**Background** Insect juvenile hormones play a critical role in regulating the development and metamorphosis of insects, specifically by controlling the transition between larval, pupal, and adult stages. Disrupting these hormonal…
**Background** Nicotinamide adenine dinucleotide (NAD) is a critical cofactor and homeostatic regulator essential for cellular energy metabolism and redox balance. It serves as a key electron carrier, being reduced to…
**Background** Familial hypercholesterolemia and various malignancies, including colorectal cancer and melanoma, present significant challenges in clinical medicine due to their complex metabolic and signaling pathways. The microsomal triglyceride transfer protein…
**Background** Colorectal cancer (CRC) remains one of the most prevalent and lethal malignancies worldwide, characterized by high recurrence rates and complex signaling pathways. Signal transducer and activator of transcription 3…
**Background** Cancer metastasis, the process by which tumor cells spread from the primary site to distant organs, is a major cause of mortality in cancer patients. This complex process relies…
The mechanical stability and degradation kinetics of injectable PCL-PEG-PCL-gelatin (Gel) and PCL-PEG-PCL-Gel/nano-hydroxyapatite (nHA) hydrogels were evaluated in a mouse subcutaneous implantation model over a 14-day period. The hydrogels were fabricated…
Droplet-based printing techniques have enabled the fabrication of a diverse array of flexible physical sensors capable of monitoring physiological signals with high sensitivity and reliability. These devices are revolutionizing healthcare…
The development of the PVK-F8T2 copolymer marks a significant milestone in the engineering of advanced materials for organic light-emitting devices (OLEDs). By integrating the hole-transporting capabilities of poly(9-vinylcarbazole) (PVK) with…
A highly efficient one-pot strategy is developed for the synthesis of hyperbranched amphiphilic polymers based on poly(ε-caprolactone) (PCL), combining organocatalytic ring-opening polymerization (ROP), thermally induced carbene insertion, and controlled radical…
This protocol outlines a systematic approach to optimize and validate critical experimental parameters essential for reliable assessment of lysosomal targeting and membrane permeabilization in cancer cells. The success of downstream…