PI3KInhibitorpi3kinhibitor

Isosorbide Mononitrate

By

Isosorbide Mononitrate

Product: Stibogluconate (sodium)

Identifier : DBSNPE000593
Drug : DB01020 (Isosorbide Mononidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 2 c.129C>A

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Monoket®(isosorbide dinidivate) [package insert]. Princeton, New Jersey: Kremes Urban Pharmaceuticals Inc.; 2014. [Link]

PMID: 12756058

Isosorbide Mononitrate

By

Isosorbide Mononitrate

Product: Necrosulfonamide

Identifier : DBSNPE000594
Drug : DB01020 (Isosorbide Mononidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 2 c.149G>A

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Monoket®(isosorbide dinidivate) [package insert]. Princeton, New Jersey: Kremes Urban Pharmaceuticals Inc.; 2014. [Link]

PMID: 12552124

Isosorbide Mononitrate

By

Isosorbide Mononitrate

Product: Nanchangmycin

Identifier : DBSNPE000595
Drug : DB01020 (Isosorbide Mononidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 3 c.162C>G

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Monoket®(isosorbide dinidivate) [package insert]. Princeton, New Jersey: Kremes Urban Pharmaceuticals Inc.; 2014. [Link]

PMID: 12970160

Isosorbide Mononitrate

By

Isosorbide Mononitrate

Product: ITSA-1

Identifier : DBSNPE000596
Drug : DB01020 (Isosorbide Mononidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 3 c.173G>A

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Monoket®(isosorbide dinidivate) [package insert]. Princeton, New Jersey: Kremes Urban Pharmaceuticals Inc.; 2014. [Link]

PMID: 11934809

Isosorbide Mononitrate

By

Isosorbide Mononitrate

Product: DFMTI

Identifier : DBSNPE000597
Drug : DB01020 (Isosorbide Mononidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 3 c.173G>A

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Monoket®(isosorbide dinidivate) [package insert]. Princeton, New Jersey: Kremes Urban Pharmaceuticals Inc.; 2014. [Link]

PMID: 12070310

Isosorbide Mononitrate

By

Isosorbide Mononitrate

Product: MS049

Identifier : DBSNPE000598
Drug : DB01020 (Isosorbide Mononidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 3 c.194C>T

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Monoket®(isosorbide dinidivate) [package insert]. Princeton, New Jersey: Kremes Urban Pharmaceuticals Inc.; 2014. [Link]

PMID: 12388318

Isosorbide Mononitrate

By

Isosorbide Mononitrate

Product: GSK6853

Identifier : DBSNPE000599
Drug : DB01020 (Isosorbide Mononidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 3 c.218T>C

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Monoket®(isosorbide dinidivate) [package insert]. Princeton, New Jersey: Kremes Urban Pharmaceuticals Inc.; 2014. [Link]

PMID: 11904449

Isosorbide Mononitrate

By

Isosorbide Mononitrate

Product: Cetrorelix (Acetate)

Identifier : DBSNPE000600
Drug : DB01020 (Isosorbide Mononidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 3 c.226G>A

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Monoket®(isosorbide dinidivate) [package insert]. Princeton, New Jersey: Kremes Urban Pharmaceuticals Inc.; 2014. [Link]

PMID: 11818367

Isosorbide Mononitrate

By

Isosorbide Mononitrate

Product: Inosine

Identifier : DBSNPE000601
Drug : DB01020 (Isosorbide Mononidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 4 c.229C>T

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Monoket®(isosorbide dinidivate) [package insert]. Princeton, New Jersey: Kremes Urban Pharmaceuticals Inc.; 2014. [Link]

PMID: 10077589

Isosorbide Mononitrate

By

Isosorbide Mononitrate

Product: BMS-986020

Identifier : DBSNPE000602
Drug : DB01020 (Isosorbide Mononidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 4 c.247C>T

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Monoket®(isosorbide dinidivate) [package insert]. Princeton, New Jersey: Kremes Urban Pharmaceuticals Inc.; 2014. [Link]

PMID: 10430862

Isosorbide Mononitrate

By

Isosorbide Mononitrate

Product: FT011

Identifier : DBSNPE000603
Drug : DB01020 (Isosorbide Mononidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 4 c.287C>A

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Monoket®(isosorbide dinidivate) [package insert]. Princeton, New Jersey: Kremes Urban Pharmaceuticals Inc.; 2014. [Link]

PMID: 10097152

Isosorbide Mononitrate

By

Isosorbide Mononitrate

Product: eFT508

Identifier : DBSNPE000604
Drug : DB01020 (Isosorbide Mononidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 4 c.316G>A

