PI3KInhibitorpi3kinhibitor

Pimozide

By

Pimozide

Product: Birinapant

Identifier : DBSNPE004732
Drug : DB01100 (Pimozide)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • C allele (rs35742686 )

Allele Name : CYP2D6*3
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Orap® (Pimozide) tablets[package insert]. Sellersville, Pennsylvania: Teva Pharmaceuticals USA; 2011. [Link]

PMID: 9703462

Pimozide

By

Pimozide

Product: 2-Deoxy-D-glucose

Identifier : DBSNPE004733
Drug : DB01100 (Pimozide)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • C allele (rs3892097 )

Allele Name : CYP2D6*4
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Orap® (Pimozide) tablets[package insert]. Sellersville, Pennsylvania: Teva Pharmaceuticals USA; 2011. [Link]

PMID: 10808247

Pimozide

By

Pimozide

Product: Ondansetron (hydrochloride dihydrate)

Identifier : DBSNPE004734
Drug : DB01100 (Pimozide)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • Whole-gene deletion

Allele Name : CYP2D6*5
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Orap® (Pimozide) tablets[package insert]. Sellersville, Pennsylvania: Teva Pharmaceuticals USA; 2011. [Link]

PMID: 6207886

Pimozide

By

Pimozide

Product: Ondansetron (Hydrochloride)

Identifier : DBSNPE004735
Drug : DB01100 (Pimozide)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 1707delT (rs5030655 )

Allele Name : CYP2D6*6
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Orap® (Pimozide) tablets[package insert]. Sellersville, Pennsylvania: Teva Pharmaceuticals USA; 2011. [Link]

PMID: 16330493

Pimozide

By

Pimozide

Product: Purvalanol B

Identifier : DBSNPE004736
Drug : DB01100 (Pimozide)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 2935A>C (rs5030867 )

Allele Name : CYP2D6*7
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Orap® (Pimozide) tablets[package insert]. Sellersville, Pennsylvania: Teva Pharmaceuticals USA; 2011. [Link]

PMID: 7530573

Pimozide

By

Pimozide

Product: Ezatiostat

Identifier : DBSNPE004737
Drug : DB01100 (Pimozide)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 1758G>T (rs5030865 )

Allele Name : CYP2D6*8
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Orap® (Pimozide) tablets[package insert]. Sellersville, Pennsylvania: Teva Pharmaceuticals USA; 2011. [Link]

PMID: 7510780

Pimozide

By

Pimozide

Product: Ezatiostat (hydrochloride)

Identifier : DBSNPE004738
Drug : DB01100 (Pimozide)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 883G>C (rs5030863 )

Allele Name : CYP2D6*11
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Orap® (Pimozide) tablets[package insert]. Sellersville, Pennsylvania: Teva Pharmaceuticals USA; 2011. [Link]

PMID: 7509286

Pimozide

By

Pimozide

Product: PD 169316

Identifier : DBSNPE004739
Drug : DB01100 (Pimozide)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 124G>A (rs5030862 )

Allele Name : CYP2D6*12
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Orap® (Pimozide) tablets[package insert]. Sellersville, Pennsylvania: Teva Pharmaceuticals USA; 2011. [Link]

PMID: 10871306

Pimozide

By

Pimozide

Product: Rigosertib

Identifier : DBSNPE004740
Drug : DB01100 (Pimozide)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • CYP2D7/2D6 hybrid gene sdivucture

Allele Name : CYP2D6*13
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Orap® (Pimozide) tablets[package insert]. Sellersville, Pennsylvania: Teva Pharmaceuticals USA; 2011. [Link]

PMID: 7582497

Pimozide

By

Pimozide

Product: Tandospirone

Identifier : DBSNPE004741
Drug : DB01100 (Pimozide)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 1758G>A (rs5030865 )

Allele Name : CYP2D6*14A
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Orap® (Pimozide) tablets[package insert]. Sellersville, Pennsylvania: Teva Pharmaceuticals USA; 2011. [Link]

PMID: 1331460

Pimozide

By

Pimozide

Product: Arctiin

Identifier : DBSNPE004742
Drug : DB01100 (Pimozide)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 137insT, 137_138insT

Allele Name : CYP2D6*15
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Orap® (Pimozide) tablets[package insert]. Sellersville, Pennsylvania: Teva Pharmaceuticals USA; 2011. [Link]

PMID: 11487522

Pimozide

By

Pimozide

Product: Trilostane

Identifier : DBSNPE004743
Drug : DB01100 (Pimozide)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 2539_2542delAACT (rs72549353 )

Allele Name : CYP2D6*19
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Orap® (Pimozide) tablets[package insert]. Sellersville, Pennsylvania: Teva Pharmaceuticals USA; 2011. [Link]

PMID: 2160369

Pimozide

By

Pimozide

Product: Resiquimod

Identifier : DBSNPE004744
Drug : DB01100 (Pimozide)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 1973_1974insG (rs72549354 )

