PI3KInhibitorpi3kinhibitor

Cevimeline

By

Cevimeline

Product: Stavudine

Identifier : DBSNPE004575
Drug : DB00185 (Cevimeline)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • C allele (rs35742686 )

Allele Name : CYP2D6*3
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor metabolizer, more adverse reactions.
References :

  1. Evoxac® capsules (cevimeline hydrochloride)[package insert]. Montvale, New Jersey: Daiichi Pharmaceutical Corporation; 2006. [Link]

PMID: 25729578

Cevimeline

By

Cevimeline

Product: Pizotifen (malate)

Identifier : DBSNPE004576
Drug : DB00185 (Cevimeline)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • C allele (rs3892097 )

Allele Name : CYP2D6*4
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor metabolizer, more adverse reactions.
References :

  1. Evoxac® capsules (cevimeline hydrochloride)[package insert]. Montvale, New Jersey: Daiichi Pharmaceutical Corporation; 2006. [Link]

PMID: 15601626

Cevimeline

By

Cevimeline

Product: Pizotifen

Identifier : DBSNPE004577
Drug : DB00185 (Cevimeline)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • Whole-gene deletion

Allele Name : CYP2D6*5
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor metabolizer, more adverse reactions.
References :

  1. Evoxac® capsules (cevimeline hydrochloride)[package insert]. Montvale, New Jersey: Daiichi Pharmaceutical Corporation; 2006. [Link]

PMID: 19837904

Cevimeline

By

Cevimeline

Product: Oxcarbazepine

Identifier : DBSNPE004578
Drug : DB00185 (Cevimeline)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 1707delT (rs5030655 )

Allele Name : CYP2D6*6
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor metabolizer, more adverse reactions.
References :

  1. Evoxac® capsules (cevimeline hydrochloride)[package insert]. Montvale, New Jersey: Daiichi Pharmaceutical Corporation; 2006. [Link]

PMID: 11756401

Cevimeline

By

Cevimeline

Product: Omeprazole

Identifier : DBSNPE004579
Drug : DB00185 (Cevimeline)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 2935A>C (rs5030867 )

Allele Name : CYP2D6*7
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor metabolizer, more adverse reactions.
References :

  1. Evoxac® capsules (cevimeline hydrochloride)[package insert]. Montvale, New Jersey: Daiichi Pharmaceutical Corporation; 2006. [Link]

PMID: 14623134

Cevimeline

By

Cevimeline

Product: Minoxidil

Identifier : DBSNPE004580
Drug : DB00185 (Cevimeline)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 1758G>T (rs5030865 )

Allele Name : CYP2D6*8
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor metabolizer, more adverse reactions.
References :

  1. Evoxac® capsules (cevimeline hydrochloride)[package insert]. Montvale, New Jersey: Daiichi Pharmaceutical Corporation; 2006. [Link]

PMID: 1425958

Cevimeline

By

Cevimeline

Product: Meropenem (trihydrate)

Identifier : DBSNPE004581
Drug : DB00185 (Cevimeline)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 883G>C (rs5030863 )

Allele Name : CYP2D6*11
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor metabolizer, more adverse reactions.
References :

  1. Evoxac® capsules (cevimeline hydrochloride)[package insert]. Montvale, New Jersey: Daiichi Pharmaceutical Corporation; 2006. [Link]

PMID: 1812009

Cevimeline

By

Cevimeline

Product: Meropenem

Identifier : DBSNPE004582
Drug : DB00185 (Cevimeline)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 124G>A (rs5030862 )

Allele Name : CYP2D6*12
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor metabolizer, more adverse reactions.
References :

  1. Evoxac® capsules (cevimeline hydrochloride)[package insert]. Montvale, New Jersey: Daiichi Pharmaceutical Corporation; 2006. [Link]

PMID: 2473637

Cevimeline

By

Cevimeline

Product: Isotretinoin

Identifier : DBSNPE004583
Drug : DB00185 (Cevimeline)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • CYP2D7/2D6 hybrid gene sdivucture

Allele Name : CYP2D6*13
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor metabolizer, more adverse reactions.
References :

  1. Evoxac® capsules (cevimeline hydrochloride)[package insert]. Montvale, New Jersey: Daiichi Pharmaceutical Corporation; 2006. [Link]

