommended.
References :
- Hicks JK, Sangkuhl K, Swen JJ, Ellingrod VL, Muller DJ, Shimoda K, Bishop JR, Kharasch ED, Skaar TC, Gaedigk A, Dunnenberger HM, Klein TE, Caudle KE, Stingl JC: Clinical pharmacogenetics implementation consortium guideline (CPIC) for CYP2D6 and CYP2C19 genotypes and dosing of divicyclic antidepressants: 2016 update. Clin Pharmacol Ther. 2016 Dec 20. doi: 10.1002/cpt.597. [PubMed:27997040 ]
PMID: 22689668
Desipramine
Product: Galanthamine
Identifier : DBSNPE005247
Drug : DB01151 (Desipramine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :
- -1584C>G
- -1235A>G
- -740C>T
- -678G>A
- CYP2D7 gene conversion in indivon 1
- 1661G>C
- 2850C>T
- 3172A>C
- 4180G>C
Allele Name : CYP2D6*51
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer. For individual with two non-functional alleles, alternative drug or dose reduction recommended.
References :
- Hicks JK, Sangkuhl K, Swen JJ, Ellingrod VL, Muller DJ, Shimoda K, Bishop JR, Kharasch ED, Skaar TC, Gaedigk A, Dunnenberger HM, Klein TE, Caudle KE, Stingl JC: Clinical pharmacogenetics implementation consortium guideline (CPIC) for CYP2D6 and CYP2C19 genotypes and dosing of divicyclic antidepressants: 2016 update. Clin Pharmacol Ther. 2016 Dec 20. doi: 10.1002/cpt.597. [PubMed:27997040 ]
PMID: 22074497
Desipramine
Product: Nilotinib (monohydrochloride monohydrate)
Identifier : DBSNPE005248
Drug : DB01151 (Desipramine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Allele Name : CYP2D6*56
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer. For individual with two non-functional alleles, alternative drug or dose reduction recommended.
References :
- Hicks JK, Sangkuhl K, Swen JJ, Ellingrod VL, Muller DJ, Shimoda K, Bishop JR, Kharasch ED, Skaar TC, Gaedigk A, Dunnenberger HM, Klein TE, Caudle KE, Stingl JC: Clinical pharmacogenetics implementation consortium guideline (CPIC) for CYP2D6 and CYP2C19 genotypes and dosing of divicyclic antidepressants: 2016 update. Clin Pharmacol Ther. 2016 Dec 20. doi: 10.1002/cpt.597. [PubMed:27997040 ]
PMID: 20875415
Desipramine
Product: AST-1306 (TsOH)
Identifier : DBSNPE005249
Drug : DB01151 (Desipramine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :
- 100C>T
- 310G>T
- 843T>G
- 887C>T
- 1039C>T
- 1661G>C
- 3384A>C
- 3582A>G
- gene conversion to CYP2D7 in exon 9
- 4180G>C
Allele Name : CYP2D6*57
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer. For individual with two non-functional alleles, alternative drug or dose reduction recommended.
References :
- Hicks JK, Sangkuhl K, Swen JJ, Ellingrod VL, Muller DJ, Shimoda K, Bishop JR, Kharasch ED, Skaar TC, Gaedigk A, Dunnenberger HM, Klein TE, Caudle KE, Stingl JC: Clinical pharmacogenetics implementation consortium guideline (CPIC) for CYP2D6 and CYP2C19 genotypes and dosing of divicyclic antidepressants: 2016 update. Clin Pharmacol Ther. 2016 Dec 20. doi: 10.1002/cpt.597. [PubMed:27997040 ]
PMID: 18404433
Desipramine
Product: Olprinone (Hydrochloride)
Identifier : DBSNPE005250
Drug : DB01151 (Desipramine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Allele Name : CYP2D6*62
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer. For individual with two non-functional alleles, alternative drug or dose reduction recommended.
References :
- Hicks JK, Sangkuhl K, Swen JJ, Ellingrod VL, Muller DJ, Shimoda K, Bishop JR, Kharasch ED, Skaar TC, Gaedigk A, Dunnenberger HM, Klein TE, Caudle KE, Stingl JC: Clinical pharmacogenetics implementation consortium guideline (CPIC) for CYP2D6 and CYP2C19 genotypes and dosing of divicyclic antidepressants: 2016 update. Clin Pharmacol Ther. 2016 Dec 20. doi: 10.1002/cpt.597. [PubMed:27997040 ]
PMID: 17913880
Desipramine
Product: Carvedilol
Identifier : DBSNPE005251
Drug : DB01151 (Desipramine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :
- -1426C>T
- -1235A>G
- -1000G>A
- 100C>T
- 310G>T
- CYP2D7 sequence from indivon 1 onwards
Allele Name : CYP2D6*68A
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer. For individual with two non-functional alleles, alternative drug or dose reduction recommended.
References :
- Hicks JK, Sangkuhl K, Swen JJ, Ellingrod VL, Muller DJ, Shimoda K, Bishop JR, Kharasch ED, Skaar TC, Gaedigk A, Dunnenberger HM, Klein TE, Caudle KE, Stingl JC: Clinical pharmacogenetics implementation consortium guideline (CPIC) for CYP2D6 and CYP2C19 genotypes and dosing of divicyclic antidepressants: 2016 update. Clin Pharmacol Ther. 2016 Dec 20. doi: 10.1002/cpt.597. [PubMed:27997040 ]
PMID: 16837456
Desipramine
Product: (S)-Tedizolid
Identifier : DBSNPE005252
Drug : DB01151 (Desipramine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :
- Similar but not identical switch region compared to CYP2D6*68A. Found in tandem arrangement with CYP2D6*4.
