PI3KInhibitorpi3kinhibitor

Pegloticase

By

Pegloticase

Product: Poziotinib

Identifier : DBSNPE002601
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 1000_1002delACC

Allele Name : Villeurbanne
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 16816845

Pegloticase

By

Pegloticase

Product: NMS-859

Identifier : DBSNPE002602
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 1006A->G

Allele Name : Torun
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 12190308

Pegloticase

By

Pegloticase

Product: AL 082D06

Identifier : DBSNPE002603
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 105_107delCAT

Allele Name : Sunderland
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 23328157

Pegloticase

By

Pegloticase

Product: Tiplaxtinin

Identifier : DBSNPE002604
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 1081G->A

Allele Name : Iwatsuki
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 1682275

Pegloticase

By

Pegloticase

Product: NVP-HSP990

Identifier : DBSNPE002605
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 1082C->T

Allele Name : Serres
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 1981354

Pegloticase

By

Pegloticase

Product: BLZ945

Identifier : DBSNPE002606
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 1084_1101delCTGAACGAGCGCAAGGCC

Allele Name : Tondela
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 1979798

Pegloticase

By

Pegloticase

Product: 6-OAU

Identifier : DBSNPE002607
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 1089C->A

Allele Name : Loma Linda
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 25107903

Pegloticase

By

Pegloticase

Product: CARM1-IN-1

Identifier : DBSNPE002608
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 1089C->G

Allele Name : Aachen
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 23626477

Pegloticase

By

Pegloticase

Product: YHO-13351

Identifier : DBSNPE002609
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 1096A->G

Allele Name : Tenri
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 6225527

Pegloticase

By

Pegloticase

Product: YHO-13177

Identifier : DBSNPE002610
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 1132G>A

Allele Name : Montpellier
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 6177209

Pegloticase

By

Pegloticase

Product: 10058-F4

Identifier : DBSNPE002611
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 1138A->G

Allele Name : Calvo Mackenna
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 7330790

Pegloticase

By

Pegloticase

Product: FAS-IN-1

Identifier : DBSNPE002612
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 1139T->C

Allele Name : Riley
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 21262970

Pegloticase

By

Pegloticase

Product: GPR40 Activator 2

Identifier : DBSNPE002613
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 1141T->C

Allele Name : Olomouc
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 11243504

Pegloticase

By

Pegloticase

Product: CDKI-73

Identifier : DBSNPE002614
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 1153T->C

Allele Name : Tomah
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 10069503

Pegloticase

By

Pegloticase

Product: RX-3117

Identifier : DBSNPE002615
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 1154G->T

Allele Name : Lynwood
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 8608784

Pegloticase

By

Pegloticase

Product: AZM475271

Identifier : DBSNPE002616
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 1155C->G

Allele Name : Madrid
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 9918600

Pegloticase

By

Pegloticase

Product: Mubritinib

Identifier : DBSNPE002617
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 1156A->G

Allele Name : Iowa, Walter Reed, Springfield
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 11179435

Pegloticase

By

Pegloticase

Product: SR1001

Identifier : DBSNPE002618
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 1160G->A

Allele Name : Beverly Hills, Genova, Iwate, Niigata, Yamaguchi
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 6346907

Pegloticase

By

Pegloticase

Product: Sapitinib

Identifier : DBSNPE002619
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 1162A->G

Allele Name : Hartford
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 7238574

Pegloticase

By

Pegloticase

Product: GNE-317

Identifier : DBSNPE002620
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 1166A->G

Allele Name : Praha
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 16388798

Pegloticase

By

Pegloticase

Product: A-836339

Identifier : DBSNPE002621
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 1175T>C

Allele Name : Krakow
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 16037679

Pegloticase

By

Pegloticase

Product: ML141

Identifier : DBSNPE002622
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 1177C->G

Allele Name : Wisconsin
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 9506246

Pegloticase

By

Pegloticase

Product: ML228

Identifier : DBSNPE002623
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 1178G->A

Allele Name : Nashville, Anaheim, Portici
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 23878024

Pegloticase

By

Pegloticase

Product: Genz-123346 (free base)

Identifier : DBSNPE002624
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 1180G->C

Allele Name : Alhambra
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 8874138

Pegloticase

By

Pegloticase

Product: Genz-123346

Identifier : DBSNPE002625
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 1187C->T