PMID: 2437111

Cevimeline

By

Cevimeline

Product: Drospirenone

Identifier : DBSNPE004584
Drug : DB00185 (Cevimeline)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 1758G>A (rs5030865 )

Allele Name : CYP2D6*14A
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor metabolizer, more adverse reactions.
References :

  1. Evoxac® capsules (cevimeline hydrochloride)[package insert]. Montvale, New Jersey: Daiichi Pharmaceutical Corporation; 2006. [Link]

PMID: 3087352

Cevimeline

By

Cevimeline

Product: Gestodene

Identifier : DBSNPE004585
Drug : DB00185 (Cevimeline)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 137insT, 137_138insT

Allele Name : CYP2D6*15
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor metabolizer, more adverse reactions.
References :

  1. Evoxac® capsules (cevimeline hydrochloride)[package insert]. Montvale, New Jersey: Daiichi Pharmaceutical Corporation; 2006. [Link]

PMID: 3416919

Cevimeline

By

Cevimeline

Product: VE-822

Identifier : DBSNPE004586
Drug : DB00185 (Cevimeline)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 2539_2542delAACT (rs72549353 )

Allele Name : CYP2D6*19
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor metabolizer, more adverse reactions.
References :

  1. Evoxac® capsules (cevimeline hydrochloride)[package insert]. Montvale, New Jersey: Daiichi Pharmaceutical Corporation; 2006. [Link]

PMID: 3019713

Cevimeline

By

Cevimeline

Product: P 22077

Identifier : DBSNPE004587
Drug : DB00185 (Cevimeline)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 1973_1974insG (rs72549354 )

Allele Name : CYP2D6*20
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor metabolizer, more adverse reactions.
References :

  1. Evoxac® capsules (cevimeline hydrochloride)[package insert]. Montvale, New Jersey: Daiichi Pharmaceutical Corporation; 2006. [Link]

PMID: 6547840

Cevimeline

By

Cevimeline

Product: Dorzolamide

Identifier : DBSNPE004588
Drug : DB00185 (Cevimeline)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 2573insC

Allele Name : CYP2D6*21
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor metabolizer, more adverse reactions.
References :

  1. Evoxac® capsules (cevimeline hydrochloride)[package insert]. Montvale, New Jersey: Daiichi Pharmaceutical Corporation; 2006. [Link]

PMID: 11734615

Cevimeline

By

Cevimeline

Product: Dorzolamide (hydrochloride)

Identifier : DBSNPE004589
Drug : DB00185 (Cevimeline)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • -1770G>A
  • -1584C>G
  • -1235A>G
  • -740C>T
  • -678G>A
  • CYP2D7 gene conversion in indivon 1
  • 310G>T
  • 746C>G
  • 843T>G
  • 1661G>C
  • 2850C>T
  • 3384A>C
  • 3584G>A
  • 3790C>T
  • 4042G>A
  • 4180G>C
  • 4481G>A

Allele Name : CYP2D6*31
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor metabolizer, more adverse reactions.
References :

  1. Evoxac® capsules (cevimeline hydrochloride)[package insert]. Montvale, New Jersey: Daiichi Pharmaceutical Corporation; 2006. [Link]

PMID: 11033059

Cevimeline

By

Cevimeline

Product: Daptomycin

Identifier : DBSNPE004590
Drug : DB00185 (Cevimeline)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 100C>T (rs1065852 )
  • -1426C>T
  • variable number of A’s in the region -1258 to -1237a
  • -1235A>G
  • -1000G>A
  • 1039C>T
  • 1661G>C
  • gene conversion to CYP2D7 in exon 9
  • 4180G>C

Allele Name : CYP2D6*36
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor metabolizer, more adverse reactions.
References :

  1. Evoxac® capsules (cevimeline hydrochloride)[package insert]. Montvale, New Jersey: Daiichi Pharmaceutical Corporation; 2006. [Link]

PMID: 10390649

Cevimeline

By

Cevimeline

Product: Acitretin (sodium)

Identifier : DBSNPE004591
Drug : DB00185 (Cevimeline)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 2587_2590delGACT (rs72549351 )

Allele Name : CYP2D6*38
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor metabolizer, more adverse reactions.
References :

