PI3KInhibitorpi3kinhibitor

Tolterodine

By

Tolterodine

Product: Cariprazine (hydrochloride)

Identifier : DBSNPE004882
Drug : DB01036 (Tolterodine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • C allele (rs35742686 )

Allele Name : CYP2D6*3
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, greater QTc interval increase in poor metabolizers, but no association of drug with Torsade de Pointes.
References :

  1. Dedivol® (tolterodine tardivate) tablets[package insert]. New York City, New York: Pharmacia & Upjohn Co, Division of Pfizer Inc; 2012. [Link]

PMID: 10323594

Tolterodine

By

Tolterodine

Product: Cariprazine

Identifier : DBSNPE004883
Drug : DB01036 (Tolterodine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • C allele (rs3892097 )

Allele Name : CYP2D6*4
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, greater QTc interval increase in poor metabolizers, but no association of drug with Torsade de Pointes.
References :

  1. Dedivol® (tolterodine tardivate) tablets[package insert]. New York City, New York: Pharmacia & Upjohn Co, Division of Pfizer Inc; 2012. [Link]

PMID: 10188788

Tolterodine

By

Tolterodine

Product: Ansamitocin P-3

Identifier : DBSNPE004884
Drug : DB01036 (Tolterodine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • Whole-gene deletion

Allele Name : CYP2D6*5
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, greater QTc interval increase in poor metabolizers, but no association of drug with Torsade de Pointes.
References :

  1. Dedivol® (tolterodine tardivate) tablets[package insert]. New York City, New York: Pharmacia & Upjohn Co, Division of Pfizer Inc; 2012. [Link]

PMID: 14700201

Tolterodine

By

Tolterodine

Product: Kinetin

Identifier : DBSNPE004885
Drug : DB01036 (Tolterodine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 1707delT (rs5030655 )

Allele Name : CYP2D6*6
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, greater QTc interval increase in poor metabolizers, but no association of drug with Torsade de Pointes.
References :

  1. Dedivol® (tolterodine tardivate) tablets[package insert]. New York City, New York: Pharmacia & Upjohn Co, Division of Pfizer Inc; 2012. [Link]

PMID: 18685025

Tolterodine

By

Tolterodine

Product: Eltrombopag (Olamine)

Identifier : DBSNPE004886
Drug : DB01036 (Tolterodine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 2935A>C (rs5030867 )

Allele Name : CYP2D6*7
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, greater QTc interval increase in poor metabolizers, but no association of drug with Torsade de Pointes.
References :

  1. Dedivol® (tolterodine tardivate) tablets[package insert]. New York City, New York: Pharmacia & Upjohn Co, Division of Pfizer Inc; 2012. [Link]

PMID: 2841451

Tolterodine

By

Tolterodine

Product: Eltrombopag

Identifier : DBSNPE004887
Drug : DB01036 (Tolterodine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 1758G>T (rs5030865 )

Allele Name : CYP2D6*8
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, greater QTc interval increase in poor metabolizers, but no association of drug with Torsade de Pointes.
References :

  1. Dedivol® (tolterodine tardivate) tablets[package insert]. New York City, New York: Pharmacia & Upjohn Co, Division of Pfizer Inc; 2012. [Link]

PMID: 6088696

Tolterodine

By

Tolterodine

Product: A 77-01

Identifier : DBSNPE004888
Drug : DB01036 (Tolterodine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 883G>C (rs5030863 )

Allele Name : CYP2D6*11
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, greater QTc interval increase in poor metabolizers, but no association of drug with Torsade de Pointes.
References :

  1. Dedivol® (tolterodine tardivate) tablets[package insert]. New York City, New York: Pharmacia & Upjohn Co, Division of Pfizer Inc; 2012. [Link]

PMID: 8930161

Tolterodine

By

Tolterodine

Product: Zileuton

Identifier : DBSNPE004889
Drug : DB01036 (Tolterodine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 124G>A (rs5030862 )

Allele Name : CYP2D6*12
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, greater QTc interval increase in poor metabolizers, but no association of drug with Torsade de Pointes.
References :

  1. Dedivol® (tolterodine tardivate) tablets[package insert]. New York City, New York: Pharmacia & Upjohn Co, Division of Pfizer Inc; 2012. [Link]

PMID: 714021

Tolterodine

By

Tolterodine

Product: DB07268

Identifier : DBSNPE004890
Drug : DB01036 (Tolterodine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • CYP2D7/2D6 hybrid gene sdivucture

Allele Name : CYP2D6*13
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, greater QTc interval increase in poor metabolizers, but no association of drug with Torsade de Pointes.
References :

  1. Dedivol® (tolterodine tardivate) tablets[package insert]. New York City, New York: Pharmacia & Upjohn Co, Division of Pfizer Inc; 2012. [Link]