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Monoket®(isosorbide dinidivate) [package insert]. Princeton, New Jersey: Kremes Urban Pharmaceuticals Inc.; 2014. [Link]

PMID: 26793050

Isosorbide Mononitrate

By

Isosorbide Mononitrate

Product: Ornipressin

Identifier : DBSNPE000605
Drug : DB01020 (Isosorbide Mononidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 5 c.350C>G

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Monoket®(isosorbide dinidivate) [package insert]. Princeton, New Jersey: Kremes Urban Pharmaceuticals Inc.; 2014. [Link]

PMID: 26441850

Isosorbide Mononitrate

By

Isosorbide Mononitrate

Product: Fertirelin

Identifier : DBSNPE000606
Drug : DB01020 (Isosorbide Mononidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 5 c.379A>G

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Monoket®(isosorbide dinidivate) [package insert]. Princeton, New Jersey: Kremes Urban Pharmaceuticals Inc.; 2014. [Link]

PMID: 26229438

Isosorbide Mononitrate

By

Isosorbide Mononitrate

Product: Lysipressin

Identifier : DBSNPE000607
Drug : DB01020 (Isosorbide Mononidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 5 c.382T>C

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Monoket®(isosorbide dinidivate) [package insert]. Princeton, New Jersey: Kremes Urban Pharmaceuticals Inc.; 2014. [Link]

PMID: 24425189

Isosorbide Mononitrate

By

Isosorbide Mononitrate

Product: Madecassoside

Identifier : DBSNPE000608
Drug : DB01020 (Isosorbide Mononidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 5 c.434C>T

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Monoket®(isosorbide dinidivate) [package insert]. Princeton, New Jersey: Kremes Urban Pharmaceuticals Inc.; 2014. [Link]

PMID: 25213831

Isosorbide Mononitrate

By

Isosorbide Mononitrate

Product: 23-Hydroxybetulinic acid

Identifier : DBSNPE000609
Drug : DB01020 (Isosorbide Mononidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 5 c.433C>T

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Monoket®(isosorbide dinidivate) [package insert]. Princeton, New Jersey: Kremes Urban Pharmaceuticals Inc.; 2014. [Link]

PMID: 24156037

Isosorbide Mononitrate

By

Isosorbide Mononitrate

Product: Tetrabenazine ((+)-)

Identifier : DBSNPE000610
Drug : DB01020 (Isosorbide Mononidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 5 c.446T>C

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Monoket®(isosorbide dinidivate) [package insert]. Princeton, New Jersey: Kremes Urban Pharmaceuticals Inc.; 2014. [Link]

PMID: 22370157

Isosorbide Mononitrate

By

Isosorbide Mononitrate

Product: Cyproconazole

Identifier : DBSNPE000611
Drug : DB01020 (Isosorbide Mononidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 6 c.478A>T

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Monoket®(isosorbide dinidivate) [package insert]. Princeton, New Jersey: Kremes Urban Pharmaceuticals Inc.; 2014. [Link]

PMID: 20203690

Isosorbide Mononitrate

By

Isosorbide Mononitrate

Product: Felypressin

Identifier : DBSNPE000612
Drug : DB01020 (Isosorbide Mononidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 6 c.478A>T

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Monoket®(isosorbide dinidivate) [package insert]. Princeton, New Jersey: Kremes Urban Pharmaceuticals Inc.; 2014. [Link]

PMID: 16651265

Isosorbide Mononitrate

By

Isosorbide Mononitrate

Product: MNS

Identifier : DBSNPE000613
Drug : DB01020 (Isosorbide Mononidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 6 c.536C>T

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Monoket®(isosorbide dinidivate) [package insert]. Princeton, New Jersey: Kremes Urban Pharmaceuticals Inc.; 2014. [Link]

PMID: 16754860

Isosorbide Mononitrate

By

Isosorbide Mononitrate

Product: Tyrphostin AG 879

Identifier : DBSNPE000614
Drug : DB01020 (Isosorbide Mononidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 6 c.535G>A

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Monoket®(isosorbide dinidivate) [package insert]. Princeton, New Jersey: Kremes Urban Pharmaceuticals Inc.; 2014. [Link]

PMID: 15537344

Isosorbide Mononitrate

By

Isosorbide Mononitrate

Product: BEC (hydrochloride)

Identifier : DBSNPE000615
Drug : DB01020 (Isosorbide Mononidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 6 c.535G>A

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Monoket®(isosorbide dinidivate) [package insert]. Princeton, New Jersey: Kremes Urban Pharmaceuticals Inc.; 2014. [Link]