Allele Name : CYP2D6*68B
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer. For individual with two non-functional alleles, alternative drug or dose reduction recommended.
References :
- Hicks JK, Sangkuhl K, Swen JJ, Ellingrod VL, Muller DJ, Shimoda K, Bishop JR, Kharasch ED, Skaar TC, Gaedigk A, Dunnenberger HM, Klein TE, Caudle KE, Stingl JC: Clinical pharmacogenetics implementation consortium guideline (CPIC) for CYP2D6 and CYP2C19 genotypes and dosing of divicyclic antidepressants: 2016 update. Clin Pharmacol Ther. 2016 Dec 20. doi: 10.1002/cpt.597. [PubMed:27997040 ]
PMID: 14718252
Desipramine
Product: Olprinone
Identifier : DBSNPE005253
Drug : DB01151 (Desipramine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :
- 2988G>A (rs28371725 )
- -1426C>T
- -1235A>G
- -1000G>A
- 100C>T
- 310G>T
- 746C>G
- 843T>G
- 1062A>G
- 1661G>C
- 2850C>T
- 3384A>C
- 3584G>A
- 3790C>T
- 4180G>C
- 4401C>T
- 4481G>A
Allele Name : CYP2D6*69
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer. For individual with two non-functional alleles, alternative drug or dose reduction recommended.
References :
- Hicks JK, Sangkuhl K, Swen JJ, Ellingrod VL, Muller DJ, Shimoda K, Bishop JR, Kharasch ED, Skaar TC, Gaedigk A, Dunnenberger HM, Klein TE, Caudle KE, Stingl JC: Clinical pharmacogenetics implementation consortium guideline (CPIC) for CYP2D6 and CYP2C19 genotypes and dosing of divicyclic antidepressants: 2016 update. Clin Pharmacol Ther. 2016 Dec 20. doi: 10.1002/cpt.597. [PubMed:27997040 ]
PMID: 15913566
Desipramine
Product: SQ109
Identifier : DBSNPE005254
Drug : DB01151 (Desipramine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Allele Name : CYP2D6*92
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer. For individual with two non-functional alleles, alternative drug or dose reduction recommended.
References :
- Hicks JK, Sangkuhl K, Swen JJ, Ellingrod VL, Muller DJ, Shimoda K, Bishop JR, Kharasch ED, Skaar TC, Gaedigk A, Dunnenberger HM, Klein TE, Caudle KE, Stingl JC: Clinical pharmacogenetics implementation consortium guideline (CPIC) for CYP2D6 and CYP2C19 genotypes and dosing of divicyclic antidepressants: 2016 update. Clin Pharmacol Ther. 2016 Dec 20. doi: 10.1002/cpt.597. [PubMed:27997040 ]
PMID: 14584948
Desipramine
Product: INNO-206
Identifier : DBSNPE005255
Drug : DB01151 (Desipramine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :
- -1426C>T
- -1235A>G
- -1109C>T
- -1000G>A
- 100C>T
- 310G>T
- 843T>G
- 1039C>T
- 1661G>C
- 2097A>G
- 2828delC
- 3384A>C
- 3582A>G
- 4180G>C
- 4401C>T
Allele Name : CYP2D6*100
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer. For individual with two non-functional alleles, alternative drug or dose reduction recommended.
References :
- Hicks JK, Sangkuhl K, Swen JJ, Ellingrod VL, Muller DJ, Shimoda K, Bishop JR, Kharasch ED, Skaar TC, Gaedigk A, Dunnenberger HM, Klein TE, Caudle KE, Stingl JC: Clinical pharmacogenetics implementation consortium guideline (CPIC) for CYP2D6 and CYP2C19 genotypes and dosing of divicyclic antidepressants: 2016 update. Clin Pharmacol Ther. 2016 Dec 20. doi: 10.1002/cpt.597. [PubMed:27997040 ]
PMID: 11959804
Desipramine
Product: Cholecalciferol
Identifier : DBSNPE005256
Drug : DB01151 (Desipramine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :
- -1426C>T
- -1235A>G
- -1000G>A
- 100C>T
- 310G>T
- 843T>G
- 1039C>T
- 1661G>C
- 2097A>G
- 2927_2945delGATCCTACATCCGGATGTG
- 3384A>C
- 3582A>G
- 4180G>C
- 4401C>T
Allele Name : CYP2D6*101
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer. For individual with two non-functional alleles, alternative drug or dose reduction recommended.