Allele Name : CYP2D6*20
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Orap® (Pimozide) tablets[package insert]. Sellersville, Pennsylvania: Teva Pharmaceuticals USA; 2011. [Link]

PMID: 2550911

Pimozide

By

Pimozide

Product: A 419259 (trihydrochloride)

Identifier : DBSNPE004745
Drug : DB01100 (Pimozide)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 2573insC

Allele Name : CYP2D6*21
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Orap® (Pimozide) tablets[package insert]. Sellersville, Pennsylvania: Teva Pharmaceuticals USA; 2011. [Link]

PMID: 17959748

Pimozide

By

Pimozide

Product: A 419259

Identifier : DBSNPE004746
Drug : DB01100 (Pimozide)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • -1770G>A
  • -1584C>G
  • -1235A>G
  • -740C>T
  • -678G>A
  • CYP2D7 gene conversion in indivon 1
  • 310G>T
  • 746C>G
  • 843T>G
  • 1661G>C
  • 2850C>T
  • 3384A>C
  • 3584G>A
  • 3790C>T
  • 4042G>A
  • 4180G>C
  • 4481G>A

Allele Name : CYP2D6*31
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Orap® (Pimozide) tablets[package insert]. Sellersville, Pennsylvania: Teva Pharmaceuticals USA; 2011. [Link]

PMID: 9718274

Pimozide

By

Pimozide

Product: WHI-P180 (hydrochloride)

Identifier : DBSNPE004747
Drug : DB01100 (Pimozide)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 100C>T (rs1065852 )
  • -1426C>T
  • variable number of A’s in the region -1258 to -1237a
  • -1235A>G
  • -1000G>A
  • 1039C>T
  • 1661G>C
  • gene conversion to CYP2D7 in exon 9
  • 4180G>C

Allele Name : CYP2D6*36
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Orap® (Pimozide) tablets[package insert]. Sellersville, Pennsylvania: Teva Pharmaceuticals USA; 2011. [Link]

PMID: 1658676

Pimozide

By

Pimozide

Product: WHI-P180

Identifier : DBSNPE004748
Drug : DB01100 (Pimozide)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 2587_2590delGACT (rs72549351 )

Allele Name : CYP2D6*38
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Orap® (Pimozide) tablets[package insert]. Sellersville, Pennsylvania: Teva Pharmaceuticals USA; 2011. [Link]

PMID: 7713168

Pimozide

By

Pimozide

Product: TAK-632

Identifier : DBSNPE004749
Drug : DB01100 (Pimozide)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 1863_1864ins(TTT CGC CCC)2 (rs72549356 )

Allele Name : CYP2D6*40
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Orap® (Pimozide) tablets[package insert]. Sellersville, Pennsylvania: Teva Pharmaceuticals USA; 2011. [Link]

PMID: 8545524

Pimozide

By

Pimozide

Product: PF-3084014

Identifier : DBSNPE004750
Drug : DB01100 (Pimozide)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 3259_3260insGT (rs72549346 )

Allele Name : CYP2D6*42
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Orap® (Pimozide) tablets[package insert]. Sellersville, Pennsylvania: Teva Pharmaceuticals USA; 2011. [Link]

PMID: 22363709

Pimozide

By

Pimozide

Product: GM6001

Identifier : DBSNPE004751
Drug : DB01100 (Pimozide)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 2950G>C

Allele Name : CYP2D6*44
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Orap® (Pimozide) tablets[package insert]. Sellersville, Pennsylvania: Teva Pharmaceuticals USA; 2011. [Link]

PMID: 21368235

Pimozide

By

Pimozide

Product: Pioglitazone

Identifier : DBSNPE004752
Drug : DB01100 (Pimozide)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 100C>T (rs1065852 )
  • -1426C>T
  • -1235A>G
  • -1000G>A
  • 73C<T
  • 1039C>T
  • 1661G>C
  • 4180G>C

Allele Name : CYP2D6*47
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Orap® (Pimozide) tablets[package insert]. Sellersville, Pennsylvania: Teva Pharmaceuticals USA; 2011. [Link]

PMID: 21188216

Pimozide

By

Pimozide

Product: Telmisartan

Identifier : DBSNPE004753
Drug : DB01100 (Pimozide)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • -1584C>G
  • -1235A>G
  • -740C>T
  • -678G>A
  • CYP2D7 gene conversion in indivon 1
  • 1661G>C
  • 2850C>T
  • 3172A>C
  • 4180G>C

Allele Name : CYP2D6*51
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Orap® (Pimozide) tablets[package insert]. Sellersville, Pennsylvania: Teva Pharmaceuticals USA; 2011. [Link]

PMID: 7545517

Pimozide

By

Pimozide

Product: Gabapentin enacarbil

Identifier : DBSNPE004754
Drug : DB01100 (Pimozide)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 3201C>T (rs72549347 )

