PI3KInhibitorpi3kinhibitor

Isosorbide Dinitrate

By

Isosorbide Dinitrate

Product: SCH00013

Identifier : DBSNPE000536
Drug : DB00883 (Isosorbide Dinidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 2 c.129C>A

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Diladivate®-SR(isosorbide dinidivate) [package insert]. Chesterbrook, Pennsylvania: Auxilium Pharmaceuticals, Inc.; 2014. [Link]

PMID: 18239068

Isosorbide Dinitrate

By

Isosorbide Dinitrate

Product: WNK463

Identifier : DBSNPE000537
Drug : DB00883 (Isosorbide Dinidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 2 c.149G>A

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Diladivate®-SR(isosorbide dinidivate) [package insert]. Chesterbrook, Pennsylvania: Auxilium Pharmaceuticals, Inc.; 2014. [Link]

PMID: 18242510

Isosorbide Dinitrate

By

Isosorbide Dinitrate

Product: Valbenazine

Identifier : DBSNPE000538
Drug : DB00883 (Isosorbide Dinidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 3 c.162C>G

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Diladivate®-SR(isosorbide dinidivate) [package insert]. Chesterbrook, Pennsylvania: Auxilium Pharmaceuticals, Inc.; 2014. [Link]

PMID: 17974624

Isosorbide Dinitrate

By

Isosorbide Dinitrate

Product: Leukadherin-1

Identifier : DBSNPE000539
Drug : DB00883 (Isosorbide Dinidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 3 c.173G>A

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Diladivate®-SR(isosorbide dinidivate) [package insert]. Chesterbrook, Pennsylvania: Auxilium Pharmaceuticals, Inc.; 2014. [Link]

PMID: 18063836

Isosorbide Dinitrate

By

Isosorbide Dinitrate

Product: Stattic

Identifier : DBSNPE000540
Drug : DB00883 (Isosorbide Dinidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 3 c.173G>A

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Diladivate®-SR(isosorbide dinidivate) [package insert]. Chesterbrook, Pennsylvania: Auxilium Pharmaceuticals, Inc.; 2014. [Link]

PMID: 18765637

Isosorbide Dinitrate

By

Isosorbide Dinitrate

Product: Cecropin B

Identifier : DBSNPE000541
Drug : DB00883 (Isosorbide Dinidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 3 c.194C>T

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Diladivate®-SR(isosorbide dinidivate) [package insert]. Chesterbrook, Pennsylvania: Auxilium Pharmaceuticals, Inc.; 2014. [Link]

PMID: 18182067

Isosorbide Dinitrate

By

Isosorbide Dinitrate

Product: Corticotropin-releasing factor (ovine)

Identifier : DBSNPE000542
Drug : DB00883 (Isosorbide Dinidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 3 c.218T>C

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Diladivate®-SR(isosorbide dinidivate) [package insert]. Chesterbrook, Pennsylvania: Auxilium Pharmaceuticals, Inc.; 2014. [Link]

PMID: 18378698

Isosorbide Dinitrate

By

Isosorbide Dinitrate

Product: Corticotropin-releasing factor (human)

Identifier : DBSNPE000543
Drug : DB00883 (Isosorbide Dinidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 3 c.226G>A

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Diladivate®-SR(isosorbide dinidivate) [package insert]. Chesterbrook, Pennsylvania: Auxilium Pharmaceuticals, Inc.; 2014. [Link]

PMID: 19088369

Isosorbide Dinitrate

By

Isosorbide Dinitrate

Product: Thymosin beta 4

Identifier : DBSNPE000544
Drug : DB00883 (Isosorbide Dinidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 4 c.229C>T

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Diladivate®-SR(isosorbide dinidivate) [package insert]. Chesterbrook, Pennsylvania: Auxilium Pharmaceuticals, Inc.; 2014. [Link]

PMID: 18753331

Isosorbide Dinitrate

By

Isosorbide Dinitrate

Product: Shikonin

Identifier : DBSNPE000545
Drug : DB00883 (Isosorbide Dinidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 4 c.247C>T

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Diladivate®-SR(isosorbide dinidivate) [package insert]. Chesterbrook, Pennsylvania: Auxilium Pharmaceuticals, Inc.; 2014. [Link]

PMID: 17823853

Isosorbide Dinitrate

By

Isosorbide Dinitrate

Product: Sinapine (thiocyanate)

Identifier : DBSNPE000546
Drug : DB00883 (Isosorbide Dinidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 4 c.287C>A

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Diladivate®-SR(isosorbide dinidivate) [package insert]. Chesterbrook, Pennsylvania: Auxilium Pharmaceuticals, Inc.; 2014. [Link]