  1. Evoxac® capsules (cevimeline hydrochloride)[package insert]. Montvale, New Jersey: Daiichi Pharmaceutical Corporation; 2006. [Link]

PMID: 24332089

Cevimeline

By

Cevimeline

Product: Acitretin

Identifier : DBSNPE004592
Drug : DB00185 (Cevimeline)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 1863_1864ins(TTT CGC CCC)2 (rs72549356 )

Allele Name : CYP2D6*40
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor metabolizer, more adverse reactions.
References :

  1. Evoxac® capsules (cevimeline hydrochloride)[package insert]. Montvale, New Jersey: Daiichi Pharmaceutical Corporation; 2006. [Link]

PMID: 14654163

Cevimeline

By

Cevimeline

Product: Levetiracetam

Identifier : DBSNPE004593
Drug : DB00185 (Cevimeline)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 3259_3260insGT (rs72549346 )

Allele Name : CYP2D6*42
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor metabolizer, more adverse reactions.
References :

  1. Evoxac® capsules (cevimeline hydrochloride)[package insert]. Montvale, New Jersey: Daiichi Pharmaceutical Corporation; 2006. [Link]

PMID: 12873795

Cevimeline

By

Cevimeline

Product: GSK 650394

Identifier : DBSNPE004594
Drug : DB00185 (Cevimeline)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 2950G>C

Allele Name : CYP2D6*44
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor metabolizer, more adverse reactions.
References :

  1. Evoxac® capsules (cevimeline hydrochloride)[package insert]. Montvale, New Jersey: Daiichi Pharmaceutical Corporation; 2006. [Link]

PMID: 2460902

Cevimeline

By

Cevimeline

Product: Tamoxifen (Citrate)

Identifier : DBSNPE004595
Drug : DB00185 (Cevimeline)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 100C>T (rs1065852 )
  • -1426C>T
  • -1235A>G
  • -1000G>A
  • 73C<T
  • 1039C>T
  • 1661G>C
  • 4180G>C

Allele Name : CYP2D6*47
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor metabolizer, more adverse reactions.
References :

  1. Evoxac® capsules (cevimeline hydrochloride)[package insert]. Montvale, New Jersey: Daiichi Pharmaceutical Corporation; 2006. [Link]

PMID: 25157640

Cevimeline

By

Cevimeline

Product: Metformin (hydrochloride)

Identifier : DBSNPE004596
Drug : DB00185 (Cevimeline)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • -1584C>G
  • -1235A>G
  • -740C>T
  • -678G>A
  • CYP2D7 gene conversion in indivon 1
  • 1661G>C
  • 2850C>T
  • 3172A>C
  • 4180G>C

Allele Name : CYP2D6*51
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor metabolizer, more adverse reactions.
References :

  1. Evoxac® capsules (cevimeline hydrochloride)[package insert]. Montvale, New Jersey: Daiichi Pharmaceutical Corporation; 2006. [Link]

PMID: 18410947

Cevimeline

By

Cevimeline

Product: Phenformin (hydrochloride)

Identifier : DBSNPE004597
Drug : DB00185 (Cevimeline)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 3201C>T (rs72549347 )

Allele Name : CYP2D6*56
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor metabolizer, more adverse reactions.
References :

  1. Evoxac® capsules (cevimeline hydrochloride)[package insert]. Montvale, New Jersey: Daiichi Pharmaceutical Corporation; 2006. [Link]

PMID: 9871577

Cevimeline

By

Cevimeline

Product: MK-8033 (hydrochloride)

Identifier : DBSNPE004598
Drug : DB00185 (Cevimeline)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 100C>T
  • 310G>T
  • 843T>G
  • 887C>T
  • 1039C>T
  • 1661G>C
  • 3384A>C
  • 3582A>G
  • gene conversion to CYP2D7 in exon 9
  • 4180G>C

Allele Name : CYP2D6*57
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor metabolizer, more adverse reactions.
References :

  1. Evoxac® capsules (cevimeline hydrochloride)[package insert]. Montvale, New Jersey: Daiichi Pharmaceutical Corporation; 2006. [Link]

PMID: 9023294

Cevimeline

By

Cevimeline

Product: Lansoprazole (sodium)

Identifier : DBSNPE004599
Drug : DB00185 (Cevimeline)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 4044C>T