PMID: 25716865

Tolterodine

By

Tolterodine

Product: KN-93 (hydrochloride)

Identifier : DBSNPE004891
Drug : DB01036 (Tolterodine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 1758G>A (rs5030865 )

Allele Name : CYP2D6*14A
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, greater QTc interval increase in poor metabolizers, but no association of drug with Torsade de Pointes.
References :

  1. Dedivol® (tolterodine tardivate) tablets[package insert]. New York City, New York: Pharmacia & Upjohn Co, Division of Pfizer Inc; 2012. [Link]

PMID: 26147123

Tolterodine

By

Tolterodine

Product: 360A (iodide)

Identifier : DBSNPE004892
Drug : DB01036 (Tolterodine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 137insT, 137_138insT

Allele Name : CYP2D6*15
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, greater QTc interval increase in poor metabolizers, but no association of drug with Torsade de Pointes.
References :

  1. Dedivol® (tolterodine tardivate) tablets[package insert]. New York City, New York: Pharmacia & Upjohn Co, Division of Pfizer Inc; 2012. [Link]

PMID: 22895728

Tolterodine

By

Tolterodine

Product: NVP-BGJ398 (phosphate)

Identifier : DBSNPE004893
Drug : DB01036 (Tolterodine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 2539_2542delAACT (rs72549353 )

Allele Name : CYP2D6*19
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, greater QTc interval increase in poor metabolizers, but no association of drug with Torsade de Pointes.
References :

  1. Dedivol® (tolterodine tardivate) tablets[package insert]. New York City, New York: Pharmacia & Upjohn Co, Division of Pfizer Inc; 2012. [Link]

PMID: 10372814

Tolterodine

By

Tolterodine

Product: Sodium Channel inhibitor 1

Identifier : DBSNPE004894
Drug : DB01036 (Tolterodine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 1973_1974insG (rs72549354 )

Allele Name : CYP2D6*20
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, greater QTc interval increase in poor metabolizers, but no association of drug with Torsade de Pointes.
References :

  1. Dedivol® (tolterodine tardivate) tablets[package insert]. New York City, New York: Pharmacia & Upjohn Co, Division of Pfizer Inc; 2012. [Link]

PMID: 8938659

Tolterodine

By

Tolterodine

Product: c-Met inhibitor 1

Identifier : DBSNPE004895
Drug : DB01036 (Tolterodine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 2573insC

Allele Name : CYP2D6*21
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, greater QTc interval increase in poor metabolizers, but no association of drug with Torsade de Pointes.
References :

  1. Dedivol® (tolterodine tardivate) tablets[package insert]. New York City, New York: Pharmacia & Upjohn Co, Division of Pfizer Inc; 2012. [Link]

PMID: 24833737

Tolterodine

By

Tolterodine

Product: AGI-6780

Identifier : DBSNPE004896
Drug : DB01036 (Tolterodine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • -1770G>A
  • -1584C>G
  • -1235A>G
  • -740C>T
  • -678G>A
  • CYP2D7 gene conversion in indivon 1
  • 310G>T
  • 746C>G
  • 843T>G
  • 1661G>C
  • 2850C>T
  • 3384A>C
  • 3584G>A
  • 3790C>T
  • 4042G>A
  • 4180G>C
  • 4481G>A

Allele Name : CYP2D6*31
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, greater QTc interval increase in poor metabolizers, but no association of drug with Torsade de Pointes.
References :

  1. Dedivol® (tolterodine tardivate) tablets[package insert]. New York City, New York: Pharmacia & Upjohn Co, Division of Pfizer Inc; 2012. [Link]

PMID: 2958300

Tolterodine

By

Tolterodine

Product: Lucidin

Identifier : DBSNPE004897
Drug : DB01036 (Tolterodine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 100C>T (rs1065852 )
  • -1426C>T
  • variable number of A’s in the region -1258 to -1237a
  • -1235A>G
  • -1000G>A
  • 1039C>T
  • 1661G>C
  • gene conversion to CYP2D7 in exon 9
  • 4180G>C

Allele Name : CYP2D6*36
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, greater QTc interval increase in poor metabolizers, but no association of drug with Torsade de Pointes.
References :

  1. Dedivol® (tolterodine tardivate) tablets[package insert]. New York City, New York: Pharmacia & Upjohn Co, Division of Pfizer Inc; 2012. [Link]

PMID: 10720641

Tolterodine

By

Tolterodine

Product: JNK-IN-7

Identifier : DBSNPE004898
Drug : DB01036 (Tolterodine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 2587_2590delGACT (rs72549351 )

