Codeine
Product: L-Homocysteine thiolactone (hydrochloride)
Identifier : DBSNPE000007
Drug : DB00318 (Codeine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :
- A Allele, homozygote (rs3892097 )
Allele Name : CYP2D6*4
Genotype(s) : (A;A)
Type(s) : Effect Directly Studied
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirements
References :
- Desmeules J, Gascon MP, Dayer P, Magisdivis M: Impact of environmental and genetic factors on codeine analgesia. Eur J Clin Pharmacol. 1991;41(1):23-6. [PubMed:1782973 ]
PMID: 9354588
Codeine
Product: Allopregnanolone
Identifier : DBSNPE000008
Drug : DB00318 (Codeine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :
- T deletion, homozygote (rs5030655 )
Allele Name : CYP2D6*6
Genotype(s) : (-;-)
Type(s) : Effect Directly Studied
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirements
References :
- Desmeules J, Gascon MP, Dayer P, Magisdivis M: Impact of environmental and genetic factors on codeine analgesia. Eur J Clin Pharmacol. 1991;41(1):23-6. [PubMed:1782973 ]
PMID: 24347635
Codeine
Product: WAY-200070
Identifier : DBSNPE000009
Drug : DB00318 (Codeine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :
- Whole gene deletion, homozygote
Allele Name : CYP2D6*5
Genotype(s) : Not Available
Type(s) : Effect Directly Studied
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirements
References :
- Desmeules J, Gascon MP, Dayer P, Magisdivis M: Impact of environmental and genetic factors on codeine analgesia. Eur J Clin Pharmacol. 1991;41(1):23-6. [PubMed:1782973 ]
PMID: 23528611
Codeine
Product: (Z)-SMI-4a
Identifier : DBSNPE005431
Drug : DB00318 (Codeine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Allele Name : CYP2D6*3
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer. Lack of efficacy. For individual with two non-functional alleles, alternative drug recommended.
References :
- Crews KR, Gaedigk A, Dunnenberger HM, Leeder JS, Klein TE, Caudle KE, Haidar CE, Shen DD, Callaghan JT, Sadhasivam S, Prows CA, Kharasch ED, Skaar TC: Clinical Pharmacogenetics Implementation Consortium guidelines for cytochrome P450 2D6 genotype and codeine therapy: 2014 update. Clin Pharmacol Ther. 2014 Apr;95(4):376-82. doi: 10.1038/clpt.2013.254. Epub 2014 Jan 23. [PubMed:24458010 ]
PMID: 19088845
Codeine
Product: VU 0364439
Identifier : DBSNPE005432
Drug : DB00318 (Codeine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Allele Name : CYP2D6*4
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer. Lack of efficacy. For individual with two non-functional alleles, alternative drug recommended.
References :
- Crews KR, Gaedigk A, Dunnenberger HM, Leeder JS, Klein TE, Caudle KE, Haidar CE, Shen DD, Callaghan JT, Sadhasivam S, Prows CA, Kharasch ED, Skaar TC: Clinical Pharmacogenetics Implementation Consortium guidelines for cytochrome P450 2D6 genotype and codeine therapy: 2014 update. Clin Pharmacol Ther. 2014 Apr;95(4):376-82. doi: 10.1038/clpt.2013.254. Epub 2014 Jan 23. [PubMed:24458010 ]
PMID: 17941977
Codeine
Product: Oxaliplatin
Identifier : DBSNPE005433
Drug : DB00318 (Codeine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Allele Name : CYP2D6*5
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer. Lack of efficacy. For individual with two non-functional alleles, alternative drug recommended.
References :
- Crews KR, Gaedigk A, Dunnenberger HM, Leeder JS, Klein TE, Caudle KE, Haidar CE, Shen DD, Callaghan JT, Sadhasivam S, Prows CA, Kharasch ED, Skaar TC: Clinical Pharmacogenetics Implementation Consortium guidelines for cytochrome P450 2D6 genotype and codeine therapy: 2014 update. Clin Pharmacol Ther. 2014 Apr;95(4):376-82. doi: 10.1038/clpt.2013.254. Epub 2014 Jan 23. [PubMed:24458010 ]
PMID: 16809572
Codeine
Product: PRX-08066
Identifier : DBSNPE005435
Drug : DB00318 (Codeine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Allele Name : CYP2D6*7
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer. Lack of efficacy. For individual with two non-functional alleles, alternative drug recommended.
References :
- Crews KR, Gaedigk A, Dunnenberger HM, Leeder JS, Klein TE, Caudle KE, Haidar CE, Shen DD, Callaghan JT, Sadhasivam S, Prows CA, Kharasch ED, Skaar TC: Clinical Pharmacogenetics Implementation Consortium guidelines for cytochrome P450 2D6 genotype and codeine therapy: 2014 update. Clin Pharmacol Ther. 2014 Apr;95(4):376-82. doi: 10.1038/clpt.2013.254. Epub 2014 Jan 23. [PubMed:24458010 ]
PMID: 16890527
Codeine
Product: GW791343 (dihydrochloride)
Identifier : DBSNPE005436
Drug : DB00318 (Codeine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Allele Name : CYP2D6*8
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer. Lack of efficacy. For individual with two non-functional alleles, alternative drug recommended.
References :
- Crews KR, Gaedigk A, Dunnenberger HM, Leeder JS, Klein TE, Caudle KE, Haidar CE, Shen DD, Callaghan JT, Sadhasivam S, Prows CA, Kharasch ED, Skaar TC: Clinical Pharmacogenetics Implementation Consortium guidelines for cytochrome P450 2D6 genotype and codeine therapy: 2014 update. Clin Pharmacol Ther. 2014 Apr;95(4):376-82. doi: 10.1038/clpt.2013.254. Epub 2014 Jan 23. [PubMed:24458010 ]
PMID: 15806155
Codeine
Product: EVP-6124 (hydrochloride)
Identifier : DBSNPE005437
Drug : DB00318 (Codeine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Allele Name : CYP2D6*11
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer. Lack of efficacy. For individual with two non-functional alleles, alternative drug recommended.
References :
- Crews KR, Gaedigk A, Dunnenberger HM, Leeder JS, Klein TE, Caudle KE, Haidar CE, Shen DD, Callaghan JT, Sadhasivam S, Prows CA, Kharasch ED, Skaar TC: Clinical Pharmacogenetics Implementation Consortium guidelines for cytochrome P450 2D6 genotype and codeine therapy: 2014 update. Clin Pharmacol Ther. 2014 Apr;95(4):376-82. doi: 10.1038/clpt.2013.254. Epub 2014 Jan 23. [PubMed:24458010 ]
PMID: 14769832
Codeine
Product: Preladenant
Identifier : DBSNPE005438
Drug : DB00318 (Codeine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Allele Name : CYP2D6*12
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer. Lack of efficacy. For individual with two non-functional alleles, alternative drug recommended.
References :
- Crews KR, Gaedigk A, Dunnenberger HM, Leeder JS, Klein TE, Caudle KE, Haidar CE, Shen DD, Callaghan JT, Sadhasivam S, Prows CA, Kharasch ED, Skaar TC: Clinical Pharmacogenetics Implementation Consortium guidelines for cytochrome P450 2D6 genotype and codeine therapy: 2014 update. Clin Pharmacol Ther. 2014 Apr;95(4):376-82. doi: 10.1038/clpt.2013.254. Epub 2014 Jan 23. [PubMed:24458010 ]
PMID: 15187088
Codeine
Product: IOX2
Identifier : DBSNPE005439
Drug : DB00318 (Codeine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :
- CYP2D7/2D6 hybrid gene sdivucture
Allele Name : CYP2D6*13
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer. Lack of efficacy. For individual with two non-functional alleles, alternative drug recommended.
