PI3KInhibitorpi3kinhibitor

Brivaracetam

By

Brivaracetam

Product: Nordihydroguaiaretic acid

Identifier : DBSNPE005014
Drug : DB05541 (Brivaracetam)
Interacting Gene/Enzyme : Cytochrome P450 2C19
Gene Name : CYP2C19
UniProt ID : P33261
Defining Change(s) :

  • 681G>A (rs4244285 )

Allele Name : CYP2C19*2A
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2C19
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Briviact® (brivaracetam) tablets[package insert]. Smyrna, Georgia: UCB Group of Companies; 2016. [Link]

PMID: 11134597

Brivaracetam

By

Brivaracetam

Product: Mefloquine (hydrochloride)

Identifier : DBSNPE005015
Drug : DB05541 (Brivaracetam)
Interacting Gene/Enzyme : Cytochrome P450 2C19
Gene Name : CYP2C19
UniProt ID : P33261
Defining Change(s) :

  • 681G>A (rs4244285 )

Allele Name : CYP2C19*2B
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2C19
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Briviact® (brivaracetam) tablets[package insert]. Smyrna, Georgia: UCB Group of Companies; 2016. [Link]

PMID: 12600694

Brivaracetam

By

Brivaracetam

Product: AGI-5198

Identifier : DBSNPE005016
Drug : DB05541 (Brivaracetam)
Interacting Gene/Enzyme : Cytochrome P450 2C19
Gene Name : CYP2C19
UniProt ID : P33261
Defining Change(s) :

  • 636G>A (rs4986893 )

Allele Name : CYP2C19*3
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2C19
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Briviact® (brivaracetam) tablets[package insert]. Smyrna, Georgia: UCB Group of Companies; 2016. [Link]

PMID: 23287738

Brivaracetam

By

Brivaracetam

Product: GSK2606414

Identifier : DBSNPE005017
Drug : DB05541 (Brivaracetam)
Interacting Gene/Enzyme : Cytochrome P450 2C19
Gene Name : CYP2C19
UniProt ID : P33261
Defining Change(s) :

  • 1A>G (rs28399504 )

Allele Name : CYP2C19*4
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2C19
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Briviact® (brivaracetam) tablets[package insert]. Smyrna, Georgia: UCB Group of Companies; 2016. [Link]

PMID: 24171469

Brivaracetam

By

Brivaracetam

Product: 4-Demethylepipodophyllotoxin

Identifier : DBSNPE005018
Drug : DB05541 (Brivaracetam)
Interacting Gene/Enzyme : Cytochrome P450 2C19
Gene Name : CYP2C19
UniProt ID : P33261
Defining Change(s) :

  • 1297C>T (rs56337013 )

Allele Name : CYP2C19*5
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2C19
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Briviact® (brivaracetam) tablets[package insert]. Smyrna, Georgia: UCB Group of Companies; 2016. [Link]

PMID: 23761908

Brivaracetam

By

Brivaracetam

Product: Cyclophosphamide

Identifier : DBSNPE005019
Drug : DB05541 (Brivaracetam)
Interacting Gene/Enzyme : Cytochrome P450 2C19
Gene Name : CYP2C19
UniProt ID : P33261
Defining Change(s) :

  • 395G>A (rs72552267 )

Allele Name : CYP2C19*6
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2C19
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Briviact® (brivaracetam) tablets[package insert]. Smyrna, Georgia: UCB Group of Companies; 2016. [Link]

PMID: 18204824

Brivaracetam

By

Brivaracetam

Product: Ifosfamide

Identifier : DBSNPE005020
Drug : DB05541 (Brivaracetam)
Interacting Gene/Enzyme : Cytochrome P450 2C19
Gene Name : CYP2C19
UniProt ID : P33261
Defining Change(s) :

  • 19294T>A (rs72558186 )

Allele Name : CYP2C19*7
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2C19
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Briviact® (brivaracetam) tablets[package insert]. Smyrna, Georgia: UCB Group of Companies; 2016. [Link]

PMID: 15886360

Brivaracetam

By

Brivaracetam

Product: Inolitazone (dihydrochloride)

Identifier : DBSNPE005021
Drug : DB05541 (Brivaracetam)
Interacting Gene/Enzyme : Cytochrome P450 2C19
Gene Name : CYP2C19
UniProt ID : P33261
Defining Change(s) :