Allele Name : Bari
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 35171

Pegloticase

By

Pegloticase

Product: K-7174 (dihydrochloride)

Identifier : DBSNPE002626
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 1192G->A

Allele Name : Puerto Limon
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 2436504

Pegloticase

By

Pegloticase

Product: K-7174

Identifier : DBSNPE002627
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 1205C>A

Allele Name : Covao do Lobo
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 2875889

Pegloticase

By

Pegloticase

Product: SCR7

Identifier : DBSNPE002628
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 1215G->A

Allele Name : Clinic
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 6236679

Pegloticase

By

Pegloticase

Product: LDN-212320

Identifier : DBSNPE002629
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 1225C->T

Allele Name : Udivecht
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 21131266

Pegloticase

By

Pegloticase

Product: ETC-1002

Identifier : DBSNPE002630
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 1226C->G

Allele Name : Suwalki
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 20977989

Pegloticase

By

Pegloticase

Product: Miriplatin

Identifier : DBSNPE002632
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 1229G->A

Allele Name : Japan, Shinagawa
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 11182255

Pegloticase

By

Pegloticase

Product: Succinyl phosphonate

Identifier : DBSNPE002633
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 1229G->C

Allele Name : Kawasaki
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 15192105

Pegloticase

By

Pegloticase

Product: Tizoxanide

Identifier : DBSNPE002634
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 1231A->G

Allele Name : Munich
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 8114011

Pegloticase

By

Pegloticase

Product: CH-223191

Identifier : DBSNPE002635
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 1284C->A

Allele Name : Georgia
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 2164693

Pegloticase

By

Pegloticase

Product: Bephenium (hydroxynaphthoate)

Identifier : DBSNPE002636
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 1292T->G

Allele Name : Sumare
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 14660743

Pegloticase

By

Pegloticase

Product: cGAMP

Identifier : DBSNPE002637
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 1318C->T

Allele Name : Telti/Kobe
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 17962722

Pegloticase

By

Pegloticase

Product: LDN-57444

Identifier : DBSNPE002638
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 1339G->A

Allele Name : Santiago de Cuba, Morioka
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 10604956

Pegloticase

By

Pegloticase

Product: LFM-A13

Identifier : DBSNPE002639
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 1358T->A

Allele Name : Harima
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 10928959

Pegloticase

By

Pegloticase

Product: Heparin (sodium salt)

Identifier : DBSNPE002640
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 1366G->C

Allele Name : Figuera da Foz
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 21873469

Pegloticase

By

Pegloticase

Product: Treosulfan

Identifier : DBSNPE002641
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 1367A>T

Allele Name : Amiens
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 23393282

Pegloticase

By

Pegloticase

Product: Irbinitinib

Identifier : DBSNPE002642
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 1376G->T, 1502T->G

Allele Name : Bangkok Noi
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 16920098

Pegloticase

By

Pegloticase

Product: VBY-825

Identifier : DBSNPE002643
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 1462G->A

Allele Name : Fukaya
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 8377843

Pegloticase

By

Pegloticase

Product: SAR7334

Identifier : DBSNPE002644
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 1463G->T

Allele Name : Campinas
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 8147269

Pegloticase

By

Pegloticase

Product: Ledipasvir (diacetone)

Identifier : DBSNPE002645
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 1465C>T

Allele Name : Buenos Aires
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 1507209

Pegloticase

By

Pegloticase

Product: AM251

Identifier : DBSNPE002646
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 1466C->T

Allele Name : Arakawa
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 24371118

Pegloticase

By

Pegloticase

Product: 5-GTP (trisodium salt)

Identifier : DBSNPE002647
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 1488_1490delGAA

Allele Name : Brighton
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 21205825

Pegloticase

By

Pegloticase

Product: Prucalopride (succinate)

Identifier : DBSNPE002648
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 159G->C

Allele Name : Kozukata
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 10980276

Pegloticase

By

Pegloticase

Product: R(+)-IAA-94

Identifier : DBSNPE002649
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 180_182delTCT

Allele Name : Amsterdam
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 10385230

Pegloticase

By

Pegloticase

Product: DO3A tert-Butyl ester

Identifier : DBSNPE002650
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 202G->A, 376A->G, 1264C>G

Allele Name : No name
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 860674

Pegloticase

By

Pegloticase

Product: BFCAs-1

Identifier : DBSNPE002651
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 224T->C

