Name :
Rhesus macaque / Cynomolgus Complement Factor D / CFD Protein, His Tag (active enzyme)
Background :
Complement Factor D (CFD) is also known as Adipsin, C3 convertase activator, Properdin Factor D (PFD), which contains one peptidase S1 domain and belongs to the peptidase S1 family. CFD / Adipsin cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. CFD / Adipsin is a serine protease that stimulates glucose transport for triglyceride accumulation in fats cells and inhibits lipolysis. Defects in CFD / Adipsin are the cause of complement Factor D deficiency which predisposes to invasive meningococcal disease.
Biological Activity :
Species :
Source :
Rhesus macaque / Cynomolgus Complement Factor D, His Tag (CFD-R52H3) is expressed from human 293 cells (HEK293). It contains AA Ile 26 – Ala 253 (Accession # H9EXC1-1). In the region Ile 26 – Ala 253, the AA sequence of Rhesus macaque and Cynomolgus Complement Factor D are homologus.
Tag :
Synonyms :
（Synonym）CFD,Adipsin,PFD,DF,Complement Factor D
Purity :
（Purity）>90% as determined by SDS-PAGE.
Storage and Stability :
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Endotoxin Level :
（Endotoxin）Less than 1.0 EU per μg by the LAL method.
Formulation :
Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 150 mM NaCl, pH8.0. Normally glycerol is added as protectant before lyophilization.
Protein Structure :
Refactoring Approach :
Please see Certificate of Analysis for specific instructions.
Protein Labeling :
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