Allele Name : CYP2D6*62
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor metabolizer, more adverse reactions.
References :

  1. Evoxac® capsules (cevimeline hydrochloride)[package insert]. Montvale, New Jersey: Daiichi Pharmaceutical Corporation; 2006. [Link]

PMID: 26733785

Cevimeline

By

Cevimeline

Product: Lansoprazole

Identifier : DBSNPE004600
Drug : DB00185 (Cevimeline)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • -1426C>T
  • -1235A>G
  • -1000G>A
  • 100C>T
  • 310G>T
  • CYP2D7 sequence from indivon 1 onwards

Allele Name : CYP2D6*68A
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor metabolizer, more adverse reactions.
References :

  1. Evoxac® capsules (cevimeline hydrochloride)[package insert]. Montvale, New Jersey: Daiichi Pharmaceutical Corporation; 2006. [Link]

PMID: 19195889

Cevimeline

By

Cevimeline

Product: (+)-Ketoconazole

Identifier : DBSNPE004601
Drug : DB00185 (Cevimeline)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • Similar but not identical switch region compared to CYP2D6*68A. Found in tandem arrangement with CYP2D6*4.

Allele Name : CYP2D6*68B
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor metabolizer, more adverse reactions.
References :

  1. Evoxac® capsules (cevimeline hydrochloride)[package insert]. Montvale, New Jersey: Daiichi Pharmaceutical Corporation; 2006. [Link]

PMID: 8528577

Cevimeline

By

Cevimeline

Product: Ketoconazole

Identifier : DBSNPE004602
Drug : DB00185 (Cevimeline)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 2988G>A (rs28371725 )
  • -1426C>T
  • -1235A>G
  • -1000G>A
  • 100C>T
  • 310G>T
  • 746C>G
  • 843T>G
  • 1062A>G
  • 1661G>C
  • 2850C>T
  • 3384A>C
  • 3584G>A
  • 3790C>T
  • 4180G>C
  • 4401C>T
  • 4481G>A

Allele Name : CYP2D6*69
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor metabolizer, more adverse reactions.
References :

  1. Evoxac® capsules (cevimeline hydrochloride)[package insert]. Montvale, New Jersey: Daiichi Pharmaceutical Corporation; 2006. [Link]

PMID: 8380498

Cevimeline

By

Cevimeline

Product: Glimepiride

Identifier : DBSNPE004603
Drug : DB00185 (Cevimeline)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 1995delC

Allele Name : CYP2D6*92
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor metabolizer, more adverse reactions.
References :

  1. Evoxac® capsules (cevimeline hydrochloride)[package insert]. Montvale, New Jersey: Daiichi Pharmaceutical Corporation; 2006. [Link]

PMID: 25307345

Cevimeline

By

Cevimeline

Product: Gatifloxacin (mesylate)

Identifier : DBSNPE004604
Drug : DB00185 (Cevimeline)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • -1426C>T
  • -1235A>G
  • -1109C>T
  • -1000G>A
  • 100C>T
  • 310G>T
  • 843T>G
  • 1039C>T
  • 1661G>C
  • 2097A>G
  • 2828delC
  • 3384A>C
  • 3582A>G
  • 4180G>C
  • 4401C>T

Allele Name : CYP2D6*100
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor metabolizer, more adverse reactions.
References :

  1. Evoxac® capsules (cevimeline hydrochloride)[package insert]. Montvale, New Jersey: Daiichi Pharmaceutical Corporation; 2006. [Link]

PMID: 24831231

Cevimeline

By

Cevimeline

Product: Gatifloxacin (hydrochloride)

Identifier : DBSNPE004605
Drug : DB00185 (Cevimeline)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • -1426C>T
  • -1235A>G
  • -1000G>A
  • 100C>T
  • 310G>T
  • 843T>G
  • 1039C>T
  • 1661G>C
  • 2097A>G
  • 2927_2945delGATCCTACATCCGGATGTG
  • 3384A>C
  • 3582A>G
  • 4180G>C
  • 4401C>T

Allele Name : CYP2D6*101
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor metabolizer, more adverse reactions.
References :

  1. Evoxac® capsules (cevimeline hydrochloride)[package insert]. Montvale, New Jersey: Daiichi Pharmaceutical Corporation; 2006. [Link]

PMID: 23155429

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