References :
- Crews KR, Gaedigk A, Dunnenberger HM, Leeder JS, Klein TE, Caudle KE, Haidar CE, Shen DD, Callaghan JT, Sadhasivam S, Prows CA, Kharasch ED, Skaar TC: Clinical Pharmacogenetics Implementation Consortium guidelines for cytochrome P450 2D6 genotype and codeine therapy: 2014 update. Clin Pharmacol Ther. 2014 Apr;95(4):376-82. doi: 10.1038/clpt.2013.254. Epub 2014 Jan 23. [PubMed:24458010 ]
PMID: 14506264
Codeine
Product: LY2811376
Identifier : DBSNPE005440
Drug : DB00318 (Codeine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Allele Name : CYP2D6*14A
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer. Lack of efficacy. For individual with two non-functional alleles, alternative drug recommended.
References :
- Crews KR, Gaedigk A, Dunnenberger HM, Leeder JS, Klein TE, Caudle KE, Haidar CE, Shen DD, Callaghan JT, Sadhasivam S, Prows CA, Kharasch ED, Skaar TC: Clinical Pharmacogenetics Implementation Consortium guidelines for cytochrome P450 2D6 genotype and codeine therapy: 2014 update. Clin Pharmacol Ther. 2014 Apr;95(4):376-82. doi: 10.1038/clpt.2013.254. Epub 2014 Jan 23. [PubMed:24458010 ]
PMID: 12176736
Codeine
Product: ZM323881
Identifier : DBSNPE005441
Drug : DB00318 (Codeine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Allele Name : CYP2D6*15
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer. Lack of efficacy. For individual with two non-functional alleles, alternative drug recommended.
References :
- Crews KR, Gaedigk A, Dunnenberger HM, Leeder JS, Klein TE, Caudle KE, Haidar CE, Shen DD, Callaghan JT, Sadhasivam S, Prows CA, Kharasch ED, Skaar TC: Clinical Pharmacogenetics Implementation Consortium guidelines for cytochrome P450 2D6 genotype and codeine therapy: 2014 update. Clin Pharmacol Ther. 2014 Apr;95(4):376-82. doi: 10.1038/clpt.2013.254. Epub 2014 Jan 23. [PubMed:24458010 ]
PMID: 12225960
Codeine
Product: Romidepsin
Identifier : DBSNPE005442
Drug : DB00318 (Codeine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :
- 2539_2542delAACT (rs72549353 )
Allele Name : CYP2D6*19
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer. Lack of efficacy. For individual with two non-functional alleles, alternative drug recommended.
References :
- Crews KR, Gaedigk A, Dunnenberger HM, Leeder JS, Klein TE, Caudle KE, Haidar CE, Shen DD, Callaghan JT, Sadhasivam S, Prows CA, Kharasch ED, Skaar TC: Clinical Pharmacogenetics Implementation Consortium guidelines for cytochrome P450 2D6 genotype and codeine therapy: 2014 update. Clin Pharmacol Ther. 2014 Apr;95(4):376-82. doi: 10.1038/clpt.2013.254. Epub 2014 Jan 23. [PubMed:24458010 ]
PMID: 12011056
Codeine
Product: Carfilzomib
Identifier : DBSNPE005443
Drug : DB00318 (Codeine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :
- 1973_1974insG (rs72549354 )
Allele Name : CYP2D6*20
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer. Lack of efficacy. For individual with two non-functional alleles, alternative drug recommended.
References :
- Crews KR, Gaedigk A, Dunnenberger HM, Leeder JS, Klein TE, Caudle KE, Haidar CE, Shen DD, Callaghan JT, Sadhasivam S, Prows CA, Kharasch ED, Skaar TC: Clinical Pharmacogenetics Implementation Consortium guidelines for cytochrome P450 2D6 genotype and codeine therapy: 2014 update. Clin Pharmacol Ther. 2014 Apr;95(4):376-82. doi: 10.1038/clpt.2013.254. Epub 2014 Jan 23. [PubMed:24458010 ]
PMID: 12359716
Codeine
Product: AST-1306
Identifier : DBSNPE005444
Drug : DB00318 (Codeine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Allele Name : CYP2D6*21
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer. Lack of efficacy. For individual with two non-functional alleles, alternative drug recommended.
References :
- Crews KR, Gaedigk A, Dunnenberger HM, Leeder JS, Klein TE, Caudle KE, Haidar CE, Shen DD, Callaghan JT, Sadhasivam S, Prows CA, Kharasch ED, Skaar TC: Clinical Pharmacogenetics Implementation Consortium guidelines for cytochrome P450 2D6 genotype and codeine therapy: 2014 update. Clin Pharmacol Ther. 2014 Apr;95(4):376-82. doi: 10.1038/clpt.2013.254. Epub 2014 Jan 23. [PubMed:24458010 ]
PMID: 11279053
Codeine
Product: CH5132799
Identifier : DBSNPE005445
Drug : DB00318 (Codeine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :
- -1770G>A
- -1584C>G
- -1235A>G
- -740C>T
- -678G>A
- CYP2D7 gene conversion in indivon 1
- 310G>T
- 746C>G
- 843T>G
- 1661G>C
- 2850C>T
- 3384A>C
- 3584G>A
- 3790C>T
- 4042G>A
- 4180G>C
- 4481G>A
Allele Name : CYP2D6*31
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer. Lack of efficacy. For individual with two non-functional alleles, alternative drug recommended.
References :
- Crews KR, Gaedigk A, Dunnenberger HM, Leeder JS, Klein TE, Caudle KE, Haidar CE, Shen DD, Callaghan JT, Sadhasivam S, Prows CA, Kharasch ED, Skaar TC: Clinical Pharmacogenetics Implementation Consortium guidelines for cytochrome P450 2D6 genotype and codeine therapy: 2014 update. Clin Pharmacol Ther. 2014 Apr;95(4):376-82. doi: 10.1038/clpt.2013.254. Epub 2014 Jan 23. [PubMed:24458010 ]
PMID: 16401644
Codeine
Product: AMG 517
Identifier : DBSNPE005446
Drug : DB00318 (Codeine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :
- 100C>T (rs1065852 )
- -1426C>T
- variable number of A’s in the region -1258 to -1237a
- -1235A>G
- -1000G>A
- 1039C>T
- 1661G>C
- gene conversion to CYP2D7 in exon 9
- 4180G>C
Allele Name : CYP2D6*36
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer. Lack of efficacy. For individual with two non-functional alleles, alternative drug recommended.
References :
- Crews KR, Gaedigk A, Dunnenberger HM, Leeder JS, Klein TE, Caudle KE, Haidar CE, Shen DD, Callaghan JT, Sadhasivam S, Prows CA, Kharasch ED, Skaar TC: Clinical Pharmacogenetics Implementation Consortium guidelines for cytochrome P450 2D6 genotype and codeine therapy: 2014 update. Clin Pharmacol Ther. 2014 Apr;95(4):376-82. doi: 10.1038/clpt.2013.254. Epub 2014 Jan 23. [PubMed:24458010 ]
PMID: 9566707
Codeine
Product: Repaglinide
Identifier : DBSNPE005447
Drug : DB00318 (Codeine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :
- 2587_2590delGACT (rs72549351 )
Allele Name : CYP2D6*38
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer. Lack of efficacy. For individual with two non-functional alleles, alternative drug recommended.
References :
- Crews KR, Gaedigk A, Dunnenberger HM, Leeder JS, Klein TE, Caudle KE, Haidar CE, Shen DD, Callaghan JT, Sadhasivam S, Prows CA, Kharasch ED, Skaar TC: Clinical Pharmacogenetics Implementation Consortium guidelines for cytochrome P450 2D6 genotype and codeine therapy: 2014 update. Clin Pharmacol Ther. 2014 Apr;95(4):376-82. doi: 10.1038/clpt.2013.254. Epub 2014 Jan 23. [PubMed:24458010 ]
PMID: 1321043
Codeine
Product: AZD1152
Identifier : DBSNPE005448
Drug : DB00318 (Codeine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :
- 1863_1864ins(TTT CGC CCC)2 (rs72549356 )
Allele Name : CYP2D6*40
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer. Lack of efficacy. For individual with two non-functional alleles, alternative drug recommended.