PMID: 22266872

Isosorbide Mononitrate

By

Isosorbide Mononitrate

Product: Ruboxistaurin (hydrochloride)

Identifier : DBSNPE000616
Drug : DB01020 (Isosorbide Mononidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 6 c.535G>A

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Monoket®(isosorbide dinidivate) [package insert]. Princeton, New Jersey: Kremes Urban Pharmaceuticals Inc.; 2014. [Link]

PMID: 20977477

Isosorbide Mononitrate

By

Isosorbide Mononitrate

Product: Selonsertib

Identifier : DBSNPE000617
Drug : DB01020 (Isosorbide Mononidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 6 c.535G>A

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Monoket®(isosorbide dinidivate) [package insert]. Princeton, New Jersey: Kremes Urban Pharmaceuticals Inc.; 2014. [Link]

PMID: 19602572

Isosorbide Mononitrate

By

Isosorbide Mononitrate

Product: Verubecestat

Identifier : DBSNPE000618
Drug : DB01020 (Isosorbide Mononidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 7 c.610T>C

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Monoket®(isosorbide dinidivate) [package insert]. Princeton, New Jersey: Kremes Urban Pharmaceuticals Inc.; 2014. [Link]

PMID: 17631492

Isosorbide Mononitrate

By

Isosorbide Mononitrate

Product: Eleclazine (hydrochloride)

Identifier : DBSNPE000619
Drug : DB01020 (Isosorbide Mononidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 7 c.610T>C

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Monoket®(isosorbide dinidivate) [package insert]. Princeton, New Jersey: Kremes Urban Pharmaceuticals Inc.; 2014. [Link]

PMID: 25512541

Isosorbide Mononitrate

By

Isosorbide Mononitrate

Product: JWH-133

Identifier : DBSNPE000620
Drug : DB01020 (Isosorbide Mononidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 7 c.611G>A

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Monoket®(isosorbide dinidivate) [package insert]. Princeton, New Jersey: Kremes Urban Pharmaceuticals Inc.; 2014. [Link]

PMID: 24457025

Isosorbide Mononitrate

By

Isosorbide Mononitrate

Product: K03861

Identifier : DBSNPE000621
Drug : DB01020 (Isosorbide Mononidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 8 c.637G>A

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Monoket®(isosorbide dinidivate) [package insert]. Princeton, New Jersey: Kremes Urban Pharmaceuticals Inc.; 2014. [Link]

PMID: 15324884

Isosorbide Mononitrate

By

Isosorbide Mononitrate

Product: DprE1-IN-2

Identifier : DBSNPE000622
Drug : DB01020 (Isosorbide Mononidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 8 c.647T>C

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Monoket®(isosorbide dinidivate) [package insert]. Princeton, New Jersey: Kremes Urban Pharmaceuticals Inc.; 2014. [Link]

PMID: 10614829

Isosorbide Mononitrate

By

Isosorbide Mononitrate

Product: EAI045

Identifier : DBSNPE000623
Drug : DB01020 (Isosorbide Mononidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 8 c.650T>C

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Monoket®(isosorbide dinidivate) [package insert]. Princeton, New Jersey: Kremes Urban Pharmaceuticals Inc.; 2014. [Link]

PMID: 15961563

Isosorbide Mononitrate

By

Isosorbide Mononitrate

Product: Pleuromutilin

Identifier : DBSNPE000624
Drug : DB01020 (Isosorbide Mononidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 8 c.655C>T

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Monoket®(isosorbide dinidivate) [package insert]. Princeton, New Jersey: Kremes Urban Pharmaceuticals Inc.; 2014. [Link]

PMID: 25205655

Isosorbide Mononitrate

By

Isosorbide Mononitrate

Product: Tomatidine

Identifier : DBSNPE000625
Drug : DB01020 (Isosorbide Mononidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 8 c.716T>G

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Monoket®(isosorbide dinidivate) [package insert]. Princeton, New Jersey: Kremes Urban Pharmaceuticals Inc.; 2014. [Link]

PMID: 20334372

Isosorbide Mononitrate

By

Isosorbide Mononitrate

Product: Chebulinic acid

Identifier : DBSNPE000626
Drug : DB01020 (Isosorbide Mononidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 8 c.719A>G

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Monoket®(isosorbide dinidivate) [package insert]. Princeton, New Jersey: Kremes Urban Pharmaceuticals Inc.; 2014. [Link]

PMID: 16610793

Isosorbide Mononitrate

By

Isosorbide Mononitrate

Product: HA15

Identifier : DBSNPE000627
Drug : DB01020 (Isosorbide Mononidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 8 c.719A>G

