PI3KInhibitorpi3kinhibitor

Sevoflurane

By

Sevoflurane

Product: TAPI-2

Identifier : DBSNPE000276
Drug : DB01236 (Sevoflurane)
Interacting Gene/Enzyme : Voltage-dependent L-type calcium channel subunit alpha-1S
Gene Name : CACNA1S
UniProt ID : Q13698
Defining Change(s) :

  • c.3257G>A (rs1800559 )

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Ultane®(sevoflurane)[package insert]. North Chicago: Illinois: AbbVie Inc.; 2014. https://emhg.org/genetics/mutations-in-ryr1/ [Link]

PMID: 1371193

Sevoflurane

By

Sevoflurane

Product: Acelarin

Identifier : DBSNPE000277
Drug : DB01236 (Sevoflurane)
Interacting Gene/Enzyme : Voltage-dependent L-type calcium channel subunit alpha-1S
Gene Name : CACNA1S
UniProt ID : Q13698
Defining Change(s) :

  • c.520C>T (rs772226819 )

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Ultane®(sevoflurane)[package insert]. North Chicago: Illinois: AbbVie Inc.; 2014. https://emhg.org/genetics/mutations-in-ryr1/ [Link]

PMID: 3131684

Sevoflurane

By

Sevoflurane

Product: Cenicriviroc

Identifier : DBSNPE000278
Drug : DB01236 (Sevoflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.103T>C (rs193922747 )

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Ultane®(sevoflurane)[package insert]. North Chicago: Illinois: AbbVie Inc.; 2014. https://emhg.org/genetics/mutations-in-ryr1/ [Link]

PMID: 12629523

Sevoflurane

By

Sevoflurane

Product: Upadacitinib

Identifier : DBSNPE000279
Drug : DB01236 (Sevoflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.487C>T (rs118192161 )

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Ultane®(sevoflurane)[package insert]. North Chicago: Illinois: AbbVie Inc.; 2014. https://emhg.org/genetics/mutations-in-ryr1/ [Link]

PMID: 10217415

Sevoflurane

By

Sevoflurane

Product: Saroglitazar

Identifier : DBSNPE000280
Drug : DB01236 (Sevoflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.488G>T (rs193922753 )

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Ultane®(sevoflurane)[package insert]. North Chicago: Illinois: AbbVie Inc.; 2014. https://emhg.org/genetics/mutations-in-ryr1/ [Link]

PMID: 9025901

Sevoflurane

By

Sevoflurane

Product: APS-2-79 (hydrochloride)

Identifier : DBSNPE000281
Drug : DB01236 (Sevoflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.742G>A (rs1801086 )

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Ultane®(sevoflurane)[package insert]. North Chicago: Illinois: AbbVie Inc.; 2014. https://emhg.org/genetics/mutations-in-ryr1/ [Link]

PMID: 16111712

Sevoflurane

By

Sevoflurane

Product: ARA290

Identifier : DBSNPE000282
Drug : DB01236 (Sevoflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.742G>C (rs1801086 )

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Ultane®(sevoflurane)[package insert]. North Chicago: Illinois: AbbVie Inc.; 2014. https://emhg.org/genetics/mutations-in-ryr1/ [Link]

PMID: 14605866

Sevoflurane

By

Sevoflurane

Product: Alexamorelin

Identifier : DBSNPE000283
Drug : DB01236 (Sevoflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.1021G>A (rs121918592 )

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Ultane®(sevoflurane)[package insert]. North Chicago: Illinois: AbbVie Inc.; 2014. https://emhg.org/genetics/mutations-in-ryr1/ [Link]

PMID: 15574503

Sevoflurane

By

Sevoflurane

Product: Dalfopristin

Identifier : DBSNPE000284
Drug : DB01236 (Sevoflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.1209C>G (rs118192116 )

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Ultane®(sevoflurane)[package insert]. North Chicago: Illinois: AbbVie Inc.; 2014. https://emhg.org/genetics/mutations-in-ryr1/ [Link]

PMID: 17392337

Sevoflurane

By

Sevoflurane

Product: Beaucage reagent

Identifier : DBSNPE000285
Drug : DB01236 (Sevoflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.1565A>C (rs118192162 )

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Ultane®(sevoflurane)[package insert]. North Chicago: Illinois: AbbVie Inc.; 2014. https://emhg.org/genetics/mutations-in-ryr1/ [Link]

PMID: 10638745

Sevoflurane

By

Sevoflurane

Product: Lusutrombopag

Identifier : DBSNPE000286
Drug : DB01236 (Sevoflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.1589G>A

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Ultane®(sevoflurane)[package insert]. North Chicago: Illinois: AbbVie Inc.; 2014. https://emhg.org/genetics/mutations-in-ryr1/ [Link]

PMID: 8250835

Sevoflurane

By

Sevoflurane

Product: CDD3506

Identifier : DBSNPE000287
Drug : DB01236 (Sevoflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.1654C>T (rs193922770 )

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Ultane®(sevoflurane)[package insert]. North Chicago: Illinois: AbbVie Inc.; 2014. https://emhg.org/genetics/mutations-in-ryr1/ [Link]