References :
- Hicks JK, Sangkuhl K, Swen JJ, Ellingrod VL, Muller DJ, Shimoda K, Bishop JR, Kharasch ED, Skaar TC, Gaedigk A, Dunnenberger HM, Klein TE, Caudle KE, Stingl JC: Clinical pharmacogenetics implementation consortium guideline (CPIC) for CYP2D6 and CYP2C19 genotypes and dosing of divicyclic antidepressants: 2016 update. Clin Pharmacol Ther. 2016 Dec 20. doi: 10.1002/cpt.597. [PubMed:27997040 ]
PMID: 16236815
Desipramine
Product: Alogliptin (Benzoate)
Identifier : DBSNPE005647
Drug : DB01151 (Desipramine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Allele Name : CYP2D6*3
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirements, higher risk for adverse side effects
References :
- Kagimoto M, Heim M, Kagimoto K, Zeugin T, Meyer UA: Multiple mutations of the human cytochrome P450IID6 gene (CYP2D6) in poor metabolizers of debrisoquine. Study of the functional significance of individual mutations by expression of chimeric genes. J Biol Chem. 1990 Oct 5;265(28):17209-14. [PubMed:2211621 ]
- Marez D, Legrand M, Sabbagh N, Lo Guidice JM, Spire C, Lafitte JJ, Meyer UA, Broly F: Polymorphism of the cytochrome P450 CYP2D6 gene in a European population: characterization of 48 mutations and 53 alleles, their frequencies and evolution. Pharmacogenetics. 1997 Jun;7(3):193-202. [PubMed:9241659 ]
- The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]
PMID: 20664056
Desipramine
Product: PI-103 (Hydrochloride)
Identifier : DBSNPE005648
Drug : DB01151 (Desipramine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Allele Name : CYP2D6*4
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirements, higher risk for adverse side effects
References :
- Kagimoto M, Heim M, Kagimoto K, Zeugin T, Meyer UA: Multiple mutations of the human cytochrome P450IID6 gene (CYP2D6) in poor metabolizers of debrisoquine. Study of the functional significance of individual mutations by expression of chimeric genes. J Biol Chem. 1990 Oct 5;265(28):17209-14. [PubMed:2211621 ]
- Gough AC, Miles JS, Spurr NK, Moss JE, Gaedigk A, Eichelbaum M, Wolf CR: Identification of the primary gene defect at the cytochrome P450 CYP2D locus. Nature. 1990 Oct 25;347(6295):773-6. [PubMed:1978251 ]
- Hanioka N, Kimura S, Meyer UA, Gonzalez FJ: The human CYP2D locus associated with a common genetic defect in drug oxidation: a G1934—-A base change in indivon 3 of a mutant CYP2D6 allele results in an aberrant 3 splice recognition site. Am J Hum Genet. 1990 Dec;47(6):994-1001. [PubMed:1978565 ]
- Yokota H, Tamura S, Furuya H, Kimura S, Watanabe M, Kanazawa I, Kondo I, Gonzalez FJ: Evidence for a new variant CYP2D6 allele CYP2D6J in a Japanese population associated with lower in vivo rates of sparteine metabolism. Pharmacogenetics. 1993 Oct;3(5):256-63. [PubMed:8287064 ]
- Marez D, Legrand M, Sabbagh N, Lo Guidice JM, Spire C, Lafitte JJ, Meyer UA, Broly F: Polymorphism of the cytochrome P450 CYP2D6 gene in a European population: characterization of 48 mutations and 53 alleles, their frequencies and evolution. Pharmacogenetics. 1997 Jun;7(3):193-202. [PubMed:9241659 ]
- Sachse C, Brockmoller J, Bauer S, Roots I: Cytochrome P450 2D6 variants in a Caucasian population: allele frequencies and phenotypic consequences. Am J Hum Genet. 1997 Feb;60(2):284-95. [PubMed:9012401 ]
- Shimada T, Tsumura F, Yamazaki H, Guengerich FP, Inoue K: Characterization of (+/-)-bufuralol hydroxylation activities in liver microsomes of Japanese and Caucasian subjects genotyped for CYP2D6. Pharmacogenetics. 2001 Mar;11(2):143-56. [PubMed:11266079 ]
- Agundez JA, Ramirez R, Hernandez M, Llerena A, Benitez J: Molecular heterogeneity at the CYP2D gene locus in Nicaraguans: impact of gene-flow from Europe. Pharmacogenetics. 1997 Aug;7(4):337-40. [PubMed:9295063 ]
- Fuselli S, Dupanloup I, Frigato E, Cruciani F, Scozzari R, Moral P, Sistonen J, Sajantila A, Barbujani G: Molecular diversity at the CYP2D6 locus in the Mediterranean region. Eur J Hum Genet. 2004 Nov;12(11):916-24. [PubMed:15340360 ]
- Gaedigk A, Bradford LD, Alander SW, Leeder JS: CYP2D6*36 gene arrangements within the cyp2d6 locus: association of CYP2D6*36 with poor metabolizer status. Drug Metab Dispos. 2006 Apr;34(4):563-9. Epub 2006 Jan 13. [PubMed:16415111 ]
- Dodgen TM, Hochfeld WE, Fickl H, Asfaha SM, Durandt C, Rheeder P, Drogemoller BI, Wright GE, Warnich L, Labuschagne CD, van Schalkwyk A, Gaedigk A, Pepper MS: Indivoduction of the AmpliChip CYP450 Test to a South African cohort: a platform comparative prospective cohort study. BMC Med Genet. 2013 Jan 29;14:20. doi: 10.1186/1471-2350-14-20. [PubMed:23356658 ]
- The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]
PMID: 2457788
Desipramine
Product: GPR120 modulator 2
Identifier : DBSNPE005649
Drug : DB01151 (Desipramine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Allele Name : CYP2D6*5
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirements, higher risk for adverse side effects
References :
- Gaedigk A, Blum M, Gaedigk R, Eichelbaum M, Meyer UA: Deletion of the entire cytochrome P450 CYP2D6 gene as a cause of impaired drug metabolism in poor metabolizers of the debrisoquine/sparteine polymorphism. Am J Hum Genet. 1991 May;48(5):943-50. [PubMed:1673290 ]
