Tioguanine
Product: Betulin
Identifier : DBSNPE000268
Drug : DB00352 (Tioguanine)
Interacting Gene/Enzyme : Thiopurine S-methyldivansferase
Gene Name : TPMT
UniProt ID : P51580
Allele Name : TPMT*2
Genotype(s) : (G;G) / (C;G)
Type(s) : ADR Directly Studied
Groups : Non-functional TPMT
Description : Severe myelosuppression and rapid bone marrow suppression.
References :
- Relling MV, Gardner EE, Sandborn WJ, Schmiegelow K, Pui CH, Yee SW, Stein CM, Carrillo M, Evans WE, Klein TE: Clinical Pharmacogenetics Implementation Consortium guidelines for thiopurine methyldivansferase genotype and thiopurine dosing. Clin Pharmacol Ther. 2011 Mar;89(3):387-91. doi: 10.1038/clpt.2010.320. Epub 2011 Jan 26. [PubMed:21270794 ]
PMID: 12037137
Tioguanine
Product: Evodiamine
Identifier : DBSNPE000269
Drug : DB00352 (Tioguanine)
Interacting Gene/Enzyme : Thiopurine S-methyldivansferase
Gene Name : TPMT
UniProt ID : P51580
Allele Name : TPMT*3A
Genotype(s) : (A;A) / (A;G)
Type(s) : ADR Directly Studied
Groups : Non-functional TPMT
Description : Severe myelosuppression and rapid bone marrow suppression.
References :
- Relling MV, Gardner EE, Sandborn WJ, Schmiegelow K, Pui CH, Yee SW, Stein CM, Carrillo M, Evans WE, Klein TE: Clinical Pharmacogenetics Implementation Consortium guidelines for thiopurine methyldivansferase genotype and thiopurine dosing. Clin Pharmacol Ther. 2011 Mar;89(3):387-91. doi: 10.1038/clpt.2010.320. Epub 2011 Jan 26. [PubMed:21270794 ]
PMID: 12070534
Tioguanine
Product: Bisindolylmaleimide I
Identifier : DBSNPE000270
Drug : DB00352 (Tioguanine)
Interacting Gene/Enzyme : Thiopurine S-methyldivansferase
Gene Name : TPMT
UniProt ID : P51580
Allele Name : TPMT*3C
Genotype(s) : (G;G) / (A;G)
Type(s) : ADR Directly Studied
Groups : Non-functional TPMT
Description : Severe myelosuppression and rapid bone marrow suppression.
References :
- Relling MV, Gardner EE, Sandborn WJ, Schmiegelow K, Pui CH, Yee SW, Stein CM, Carrillo M, Evans WE, Klein TE: Clinical Pharmacogenetics Implementation Consortium guidelines for thiopurine methyldivansferase genotype and thiopurine dosing. Clin Pharmacol Ther. 2011 Mar;89(3):387-91. doi: 10.1038/clpt.2010.320. Epub 2011 Jan 26. [PubMed:21270794 ]
PMID: 8197152
Tioguanine
Product: COH29
Identifier : DBSNPE000271
Drug : DB00352 (Tioguanine)
Interacting Gene/Enzyme : Thiopurine S-methyldivansferase
Gene Name : TPMT
UniProt ID : P51580
Allele Name : TMPT*4A
Genotype(s) : (A;A) / (A;G)
Type(s) : ADR Directly Studied
Groups : Non-functional TPMT
Description : Severe myelosuppression and rapid bone marrow suppression.
References :
- Relling MV, Gardner EE, Sandborn WJ, Schmiegelow K, Pui CH, Yee SW, Stein CM, Carrillo M, Evans WE, Klein TE: Clinical Pharmacogenetics Implementation Consortium guidelines for thiopurine methyldivansferase genotype and thiopurine dosing. Clin Pharmacol Ther. 2011 Mar;89(3):387-91. doi: 10.1038/clpt.2010.320. Epub 2011 Jan 26. [PubMed:21270794 ]
PMID: 20412427
Tioguanine
Product: Calcitriol D7
Identifier : DBSNPE006059
Drug : DB00352 (Tioguanine)
Interacting Gene/Enzyme : Thiopurine S-methyldivansferase
Gene Name : TPMT
UniProt ID : P51580
Allele Name : TMPT*2
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional TPMT
Description : Severe myelosuppression and rapid bone marrow suppression.
References :
- Medical Genetics Summaries: Azathioprine Therapy and TPMT Genotype [Link]
PMID: 23818859
Tioguanine
Product: Calcitetrol
Identifier : DBSNPE006060
Drug : DB00352 (Tioguanine)
Interacting Gene/Enzyme : Thiopurine S-methyldivansferase
Gene Name : TPMT
UniProt ID : P51580
Defining Change(s) :
- c.460G>A (rs1800460 )
- c.719A>G (rs1142345 )
Allele Name : TMPT*3A
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional TPMT
Description : Severe myelosuppression and rapid bone marrow suppression.
References :
- Medical Genetics Summaries: Azathioprine Therapy and TPMT Genotype [Link]
PMID: 22588303
Tioguanine
Product: 1alpha, 24, 25-Trihydroxy VD3
Identifier : DBSNPE006061
Drug : DB00352 (Tioguanine)
Interacting Gene/Enzyme : Thiopurine S-methyldivansferase
Gene Name : TPMT
UniProt ID : P51580
Allele Name : TMPT*3B
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional TPMT
Description : Severe myelosuppression and rapid bone marrow suppression.
References :
- Medical Genetics Summaries: Azathioprine Therapy and TPMT Genotype [Link]
PMID: 17497022
Tioguanine
Product: 24, 25-Dihydroxy VD4
Identifier : DBSNPE006062
Drug : DB00352 (Tioguanine)
Interacting Gene/Enzyme : Thiopurine S-methyldivansferase
Gene Name : TPMT
UniProt ID : P51580
Allele Name : TMPT*3C
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional TPMT
Description : Severe myelosuppression and rapid bone marrow suppression.
References :
- Medical Genetics Summaries: Azathioprine Therapy and TPMT Genotype [Link]
PMID: 16269450
Tioguanine
Product: 1alpha-Hydroxy VD5
Identifier : DBSNPE006063
Drug : DB00352 (Tioguanine)
Interacting Gene/Enzyme : Thiopurine S-methyldivansferase
Gene Name : TPMT
UniProt ID : P51580
Allele Name : TMPT*4A
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Non-functional TPMT
Description : Severe myelosuppression and rapid bone marrow suppression.
References :
- Medical Genetics Summaries: Azathioprine Therapy and TPMT Genotype [Link]
PMID: 12801232