Name :
AKT1 (Human) Recombinant Protein
Biological Activity :
Human AKT1 (NM_005163, 106 a.a. – 480 a.a) partial recombinant protein with GST-His tag expressed in Sf9 cells.Bioactive Protein,Bioactive Proteins,Bioactive,Active,Functional Protein,Functional Proteins
Tag :
Result of activity analysis
Protein Accession No. :
NM_005163
Protein Accession No.URL :
https://www.ncbi.nlm.nih.gov/gene?cmd=Retrieve&dopt=Graphics&list_uids=207
Amino Acid Sequence :
Molecular Weight :
77.83199999999979
Storage and Stability :
Store at -80°C.Aliquot to avoid repeated freezing and thawing
Host :
insect
Interspecies Antigen Sequence :
Preparation Method :
Insect cell (Sf9) expression system
Purification :
One-step affinity purification using GSH-agarose
Quality Control Testing :
2 ug/lane SDS-PAGE Stained with Coomassie Blue
Storage Buffer :
In 50 mM Tris-HCl, 100 mM NaCl, pH 8.0. (5 mM DTT, 15 mM reduced glutathione, 20% glycerol)
Applications :
Functional Study， SDS-PAGE，
Gene Name :
AKT1
Gene Alias :
AKT, MGC99656, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA
Gene Description :
v-akt murine thymoma viral oncogene homolog 1
Gene Summary :
The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq
Other Designations :
RAC-alpha serine/threonine-protein kinase|murine thymoma viral (v-akt) oncogene homolog-1|protein kinase B|rac protein kinase alpha
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