Allele Name : CYP2D6*56
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Orap® (Pimozide) tablets[package insert]. Sellersville, Pennsylvania: Teva Pharmaceuticals USA; 2011. [Link]

PMID: 1321907

Pimozide

By

Pimozide

Product: Honokiol

Identifier : DBSNPE004755
Drug : DB01100 (Pimozide)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 100C>T
  • 310G>T
  • 843T>G
  • 887C>T
  • 1039C>T
  • 1661G>C
  • 3384A>C
  • 3582A>G
  • gene conversion to CYP2D7 in exon 9
  • 4180G>C

Allele Name : CYP2D6*57
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Orap® (Pimozide) tablets[package insert]. Sellersville, Pennsylvania: Teva Pharmaceuticals USA; 2011. [Link]

PMID: 8234901

Pimozide

By

Pimozide

Product: GNE-617

Identifier : DBSNPE004756
Drug : DB01100 (Pimozide)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 4044C>T

Allele Name : CYP2D6*62
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Orap® (Pimozide) tablets[package insert]. Sellersville, Pennsylvania: Teva Pharmaceuticals USA; 2011. [Link]

PMID: 1384914

Pimozide

By

Pimozide

Product: BAY 57-1293

Identifier : DBSNPE004757
Drug : DB01100 (Pimozide)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • -1426C>T
  • -1235A>G
  • -1000G>A
  • 100C>T
  • 310G>T
  • CYP2D7 sequence from indivon 1 onwards

Allele Name : CYP2D6*68A
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Orap® (Pimozide) tablets[package insert]. Sellersville, Pennsylvania: Teva Pharmaceuticals USA; 2011. [Link]

PMID: 8185607

Pimozide

By

Pimozide

Product: Rosiglitazone (maleate)

Identifier : DBSNPE004758
Drug : DB01100 (Pimozide)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • Similar but not identical switch region compared to CYP2D6*68A. Found in tandem arrangement with CYP2D6*4.

Allele Name : CYP2D6*68B
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Orap® (Pimozide) tablets[package insert]. Sellersville, Pennsylvania: Teva Pharmaceuticals USA; 2011. [Link]

PMID: 1380373

Pimozide

By

Pimozide

Product: A 839977

Identifier : DBSNPE004759
Drug : DB01100 (Pimozide)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 2988G>A (rs28371725 )
  • -1426C>T
  • -1235A>G
  • -1000G>A
  • 100C>T
  • 310G>T
  • 746C>G
  • 843T>G
  • 1062A>G
  • 1661G>C
  • 2850C>T
  • 3384A>C
  • 3584G>A
  • 3790C>T
  • 4180G>C
  • 4401C>T
  • 4481G>A

Allele Name : CYP2D6*69
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Orap® (Pimozide) tablets[package insert]. Sellersville, Pennsylvania: Teva Pharmaceuticals USA; 2011. [Link]

PMID: 1710662

Pimozide

By

Pimozide

Product: ICI 118,551 (hydrochloride)

Identifier : DBSNPE004760
Drug : DB01100 (Pimozide)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • 1995delC

Allele Name : CYP2D6*92
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Orap® (Pimozide) tablets[package insert]. Sellersville, Pennsylvania: Teva Pharmaceuticals USA; 2011. [Link]

PMID: 18930726

Pimozide

By

Pimozide

Product: CMX001

Identifier : DBSNPE004761
Drug : DB01100 (Pimozide)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • -1426C>T
  • -1235A>G
  • -1109C>T
  • -1000G>A
  • 100C>T
  • 310G>T
  • 843T>G
  • 1039C>T
  • 1661G>C
  • 2097A>G
  • 2828delC
  • 3384A>C
  • 3582A>G
  • 4180G>C
  • 4401C>T

Allele Name : CYP2D6*100
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Orap® (Pimozide) tablets[package insert]. Sellersville, Pennsylvania: Teva Pharmaceuticals USA; 2011. [Link]

PMID: 1375857

Pimozide

By

Pimozide

Product: Refametinib (R enantiomer)

Identifier : DBSNPE004762
Drug : DB01100 (Pimozide)
Interacting Gene/Enzyme : Cytochrome P450 2D6
Gene Name : CYP2D6
UniProt ID : P10635
Defining Change(s) :

  • -1426C>T
  • -1235A>G
  • -1000G>A
  • 100C>T
  • 310G>T
  • 843T>G
  • 1039C>T
  • 1661G>C
  • 2097A>G
  • 2927_2945delGATCCTACATCCGGATGTG
  • 3384A>C
  • 3582A>G
  • 4180G>C
  • 4401C>T

Allele Name : CYP2D6*101
Genotype(s) : Not Available
Type(s) : Effect Inferred
Groups : Non-functional CYP2D6
Description : Poor drug metabolizer, lower dose requirement.
References :

  1. Orap® (Pimozide) tablets[package insert]. Sellersville, Pennsylvania: Teva Pharmaceuticals USA; 2011. [Link]

PMID: 1712430

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