Product Name :
PU-WS13
Description:
PU-WS13 is a selective Grp94 inhibitor, with an EC50 of 0.22 μM.
CAS:
1454619-14-7
Molecular Weight:
411.35
Formula:
C17H20Cl2N6S
Chemical Name:
8-[(3,5-dichlorophenyl)sulfanyl]-9-3-[(propan-2-yl)amino]propyl-9H-purin-6-amine
Smiles :
CC(C)NCCCN1C2=NC=NC(N)=C2N=C1SC1C=C(Cl)C=C(Cl)C=1
InChiKey:
JYSLFQTWNRYWJT-UHFFFAOYSA-N
InChi :
InChI=1S/C17H20Cl2N6S/c1-10(2)21-4-3-5-25-16-14(15(20)22-9-23-16)24-17(25)26-13-7-11(18)6-12(19)8-13/h6-10,21H,3-5H2,1-2H3,(H2,20,22,23)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
PU-WS13 is a selective Grp94 inhibitor, with an EC50 of 0.22 μM.|Product information|CAS Number: 1454619-14-7|Molecular Weight: 411.35|Formula: C17H20Cl2N6S|Chemical Name: 8-[(3,5-dichlorophenyl)sulfanyl]-9-3-[(propan-2-yl)amino]propyl-9H-purin-6-amine|Smiles: CC(C)NCCCN1C2=NC=NC(N)=C2N=C1SC1C=C(Cl)C=C(Cl)C=1|InChiKey: JYSLFQTWNRYWJT-UHFFFAOYSA-N|InChi: InChI=1S/C17H20Cl2N6S/c1-10(2)21-4-3-5-25-16-14(15(20)22-9-23-16)24-17(25)26-13-7-11(18)6-12(19)8-13/h6-10,21H,3-5H2,1-2H3,(H2,20,22,23)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : ≥ 40 mg/mL (97.Melatonin medchemexpress 24 mM).Isosorbide mononitrate supplier |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:32568564 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|PU-WS13 is a Grp94 inhibitor, with an EC50 of 0.22 μM. PU-WS13 also slightly suppresses Hsp90α, Hsp90β and Trap-1, with EC50s of 27.3, 41.8 and 7.3 μM, respectively. PU-WS13 (2.5-20 μM) shows no toxicity on two nonmalignant cell lines. PU-WS13 (15 μM) disrupts the circular architecture of HER2 at the plasma membrane of SKBr3 cells mediated through Grp94. PU-WS13 inhibits Grp94, and the inhibition induces apoptosis in and reduce the viability of HER2 overexpressing breast cancer cells.|Products are for research use only. Not for human use.|