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Monoket®(isosorbide dinidivate) [package insert]. Princeton, New Jersey: Kremes Urban Pharmaceuticals Inc.; 2014. [Link]

PMID: 20383709

Isosorbide Mononitrate

By

Isosorbide Mononitrate

Product: Benzocaine

Identifier : DBSNPE000628
Drug : DB01020 (Isosorbide Mononidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 8 Not reported

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Monoket®(isosorbide dinidivate) [package insert]. Princeton, New Jersey: Kremes Urban Pharmaceuticals Inc.; 2014. [Link]

PMID: 12624540

Isosorbide Mononitrate

By

Isosorbide Mononitrate

Product: LY2365109 (hydrochloride)

Identifier : DBSNPE000629
Drug : DB01020 (Isosorbide Mononidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 9 c.757G>A

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Monoket®(isosorbide dinidivate) [package insert]. Princeton, New Jersey: Kremes Urban Pharmaceuticals Inc.; 2014. [Link]

PMID: 9618436

Isosorbide Mononitrate

By

Isosorbide Mononitrate

Product: SRI-011381 (hydrochloride)

Identifier : DBSNPE000630
Drug : DB01020 (Isosorbide Mononidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 9 c.757G>A

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Monoket®(isosorbide dinidivate) [package insert]. Princeton, New Jersey: Kremes Urban Pharmaceuticals Inc.; 2014. [Link]

PMID: 6538611

Isosorbide Mononitrate

By

Isosorbide Mononitrate

Product: SZL P1-41

Identifier : DBSNPE000631
Drug : DB01020 (Isosorbide Mononidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 9 c.757G>A

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Monoket®(isosorbide dinidivate) [package insert]. Princeton, New Jersey: Kremes Urban Pharmaceuticals Inc.; 2014. [Link]

PMID: 25167991

Isosorbide Mononitrate

By

Isosorbide Mononitrate

Product: Benzophenonetetracarboxylic acid

Identifier : DBSNPE000632
Drug : DB01020 (Isosorbide Mononidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 9 c.757G>A

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Monoket®(isosorbide dinidivate) [package insert]. Princeton, New Jersey: Kremes Urban Pharmaceuticals Inc.; 2014. [Link]

PMID: 26579463

Isosorbide Mononitrate

By

Isosorbide Mononitrate

Product: Cynaroside

Identifier : DBSNPE000633
Drug : DB01020 (Isosorbide Mononidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 9 c.766_768del

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Monoket®(isosorbide dinidivate) [package insert]. Princeton, New Jersey: Kremes Urban Pharmaceuticals Inc.; 2014. [Link]

PMID: 26451596

Isosorbide Mononitrate

By

Isosorbide Mononitrate

Product: Hexaconazole

Identifier : DBSNPE000634
Drug : DB01020 (Isosorbide Mononidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 9 c.775C>T

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Monoket®(isosorbide dinidivate) [package insert]. Princeton, New Jersey: Kremes Urban Pharmaceuticals Inc.; 2014. [Link]

PMID: 11704975

Isosorbide Mononitrate

By

Isosorbide Mononitrate

Product: Chebulagic acid

Identifier : DBSNPE000635
Drug : DB01020 (Isosorbide Mononidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 9 c.815_817del

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Monoket®(isosorbide dinidivate) [package insert]. Princeton, New Jersey: Kremes Urban Pharmaceuticals Inc.; 2014. [Link]

PMID: 10465261

Isosorbide Mononitrate

By

Isosorbide Mononitrate

Product: Gracillin

Identifier : DBSNPE000636
Drug : DB01020 (Isosorbide Mononidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 9 c.827C>T

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Monoket®(isosorbide dinidivate) [package insert]. Princeton, New Jersey: Kremes Urban Pharmaceuticals Inc.; 2014. [Link]

PMID: 17115070

Isosorbide Mononitrate

By

Isosorbide Mononitrate

Product: Rebaudioside A

Identifier : DBSNPE000637
Drug : DB01020 (Isosorbide Mononidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 9 c.875G>A

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Monoket®(isosorbide dinidivate) [package insert]. Princeton, New Jersey: Kremes Urban Pharmaceuticals Inc.; 2014. [Link]

PMID: 15713417

Isosorbide Mononitrate

By

Isosorbide Mononitrate

Product: Hypericin

Identifier : DBSNPE000638
Drug : DB01020 (Isosorbide Mononidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 9 c.875G>A

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Monoket®(isosorbide dinidivate) [package insert]. Princeton, New Jersey: Kremes Urban Pharmaceuticals Inc.; 2014. [Link]

