Lapatinib
Product: Heptamethine cyanine dye-1
Identifier : DBSNPE000262
Drug : DB01259 (Lapatinib)
Interacting Gene/Enzyme : HLA class II histocompatibility antigen, DQ alpha 1 chain
Gene Name : HLA-DQA1
UniProt ID : P01909
Allele Name : HLA-DQA1*02:01
Genotype(s) : Not Available
Type(s) : ADR Directly Studied
Groups : Not Available
Description : Hepatoxicity
References :
- Spraggs CF, Budde LR, Briley LP, Bing N, Cox CJ, King KS, Whittaker JC, Mooser VE, Preston AJ, Stein SH, Cardon LR: HLA-DQA1*02:01 is a major risk factor for lapatinib-induced hepatotoxicity in women with advanced breast cancer. J Clin Oncol. 2011 Feb 20;29(6):667-73. doi: 10.1200/JCO.2010.31.3197. Epub 2011 Jan 18. [PubMed:21245432 ]
PMID: 22479400
Lapatinib
Product: Roflumilast Impurity E
Identifier : DBSNPE000263
Drug : DB01259 (Lapatinib)
Interacting Gene/Enzyme : HLA class II histocompatibility antigen, DRB1-11 beta chain
Gene Name : HLA-DRB1
UniProt ID : P20039
Allele Name : HLA-DRB1*07:01
Genotype(s) : Not Available
Type(s) : ADR Directly Studied
Groups : Not Available
Description : Hepatoxicity
References :
- Spraggs CF, Budde LR, Briley LP, Bing N, Cox CJ, King KS, Whittaker JC, Mooser VE, Preston AJ, Stein SH, Cardon LR: HLA-DQA1*02:01 is a major risk factor for lapatinib-induced hepatotoxicity in women with advanced breast cancer. J Clin Oncol. 2011 Feb 20;29(6):667-73. doi: 10.1200/JCO.2010.31.3197. Epub 2011 Jan 18. [PubMed:21245432 ]
PMID: 9595431
Lapatinib
Product: IDO-IN-2
Identifier : DBSNPE000264
Drug : DB01259 (Lapatinib)
Interacting Gene/Enzyme : HLA class II histocompatibility antigen, DQ beta 1 chain
Gene Name : HLA-DQB1
UniProt ID : P01920
Allele Name : HLA-DQB1*02:02
Genotype(s) : Not Available
Type(s) : ADR Directly Studied
Groups : Not Available
Description : Hepatoxicity
References :
- Spraggs CF, Budde LR, Briley LP, Bing N, Cox CJ, King KS, Whittaker JC, Mooser VE, Preston AJ, Stein SH, Cardon LR: HLA-DQA1*02:01 is a major risk factor for lapatinib-induced hepatotoxicity in women with advanced breast cancer. J Clin Oncol. 2011 Feb 20;29(6):667-73. doi: 10.1200/JCO.2010.31.3197. Epub 2011 Jan 18. [PubMed:21245432 ]
PMID: 9023305
Lapatinib
Product: (1S,3R,5R)-PIM447 (dihydrochloride)
Identifier : DBSNPE000265
Drug : DB01259 (Lapatinib)
Interacting Gene/Enzyme : Tenascin-X
Gene Name : TNXB
UniProt ID : P22105
Allele Name : Not Available
Genotype(s) : (C;C) / (C;T)
Type(s) : ADR Directly Studied
Groups : Not Available
Description : Hepatoxicity
References :
- Spraggs CF, Budde LR, Briley LP, Bing N, Cox CJ, King KS, Whittaker JC, Mooser VE, Preston AJ, Stein SH, Cardon LR: HLA-DQA1*02:01 is a major risk factor for lapatinib-induced hepatotoxicity in women with advanced breast cancer. J Clin Oncol. 2011 Feb 20;29(6):667-73. doi: 10.1200/JCO.2010.31.3197. Epub 2011 Jan 18. [PubMed:21245432 ]
PMID: 8336519