  • 557G>C (rs140278421 )
  • 991A>G

Allele Name : CYP2C19*22
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2C19
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Briviact® (brivaracetam) tablets[package insert]. Smyrna, Georgia: UCB Group of Companies; 2016. [Link]

PMID: 12401809

Brivaracetam

By

Brivaracetam

Product: Pemetrexed (disodium hemipenta hydrate)

Identifier : DBSNPE005022
Drug : DB05541 (Brivaracetam)
Interacting Gene/Enzyme : Cytochrome P450 2C19
Gene Name : CYP2C19
UniProt ID : P33261
Defining Change(s) :

  • 99C>T (rs17885098 )
  • 991A>G (rs3758581 )
  • 1004G>A (rs118203757 )
  • 1197A>G

Allele Name : CYP2C19*24
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2C19
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Briviact® (brivaracetam) tablets[package insert]. Smyrna, Georgia: UCB Group of Companies; 2016. [Link]

PMID: 12130646

Brivaracetam

By

Brivaracetam

Product: SCH772984

Identifier : DBSNPE005023
Drug : DB05541 (Brivaracetam)
Interacting Gene/Enzyme : Cytochrome P450 2C19
Gene Name : CYP2C19
UniProt ID : P33261
Defining Change(s) :

  • 12662A>G (rs12769205 )

Allele Name : CYP2C19*35
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2C19
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Briviact® (brivaracetam) tablets[package insert]. Smyrna, Georgia: UCB Group of Companies; 2016. [Link]

PMID: 18325633

Brivaracetam

By

Brivaracetam

Product: Cyclophosphamide

Identifier : DBSNPE005019
Drug : DB05541 (Brivaracetam)
Interacting Gene/Enzyme : Cytochrome P450 2C19
Gene Name : CYP2C19
UniProt ID : P33261
Defining Change(s) :

  • 395G>A (rs72552267 )

Allele Name : CYP2C19*6
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2C19
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Briviact® (brivaracetam) tablets[package insert]. Smyrna, Georgia: UCB Group of Companies; 2016. [Link]

PMID: 18204824

Brivaracetam

By

Brivaracetam

Product: Ifosfamide

Identifier : DBSNPE005020
Drug : DB05541 (Brivaracetam)
Interacting Gene/Enzyme : Cytochrome P450 2C19
Gene Name : CYP2C19
UniProt ID : P33261
Defining Change(s) :

  • 19294T>A (rs72558186 )

Allele Name : CYP2C19*7
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2C19
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Briviact® (brivaracetam) tablets[package insert]. Smyrna, Georgia: UCB Group of Companies; 2016. [Link]

PMID: 15886360

Brivaracetam

By

Brivaracetam

Product: Inolitazone (dihydrochloride)

Identifier : DBSNPE005021
Drug : DB05541 (Brivaracetam)
Interacting Gene/Enzyme : Cytochrome P450 2C19
Gene Name : CYP2C19
UniProt ID : P33261
Defining Change(s) :

  • 557G>C (rs140278421 )
  • 991A>G

Allele Name : CYP2C19*22
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2C19
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Briviact® (brivaracetam) tablets[package insert]. Smyrna, Georgia: UCB Group of Companies; 2016. [Link]

PMID: 12401809

Brivaracetam

By

Brivaracetam

Product: Pemetrexed (disodium hemipenta hydrate)

Identifier : DBSNPE005022
Drug : DB05541 (Brivaracetam)
Interacting Gene/Enzyme : Cytochrome P450 2C19
Gene Name : CYP2C19
UniProt ID : P33261
Defining Change(s) :

  • 99C>T (rs17885098 )
  • 991A>G (rs3758581 )
  • 1004G>A (rs118203757 )
  • 1197A>G

Allele Name : CYP2C19*24
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2C19
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Briviact® (brivaracetam) tablets[package insert]. Smyrna, Georgia: UCB Group of Companies; 2016. [Link]

PMID: 12130646

Brivaracetam

By

Brivaracetam

Product: SCH772984

Identifier : DBSNPE005023
Drug : DB05541 (Brivaracetam)
Interacting Gene/Enzyme : Cytochrome P450 2C19
Gene Name : CYP2C19
UniProt ID : P33261
Defining Change(s) :

  • 12662A>G (rs12769205 )

Allele Name : CYP2C19*35
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2C19
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Briviact® (brivaracetam) tablets[package insert]. Smyrna, Georgia: UCB Group of Companies; 2016. [Link]

PMID: 18325633

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