PMID: 2554753

Sevoflurane

By

Sevoflurane

Product: CDD3505

Identifier : DBSNPE000288
Drug : DB01236 (Sevoflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.1840C>T (rs118192172 )

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Ultane®(sevoflurane)[package insert]. North Chicago: Illinois: AbbVie Inc.; 2014. https://emhg.org/genetics/mutations-in-ryr1/ [Link]

PMID: 15522877

Sevoflurane

By

Sevoflurane

Product: TUG-891

Identifier : DBSNPE000289
Drug : DB01236 (Sevoflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.1841G>T (rs193922772 )

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Ultane®(sevoflurane)[package insert]. North Chicago: Illinois: AbbVie Inc.; 2014. https://emhg.org/genetics/mutations-in-ryr1/ [Link]

PMID: 10328886

Sevoflurane

By

Sevoflurane

Product: Bisantrene

Identifier : DBSNPE000290
Drug : DB01236 (Sevoflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.6487C>T (rs118192175 )

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Ultane®(sevoflurane)[package insert]. North Chicago: Illinois: AbbVie Inc.; 2014. https://emhg.org/genetics/mutations-in-ryr1/ [Link]

PMID: 25590233

Sevoflurane

By

Sevoflurane

Product: CPI-455

Identifier : DBSNPE000291
Drug : DB01236 (Sevoflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.6488G>A (rs118192163 )

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Ultane®(sevoflurane)[package insert]. North Chicago: Illinois: AbbVie Inc.; 2014. https://emhg.org/genetics/mutations-in-ryr1/ [Link]

PMID: 25284282

Sevoflurane

By

Sevoflurane

Product: SQ22536

Identifier : DBSNPE000292
Drug : DB01236 (Sevoflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.6502G>A (rs118192176 )

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Ultane®(sevoflurane)[package insert]. North Chicago: Illinois: AbbVie Inc.; 2014. https://emhg.org/genetics/mutations-in-ryr1/ [Link]

PMID: 23934019

Sevoflurane

By

Sevoflurane

Product: CZ415

Identifier : DBSNPE000293
Drug : DB01236 (Sevoflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.6617C>G (rs118192177 )

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Ultane®(sevoflurane)[package insert]. North Chicago: Illinois: AbbVie Inc.; 2014. https://emhg.org/genetics/mutations-in-ryr1/ [Link]

PMID: 20479243

Sevoflurane

By

Sevoflurane

Product: Cebranopadol ((1α,4α)stereoisomer)

Identifier : DBSNPE000294
Drug : DB01236 (Sevoflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.6617C>T (rs118192177 )

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Ultane®(sevoflurane)[package insert]. North Chicago: Illinois: AbbVie Inc.; 2014. https://emhg.org/genetics/mutations-in-ryr1/ [Link]

PMID: 27437083

Sevoflurane

By

Sevoflurane

Product: LY 344864 (S-enantiomer)

Identifier : DBSNPE000295
Drug : DB01236 (Sevoflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.7007G>A

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Ultane®(sevoflurane)[package insert]. North Chicago: Illinois: AbbVie Inc.; 2014. https://emhg.org/genetics/mutations-in-ryr1/ [Link]

PMID: 21825001

Sevoflurane

By

Sevoflurane

Product: Hesperetin

Identifier : DBSNPE000296
Drug : DB01236 (Sevoflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.7048G>A (rs193922802 )

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Ultane®(sevoflurane)[package insert]. North Chicago: Illinois: AbbVie Inc.; 2014. https://emhg.org/genetics/mutations-in-ryr1/ [Link]

PMID: 11242081

Sevoflurane

By

Sevoflurane

Product: NVP-CGM097 (stereoisomer)

Identifier : DBSNPE000297
Drug : DB01236 (Sevoflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.7124G>C (rs193922807 )

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Ultane®(sevoflurane)[package insert]. North Chicago: Illinois: AbbVie Inc.; 2014. https://emhg.org/genetics/mutations-in-ryr1/ [Link]

PMID: 19263460

Sevoflurane

By

Sevoflurane

Product: RSV604 (R enantiomer)

Identifier : DBSNPE000298
Drug : DB01236 (Sevoflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.7282G>A (rs193922809 )

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Ultane®(sevoflurane)[package insert]. North Chicago: Illinois: AbbVie Inc.; 2014. https://emhg.org/genetics/mutations-in-ryr1/ [Link]

PMID: 26011238

Sevoflurane

By

Sevoflurane

Product: RSV604 (racemate)

Identifier : DBSNPE000299
Drug : DB01236 (Sevoflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.7300G>A (rs121918593 )

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Ultane®(sevoflurane)[package insert]. North Chicago: Illinois: AbbVie Inc.; 2014. https://emhg.org/genetics/mutations-in-ryr1/ [Link]

PMID: 11815368

Sevoflurane

By

Sevoflurane

Product: PNU-282987 (S enantiomer free base)

Identifier : DBSNPE000300
Drug : DB01236 (Sevoflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.7304G>A (rs28933396 )