References :
- Crews KR, Gaedigk A, Dunnenberger HM, Leeder JS, Klein TE, Caudle KE, Haidar CE, Shen DD, Callaghan JT, Sadhasivam S, Prows CA, Kharasch ED, Skaar TC: Clinical Pharmacogenetics Implementation Consortium guidelines for cytochrome P450 2D6 genotype and codeine therapy: 2014 update. Clin Pharmacol Ther. 2014 Apr;95(4):376-82. doi: 10.1038/clpt.2013.254. Epub 2014 Jan 23. [PubMed:24458010 ]
PMID: 17628524
Codeine
Product: SRT3109
Identifier : DBSNPE005449
Drug : DB00318 (Codeine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :
- 3259_3260insGT (rs72549346 )
Allele Name : CYP2D6*42
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer. Lack of efficacy. For individual with two non-functional alleles, alternative drug recommended.
References :
- Crews KR, Gaedigk A, Dunnenberger HM, Leeder JS, Klein TE, Caudle KE, Haidar CE, Shen DD, Callaghan JT, Sadhasivam S, Prows CA, Kharasch ED, Skaar TC: Clinical Pharmacogenetics Implementation Consortium guidelines for cytochrome P450 2D6 genotype and codeine therapy: 2014 update. Clin Pharmacol Ther. 2014 Apr;95(4):376-82. doi: 10.1038/clpt.2013.254. Epub 2014 Jan 23. [PubMed:24458010 ]
PMID: 17509155
Codeine
Product: PF-04971729
Identifier : DBSNPE005450
Drug : DB00318 (Codeine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Allele Name : CYP2D6*44
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer. Lack of efficacy. For individual with two non-functional alleles, alternative drug recommended.
References :
- Crews KR, Gaedigk A, Dunnenberger HM, Leeder JS, Klein TE, Caudle KE, Haidar CE, Shen DD, Callaghan JT, Sadhasivam S, Prows CA, Kharasch ED, Skaar TC: Clinical Pharmacogenetics Implementation Consortium guidelines for cytochrome P450 2D6 genotype and codeine therapy: 2014 update. Clin Pharmacol Ther. 2014 Apr;95(4):376-82. doi: 10.1038/clpt.2013.254. Epub 2014 Jan 23. [PubMed:24458010 ]
PMID: 7594622
Codeine
Product: GDC-0068
Identifier : DBSNPE005451
Drug : DB00318 (Codeine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :
- 100C>T (rs1065852 )
- -1426C>T
- -1235A>G
- -1000G>A
- 73C<T
- 1039C>T
- 1661G>C
- 4180G>C
Allele Name : CYP2D6*47
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer. Lack of efficacy. For individual with two non-functional alleles, alternative drug recommended.
References :
- Crews KR, Gaedigk A, Dunnenberger HM, Leeder JS, Klein TE, Caudle KE, Haidar CE, Shen DD, Callaghan JT, Sadhasivam S, Prows CA, Kharasch ED, Skaar TC: Clinical Pharmacogenetics Implementation Consortium guidelines for cytochrome P450 2D6 genotype and codeine therapy: 2014 update. Clin Pharmacol Ther. 2014 Apr;95(4):376-82. doi: 10.1038/clpt.2013.254. Epub 2014 Jan 23. [PubMed:24458010 ]
PMID: 1316230
Codeine
Product: Posaconazole
Identifier : DBSNPE005452
Drug : DB00318 (Codeine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :
- -1584C>G
- -1235A>G
- -740C>T
- -678G>A
- CYP2D7 gene conversion in indivon 1
- 1661G>C
- 2850C>T
- 3172A>C
- 4180G>C
Allele Name : CYP2D6*51
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer. Lack of efficacy. For individual with two non-functional alleles, alternative drug recommended.
References :
- Crews KR, Gaedigk A, Dunnenberger HM, Leeder JS, Klein TE, Caudle KE, Haidar CE, Shen DD, Callaghan JT, Sadhasivam S, Prows CA, Kharasch ED, Skaar TC: Clinical Pharmacogenetics Implementation Consortium guidelines for cytochrome P450 2D6 genotype and codeine therapy: 2014 update. Clin Pharmacol Ther. 2014 Apr;95(4):376-82. doi: 10.1038/clpt.2013.254. Epub 2014 Jan 23. [PubMed:24458010 ]
PMID: 24788043
Codeine
Product: Rofecoxib
Identifier : DBSNPE005453
Drug : DB00318 (Codeine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Allele Name : CYP2D6*56
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer. Lack of efficacy. For individual with two non-functional alleles, alternative drug recommended.
References :
- Crews KR, Gaedigk A, Dunnenberger HM, Leeder JS, Klein TE, Caudle KE, Haidar CE, Shen DD, Callaghan JT, Sadhasivam S, Prows CA, Kharasch ED, Skaar TC: Clinical Pharmacogenetics Implementation Consortium guidelines for cytochrome P450 2D6 genotype and codeine therapy: 2014 update. Clin Pharmacol Ther. 2014 Apr;95(4):376-82. doi: 10.1038/clpt.2013.254. Epub 2014 Jan 23. [PubMed:24458010 ]
PMID: 1875784
Codeine
Product: WAY 316606
Identifier : DBSNPE005454
Drug : DB00318 (Codeine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :
- 100C>T
- 310G>T
- 843T>G
- 887C>T
- 1039C>T
- 1661G>C
- 3384A>C
- 3582A>G
- gene conversion to CYP2D7 in exon 9
- 4180G>C
Allele Name : CYP2D6*57
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer. Lack of efficacy. For individual with two non-functional alleles, alternative drug recommended.
References :
- Crews KR, Gaedigk A, Dunnenberger HM, Leeder JS, Klein TE, Caudle KE, Haidar CE, Shen DD, Callaghan JT, Sadhasivam S, Prows CA, Kharasch ED, Skaar TC: Clinical Pharmacogenetics Implementation Consortium guidelines for cytochrome P450 2D6 genotype and codeine therapy: 2014 update. Clin Pharmacol Ther. 2014 Apr;95(4):376-82. doi: 10.1038/clpt.2013.254. Epub 2014 Jan 23. [PubMed:24458010 ]
PMID: 3385217
Codeine
Product: DGAT-1 inhibitor 2
Identifier : DBSNPE005455
Drug : DB00318 (Codeine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Allele Name : CYP2D6*62
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer. Lack of efficacy. For individual with two non-functional alleles, alternative drug recommended.
References :
- Crews KR, Gaedigk A, Dunnenberger HM, Leeder JS, Klein TE, Caudle KE, Haidar CE, Shen DD, Callaghan JT, Sadhasivam S, Prows CA, Kharasch ED, Skaar TC: Clinical Pharmacogenetics Implementation Consortium guidelines for cytochrome P450 2D6 genotype and codeine therapy: 2014 update. Clin Pharmacol Ther. 2014 Apr;95(4):376-82. doi: 10.1038/clpt.2013.254. Epub 2014 Jan 23. [PubMed:24458010 ]
PMID: 3917470
Codeine
Product: CTEP
Identifier : DBSNPE005456
Drug : DB00318 (Codeine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :
- -1426C>T
- -1235A>G
- -1000G>A
- 100C>T
- 310G>T
- CYP2D7 sequence from indivon 1 onwards
Allele Name : CYP2D6*68A
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer. Lack of efficacy. For individual with two non-functional alleles, alternative drug recommended.