Allele Name : Swansea
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 871093

Pegloticase

By

Pegloticase

Product: DOTA derivative

Identifier : DBSNPE002652
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 281_283delAGA

Allele Name : Urayasu
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 25045085

Pegloticase

By

Pegloticase

Product: PKR-IN-1

Identifier : DBSNPE002653
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 317C->G544C->T592C->T

Allele Name : Vancouver
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 22156496

Pegloticase

By

Pegloticase

Product: Ginsenoside Rh4

Identifier : DBSNPE002654
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 376A->G, 1159C->T

Allele Name : Mt Sinai
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 16730977

Pegloticase

By

Pegloticase

Product: Ginsenoside C-K

Identifier : DBSNPE002655
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 488G->A

Allele Name : Plymouth
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 1613748

Pegloticase

By

Pegloticase

Product: Dihydrochelerythrine

Identifier : DBSNPE002656
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 514C->T

Allele Name : Volendam
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 2308927

Pegloticase

By

Pegloticase

Product: Dihydrosanguinarine

Identifier : DBSNPE002657
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 527A->G

Allele Name : Shinshu
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 8692899

Pegloticase

By

Pegloticase

Product: Corynoxine B

Identifier : DBSNPE002658
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 535A->T

Allele Name : Chikugo
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 8549627

Pegloticase

By

Pegloticase

Product: Corynoxine

Identifier : DBSNPE002659
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 561_563delCTC

Allele Name : Tsukui
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 16498503

Pegloticase

By

Pegloticase

Product: Cimiracemoside D

Identifier : DBSNPE002660
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 573C>G

Allele Name : Pedoplis-Ckaro
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 1716826

Pegloticase

By

Pegloticase

Product: Wilforine

Identifier : DBSNPE002661
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 593G->C

Allele Name : Santiago
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 2903545

Pegloticase

By

Pegloticase

Product: Cinobufotalin

Identifier : DBSNPE002662
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 637G->T

Allele Name : Minnesota, Marion, Gastonia, LeJeune
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 2874823

Pegloticase

By

Pegloticase

Product: Pseudobufarenogin

Identifier : DBSNPE002663
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 637G->T, 1037A->T

Allele Name : Cincinnati
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 6112034

Pegloticase

By

Pegloticase

Product: Bufotalin

Identifier : DBSNPE002664
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 648T->G

Allele Name : Harilaou
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 6112035

Pegloticase

By

Pegloticase

Product: Bufalin

Identifier : DBSNPE002665
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 683_685delACA

Allele Name : North Dallas
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 6105207

Pegloticase

By

Pegloticase

Product: Arenobufagin

Identifier : DBSNPE002666
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 695G->A

Allele Name : Asahikawa
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 43449

Pegloticase

By

Pegloticase

Product: IKarisoside A

Identifier : DBSNPE002668
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 724_729delGGCACT

Allele Name : Stonybrook
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 25805997

Pegloticase

By

Pegloticase

Product: Sagittatoside B

Identifier : DBSNPE002669
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 769C->G

Allele Name : Wayne
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 17891168

Pegloticase

By

Pegloticase

Product: Sagittatoside A

Identifier : DBSNPE002670
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 806G->A

Allele Name : Aveiro
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 8842448

Pegloticase

By

Pegloticase

Product: Ikarisoside F

Identifier : DBSNPE002671
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 820G->A

Allele Name : Cleveland Corum
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 7907797

Pegloticase

By

Pegloticase

Product: Prinaberel

Identifier : DBSNPE002672
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 821A>T

Allele Name : Lille
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 2894879

Pegloticase

By

Pegloticase

Product: Gilteritinib

Identifier : DBSNPE002673
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 825G>C

Allele Name : Bangkok
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 15131002

Pegloticase

By

Pegloticase

Product: NS11394

Identifier : DBSNPE002674
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 826C->T

Allele Name : Sugao
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 1383495

Pegloticase

By

Pegloticase

Product: Fexaramine

Identifier : DBSNPE002675
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 832T->C

Allele Name : La Jolla
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 22011436

Pegloticase

By

Pegloticase

Product: Haloxon

Identifier : DBSNPE002676
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 833C->T

Allele Name : Wexham
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 16954192

Pegloticase

By

Pegloticase

Product: Corylin

Identifier : DBSNPE002677
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 851T>C