PMID: 15175332

Isosorbide Mononitrate

By

Isosorbide Mononitrate

Product: Mertansine

Identifier : DBSNPE000639
Drug : DB01020 (Isosorbide Mononidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 9 c.875G>A

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Monoket®(isosorbide dinidivate) [package insert]. Princeton, New Jersey: Kremes Urban Pharmaceuticals Inc.; 2014. [Link]

PMID: 7976808

Isosorbide Mononitrate

By

Isosorbide Mononitrate

Product: (+)-DHMEQ

Identifier : DBSNPE000640
Drug : DB01020 (Isosorbide Mononidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 9 c.882_884delinsAA

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Monoket®(isosorbide dinidivate) [package insert]. Princeton, New Jersey: Kremes Urban Pharmaceuticals Inc.; 2014. [Link]

PMID: 2242003

Isosorbide Mononitrate

By

Isosorbide Mononitrate

Product: Lasmiditan (hydrochloride)

Identifier : DBSNPE000641
Drug : DB01020 (Isosorbide Mononidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 9 c.895_897del

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Monoket®(isosorbide dinidivate) [package insert]. Princeton, New Jersey: Kremes Urban Pharmaceuticals Inc.; 2014. [Link]

PMID: 6548377

Isosorbide Mononitrate

By

Isosorbide Mononitrate

Product: Peptide M

Identifier : DBSNPE000642
Drug : DB01020 (Isosorbide Mononidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Indivon 4 c.418-2A>G

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Monoket®(isosorbide dinidivate) [package insert]. Princeton, New Jersey: Kremes Urban Pharmaceuticals Inc.; 2014. [Link]

PMID: 21392396

Isosorbide Mononitrate

By

Isosorbide Mononitrate

Product: (-)-DHMEQ

Identifier : DBSNPE000643
Drug : DB01020 (Isosorbide Mononidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Indivon 4 c.418-1G>A

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Monoket®(isosorbide dinidivate) [package insert]. Princeton, New Jersey: Kremes Urban Pharmaceuticals Inc.; 2014. [Link]

PMID: 19244106

Isosorbide Mononitrate

By

Isosorbide Mononitrate

Product: XMU-MP-1

Identifier : DBSNPE000644
Drug : DB01020 (Isosorbide Mononidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Indivon 5 c.548

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Monoket®(isosorbide dinidivate) [package insert]. Princeton, New Jersey: Kremes Urban Pharmaceuticals Inc.; 2014. [Link]

PMID: 16690721

Isosorbide Mononitrate

By

Isosorbide Mononitrate

Product: Benzenepentacarboxylic Acid

Identifier : DBSNPE000645
Drug : DB01020 (Isosorbide Mononidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Indivon 5 c.548

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Monoket®(isosorbide dinidivate) [package insert]. Princeton, New Jersey: Kremes Urban Pharmaceuticals Inc.; 2014. [Link]

PMID: 9443403

Isosorbide Mononitrate

By

Isosorbide Mononitrate

Product: CL-82198

Identifier : DBSNPE000646
Drug : DB01020 (Isosorbide Mononidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Indivon 5 c.547+2T>C

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Monoket®(isosorbide dinidivate) [package insert]. Princeton, New Jersey: Kremes Urban Pharmaceuticals Inc.; 2014. [Link]

PMID: 9927308

Isosorbide Mononitrate

By

Isosorbide Mononitrate

Product: Mivebresib

Identifier : DBSNPE000647
Drug : DB01020 (Isosorbide Mononidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Indivon 5 c.547+8G>C

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Monoket®(isosorbide dinidivate) [package insert]. Princeton, New Jersey: Kremes Urban Pharmaceuticals Inc.; 2014. [Link]

PMID: 21652696

Isosorbide Mononitrate

By

Isosorbide Mononitrate

Product: Fatostatin A

Identifier : DBSNPE000648
Drug : DB01020 (Isosorbide Mononidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Indivon 6 c.631+1G>A

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Monoket®(isosorbide dinidivate) [package insert]. Princeton, New Jersey: Kremes Urban Pharmaceuticals Inc.; 2014. [Link]

PMID: 19730705

Isosorbide Mononitrate

By

Isosorbide Mononitrate

Product: SBI-0206965

Identifier : DBSNPE000649
Drug : DB01020 (Isosorbide Mononidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Indivon 8 c.818-1G>T

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Monoket®(isosorbide dinidivate) [package insert]. Princeton, New Jersey: Kremes Urban Pharmaceuticals Inc.; 2014. [Link]

PMID: 9751507

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