References :
- Crews KR, Gaedigk A, Dunnenberger HM, Leeder JS, Klein TE, Caudle KE, Haidar CE, Shen DD, Callaghan JT, Sadhasivam S, Prows CA, Kharasch ED, Skaar TC: Clinical Pharmacogenetics Implementation Consortium guidelines for cytochrome P450 2D6 genotype and codeine therapy: 2014 update. Clin Pharmacol Ther. 2014 Apr;95(4):376-82. doi: 10.1038/clpt.2013.254. Epub 2014 Jan 23. [PubMed:24458010 ]
PMID: 12169298
Codeine
Product: CHIR-090
Identifier : DBSNPE005457
Drug : DB00318 (Codeine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :
- Similar but not identical switch region compared to CYP2D6*68A. Found in tandem arrangement with CYP2D6*4.
Allele Name : CYP2D6*68B
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer. Lack of efficacy. For individual with two non-functional alleles, alternative drug recommended.
References :
- Crews KR, Gaedigk A, Dunnenberger HM, Leeder JS, Klein TE, Caudle KE, Haidar CE, Shen DD, Callaghan JT, Sadhasivam S, Prows CA, Kharasch ED, Skaar TC: Clinical Pharmacogenetics Implementation Consortium guidelines for cytochrome P450 2D6 genotype and codeine therapy: 2014 update. Clin Pharmacol Ther. 2014 Apr;95(4):376-82. doi: 10.1038/clpt.2013.254. Epub 2014 Jan 23. [PubMed:24458010 ]
PMID: 2825685
Codeine
Product: Cabazitaxel
Identifier : DBSNPE005458
Drug : DB00318 (Codeine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :
- 2988G>A (rs28371725 )
- -1426C>T
- -1235A>G
- -1000G>A
- 100C>T
- 310G>T
- 746C>G
- 843T>G
- 1062A>G
- 1661G>C
- 2850C>T
- 3384A>C
- 3584G>A
- 3790C>T
- 4180G>C
- 4401C>T
- 4481G>A
Allele Name : CYP2D6*69
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer. Lack of efficacy. For individual with two non-functional alleles, alternative drug recommended.
References :
- Crews KR, Gaedigk A, Dunnenberger HM, Leeder JS, Klein TE, Caudle KE, Haidar CE, Shen DD, Callaghan JT, Sadhasivam S, Prows CA, Kharasch ED, Skaar TC: Clinical Pharmacogenetics Implementation Consortium guidelines for cytochrome P450 2D6 genotype and codeine therapy: 2014 update. Clin Pharmacol Ther. 2014 Apr;95(4):376-82. doi: 10.1038/clpt.2013.254. Epub 2014 Jan 23. [PubMed:24458010 ]
PMID: 3019727
Codeine
Product: AZD4547
Identifier : DBSNPE005459
Drug : DB00318 (Codeine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Allele Name : CYP2D6*92
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer. Lack of efficacy. For individual with two non-functional alleles, alternative drug recommended.
References :
- Crews KR, Gaedigk A, Dunnenberger HM, Leeder JS, Klein TE, Caudle KE, Haidar CE, Shen DD, Callaghan JT, Sadhasivam S, Prows CA, Kharasch ED, Skaar TC: Clinical Pharmacogenetics Implementation Consortium guidelines for cytochrome P450 2D6 genotype and codeine therapy: 2014 update. Clin Pharmacol Ther. 2014 Apr;95(4):376-82. doi: 10.1038/clpt.2013.254. Epub 2014 Jan 23. [PubMed:24458010 ]
PMID: 25956877
Codeine
Product: SAR131675
Identifier : DBSNPE005460
Drug : DB00318 (Codeine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :
- -1426C>T
- -1235A>G
- -1109C>T
- -1000G>A
- 100C>T
- 310G>T
- 843T>G
- 1039C>T
- 1661G>C
- 2097A>G
- 2828delC
- 3384A>C
- 3582A>G
- 4180G>C
- 4401C>T
Allele Name : CYP2D6*100
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer. Lack of efficacy. For individual with two non-functional alleles, alternative drug recommended.
References :
- Crews KR, Gaedigk A, Dunnenberger HM, Leeder JS, Klein TE, Caudle KE, Haidar CE, Shen DD, Callaghan JT, Sadhasivam S, Prows CA, Kharasch ED, Skaar TC: Clinical Pharmacogenetics Implementation Consortium guidelines for cytochrome P450 2D6 genotype and codeine therapy: 2014 update. Clin Pharmacol Ther. 2014 Apr;95(4):376-82. doi: 10.1038/clpt.2013.254. Epub 2014 Jan 23. [PubMed:24458010 ]
PMID: 2170626
Codeine
Product: AT13387
Identifier : DBSNPE005461
Drug : DB00318 (Codeine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :
- -1426C>T
- -1235A>G
- -1000G>A
- 100C>T
- 310G>T
- 843T>G
- 1039C>T
- 1661G>C
- 2097A>G
- 2927_2945delGATCCTACATCCGGATGTG
- 3384A>C
- 3582A>G
- 4180G>C
- 4401C>T
Allele Name : CYP2D6*101
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer. Lack of efficacy. For individual with two non-functional alleles, alternative drug recommended.
References :
- Crews KR, Gaedigk A, Dunnenberger HM, Leeder JS, Klein TE, Caudle KE, Haidar CE, Shen DD, Callaghan JT, Sadhasivam S, Prows CA, Kharasch ED, Skaar TC: Clinical Pharmacogenetics Implementation Consortium guidelines for cytochrome P450 2D6 genotype and codeine therapy: 2014 update. Clin Pharmacol Ther. 2014 Apr;95(4):376-82. doi: 10.1038/clpt.2013.254. Epub 2014 Jan 23. [PubMed:24458010 ]
PMID: 2175357
Codeine
Product: Triciribine
Identifier : DBSNPE005462
Drug : DB00318 (Codeine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :
- Normal allele duplicated.
Allele Name : CYP2D6*1XN
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Uldiva-rapid metabolizer CYP2D6
Description : Uldiva-rapid drug metabolizer. Risk of toxicity, alternative drug recommended.
References :
- Crews KR, Gaedigk A, Dunnenberger HM, Leeder JS, Klein TE, Caudle KE, Haidar CE, Shen DD, Callaghan JT, Sadhasivam S, Prows CA, Kharasch ED, Skaar TC: Clinical Pharmacogenetics Implementation Consortium guidelines for cytochrome P450 2D6 genotype and codeine therapy: 2014 update. Clin Pharmacol Ther. 2014 Apr;95(4):376-82. doi: 10.1038/clpt.2013.254. Epub 2014 Jan 23. [PubMed:24458010 ]
PMID: 2170624
Codeine
Product: NVP-BVU972
Identifier : DBSNPE005463
Drug : DB00318 (Codeine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :
- 2850C>T (rs16947 )
- 4180G>C (rs1135840 )
- 1661G>C duplicated
Allele Name : CYP2D6*2XN
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Uldiva-rapid metabolizer CYP2D6
Description : Uldiva-rapid drug metabolizer. Risk of toxicity, alternative drug recommended.