- Steen VM, Molven A, Aarskog NK, Gulbrandsen AK: Homologous unequal cross-over involving a 2.8 kb direct repeat as a mechanism for the generation of allelic variants of human cytochrome P450 CYP2D6 gene. Hum Mol Genet. 1995 Dec;4(12):2251-7. [PubMed:8634695 ]
- The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]
PMID: 6141286
Desipramine
Product: GPR120 modulator 1
Identifier : DBSNPE005650
Drug : DB01151 (Desipramine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Allele Name : CYP2D6*6
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirements, higher risk for adverse side effects
References :
- Saxena R, Shaw GL, Relling MV, Frame JN, Moir DT, Evans WE, Caporaso N, Weiffenbach B: Identification of a new variant CYP2D6 allele with a single base deletion in exon 3 and its association with the poor metabolizer phenotype. Hum Mol Genet. 1994 Jun;3(6):923-6. [PubMed:7951238 ]
- Evert B, Griese EU, Eichelbaum M: Cloning and sequencing of a new non-functional CYP2D6 allele: deletion of T1795 in exon 3 generates a premature stop codon. Pharmacogenetics. 1994 Oct;4(5):271-4. [PubMed:7894499 ]
- Daly AK, Leathart JB, London SJ, Idle JR: An inactive cytochrome P450 CYP2D6 allele containing a deletion and a base substitution. Hum Genet. 1995 Mar;95(3):337-41. [PubMed:7868129 ]
- Marez D, Legrand M, Sabbagh N, Lo Guidice JM, Spire C, Lafitte JJ, Meyer UA, Broly F: Polymorphism of the cytochrome P450 CYP2D6 gene in a European population: characterization of 48 mutations and 53 alleles, their frequencies and evolution. Pharmacogenetics. 1997 Jun;7(3):193-202. [PubMed:9241659 ]
- The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]
PMID: 6144253
Desipramine
Product: Linezolid
Identifier : DBSNPE005651
Drug : DB01151 (Desipramine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Allele Name : CYP2D6*7
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirements, higher risk for adverse side effects
References :
- Evert B, Griese EU, Eichelbaum M: A missense mutation in exon 6 of the CYP2D6 gene leading to a histidine 324 to proline exchange is associated with the poor metabolizer phenotype of sparteine. Naunyn Schmiedebergs Arch Pharmacol. 1994 Oct;350(4):434-9. [PubMed:7845481 ]
- The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]
PMID: 15520047
Desipramine
Product: Gemcitabine (Hydrochloride)
Identifier : DBSNPE005652
Drug : DB01151 (Desipramine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Allele Name : CYP2D6*8
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirements, higher risk for adverse side effects
References :
- Broly F, Marez D, Lo Guidice JM, Sabbagh N, Legrand M, Boone P, Meyer UA: A nonsense mutation in the cytochrome P450 CYP2D6 gene identified in a Caucasian with an enzyme deficiency. Hum Genet. 1995 Nov;96(5):601-3. [PubMed:8530011 ]
- The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]
PMID: 8937426
Desipramine
Product: Tropisetron (Hydrochloride)
Identifier : DBSNPE005653
Drug : DB01151 (Desipramine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Allele Name : CYP2D6*11
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirements, higher risk for adverse side effects
References :
- Marez D, Sabbagh N, Legrand M, Lo-Guidice JM, Boone P, Broly F: A novel CYP2D6 allele with an abolished splice recognition site associated with the poor metabolizer phenotype. Pharmacogenetics. 1995 Oct;5(5):305-11. [PubMed:8563771 ]
- The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]
PMID: 25740525
Desipramine
Product: Lorcaserin (Hydrochloride)
Identifier : DBSNPE005654
Drug : DB01151 (Desipramine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Allele Name : CYP2D6*12
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirements, higher risk for adverse side effects
References :
- Marez D, Legrand M, Sabbagh N, Lo-Guidice JM, Boone P, Broly F: An additional allelic variant of the CYP2D6 gene causing impaired metabolism of sparteine. Hum Genet. 1996 May;97(5):668-70. [PubMed:8655150 ]
- The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]
PMID: 26617436
Desipramine
Product: MLN 2480
Identifier : DBSNPE005655
Drug : DB01151 (Desipramine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :
- CYP2D7/2D6 hybrid gene sdivucture
Allele Name : CYP2D6*13
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirements, higher risk for adverse side effects
References :
- Panserat S, Mura C, Gerard N, Vincent-Viry M, Galteau MM, Jacoz-Aigrain E, Krishnamoorthy R: An unequal cross-over event within the CYP2D gene cluster generates a chimeric CYP2D7/CYP2D6 gene which is associated with the poor metabolizer phenotype. Br J Clin Pharmacol. 1995 Oct;40(4):361-7. [PubMed:8554938 ]
- Black JL 3rd, Walker DL, OKane DJ, Harmandayan M: Frequency of undetected CYP2D6 hybrid genes in clinical samples: impact on phenotype prediction. Drug Metab Dispos. 2012 Jan;40(1):111-9. doi: 10.1124/dmd.111.040832. Epub 2011 Oct 17. [PubMed:22004686 ]
- Gaedigk A, Fuhr U, Johnson C, Berard LA, Bradford D, Leeder JS: CYP2D7-2D6 hybrid tandems: identification of novel CYP2D6 duplication arrangements and implications for phenotype prediction. Pharmacogenomics. 2010 Jan;11(1):43-53. doi: 10.2217/pgs.09.133. [PubMed:20017671 ]