Allele Name : CYP2D6*38
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, greater QTc interval increase in poor metabolizers, but no association of drug with Torsade de Pointes.
References :

  1. Dedivol® (tolterodine tardivate) tablets[package insert]. New York City, New York: Pharmacia & Upjohn Co, Division of Pfizer Inc; 2012. [Link]

PMID: 10411611

Tolterodine

By

Tolterodine

Product: Retinyl glucoside

Identifier : DBSNPE004899
Drug : DB01036 (Tolterodine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 1863_1864ins(TTT CGC CCC)2 (rs72549356 )

Allele Name : CYP2D6*40
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, greater QTc interval increase in poor metabolizers, but no association of drug with Torsade de Pointes.
References :

  1. Dedivol® (tolterodine tardivate) tablets[package insert]. New York City, New York: Pharmacia & Upjohn Co, Division of Pfizer Inc; 2012. [Link]

PMID: 5830966

Tolterodine

By

Tolterodine

Product: MB05032

Identifier : DBSNPE004900
Drug : DB01036 (Tolterodine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 3259_3260insGT (rs72549346 )

Allele Name : CYP2D6*42
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, greater QTc interval increase in poor metabolizers, but no association of drug with Torsade de Pointes.
References :

  1. Dedivol® (tolterodine tardivate) tablets[package insert]. New York City, New York: Pharmacia & Upjohn Co, Division of Pfizer Inc; 2012. [Link]

PMID: 22553034

Tolterodine

By

Tolterodine

Product: Puromycin aminonucleoside

Identifier : DBSNPE004901
Drug : DB01036 (Tolterodine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 2950G>C

Allele Name : CYP2D6*44
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, greater QTc interval increase in poor metabolizers, but no association of drug with Torsade de Pointes.
References :

  1. Dedivol® (tolterodine tardivate) tablets[package insert]. New York City, New York: Pharmacia & Upjohn Co, Division of Pfizer Inc; 2012. [Link]

PMID: 24307202

Tolterodine

By

Tolterodine

Product: Tanaproget

Identifier : DBSNPE004902
Drug : DB01036 (Tolterodine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 100C>T (rs1065852 )
  • -1426C>T
  • -1235A>G
  • -1000G>A
  • 73C<T
  • 1039C>T
  • 1661G>C
  • 4180G>C

Allele Name : CYP2D6*47
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, greater QTc interval increase in poor metabolizers, but no association of drug with Torsade de Pointes.
References :

  1. Dedivol® (tolterodine tardivate) tablets[package insert]. New York City, New York: Pharmacia & Upjohn Co, Division of Pfizer Inc; 2012. [Link]

PMID: 21358117

Tolterodine

By

Tolterodine

Product: AH 6809

Identifier : DBSNPE004903
Drug : DB01036 (Tolterodine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • -1584C>G
  • -1235A>G
  • -740C>T
  • -678G>A
  • CYP2D7 gene conversion in indivon 1
  • 1661G>C
  • 2850C>T
  • 3172A>C
  • 4180G>C

Allele Name : CYP2D6*51
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, greater QTc interval increase in poor metabolizers, but no association of drug with Torsade de Pointes.
References :

  1. Dedivol® (tolterodine tardivate) tablets[package insert]. New York City, New York: Pharmacia & Upjohn Co, Division of Pfizer Inc; 2012. [Link]

PMID: 7952627

Tolterodine

By

Tolterodine

Product: PD 123319

Identifier : DBSNPE004904
Drug : DB01036 (Tolterodine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 3201C>T (rs72549347 )

Allele Name : CYP2D6*56
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, greater QTc interval increase in poor metabolizers, but no association of drug with Torsade de Pointes.
References :

  1. Dedivol® (tolterodine tardivate) tablets[package insert]. New York City, New York: Pharmacia & Upjohn Co, Division of Pfizer Inc; 2012. [Link]

PMID: 11392625

Tolterodine

By

Tolterodine

Product: PD 123319 (ditrifluoroacetate)

Identifier : DBSNPE004905
Drug : DB01036 (Tolterodine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 100C>T
  • 310G>T
  • 843T>G
  • 887C>T
  • 1039C>T
  • 1661G>C
  • 3384A>C
  • 3582A>G
  • gene conversion to CYP2D7 in exon 9
  • 4180G>C

Allele Name : CYP2D6*57
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, greater QTc interval increase in poor metabolizers, but no association of drug with Torsade de Pointes.
References :

  1. Dedivol® (tolterodine tardivate) tablets[package insert]. New York City, New York: Pharmacia & Upjohn Co, Division of Pfizer Inc; 2012. [Link]

PMID: 9200560

Tolterodine

By

Tolterodine

Product: XL-147

Identifier : DBSNPE004906
Drug : DB01036 (Tolterodine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 4044C>T