Allele Name : Piodivkow
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 11179434

Pegloticase

By

Pegloticase

Product: Bakuchiol

Identifier : DBSNPE002678
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 910G->T

Allele Name : West Virginia
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 7675114

Pegloticase

By

Pegloticase

Product: Bavachinin

Identifier : DBSNPE002679
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 921G->C

Allele Name : Omiya
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 8308858

Pegloticase

By

Pegloticase

Product: Penicillin G (potassium)

Identifier : DBSNPE002680
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 953_976delCCACCAAAGGGTACCTGGAC GACC

Allele Name : Nara
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 12411423

Pegloticase

By

Pegloticase

Product: AT-101 (acetic acid)

Identifier : DBSNPE002681
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 962G->A

Allele Name : Manhattan
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 15115383

Pegloticase

By

Pegloticase

Product: Pyridostatin (hydrochloride)

Identifier : DBSNPE002682
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 964T->C

Allele Name : Rehevot
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 14530216

Pegloticase

By

Pegloticase

Product: MDL 105519

Identifier : DBSNPE002683
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 99A->G
  • 1360C->T

Allele Name : Honiara
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 1963802

Pegloticase

By

Pegloticase

Product: Diethylcarbamazine (citrate)

Identifier : DBSNPE002684
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 1246G->A

Allele Name : Tokyo, Fukushima
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 1695431

Pegloticase

By

Pegloticase

Product: Pyrantel (tartrate)

Identifier : DBSNPE002685
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 1003G->A

Allele Name : Chatham
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 2540269

Pegloticase

By

Pegloticase

Product: Pyrantel (pamoate)

Identifier : DBSNPE002686
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 1004C->A

Allele Name : Fushan
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 27510032

Pegloticase

By

Pegloticase

Product: GMX1778

Identifier : DBSNPE002687
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 1052G->T

Allele Name : Partenope
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 24192459

Pegloticase

By

Pegloticase

Product: 2,4-Pyrimidinediamine with linker

Identifier : DBSNPE002688
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 1057C->T

Allele Name : Ierapediva
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 1328529

Pegloticase

By

Pegloticase

Product: Bithionol

Identifier : DBSNPE002689
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 1193A->G

Allele Name : Anadia
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 15695163

Pegloticase

By

Pegloticase

Product: Radafaxine (hydrochloride)

Identifier : DBSNPE002690
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 1220A->C

Allele Name : Abeno
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 15821027

Pegloticase

By

Pegloticase

Product: FTI-277 (hydrochloride)

Identifier : DBSNPE002691
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 1291G->A

Allele Name : Surabaya
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 25205969

Pegloticase

By

Pegloticase

Product: FTI-277

Identifier : DBSNPE002692
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 1316G->C

Allele Name : Pawnee
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 15033391

Pegloticase

By

Pegloticase

Product: CBB1003 (hydrochloride)

Identifier : DBSNPE002693
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 1342A->G

Allele Name : S. Antioco
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 15447739

Pegloticase

By

Pegloticase

Product: CBB1007 (hydrochloride)

Identifier : DBSNPE002694
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 1347G->C

Allele Name : Cassano
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 17343831

Pegloticase

By

Pegloticase

Product: PHA-767491 (hydrochloride)

Identifier : DBSNPE002695
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 1347G->C
  • 1360C->T

Allele Name : Hermoupolis
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 15466447

Pegloticase

By

Pegloticase

Product: Primaquine (Diphosphate)

Identifier : DBSNPE002696
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 1360C->T

Allele Name : Union,Maewo, Chinese-2, Kalo
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 7998987

Pegloticase

By

Pegloticase

Product: Y16

Identifier : DBSNPE002697
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 1361G->A

Allele Name : Andalus
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 7957622

Pegloticase

By

Pegloticase

Product: Rhosin

Identifier : DBSNPE002698
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 1376G->C

Allele Name : Cosenza
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 26090474

Pegloticase

By

Pegloticase

Product: Rhosin (hydrochloride)

Identifier : DBSNPE002699
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 1376G->T

Allele Name : Canton, Taiwan- Hakka, Gifu-like, Agrigento-like
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 18683917

Pegloticase

By

Pegloticase

Product: Eprinomectin

Identifier : DBSNPE002700
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 1387C->A

Allele Name : Flores
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 15863333