- Gaedigk A, Jaime LK, Bertino JS Jr, Berard A, Pratt VM, Bradfordand LD, Leeder JS: Identification of Novel CYP2D7-2D6 Hybrids: Non-Functional and Functional Variants. Front Pharmacol. 2010 Oct 4;1:121. doi: 10.3389/fphar.2010.00121. eCollection 2010. [PubMed:21833166 ]
- Daly AK, Fairbrother KS, Andreassen OA, London SJ, Idle JR, Steen VM: Characterization and PCR-based detection of two different hybrid CYP2D7P/CYP2D6 alleles associated with the poor metabolizer phenotype. Pharmacogenetics. 1996 Aug;6(4):319-28. [PubMed:8873218 ]
- Gaedigk A, Coetsee C: The CYP2D6 gene locus in South African Coloureds: unique allele disdivibutions, novel alleles and gene arrangements. Eur J Clin Pharmacol. 2008 May;64(5):465-75. doi: 10.1007/s00228-007-0445-7. Epub 2008 Jan 17. [PubMed:18202841 ]
- The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]
PMID: 24641310
Desipramine
Product: Darunavir (Ethanolate)
Identifier : DBSNPE005656
Drug : DB01151 (Desipramine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Allele Name : CYP2D6*14A
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirements, higher risk for adverse side effects
References :
- Wang SL, Lai MD, Huang JD: G169R mutation diminishes the metabolic activity of CYP2D6 in Chinese. Drug Metab Dispos. 1999 Mar;27(3):385-8. [PubMed:10064570 ]
- Sakuyama K, Sasaki T, Ujiie S, Obata K, Mizugaki M, Ishikawa M, Hiratsuka M: Functional characterization of 17 CYP2D6 allelic variants (CYP2D6.2, 10, 14A-B, 18, 27, 36, 39, 47-51, 53-55, and 57). Drug Metab Dispos. 2008 Dec;36(12):2460-7. doi: 10.1124/dmd.108.023242. Epub 2008 Sep 10. [PubMed:18784265 ]
- The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]
PMID: 25433234
Desipramine
Product: Darunavir
Identifier : DBSNPE005657
Drug : DB01151 (Desipramine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Allele Name : CYP2D6*15
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirements, higher risk for adverse side effects
References :
- Sachse C, Brockmoller J, Bauer S, Reum T, Roots I: A rare insertion of T226 in exon 1 of CYP2D6 causes a frameshift and is associated with the poor metabolizer phenotype: CYP2D6*15. Pharmacogenetics. 1996 Jun;6(3):269-72. [PubMed:8807669 ]
- The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]
PMID: 25567365
Desipramine
Product: CYT387 (sulfate salt)
Identifier : DBSNPE005658
Drug : DB01151 (Desipramine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :
- 2539_2542delAACT (rs72549353 )
Allele Name : CYP2D6*19
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirements, higher risk for adverse side effects
References :
- Marez D, Legrand M, Sabbagh N, Lo Guidice JM, Spire C, Lafitte JJ, Meyer UA, Broly F: Polymorphism of the cytochrome P450 CYP2D6 gene in a European population: characterization of 48 mutations and 53 alleles, their frequencies and evolution. Pharmacogenetics. 1997 Jun;7(3):193-202. [PubMed:9241659 ]
- The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]
PMID: 19339608
Desipramine
Product: A-803467
Identifier : DBSNPE005659
Drug : DB01151 (Desipramine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :
- 1973_1974insG (rs72549354 )
Allele Name : CYP2D6*20
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirements, higher risk for adverse side effects
References :
- Marez-Allorge D, Ellis SW, Lo Guidice JM, Tucker GT, Broly F: A rare G2061 insertion affecting the open reading frame of CYP2D6 and responsible for the poor metabolizer phenotype. Pharmacogenetics. 1999 Jun;9(3):393-6. [PubMed:10471072 ]
- The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]
PMID: 25799991
Desipramine
Product: GSK2636771
Identifier : DBSNPE005660
Drug : DB01151 (Desipramine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Allele Name : CYP2D6*21
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirements, higher risk for adverse side effects
References :
- Chida M, Yokoi T, Nemoto N, Inaba M, Kinoshita M, Kamataki T: A new variant CYP2D6 allele (CYP2D6*21) with a single base insertion in exon 5 in a Japanese population associated with a poor metabolizer phenotype. Pharmacogenetics. 1999 Jun;9(3):287-93. [PubMed:10471060 ]
- Yamazaki H, Kiyotani K, Tsubuko S, Matsunaga M, Fujieda M, Saito T, Miura J, Kobayashi S, Kamataki T: Two novel haplotypes of CYP2D6 gene in a Japanese population. Drug Metab Pharmacokinet. 2003;18(4):269-71. [PubMed:15618746 ]
- The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]
PMID: 23025719
Desipramine
Product: TAK-438
Identifier : DBSNPE005661
Drug : DB01151 (Desipramine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :
- -1770G>A
- -1584C>G
- -1235A>G
- -740C>T
- -678G>A
- CYP2D7 gene conversion in indivon 1
- 310G>T
- 746C>G
- 843T>G
- 1661G>C
- 2850C>T
- 3384A>C
- 3584G>A
- 3790C>T
- 4042G>A
- 4180G>C
- 4481G>A
Allele Name : CYP2D6*31
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirements, higher risk for adverse side effects
References :
- Marez D, Legrand M, Sabbagh N, Lo Guidice JM, Spire C, Lafitte JJ, Meyer UA, Broly F: Polymorphism of the cytochrome P450 CYP2D6 gene in a European population: characterization of 48 mutations and 53 alleles, their frequencies and evolution. Pharmacogenetics. 1997 Jun;7(3):193-202. [PubMed:9241659 ]