Allele Name : CYP2D6*62
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, greater QTc interval increase in poor metabolizers, but no association of drug with Torsade de Pointes.
References :

  1. Dedivol® (tolterodine tardivate) tablets[package insert]. New York City, New York: Pharmacia & Upjohn Co, Division of Pfizer Inc; 2012. [Link]

PMID: 1579545

Tolterodine

By

Tolterodine

Product: Gabapentin

Identifier : DBSNPE004907
Drug : DB01036 (Tolterodine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • -1426C>T
  • -1235A>G
  • -1000G>A
  • 100C>T
  • 310G>T
  • CYP2D7 sequence from indivon 1 onwards

Allele Name : CYP2D6*68A
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, greater QTc interval increase in poor metabolizers, but no association of drug with Torsade de Pointes.
References :

  1. Dedivol® (tolterodine tardivate) tablets[package insert]. New York City, New York: Pharmacia & Upjohn Co, Division of Pfizer Inc; 2012. [Link]

PMID: 3054859

Tolterodine

By

Tolterodine

Product: CC-930

Identifier : DBSNPE004908
Drug : DB01036 (Tolterodine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • Similar but not identical switch region compared to CYP2D6*68A. Found in tandem arrangement with CYP2D6*4.

Allele Name : CYP2D6*68B
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, greater QTc interval increase in poor metabolizers, but no association of drug with Torsade de Pointes.
References :

  1. Dedivol® (tolterodine tardivate) tablets[package insert]. New York City, New York: Pharmacia & Upjohn Co, Division of Pfizer Inc; 2012. [Link]

PMID: 1242377

Tolterodine

By

Tolterodine

Product: TCS 359

Identifier : DBSNPE004909
Drug : DB01036 (Tolterodine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 2988G>A (rs28371725 )
  • -1426C>T
  • -1235A>G
  • -1000G>A
  • 100C>T
  • 310G>T
  • 746C>G
  • 843T>G
  • 1062A>G
  • 1661G>C
  • 2850C>T
  • 3384A>C
  • 3584G>A
  • 3790C>T
  • 4180G>C
  • 4401C>T
  • 4481G>A

Allele Name : CYP2D6*69
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, greater QTc interval increase in poor metabolizers, but no association of drug with Torsade de Pointes.
References :

  1. Dedivol® (tolterodine tardivate) tablets[package insert]. New York City, New York: Pharmacia & Upjohn Co, Division of Pfizer Inc; 2012. [Link]

PMID: 17146471

Tolterodine

By

Tolterodine

Product: Dutasteride

Identifier : DBSNPE004910
Drug : DB01036 (Tolterodine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 1995delC

Allele Name : CYP2D6*92
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, greater QTc interval increase in poor metabolizers, but no association of drug with Torsade de Pointes.
References :

  1. Dedivol® (tolterodine tardivate) tablets[package insert]. New York City, New York: Pharmacia & Upjohn Co, Division of Pfizer Inc; 2012. [Link]

PMID: 10411607

Tolterodine

By

Tolterodine

Product: INCB28060

Identifier : DBSNPE004911
Drug : DB01036 (Tolterodine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • -1426C>T
  • -1235A>G
  • -1109C>T
  • -1000G>A
  • 100C>T
  • 310G>T
  • 843T>G
  • 1039C>T
  • 1661G>C
  • 2097A>G
  • 2828delC
  • 3384A>C
  • 3582A>G
  • 4180G>C
  • 4401C>T

Allele Name : CYP2D6*100
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, greater QTc interval increase in poor metabolizers, but no association of drug with Torsade de Pointes.
References :

  1. Dedivol® (tolterodine tardivate) tablets[package insert]. New York City, New York: Pharmacia & Upjohn Co, Division of Pfizer Inc; 2012. [Link]

PMID: 9774240

Tolterodine

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Tolterodine

Product: Alvimopan (dihydrate)

Identifier : DBSNPE004912
Drug : DB01036 (Tolterodine)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • -1426C>T
  • -1235A>G
  • -1000G>A
  • 100C>T
  • 310G>T
  • 843T>G
  • 1039C>T
  • 1661G>C
  • 2097A>G
  • 2927_2945delGATCCTACATCCGGATGTG
  • 3384A>C
  • 3582A>G
  • 4180G>C
  • 4401C>T

Allele Name : CYP2D6*101
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, greater QTc interval increase in poor metabolizers, but no association of drug with Torsade de Pointes.
References :

  1. Dedivol® (tolterodine tardivate) tablets[package insert]. New York City, New York: Pharmacia & Upjohn Co, Division of Pfizer Inc; 2012. [Link]

PMID: 10906799

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