Pegloticase

By

Pegloticase

Product: Bephenium

Identifier : DBSNPE002701
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 1388G->A

Allele Name : Kaiping, Anant, Dhon, Sapporo-like, Wosera
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 10215700

Pegloticase

By

Pegloticase

Product: Dichlorophen

Identifier : DBSNPE002702
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 169C->T

Allele Name : Kamogawa
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 10215699

Pegloticase

By

Pegloticase

Product: Hexachlorophene

Identifier : DBSNPE002703
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 179T>C

Allele Name : Costanzo
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 7473144

Pegloticase

By

Pegloticase

Product: SP2509

Identifier : DBSNPE002704
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 185C->A

Allele Name : Amazonia
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 11714875

Pegloticase

By

Pegloticase

Product: DBPR108

Identifier : DBSNPE002705
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 196T->A

Allele Name : Songklanagarind
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 10072195

Pegloticase

By

Pegloticase

Product: SKF-86002

Identifier : DBSNPE002706
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 202G->A
  • 871G->A

Allele Name : Hechi
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 7830269

Pegloticase

By

Pegloticase

Product: ML224

Identifier : DBSNPE002707
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 208T->C

Allele Name : Namouru
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 7834183

Pegloticase

By

Pegloticase

Product: Siponimod

Identifier : DBSNPE002708
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 352T>C

Allele Name : Bao Loc
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 1330590

Pegloticase

By

Pegloticase

Product: CID-797718

Identifier : DBSNPE002709
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 375G->T, 379G->T383T->C384C>T

Allele Name : Crispim
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 19345233

Pegloticase

By

Pegloticase

Product: INT-747

Identifier : DBSNPE002710
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 376A->G
  • 463C->G

Allele Name : Acrokorinthos
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 18469850

Pegloticase

By

Pegloticase

Product: VER-155008

Identifier : DBSNPE002711
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 376A->G
  • 542A->T

Allele Name : Santa Maria
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 17129577

Pegloticase

By

Pegloticase

Product: Oleanolic Acid

Identifier : DBSNPE002712
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 376A->G
  • 871G->A

Allele Name : Ananindeua
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 28526411

Pegloticase

By

Pegloticase

Product: Ursolic acid

Identifier : DBSNPE002713
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 383T->C

Allele Name : Vanua Lava
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 18305012

Pegloticase

By

Pegloticase

Product: Dihydromyricetin

Identifier : DBSNPE002714
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 406C->T

Allele Name : Valladolid
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 16310812

Pegloticase

By

Pegloticase

Product: Sanguinarine

Identifier : DBSNPE002715
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 409C->T

Allele Name : Belem
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 15466448

Pegloticase

By

Pegloticase

Product: Ozagrel (sodium)

Identifier : DBSNPE002716
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 442G->A

Allele Name : Liuzhou
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 12013409

Pegloticase

By

Pegloticase

Product: CX-4945 (sodium salt)

Identifier : DBSNPE002717
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 473G>A

Allele Name : Shenzen
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 16432504

Pegloticase

By

Pegloticase

Product: Chloroquine (diphosphate)

Identifier : DBSNPE002718
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 493A->G

Allele Name : Taipei “Chinese- 3”
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 12488429

Pegloticase

By

Pegloticase

Product: Tofogliflozin

Identifier : DBSNPE002719
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 496C>T

Allele Name : Toledo
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 11498525

Pegloticase

By

Pegloticase

Product: Tofogliflozin (hydrate)

Identifier : DBSNPE002720
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 497G->A

Allele Name : Naone
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 16769092

Pegloticase

By

Pegloticase

Product: GS967

Identifier : DBSNPE002721
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 517T->C

Allele Name : Nankang
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 15665857

Pegloticase

By

Pegloticase

Product: PNU-282987

Identifier : DBSNPE002722
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 519C->G

Allele Name : Miaoli
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 15947036

Pegloticase

By

Pegloticase

Product: Ro-3306

Identifier : DBSNPE002723
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 563C->T

Allele Name : Mediterranean, Dallas, Panama‚ Sassari, Cagliari, Birmingham
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 21839070

Pegloticase

By

Pegloticase

Product: (-)-Epicatechin gallate

Identifier : DBSNPE002724
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 592C->T

Allele Name : Coimbra Shunde
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 18811133