References :
- Crews KR, Gaedigk A, Dunnenberger HM, Leeder JS, Klein TE, Caudle KE, Haidar CE, Shen DD, Callaghan JT, Sadhasivam S, Prows CA, Kharasch ED, Skaar TC: Clinical Pharmacogenetics Implementation Consortium guidelines for cytochrome P450 2D6 genotype and codeine therapy: 2014 update. Clin Pharmacol Ther. 2014 Apr;95(4):376-82. doi: 10.1038/clpt.2013.254. Epub 2014 Jan 23. [PubMed:24458010 ]
PMID: 26426079
Codeine
Product: Vigabatrin
Identifier : DBSNPE005616
Drug : DB00318 (Codeine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Allele Name : CYP2D6*3
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirements
References :
- Kagimoto M, Heim M, Kagimoto K, Zeugin T, Meyer UA: Multiple mutations of the human cytochrome P450IID6 gene (CYP2D6) in poor metabolizers of debrisoquine. Study of the functional significance of individual mutations by expression of chimeric genes. J Biol Chem. 1990 Oct 5;265(28):17209-14. [PubMed:2211621 ]
- Marez D, Legrand M, Sabbagh N, Lo Guidice JM, Spire C, Lafitte JJ, Meyer UA, Broly F: Polymorphism of the cytochrome P450 CYP2D6 gene in a European population: characterization of 48 mutations and 53 alleles, their frequencies and evolution. Pharmacogenetics. 1997 Jun;7(3):193-202. [PubMed:9241659 ]
- The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]
PMID: 8818342
Codeine
Product: Voreloxin
Identifier : DBSNPE005617
Drug : DB00318 (Codeine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Allele Name : CYP2D6*4
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirements
References :
- Kagimoto M, Heim M, Kagimoto K, Zeugin T, Meyer UA: Multiple mutations of the human cytochrome P450IID6 gene (CYP2D6) in poor metabolizers of debrisoquine. Study of the functional significance of individual mutations by expression of chimeric genes. J Biol Chem. 1990 Oct 5;265(28):17209-14. [PubMed:2211621 ]
- Gough AC, Miles JS, Spurr NK, Moss JE, Gaedigk A, Eichelbaum M, Wolf CR: Identification of the primary gene defect at the cytochrome P450 CYP2D locus. Nature. 1990 Oct 25;347(6295):773-6. [PubMed:1978251 ]
- Hanioka N, Kimura S, Meyer UA, Gonzalez FJ: The human CYP2D locus associated with a common genetic defect in drug oxidation: a G1934—-A base change in indivon 3 of a mutant CYP2D6 allele results in an aberrant 3 splice recognition site. Am J Hum Genet. 1990 Dec;47(6):994-1001. [PubMed:1978565 ]
- Yokota H, Tamura S, Furuya H, Kimura S, Watanabe M, Kanazawa I, Kondo I, Gonzalez FJ: Evidence for a new variant CYP2D6 allele CYP2D6J in a Japanese population associated with lower in vivo rates of sparteine metabolism. Pharmacogenetics. 1993 Oct;3(5):256-63. [PubMed:8287064 ]
- Marez D, Legrand M, Sabbagh N, Lo Guidice JM, Spire C, Lafitte JJ, Meyer UA, Broly F: Polymorphism of the cytochrome P450 CYP2D6 gene in a European population: characterization of 48 mutations and 53 alleles, their frequencies and evolution. Pharmacogenetics. 1997 Jun;7(3):193-202. [PubMed:9241659 ]
- Sachse C, Brockmoller J, Bauer S, Roots I: Cytochrome P450 2D6 variants in a Caucasian population: allele frequencies and phenotypic consequences. Am J Hum Genet. 1997 Feb;60(2):284-95. [PubMed:9012401 ]
- Shimada T, Tsumura F, Yamazaki H, Guengerich FP, Inoue K: Characterization of (+/-)-bufuralol hydroxylation activities in liver microsomes of Japanese and Caucasian subjects genotyped for CYP2D6. Pharmacogenetics. 2001 Mar;11(2):143-56. [PubMed:11266079 ]
- Agundez JA, Ramirez R, Hernandez M, Llerena A, Benitez J: Molecular heterogeneity at the CYP2D gene locus in Nicaraguans: impact of gene-flow from Europe. Pharmacogenetics. 1997 Aug;7(4):337-40. [PubMed:9295063 ]
- Fuselli S, Dupanloup I, Frigato E, Cruciani F, Scozzari R, Moral P, Sistonen J, Sajantila A, Barbujani G: Molecular diversity at the CYP2D6 locus in the Mediterranean region. Eur J Hum Genet. 2004 Nov;12(11):916-24. [PubMed:15340360 ]
- Gaedigk A, Bradford LD, Alander SW, Leeder JS: CYP2D6*36 gene arrangements within the cyp2d6 locus: association of CYP2D6*36 with poor metabolizer status. Drug Metab Dispos. 2006 Apr;34(4):563-9. Epub 2006 Jan 13. [PubMed:16415111 ]
- Dodgen TM, Hochfeld WE, Fickl H, Asfaha SM, Durandt C, Rheeder P, Drogemoller BI, Wright GE, Warnich L, Labuschagne CD, van Schalkwyk A, Gaedigk A, Pepper MS: Indivoduction of the AmpliChip CYP450 Test to a South African cohort: a platform comparative prospective cohort study. BMC Med Genet. 2013 Jan 29;14:20. doi: 10.1186/1471-2350-14-20. [PubMed:23356658 ]
- The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]
PMID: 10644042
Codeine
Product: Fenretinide
Identifier : DBSNPE005618
Drug : DB00318 (Codeine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Allele Name : CYP2D6*5
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirements
References :
- Gaedigk A, Blum M, Gaedigk R, Eichelbaum M, Meyer UA: Deletion of the entire cytochrome P450 CYP2D6 gene as a cause of impaired drug metabolism in poor metabolizers of the debrisoquine/sparteine polymorphism. Am J Hum Genet. 1991 May;48(5):943-50. [PubMed:1673290 ]
- Steen VM, Molven A, Aarskog NK, Gulbrandsen AK: Homologous unequal cross-over involving a 2.8 kb direct repeat as a mechanism for the generation of allelic variants of human cytochrome P450 CYP2D6 gene. Hum Mol Genet. 1995 Dec;4(12):2251-7. [PubMed:8634695 ]
- The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]
PMID: 226672
Codeine
Product: ALK inhibitor 1
Identifier : DBSNPE005619
Drug : DB00318 (Codeine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Allele Name : CYP2D6*6
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirements
References :
- Saxena R, Shaw GL, Relling MV, Frame JN, Moir DT, Evans WE, Caporaso N, Weiffenbach B: Identification of a new variant CYP2D6 allele with a single base deletion in exon 3 and its association with the poor metabolizer phenotype. Hum Mol Genet. 1994 Jun;3(6):923-6. [PubMed:7951238 ]
- Evert B, Griese EU, Eichelbaum M: Cloning and sequencing of a new non-functional CYP2D6 allele: deletion of T1795 in exon 3 generates a premature stop codon. Pharmacogenetics. 1994 Oct;4(5):271-4. [PubMed:7894499 ]
- Daly AK, Leathart JB, London SJ, Idle JR: An inactive cytochrome P450 CYP2D6 allele containing a deletion and a base substitution. Hum Genet. 1995 Mar;95(3):337-41. [PubMed:7868129 ]
- Marez D, Legrand M, Sabbagh N, Lo Guidice JM, Spire C, Lafitte JJ, Meyer UA, Broly F: Polymorphism of the cytochrome P450 CYP2D6 gene in a European population: characterization of 48 mutations and 53 alleles, their frequencies and evolution. Pharmacogenetics. 1997 Jun;7(3):193-202. [PubMed:9241659 ]
- The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]
PMID: 25738589
Codeine
Product: ENMD-2076
Identifier : DBSNPE005620
Drug : DB00318 (Codeine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Allele Name : CYP2D6*7
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirements
References :
