To take a look at no matter whether GGAP2 and mutant GGAP2 impacted AP-one transcription we utilized internet site directed mutagenesis to engineer GGAP2 expression constructs containing 9 diverse missense mutations
The GTPase domain is also a essential regulator of GGAP2 action. We as a result examined cDNAs from 23 cancers and 12 benign tissues for GTPase area mutations. The benefits…