Pegloticase

By

Pegloticase

Product: Psoralidin

Identifier : DBSNPE002725
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 593G>A

Allele Name : Nilgiri
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 18817367

Pegloticase

By

Pegloticase

Product: Bavachalcone

Identifier : DBSNPE002726
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 679C->T

Allele Name : Radlowo
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 18635748

Pegloticase

By

Pegloticase

Product: (-)-Epigallocatechin

Identifier : DBSNPE002727
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 811G>C

Allele Name : Roubaix
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 17154494

Pegloticase

By

Pegloticase

Product: Peimisine

Identifier : DBSNPE002728
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 835A->G

Allele Name : Haikou
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 2942013

Pegloticase

By

Pegloticase

Product: Peiminine

Identifier : DBSNPE002729
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 835A->T

Allele Name : Chinese-1
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 25482934

Pegloticase

By

Pegloticase

Product: Peimine

Identifier : DBSNPE002730
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 848A>G

Allele Name : Mizushima
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 24696042

Pegloticase

By

Pegloticase

Product: Aloe emodin

Identifier : DBSNPE002731
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 853C->T

Allele Name : Osaka
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 19413568

Pegloticase

By

Pegloticase

Product: Chlorogenic acid

Identifier : DBSNPE002732
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 871G->A

Allele Name : Viangchan, Jammu
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 18983139

Pegloticase

By

Pegloticase

Product: (-)-Epicatechin

Identifier : DBSNPE002733
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 916G->A

Allele Name : Seoul
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 16213481

Pegloticase

By

Pegloticase

Product: Dalasetron (Mesylate hydrate)

Identifier : DBSNPE002734
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 929G->A

Allele Name : Ludhiana
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 16366610

Pegloticase

By

Pegloticase

Product: Dalasetron (Mesylate)

Identifier : DBSNPE002736
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 1024C->T

Allele Name : Chinese-5
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 15454206

Pegloticase

By

Pegloticase

Product: Dolasetron

Identifier : DBSNPE002737
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 130G>A

Allele Name : Rignano
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 27773822

Pegloticase

By

Pegloticase

Product: Brefeldin A

Identifier : DBSNPE002738
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 131C->G

Allele Name : Orissa
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 19413570

Pegloticase

By

Pegloticase

Product: Forodesine

Identifier : DBSNPE002739
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 1380G>C

Allele Name : G6PDNice
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 14722321

Pegloticase

By

Pegloticase

Product: Forodesine (hydrochloride)

Identifier : DBSNPE002740
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 1387C->T

Allele Name : Kamiube, Keelung
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 12954048

Pegloticase

By

Pegloticase

Product: Taltobulin (trifluoroacetate)

Identifier : DBSNPE002741
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 1400C->G

Allele Name : Neapolis
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 20534345

Pegloticase

By

Pegloticase

Product: SBE13

Identifier : DBSNPE002742
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 143T->C

Allele Name : Aures
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 20201064

Pegloticase

By

Pegloticase

Product: SBE13 (Hydrochloride)

Identifier : DBSNPE002743
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 1442C->G

Allele Name : Split
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 20534339

Pegloticase

By

Pegloticase

Product: (-)-MK 801 (Maleate)

Identifier : DBSNPE002744
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 148C->T

Allele Name : Kambos
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 25730130

Pegloticase

By

Pegloticase

Product: Pyridoclax

Identifier : DBSNPE002745
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 170G>A

Allele Name : Palesdivina
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 22821148

Pegloticase

By

Pegloticase

Product: Bikinin

Identifier : DBSNPE002746
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 172G->A

Allele Name : Metaponto
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 21931675

Pegloticase

By

Pegloticase

Product: Tipifarnib (S enantiomer)

Identifier : DBSNPE002747
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 185C->T

Allele Name : Musashino
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 15155757

Pegloticase

By

Pegloticase

Product: Catechin

Identifier : DBSNPE002748
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 202G->A

Allele Name : Asahi
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 23625935

Pegloticase

By

Pegloticase

Product: Corylifol A

Identifier : DBSNPE002749
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 202G->A
  • 376A->G

Allele Name : A- (202), Ferrara I
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 18273021

Pegloticase

By

Pegloticase

Product: 1-O-Acetylbritannilactone

Identifier : DBSNPE002750
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 209A->G

Allele Name : Murcia Oristano
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 15708855