- Evert B, Griese EU, Eichelbaum M: A missense mutation in exon 6 of the CYP2D6 gene leading to a histidine 324 to proline exchange is associated with the poor metabolizer phenotype of sparteine. Naunyn Schmiedebergs Arch Pharmacol. 1994 Oct;350(4):434-9. [PubMed:7845481 ]
- The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]
PMID: 23250865
Codeine
Product: ASP3026
Identifier : DBSNPE005621
Drug : DB00318 (Codeine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Allele Name : CYP2D6*8
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirements
References :
- Broly F, Marez D, Lo Guidice JM, Sabbagh N, Legrand M, Boone P, Meyer UA: A nonsense mutation in the cytochrome P450 CYP2D6 gene identified in a Caucasian with an enzyme deficiency. Hum Genet. 1995 Nov;96(5):601-3. [PubMed:8530011 ]
- The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]
PMID: 9023272
Codeine
Product: TG 100801 (Hydrochloride)
Identifier : DBSNPE005622
Drug : DB00318 (Codeine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Allele Name : CYP2D6*11
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirements
References :
- Marez D, Sabbagh N, Legrand M, Lo-Guidice JM, Boone P, Broly F: A novel CYP2D6 allele with an abolished splice recognition site associated with the poor metabolizer phenotype. Pharmacogenetics. 1995 Oct;5(5):305-11. [PubMed:8563771 ]
- The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]
PMID: 8819523
Codeine
Product: TG 100801
Identifier : DBSNPE005623
Drug : DB00318 (Codeine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Allele Name : CYP2D6*12
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirements
References :
- Marez D, Legrand M, Sabbagh N, Lo-Guidice JM, Boone P, Broly F: An additional allelic variant of the CYP2D6 gene causing impaired metabolism of sparteine. Hum Genet. 1996 May;97(5):668-70. [PubMed:8655150 ]
- The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]
PMID: 8819522
Codeine
Product: TG 100572 (Hydrochloride)
Identifier : DBSNPE005624
Drug : DB00318 (Codeine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :
- CYP2D7/2D6 hybrid gene sdivucture
Allele Name : CYP2D6*13
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirements
References :
- Panserat S, Mura C, Gerard N, Vincent-Viry M, Galteau MM, Jacoz-Aigrain E, Krishnamoorthy R: An unequal cross-over event within the CYP2D gene cluster generates a chimeric CYP2D7/CYP2D6 gene which is associated with the poor metabolizer phenotype. Br J Clin Pharmacol. 1995 Oct;40(4):361-7. [PubMed:8554938 ]
- Black JL 3rd, Walker DL, OKane DJ, Harmandayan M: Frequency of undetected CYP2D6 hybrid genes in clinical samples: impact on phenotype prediction. Drug Metab Dispos. 2012 Jan;40(1):111-9. doi: 10.1124/dmd.111.040832. Epub 2011 Oct 17. [PubMed:22004686 ]
- Gaedigk A, Fuhr U, Johnson C, Berard LA, Bradford D, Leeder JS: CYP2D7-2D6 hybrid tandems: identification of novel CYP2D6 duplication arrangements and implications for phenotype prediction. Pharmacogenomics. 2010 Jan;11(1):43-53. doi: 10.2217/pgs.09.133. [PubMed:20017671 ]
- Gaedigk A, Jaime LK, Bertino JS Jr, Berard A, Pratt VM, Bradfordand LD, Leeder JS: Identification of Novel CYP2D7-2D6 Hybrids: Non-Functional and Functional Variants. Front Pharmacol. 2010 Oct 4;1:121. doi: 10.3389/fphar.2010.00121. eCollection 2010. [PubMed:21833166 ]
- Daly AK, Fairbrother KS, Andreassen OA, London SJ, Idle JR, Steen VM: Characterization and PCR-based detection of two different hybrid CYP2D7P/CYP2D6 alleles associated with the poor metabolizer phenotype. Pharmacogenetics. 1996 Aug;6(4):319-28. [PubMed:8873218 ]
- Gaedigk A, Coetsee C: The CYP2D6 gene locus in South African Coloureds: unique allele disdivibutions, novel alleles and gene arrangements. Eur J Clin Pharmacol. 2008 May;64(5):465-75. doi: 10.1007/s00228-007-0445-7. Epub 2008 Jan 17. [PubMed:18202841 ]
- The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]
PMID: 15550574
Codeine
Product: TG 100572
Identifier : DBSNPE005625
Drug : DB00318 (Codeine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Allele Name : CYP2D6*14A
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirements
References :
- Wang SL, Lai MD, Huang JD: G169R mutation diminishes the metabolic activity of CYP2D6 in Chinese. Drug Metab Dispos. 1999 Mar;27(3):385-8. [PubMed:10064570 ]
- Sakuyama K, Sasaki T, Ujiie S, Obata K, Mizugaki M, Ishikawa M, Hiratsuka M: Functional characterization of 17 CYP2D6 allelic variants (CYP2D6.2, 10, 14A-B, 18, 27, 36, 39, 47-51, 53-55, and 57). Drug Metab Dispos. 2008 Dec;36(12):2460-7. doi: 10.1124/dmd.108.023242. Epub 2008 Sep 10. [PubMed:18784265 ]
- The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]
PMID: 10935673
Codeine
Product: E-3810
Identifier : DBSNPE005626
Drug : DB00318 (Codeine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Allele Name : CYP2D6*15
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirements
References :
- Sachse C, Brockmoller J, Bauer S, Reum T, Roots I: A rare insertion of T226 in exon 1 of CYP2D6 causes a frameshift and is associated with the poor metabolizer phenotype: CYP2D6*15. Pharmacogenetics. 1996 Jun;6(3):269-72. [PubMed:8807669 ]
- The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]
PMID: 8672353
Codeine
Product: Dapagliflozin
Identifier : DBSNPE005627
Drug : DB00318 (Codeine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :
- 2539_2542delAACT (rs72549353 )
Allele Name : CYP2D6*19
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirements
References :
- Marez D, Legrand M, Sabbagh N, Lo Guidice JM, Spire C, Lafitte JJ, Meyer UA, Broly F: Polymorphism of the cytochrome P450 CYP2D6 gene in a European population: characterization of 48 mutations and 53 alleles, their frequencies and evolution. Pharmacogenetics. 1997 Jun;7(3):193-202. [PubMed:9241659 ]
- The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]
PMID: 1848733
Codeine
Product: MK-4827
Identifier : DBSNPE005628
Drug : DB00318 (Codeine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :
- 1973_1974insG (rs72549354 )
Allele Name : CYP2D6*20
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirements
References :
- Marez-Allorge D, Ellis SW, Lo Guidice JM, Tucker GT, Broly F: A rare G2061 insertion affecting the open reading frame of CYP2D6 and responsible for the poor metabolizer phenotype. Pharmacogenetics. 1999 Jun;9(3):393-6. [PubMed:10471072 ]
- The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]
PMID: 6177320
Codeine
Product: AST 487
Identifier : DBSNPE005629
Drug : DB00318 (Codeine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Allele Name : CYP2D6*21
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirements
References :
- Chida M, Yokoi T, Nemoto N, Inaba M, Kinoshita M, Kamataki T: A new variant CYP2D6 allele (CYP2D6*21) with a single base insertion in exon 5 in a Japanese population associated with a poor metabolizer phenotype. Pharmacogenetics. 1999 Jun;9(3):287-93. [PubMed:10471060 ]