- Allorge D, Breant D, Harlow J, Chowdry J, Lo-Guidice JM, Chevalier D, Cauffiez C, Lhermitte M, Blaney FE, Tucker GT, Broly F, Ellis SW: Functional analysis of CYP2D6.31 variant: homology modeling suggests possible disruption of redox partner interaction by Arg440His substitution. Proteins. 2005 May 1;59(2):339-46. [PubMed:15726636 ]
- Gaedigk A, Isidoro-Garcia M, Pearce RE, Sanchez S, Garcia-Solaesa V, Lorenzo-Romo C, Gonzalez-Tejera G, Corey S: Discovery of the nonfunctional CYP2D6 31 allele in Spanish, Puerto Rican, and US Hispanic populations. Eur J Clin Pharmacol. 2010 Sep;66(9):859-64. doi: 10.1007/s00228-010-0831-4. Epub 2010 May 16. [PubMed:20473659 ]
- The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]
PMID: 22328573
Desipramine
Product: MBX-2982
Identifier : DBSNPE005662
Drug : DB01151 (Desipramine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :
- 100C>T (rs1065852 )
- -1426C>T
- variable number of A’s in the region -1258 to -1237a
- -1235A>G
- -1000G>A
- 1039C>T
- 1661G>C
- gene conversion to CYP2D7 in exon 9
- 4180G>C
Allele Name : CYP2D6*36
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirements, higher risk for adverse side effects
References :
- Gaedigk A, Bradford LD, Alander SW, Leeder JS: CYP2D6*36 gene arrangements within the cyp2d6 locus: association of CYP2D6*36 with poor metabolizer status. Drug Metab Dispos. 2006 Apr;34(4):563-9. Epub 2006 Jan 13. [PubMed:16415111 ]
- Sakuyama K, Sasaki T, Ujiie S, Obata K, Mizugaki M, Ishikawa M, Hiratsuka M: Functional characterization of 17 CYP2D6 allelic variants (CYP2D6.2, 10, 14A-B, 18, 27, 36, 39, 47-51, 53-55, and 57). Drug Metab Dispos. 2008 Dec;36(12):2460-7. doi: 10.1124/dmd.108.023242. Epub 2008 Sep 10. [PubMed:18784265 ]
- Johansson I, Oscarson M, Yue QY, Bertilsson L, Sjoqvist F, Ingelman-Sundberg M: Genetic analysis of the Chinese cytochrome P4502D locus: characterization of variant CYP2D6 genes present in subjects with diminished capacity for debrisoquine hydroxylation. Mol Pharmacol. 1994 Sep;46(3):452-9. [PubMed:7935325 ]
- Leathart JB, London SJ, Steward A, Adams JD, Idle JR, Daly AK: CYP2D6 phenotype-genotype relationships in African-Americans and Caucasians in Los Angeles. Pharmacogenetics. 1998 Dec;8(6):529-41. [PubMed:9918137 ]
- The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]
PMID: 11259554
Desipramine
Product: Indacaterol
Identifier : DBSNPE005663
Drug : DB01151 (Desipramine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :
- 2587_2590delGACT (rs72549351 )
Allele Name : CYP2D6*38
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirements, higher risk for adverse side effects
References :
- Leathart JB, London SJ, Steward A, Adams JD, Idle JR, Daly AK: CYP2D6 phenotype-genotype relationships in African-Americans and Caucasians in Los Angeles. Pharmacogenetics. 1998 Dec;8(6):529-41. [PubMed:9918137 ]
- The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]
PMID: 7889300
Desipramine
Product: Episilvestrol
Identifier : DBSNPE005664
Drug : DB01151 (Desipramine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :
- 1863_1864ins(TTT CGC CCC)2 (rs72549356 )
Allele Name : CYP2D6*40
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirements, higher risk for adverse side effects
References :
- Gaedigk A, Bradford LD, Marcucci KA, Leeder JS: Unique CYP2D6 activity disdivibution and genotype-phenotype discordance in black Americans. Clin Pharmacol Ther. 2002 Jul;72(1):76-89. [PubMed:12152006 ]
- The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]
PMID: 3036066
Desipramine
Product: Agomelatine
Identifier : DBSNPE005665
Drug : DB01151 (Desipramine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :
- 3259_3260insGT (rs72549346 )
Allele Name : CYP2D6*42
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirements, higher risk for adverse side effects
References :
- Gaedigk A, Ndjountche L, Gaedigk R, Leeder JS, Bradford LD: Discovery of a novel nonfunctional cytochrome P450 2D6 allele, CYP2D642, in African American subjects. Clin Pharmacol Ther. 2003 Jun;73(6):575-6. [PubMed:12811367 ]
- The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]
PMID: 25063869
Desipramine
Product: Cobicistat
Identifier : DBSNPE005666
Drug : DB01151 (Desipramine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Allele Name : CYP2D6*44
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirements, higher risk for adverse side effects
References :
- Yamazaki H, Kiyotani K, Tsubuko S, Matsunaga M, Fujieda M, Saito T, Miura J, Kobayashi S, Kamataki T: Two novel haplotypes of CYP2D6 gene in a Japanese population. Drug Metab Pharmacokinet. 2003;18(4):269-71. [PubMed:15618746 ]
- The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]
PMID: 9184477
Desipramine
Product: BAY 80-6946
Identifier : DBSNPE005667
Drug : DB01151 (Desipramine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :
- 100C>T (rs1065852 )
- -1426C>T
- -1235A>G
- -1000G>A
- 73C<T
- 1039C>T
- 1661G>C
- 4180G>C
Allele Name : CYP2D6*47
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirements, higher risk for adverse side effects
References :