Pegloticase

By

Pegloticase

Product: Britannilactone

Identifier : DBSNPE002751
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 241C->T

Allele Name : Ube Konan
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 12837541

Pegloticase

By

Pegloticase

Product: Octahydrocurcumin

Identifier : DBSNPE002752
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 242G->A

Allele Name : Lagosanto
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 10882143

Pegloticase

By

Pegloticase

Product: Tetrahydrocurcumin

Identifier : DBSNPE002753
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 274C->T

Allele Name : Guangzhou
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 23056207

Pegloticase

By

Pegloticase

Product: AKBA

Identifier : DBSNPE002754
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 323T->A

Allele Name : Hammersmith
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 1775198

Pegloticase

By

Pegloticase

Product: Tubeimoside II

Identifier : DBSNPE002755
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 34G->T

Allele Name : Sinnai
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 6721841

Pegloticase

By

Pegloticase

Product: Ginkgetin

Identifier : DBSNPE002756
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 376A->G
  • 680G->T

Allele Name : A- (680)
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 15670930

Pegloticase

By

Pegloticase

Product: Isoastragaloside II

Identifier : DBSNPE002757
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 376A->G
  • 968T->C

Allele Name : A- (968), Betica,Selma, Guantanamo
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 8222132

Pegloticase

By

Pegloticase

Product: Isoastragaloside I

Identifier : DBSNPE002758
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 383T>G

Allele Name : Salerno Pyrgos
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 2272362

Pegloticase

By

Pegloticase

Product: Aloin B

Identifier : DBSNPE002759
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 392G->T

Allele Name : Quing Yan
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 12690435

Pegloticase

By

Pegloticase

Product: Telocinobufagin

Identifier : DBSNPE002760
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 40G->A

Allele Name : Lages
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 8982495

Pegloticase

By

Pegloticase

Product: Gamabufotalin

Identifier : DBSNPE002761
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 466G->A

Allele Name : Ilesha
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 8747199

Pegloticase

By

Pegloticase

Product: BCX4430 (freebase)

Identifier : DBSNPE002762
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 487G->A

Allele Name : Mahidol
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 7693281

Pegloticase

By

Pegloticase

Product: BCX 4430

Identifier : DBSNPE002764
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 634A->G

Allele Name : Sibari
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 27984184

Pegloticase

By

Pegloticase

Product: Oxytocin (acetate)

Identifier : DBSNPE002765
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 680G->A

Allele Name : Mexico City
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 26095697

Pegloticase

By

Pegloticase

Product: Glyparamide

Identifier : DBSNPE002766
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 703C->T

Allele Name : Nanning
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 25970616

Pegloticase

By

Pegloticase

Product: NS-304

Identifier : DBSNPE002767
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 844G->C

Allele Name : Seattle, Lodi, Modena, Ferrara II, Athens-like
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 25411492

Pegloticase

By

Pegloticase

Product: Gemcitabine (elaidate)

Identifier : DBSNPE002768
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 844G->T

Allele Name : Bajo Maumere
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 24314731

Pegloticase

By

Pegloticase

Product: Mps1-IN-1

Identifier : DBSNPE002769
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 854G->A

Allele Name : Montalbano
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 24105416

Pegloticase

By

Pegloticase

Product: Tetrodotoxin (citrate)

Identifier : DBSNPE002770
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 949G->A

Allele Name : Kalyan-Kerala, Jamnaga, Rohini
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 22355569

Pegloticase

By

Pegloticase

Product: Tetrodotoxin

Identifier : DBSNPE002771
Drug : DB09208 (Pegloticase)
Interacting Gene/Enzyme : Glucose-6-phosphate 1-dehydrogenase
Gene Name : G6PD
UniProt ID : P11413
Defining Change(s) :

  • 95A->G

Allele Name : Gaohe
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : G6PD deficiency
Description : Increased risk of potentially fatal hemolytic anemia and methemoglobinemia.
References :

  1. Owens RE, Swanson H, Twilla JD: Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency. J Clin Rheumatol. 2016 Mar;22(2):97-8. doi: 10.1097/RHU.0000000000000370. [PubMed:26906307 ]
  2. Krystexxa® (pegloticase injection)[package insert]. Glendale, Wisconsin: Crealta Pharmaceuticals LLC; 2016. [Link]

PMID: 23015434

By

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