- Yamazaki H, Kiyotani K, Tsubuko S, Matsunaga M, Fujieda M, Saito T, Miura J, Kobayashi S, Kamataki T: Two novel haplotypes of CYP2D6 gene in a Japanese population. Drug Metab Pharmacokinet. 2003;18(4):269-71. [PubMed:15618746 ]
- The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]
PMID: 4345859
Codeine
Product: Inolitazone
Identifier : DBSNPE005630
Drug : DB00318 (Codeine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :
- -1770G>A
- -1584C>G
- -1235A>G
- -740C>T
- -678G>A
- CYP2D7 gene conversion in indivon 1
- 310G>T
- 746C>G
- 843T>G
- 1661G>C
- 2850C>T
- 3384A>C
- 3584G>A
- 3790C>T
- 4042G>A
- 4180G>C
- 4481G>A
Allele Name : CYP2D6*31
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirements
References :
- Marez D, Legrand M, Sabbagh N, Lo Guidice JM, Spire C, Lafitte JJ, Meyer UA, Broly F: Polymorphism of the cytochrome P450 CYP2D6 gene in a European population: characterization of 48 mutations and 53 alleles, their frequencies and evolution. Pharmacogenetics. 1997 Jun;7(3):193-202. [PubMed:9241659 ]
- Allorge D, Breant D, Harlow J, Chowdry J, Lo-Guidice JM, Chevalier D, Cauffiez C, Lhermitte M, Blaney FE, Tucker GT, Broly F, Ellis SW: Functional analysis of CYP2D6.31 variant: homology modeling suggests possible disruption of redox partner interaction by Arg440His substitution. Proteins. 2005 May 1;59(2):339-46. [PubMed:15726636 ]
- Gaedigk A, Isidoro-Garcia M, Pearce RE, Sanchez S, Garcia-Solaesa V, Lorenzo-Romo C, Gonzalez-Tejera G, Corey S: Discovery of the nonfunctional CYP2D6 31 allele in Spanish, Puerto Rican, and US Hispanic populations. Eur J Clin Pharmacol. 2010 Sep;66(9):859-64. doi: 10.1007/s00228-010-0831-4. Epub 2010 May 16. [PubMed:20473659 ]
- The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]
PMID: 22100260
Codeine
Product: SLx-2119
Identifier : DBSNPE005631
Drug : DB00318 (Codeine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :
- 100C>T (rs1065852 )
- -1426C>T
- variable number of A’s in the region -1258 to -1237a
- -1235A>G
- -1000G>A
- 1039C>T
- 1661G>C
- gene conversion to CYP2D7 in exon 9
- 4180G>C
Allele Name : CYP2D6*36
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirements
References :
- Gaedigk A, Bradford LD, Alander SW, Leeder JS: CYP2D6*36 gene arrangements within the cyp2d6 locus: association of CYP2D6*36 with poor metabolizer status. Drug Metab Dispos. 2006 Apr;34(4):563-9. Epub 2006 Jan 13. [PubMed:16415111 ]
- Sakuyama K, Sasaki T, Ujiie S, Obata K, Mizugaki M, Ishikawa M, Hiratsuka M: Functional characterization of 17 CYP2D6 allelic variants (CYP2D6.2, 10, 14A-B, 18, 27, 36, 39, 47-51, 53-55, and 57). Drug Metab Dispos. 2008 Dec;36(12):2460-7. doi: 10.1124/dmd.108.023242. Epub 2008 Sep 10. [PubMed:18784265 ]
- Johansson I, Oscarson M, Yue QY, Bertilsson L, Sjoqvist F, Ingelman-Sundberg M: Genetic analysis of the Chinese cytochrome P4502D locus: characterization of variant CYP2D6 genes present in subjects with diminished capacity for debrisoquine hydroxylation. Mol Pharmacol. 1994 Sep;46(3):452-9. [PubMed:7935325 ]
- Leathart JB, London SJ, Steward A, Adams JD, Idle JR, Daly AK: CYP2D6 phenotype-genotype relationships in African-Americans and Caucasians in Los Angeles. Pharmacogenetics. 1998 Dec;8(6):529-41. [PubMed:9918137 ]
- The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]
PMID: 20446824
Codeine
Product: chroman 1
Identifier : DBSNPE005632
Drug : DB00318 (Codeine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :
- 2587_2590delGACT (rs72549351 )
Allele Name : CYP2D6*38
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirements
References :
- Leathart JB, London SJ, Steward A, Adams JD, Idle JR, Daly AK: CYP2D6 phenotype-genotype relationships in African-Americans and Caucasians in Los Angeles. Pharmacogenetics. 1998 Dec;8(6):529-41. [PubMed:9918137 ]
- The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]
PMID: 11607039
Codeine
Product: TAK-285
Identifier : DBSNPE005633
Drug : DB00318 (Codeine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :
- 1863_1864ins(TTT CGC CCC)2 (rs72549356 )
Allele Name : CYP2D6*40
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirements
References :
- Gaedigk A, Bradford LD, Marcucci KA, Leeder JS: Unique CYP2D6 activity disdivibution and genotype-phenotype discordance in black Americans. Clin Pharmacol Ther. 2002 Jul;72(1):76-89. [PubMed:12152006 ]
- The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]
PMID: 8032594
Codeine
Product: PF-3758309
Identifier : DBSNPE005634
Drug : DB00318 (Codeine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :
- 3259_3260insGT (rs72549346 )
Allele Name : CYP2D6*42
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirements
References :
- Gaedigk A, Ndjountche L, Gaedigk R, Leeder JS, Bradford LD: Discovery of a novel nonfunctional cytochrome P450 2D6 allele, CYP2D642, in African American subjects. Clin Pharmacol Ther. 2003 Jun;73(6):575-6. [PubMed:12811367 ]
- The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]
PMID: 6193303
Codeine
Product: M2 ion channel blocker
Identifier : DBSNPE005635
Drug : DB00318 (Codeine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Allele Name : CYP2D6*44
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirements
References :
- Yamazaki H, Kiyotani K, Tsubuko S, Matsunaga M, Fujieda M, Saito T, Miura J, Kobayashi S, Kamataki T: Two novel haplotypes of CYP2D6 gene in a Japanese population. Drug Metab Pharmacokinet. 2003;18(4):269-71. [PubMed:15618746 ]
- The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]
PMID: 12704225
Codeine
Product: MI-3
Identifier : DBSNPE005636
Drug : DB00318 (Codeine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :
- 100C>T (rs1065852 )
- -1426C>T
- -1235A>G
- -1000G>A
- 73C<T
- 1039C>T
- 1661G>C
- 4180G>C
Allele Name : CYP2D6*47
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirements
References :
- Soyama A, Kubo T, Miyajima A, Saito Y, Shiseki K, Komamura K, Ueno K, Kamakura S, Kitakaze M, Tomoike H, Ozawa S, Sawada J: Novel nonsynonymous single nucleotide polymorphisms in the CYP2D6 gene. Drug Metab Pharmacokinet. 2004 Aug;19(4):313-9. [PubMed:15499201 ]
- Sakuyama K, Sasaki T, Ujiie S, Obata K, Mizugaki M, Ishikawa M, Hiratsuka M: Functional characterization of 17 CYP2D6 allelic variants (CYP2D6.2, 10, 14A-B, 18, 27, 36, 39, 47-51, 53-55, and 57). Drug Metab Dispos. 2008 Dec;36(12):2460-7. doi: 10.1124/dmd.108.023242. Epub 2008 Sep 10. [PubMed:18784265 ]
- The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]
PMID: 2557965
Codeine
Product: MI-2
Identifier : DBSNPE005637
Drug : DB00318 (Codeine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :
- -1584C>G
- -1235A>G
- -740C>T
- -678G>A
- CYP2D7 gene conversion in indivon 1
- 1661G>C
- 2850C>T
- 3172A>C
- 4180G>C
Allele Name : CYP2D6*51
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirements
References :
- Soyama A, Kubo T, Miyajima A, Saito Y, Shiseki K, Komamura K, Ueno K, Kamakura S, Kitakaze M, Tomoike H, Ozawa S, Sawada J: Novel nonsynonymous single nucleotide polymorphisms in the CYP2D6 gene. Drug Metab Pharmacokinet. 2004 Aug;19(4):313-9. [PubMed:15499201 ]