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Ultane®(sevoflurane)[package insert]. North Chicago: Illinois: AbbVie Inc.; 2014. https://emhg.org/genetics/mutations-in-ryr1/ [Link]

PMID: 18204474

Sevoflurane

By

Sevoflurane

Product: EGF816 (S-enantiomer)

Identifier : DBSNPE000301
Drug : DB01236 (Sevoflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.7360C>T (rs193922816 )

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Ultane®(sevoflurane)[package insert]. North Chicago: Illinois: AbbVie Inc.; 2014. https://emhg.org/genetics/mutations-in-ryr1/ [Link]

PMID: 16955146

Sevoflurane

By

Sevoflurane

Product: GDC-0834 (S-enantiomer)

Identifier : DBSNPE000302
Drug : DB01236 (Sevoflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.7361G>A (rs118192122 )

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Ultane®(sevoflurane)[package insert]. North Chicago: Illinois: AbbVie Inc.; 2014. https://emhg.org/genetics/mutations-in-ryr1/ [Link]

PMID: 12086987

Sevoflurane

By

Sevoflurane

Product: INT-777 (R-enantiomer)

Identifier : DBSNPE000303
Drug : DB01236 (Sevoflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.7372C>T (rs28933397 )

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Ultane®(sevoflurane)[package insert]. North Chicago: Illinois: AbbVie Inc.; 2014. https://emhg.org/genetics/mutations-in-ryr1/ [Link]

PMID: 16955067

Sevoflurane

By

Sevoflurane

Product: Mavoglurant (racemate)

Identifier : DBSNPE000304
Drug : DB01236 (Sevoflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.7373G>A (rs121918594 )

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Ultane®(sevoflurane)[package insert]. North Chicago: Illinois: AbbVie Inc.; 2014. https://emhg.org/genetics/mutations-in-ryr1/ [Link]

PMID: 11141091

Sevoflurane

By

Sevoflurane

Product: Litronesib (Racemate)

Identifier : DBSNPE000305
Drug : DB01236 (Sevoflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.7522C>T (rs118192178 )

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Ultane®(sevoflurane)[package insert]. North Chicago: Illinois: AbbVie Inc.; 2014. https://emhg.org/genetics/mutations-in-ryr1/ [Link]

PMID: 15863272

Sevoflurane

By

Sevoflurane

Product: AMG 487 (S-enantiomer)

Identifier : DBSNPE000306
Drug : DB01236 (Sevoflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.7523G>A

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Ultane®(sevoflurane)[package insert]. North Chicago: Illinois: AbbVie Inc.; 2014. https://emhg.org/genetics/mutations-in-ryr1/ [Link]

PMID: 15302681

Sevoflurane

By

Sevoflurane

Product: TGR-1202 (R-enantiomer)

Identifier : DBSNPE000307
Drug : DB01236 (Sevoflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.14387A>G (rs118192167 )

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Ultane®(sevoflurane)[package insert]. North Chicago: Illinois: AbbVie Inc.; 2014. https://emhg.org/genetics/mutations-in-ryr1/ [Link]

PMID: 12695532

Sevoflurane

By

Sevoflurane

Product: BET-BAY 002 (S enantiomer)

Identifier : DBSNPE000308
Drug : DB01236 (Sevoflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.14477C>T (rs121918595 )

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Ultane®(sevoflurane)[package insert]. North Chicago: Illinois: AbbVie Inc.; 2014. https://emhg.org/genetics/mutations-in-ryr1/ [Link]

PMID: 24386190

Sevoflurane

By

Sevoflurane

Product: Taranabant ((1R,2R)stereoisomer)

Identifier : DBSNPE000309
Drug : DB01236 (Sevoflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.14497C>T

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Ultane®(sevoflurane)[package insert]. North Chicago: Illinois: AbbVie Inc.; 2014. https://emhg.org/genetics/mutations-in-ryr1/ [Link]

PMID: 21187674

Sevoflurane

By

Sevoflurane

Product: DHMEQ (racemate)

Identifier : DBSNPE000310
Drug : DB01236 (Sevoflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.14512C>G (rs193922878 )

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Ultane®(sevoflurane)[package insert]. North Chicago: Illinois: AbbVie Inc.; 2014. https://emhg.org/genetics/mutations-in-ryr1/ [Link]

PMID: 10460232

Sevoflurane

By

Sevoflurane

Product: Bavachin

Identifier : DBSNPE000311
Drug : DB01236 (Sevoflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.14582G>A (rs63749869 )

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Ultane®(sevoflurane)[package insert]. North Chicago: Illinois: AbbVie Inc.; 2014. https://emhg.org/genetics/mutations-in-ryr1/ [Link]

PMID: 8393456

Sevoflurane

By

Sevoflurane

Product: Paeonol

Identifier : DBSNPE000312
Drug : DB01236 (Sevoflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.14693T>C (rs118192170 )

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Ultane®(sevoflurane)[package insert]. North Chicago: Illinois: AbbVie Inc.; 2014. https://emhg.org/genetics/mutations-in-ryr1/ [Link]

PMID: 25843049

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