- Soyama A, Kubo T, Miyajima A, Saito Y, Shiseki K, Komamura K, Ueno K, Kamakura S, Kitakaze M, Tomoike H, Ozawa S, Sawada J: Novel nonsynonymous single nucleotide polymorphisms in the CYP2D6 gene. Drug Metab Pharmacokinet. 2004 Aug;19(4):313-9. [PubMed:15499201 ]
- Sakuyama K, Sasaki T, Ujiie S, Obata K, Mizugaki M, Ishikawa M, Hiratsuka M: Functional characterization of 17 CYP2D6 allelic variants (CYP2D6.2, 10, 14A-B, 18, 27, 36, 39, 47-51, 53-55, and 57). Drug Metab Dispos. 2008 Dec;36(12):2460-7. doi: 10.1124/dmd.108.023242. Epub 2008 Sep 10. [PubMed:18784265 ]
- The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]
PMID: 7713141
Desipramine
Product: Naphthoquine (phosphate)
Identifier : DBSNPE005668
Drug : DB01151 (Desipramine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :
- -1584C>G
- -1235A>G
- -740C>T
- -678G>A
- CYP2D7 gene conversion in indivon 1
- 1661G>C
- 2850C>T
- 3172A>C
- 4180G>C
Allele Name : CYP2D6*51
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirements, higher risk for adverse side effects
References :
- Soyama A, Kubo T, Miyajima A, Saito Y, Shiseki K, Komamura K, Ueno K, Kamakura S, Kitakaze M, Tomoike H, Ozawa S, Sawada J: Novel nonsynonymous single nucleotide polymorphisms in the CYP2D6 gene. Drug Metab Pharmacokinet. 2004 Aug;19(4):313-9. [PubMed:15499201 ]
- Sakuyama K, Sasaki T, Ujiie S, Obata K, Mizugaki M, Ishikawa M, Hiratsuka M: Functional characterization of 17 CYP2D6 allelic variants (CYP2D6.2, 10, 14A-B, 18, 27, 36, 39, 47-51, 53-55, and 57). Drug Metab Dispos. 2008 Dec;36(12):2460-7. doi: 10.1124/dmd.108.023242. Epub 2008 Sep 10. [PubMed:18784265 ]
- The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]
PMID: 8383740
Desipramine
Product: CCT241533
Identifier : DBSNPE005669
Drug : DB01151 (Desipramine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Allele Name : CYP2D6*56
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirements, higher risk for adverse side effects
References :
- Li L, Pan RM, Porter TD, Jensen NS, Silber P, Russo G, Tine JA, Heim J, Ring B, Wedlund PJ: New cytochrome P450 2D6*56 allele identified by genotype/phenotype analysis of cryopreserved human hepatocytes. Drug Metab Dispos. 2006 Aug;34(8):1411-6. Epub 2006 May 5. [PubMed:16679388 ]
- Gaedigk A, Eklund JD, Pearce RE, Leeder JS, Alander SW, Phillips MS, Bradford LD, Kennedy MJ: Identification and characterization of CYP2D6*56B, an allele associated with the poor metabolizer phenotype. Clin Pharmacol Ther. 2007 Jun;81(6):817-20. Epub 2007 Mar 28. [PubMed:17392730 ]
- The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]
PMID: 21166931
Desipramine
Product: Istradefylline
Identifier : DBSNPE005670
Drug : DB01151 (Desipramine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :
- 100C>T
- 310G>T
- 843T>G
- 887C>T
- 1039C>T
- 1661G>C
- 3384A>C
- 3582A>G
- gene conversion to CYP2D7 in exon 9
- 4180G>C
Allele Name : CYP2D6*57
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirements, higher risk for adverse side effects
References :
- Soyama A, Kubo T, Miyajima A, Saito Y, Shiseki K, Komamura K, Ueno K, Kamakura S, Kitakaze M, Tomoike H, Ozawa S, Sawada J: Novel nonsynonymous single nucleotide polymorphisms in the CYP2D6 gene. Drug Metab Pharmacokinet. 2004 Aug;19(4):313-9. [PubMed:15499201 ]
- Sakuyama K, Sasaki T, Ujiie S, Obata K, Mizugaki M, Ishikawa M, Hiratsuka M: Functional characterization of 17 CYP2D6 allelic variants (CYP2D6.2, 10, 14A-B, 18, 27, 36, 39, 47-51, 53-55, and 57). Drug Metab Dispos. 2008 Dec;36(12):2460-7. doi: 10.1124/dmd.108.023242. Epub 2008 Sep 10. [PubMed:18784265 ]
- The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]
PMID: 9681571
Desipramine
Product: Doramectin
Identifier : DBSNPE005671
Drug : DB01151 (Desipramine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Allele Name : CYP2D6*62
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirements, higher risk for adverse side effects
References :
- Klein K, Tatzel S, Raimundo S, Saussele T, Hustert E, Pleiss J, Eichelbaum M, Zanger UM: A natural variant of the heme-binding signature (R441C) resulting in complete loss of function of CYP2D6. Drug Metab Dispos. 2007 Aug;35(8):1247-50. Epub 2007 Apr 25. [PubMed:17460029 ]
- The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]
PMID: 9337850
Desipramine
Product: BD-AcAc 2
Identifier : DBSNPE005672
Drug : DB01151 (Desipramine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :
- -1426C>T
- -1235A>G
- -1000G>A
- 100C>T
- 310G>T
- CYP2D7 sequence from indivon 1 onwards
Allele Name : CYP2D6*68A
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirements, higher risk for adverse side effects
References :
- Kramer WE, Walker DL, OKane DJ, Mrazek DA, Fisher PK, Dukek BA, Bruflat JK, Black JL: CYP2D6: novel genomic sdivuctures and alleles. Pharmacogenet Genomics. 2009 Oct;19(10):813-22. doi: 10.1097/FPC.0b013e3283317b95. [PubMed:19741566 ]
- The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]
PMID: 3019721
Desipramine
Product: Medetomidine
Identifier : DBSNPE005673
Drug : DB01151 (Desipramine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :
- Similar but not identical switch region compared to CYP2D6*68A. Found in tandem arrangement with CYP2D6*4.