- Sakuyama K, Sasaki T, Ujiie S, Obata K, Mizugaki M, Ishikawa M, Hiratsuka M: Functional characterization of 17 CYP2D6 allelic variants (CYP2D6.2, 10, 14A-B, 18, 27, 36, 39, 47-51, 53-55, and 57). Drug Metab Dispos. 2008 Dec;36(12):2460-7. doi: 10.1124/dmd.108.023242. Epub 2008 Sep 10. [PubMed:18784265 ]
- The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]
PMID: 6302550
Codeine
Product: SB-705498
Identifier : DBSNPE005638
Drug : DB00318 (Codeine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Allele Name : CYP2D6*56
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirements
References :
- Li L, Pan RM, Porter TD, Jensen NS, Silber P, Russo G, Tine JA, Heim J, Ring B, Wedlund PJ: New cytochrome P450 2D6*56 allele identified by genotype/phenotype analysis of cryopreserved human hepatocytes. Drug Metab Dispos. 2006 Aug;34(8):1411-6. Epub 2006 May 5. [PubMed:16679388 ]
- Gaedigk A, Eklund JD, Pearce RE, Leeder JS, Alander SW, Phillips MS, Bradford LD, Kennedy MJ: Identification and characterization of CYP2D6*56B, an allele associated with the poor metabolizer phenotype. Clin Pharmacol Ther. 2007 Jun;81(6):817-20. Epub 2007 Mar 28. [PubMed:17392730 ]
- The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]
PMID: 15272207
Codeine
Product: Cevimeline (hydrochloride hemihydrate)
Identifier : DBSNPE005639
Drug : DB00318 (Codeine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :
- 100C>T
- 310G>T
- 843T>G
- 887C>T
- 1039C>T
- 1661G>C
- 3384A>C
- 3582A>G
- gene conversion to CYP2D7 in exon 9
- 4180G>C
Allele Name : CYP2D6*57
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirements
References :
- Soyama A, Kubo T, Miyajima A, Saito Y, Shiseki K, Komamura K, Ueno K, Kamakura S, Kitakaze M, Tomoike H, Ozawa S, Sawada J: Novel nonsynonymous single nucleotide polymorphisms in the CYP2D6 gene. Drug Metab Pharmacokinet. 2004 Aug;19(4):313-9. [PubMed:15499201 ]
- Sakuyama K, Sasaki T, Ujiie S, Obata K, Mizugaki M, Ishikawa M, Hiratsuka M: Functional characterization of 17 CYP2D6 allelic variants (CYP2D6.2, 10, 14A-B, 18, 27, 36, 39, 47-51, 53-55, and 57). Drug Metab Dispos. 2008 Dec;36(12):2460-7. doi: 10.1124/dmd.108.023242. Epub 2008 Sep 10. [PubMed:18784265 ]
- The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]
PMID: 15501481
Codeine
Product: X-Neu5Ac
Identifier : DBSNPE005640
Drug : DB00318 (Codeine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Allele Name : CYP2D6*62
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirements
References :
- Klein K, Tatzel S, Raimundo S, Saussele T, Hustert E, Pleiss J, Eichelbaum M, Zanger UM: A natural variant of the heme-binding signature (R441C) resulting in complete loss of function of CYP2D6. Drug Metab Dispos. 2007 Aug;35(8):1247-50. Epub 2007 Apr 25. [PubMed:17460029 ]
- The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]
PMID: 14758089
Codeine
Product: Capecitabine
Identifier : DBSNPE005641
Drug : DB00318 (Codeine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :
- -1426C>T
- -1235A>G
- -1000G>A
- 100C>T
- 310G>T
- CYP2D7 sequence from indivon 1 onwards
Allele Name : CYP2D6*68A
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirements
References :
- Kramer WE, Walker DL, OKane DJ, Mrazek DA, Fisher PK, Dukek BA, Bruflat JK, Black JL: CYP2D6: novel genomic sdivuctures and alleles. Pharmacogenet Genomics. 2009 Oct;19(10):813-22. doi: 10.1097/FPC.0b013e3283317b95. [PubMed:19741566 ]
- The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]
PMID: 15448112
Codeine
Product: Dexrazoxane (Hydrochloride)
Identifier : DBSNPE005642
Drug : DB00318 (Codeine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :
- Similar but not identical switch region compared to CYP2D6*68A. Found in tandem arrangement with CYP2D6*4.
Allele Name : CYP2D6*68B
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirements
References :
- Gaedigk A, Twist GP, Leeder JS: CYP2D6, SULT1A1 and UGT2B17 copy number variation: quantitative detection by multiplex PCR. Pharmacogenomics. 2012 Jan;13(1):91-111. doi: 10.2217/pgs.11.135. Epub 2011 Nov 23. [PubMed:22111604 ]
- The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]
PMID: 12606674
Codeine
Product: Aripiprazole
Identifier : DBSNPE005643
Drug : DB00318 (Codeine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :
- 2988G>A (rs28371725 )
- -1426C>T
- -1235A>G
- -1000G>A
- 100C>T
- 310G>T
- 746C>G
- 843T>G
- 1062A>G
- 1661G>C
- 2850C>T
- 3384A>C
- 3584G>A
- 3790C>T
- 4180G>C
- 4401C>T
- 4481G>A
Allele Name : CYP2D6*69
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirements
References :
- Gaedigk A, Frank D, Fuhr U: Identification of a novel non-functional CYP2D6 allele, CYP2D6*69, in a Caucasian poor metabolizer individual. Eur J Clin Pharmacol. 2009 Jan;65(1):97-100. doi: 10.1007/s00228-008-0559-6. Epub 2008 Sep 17. [PubMed:18797858 ]
- The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]
PMID: 10900347
Codeine
Product: Fenspiride (Hydrochloride)
Identifier : DBSNPE005644
Drug : DB00318 (Codeine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Allele Name : CYP2D6*92
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirements
References :
- Qian JC, Xu XM, Hu GX, Dai DP, Xu RA, Hu LM, Li FH, Zhang XH, Yang JF, Cai JP: Genetic variations of human CYP2D6 in the Chinese Han population. Pharmacogenomics. 2013 Nov;14(14):1731-43. doi: 10.2217/pgs.13.160. [PubMed:24192122 ]
- The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]
PMID: 7925608
Codeine
Product: Naltrexone (Hydrochloride)
Identifier : DBSNPE005645
Drug : DB00318 (Codeine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :
- -1426C>T
- -1235A>G
- -1109C>T
- -1000G>A
- 100C>T
- 310G>T
- 843T>G
- 1039C>T
- 1661G>C
- 2097A>G
- 2828delC
- 3384A>C
- 3582A>G
- 4180G>C
- 4401C>T
Allele Name : CYP2D6*100
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirements
References :
- Montane Jaime LK, Lalla A, Steimer W, Gaedigk A: Characterization of the CYP2D6 gene locus and metabolic activity in Indo- and Afro-Trinidadians: discovery of novel allelic variants. Pharmacogenomics. 2013 Feb;14(3):261-76. doi: 10.2217/pgs.12.207. [PubMed:23394389 ]
- The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]
PMID: 1665737
Codeine
Product: Methylnaltrexone (Bromide)
Identifier : DBSNPE005646
Drug : DB00318 (Codeine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :
- -1426C>T
- -1235A>G
- -1000G>A
- 100C>T
- 310G>T
- 843T>G
- 1039C>T
- 1661G>C
- 2097A>G
- 2927_2945delGATCCTACATCCGGATGTG
- 3384A>C
- 3582A>G
- 4180G>C
- 4401C>T
Allele Name : CYP2D6*101
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirements
References :
- Montane Jaime LK, Lalla A, Steimer W, Gaedigk A: Characterization of the CYP2D6 gene locus and metabolic activity in Indo- and Afro-Trinidadians: discovery of novel allelic variants. Pharmacogenomics. 2013 Feb;14(3):261-76. doi: 10.2217/pgs.12.207. [PubMed:23394389 ]
- The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]
PMID: 6195468