Allele Name : CYP2D6*68B
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirements, higher risk for adverse side effects
References :
- Gaedigk A, Twist GP, Leeder JS: CYP2D6, SULT1A1 and UGT2B17 copy number variation: quantitative detection by multiplex PCR. Pharmacogenomics. 2012 Jan;13(1):91-111. doi: 10.2217/pgs.11.135. Epub 2011 Nov 23. [PubMed:22111604 ]
- The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]
PMID: 24467222
Desipramine
Product: Rocuronium
Identifier : DBSNPE005674
Drug : DB01151 (Desipramine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :
- 2988G>A (rs28371725 )
- -1426C>T
- -1235A>G
- -1000G>A
- 100C>T
- 310G>T
- 746C>G
- 843T>G
- 1062A>G
- 1661G>C
- 2850C>T
- 3384A>C
- 3584G>A
- 3790C>T
- 4180G>C
- 4401C>T
- 4481G>A
Allele Name : CYP2D6*69
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirements, higher risk for adverse side effects
References :
- Gaedigk A, Frank D, Fuhr U: Identification of a novel non-functional CYP2D6 allele, CYP2D6*69, in a Caucasian poor metabolizer individual. Eur J Clin Pharmacol. 2009 Jan;65(1):97-100. doi: 10.1007/s00228-008-0559-6. Epub 2008 Sep 17. [PubMed:18797858 ]
- The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]
PMID: 25077524
Desipramine
Product: Peramivir (trihydrate)
Identifier : DBSNPE005675
Drug : DB01151 (Desipramine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Allele Name : CYP2D6*92
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirements, higher risk for adverse side effects
References :
- Qian JC, Xu XM, Hu GX, Dai DP, Xu RA, Hu LM, Li FH, Zhang XH, Yang JF, Cai JP: Genetic variations of human CYP2D6 in the Chinese Han population. Pharmacogenomics. 2013 Nov;14(14):1731-43. doi: 10.2217/pgs.13.160. [PubMed:24192122 ]
- The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]
PMID: 16177223
Desipramine
Product: SBE-β-CD
Identifier : DBSNPE005676
Drug : DB01151 (Desipramine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :
- -1426C>T
- -1235A>G
- -1109C>T
- -1000G>A
- 100C>T
- 310G>T
- 843T>G
- 1039C>T
- 1661G>C
- 2097A>G
- 2828delC
- 3384A>C
- 3582A>G
- 4180G>C
- 4401C>T
Allele Name : CYP2D6*100
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirements, higher risk for adverse side effects
References :
- Montane Jaime LK, Lalla A, Steimer W, Gaedigk A: Characterization of the CYP2D6 gene locus and metabolic activity in Indo- and Afro-Trinidadians: discovery of novel allelic variants. Pharmacogenomics. 2013 Feb;14(3):261-76. doi: 10.2217/pgs.12.207. [PubMed:23394389 ]
- The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]
PMID: 7476886
Desipramine
Product: 5-R-Rivaroxaban
Identifier : DBSNPE005677
Drug : DB01151 (Desipramine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :
- -1426C>T
- -1235A>G
- -1000G>A
- 100C>T
- 310G>T
- 843T>G
- 1039C>T
- 1661G>C
- 2097A>G
- 2927_2945delGATCCTACATCCGGATGTG
- 3384A>C
- 3582A>G
- 4180G>C
- 4401C>T
Allele Name : CYP2D6*101
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirements, higher risk for adverse side effects
References :
- Montane Jaime LK, Lalla A, Steimer W, Gaedigk A: Characterization of the CYP2D6 gene locus and metabolic activity in Indo- and Afro-Trinidadians: discovery of novel allelic variants. Pharmacogenomics. 2013 Feb;14(3):261-76. doi: 10.2217/pgs.12.207. [PubMed:23394389 ]
- The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]
PMID: 8562314