PMID: 18407594

Isosorbide Dinitrate

By

Isosorbide Dinitrate

Product: Sinensetin

Identifier : DBSNPE000547
Drug : DB00883 (Isosorbide Dinidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 4 c.316G>A

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Diladivate®-SR(isosorbide dinidivate) [package insert]. Chesterbrook, Pennsylvania: Auxilium Pharmaceuticals, Inc.; 2014. [Link]

PMID: 17569756

Isosorbide Dinitrate

By

Isosorbide Dinitrate

Product: HMN-176

Identifier : DBSNPE000548
Drug : DB00883 (Isosorbide Dinidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 5 c.350C>G

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Diladivate®-SR(isosorbide dinidivate) [package insert]. Chesterbrook, Pennsylvania: Auxilium Pharmaceuticals, Inc.; 2014. [Link]

PMID: 17308128

Isosorbide Dinitrate

By

Isosorbide Dinitrate

Product: TCS 401

Identifier : DBSNPE000549
Drug : DB00883 (Isosorbide Dinidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 5 c.379A>G

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Diladivate®-SR(isosorbide dinidivate) [package insert]. Chesterbrook, Pennsylvania: Auxilium Pharmaceuticals, Inc.; 2014. [Link]

PMID: 17584965

Isosorbide Dinitrate

By

Isosorbide Dinitrate

Product: [D-Ala2]leucine-enkephalin

Identifier : DBSNPE000550
Drug : DB00883 (Isosorbide Dinidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 5 c.382T>C

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Diladivate®-SR(isosorbide dinidivate) [package insert]. Chesterbrook, Pennsylvania: Auxilium Pharmaceuticals, Inc.; 2014. [Link]

PMID: 17499741

Isosorbide Dinitrate

By

Isosorbide Dinitrate

Product: Ganoderic acid A

Identifier : DBSNPE000551
Drug : DB00883 (Isosorbide Dinidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 5 c.434C>T

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Diladivate®-SR(isosorbide dinidivate) [package insert]. Chesterbrook, Pennsylvania: Auxilium Pharmaceuticals, Inc.; 2014. [Link]

PMID: 17463000

Isosorbide Dinitrate

By

Isosorbide Dinitrate

Product: Theaflavin

Identifier : DBSNPE000552
Drug : DB00883 (Isosorbide Dinidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 5 c.433C>T

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Diladivate®-SR(isosorbide dinidivate) [package insert]. Chesterbrook, Pennsylvania: Auxilium Pharmaceuticals, Inc.; 2014. [Link]

PMID: 17591692

Isosorbide Dinitrate

By

Isosorbide Dinitrate

Product: WST-8

Identifier : DBSNPE000553
Drug : DB00883 (Isosorbide Dinidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 5 c.446T>C

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Diladivate®-SR(isosorbide dinidivate) [package insert]. Chesterbrook, Pennsylvania: Auxilium Pharmaceuticals, Inc.; 2014. [Link]

PMID: 17934250

Isosorbide Dinitrate

By

Isosorbide Dinitrate

Product: Midecamycin

Identifier : DBSNPE000554
Drug : DB00883 (Isosorbide Dinidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 6 c.478A>T

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Diladivate®-SR(isosorbide dinidivate) [package insert]. Chesterbrook, Pennsylvania: Auxilium Pharmaceuticals, Inc.; 2014. [Link]

PMID: 17473282

Isosorbide Dinitrate

By

Isosorbide Dinitrate

Product: Procyclidine (hydrochloride)

Identifier : DBSNPE000555
Drug : DB00883 (Isosorbide Dinidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 6 c.478A>T

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Diladivate®-SR(isosorbide dinidivate) [package insert]. Chesterbrook, Pennsylvania: Auxilium Pharmaceuticals, Inc.; 2014. [Link]

PMID: 17717078

Isosorbide Dinitrate

By

Isosorbide Dinitrate

Product: Oxantel (pamoate)

Identifier : DBSNPE000556
Drug : DB00883 (Isosorbide Dinidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 6 c.536C>T

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Diladivate®-SR(isosorbide dinidivate) [package insert]. Chesterbrook, Pennsylvania: Auxilium Pharmaceuticals, Inc.; 2014. [Link]

PMID: 17909066

Isosorbide Dinitrate

By

Isosorbide Dinitrate

Product: Ceruletide

Identifier : DBSNPE000557
Drug : DB00883 (Isosorbide Dinidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 6 c.535G>A

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Diladivate®-SR(isosorbide dinidivate) [package insert]. Chesterbrook, Pennsylvania: Auxilium Pharmaceuticals, Inc.; 2014. [Link]

PMID: 17895382

Isosorbide Dinitrate

By

Isosorbide Dinitrate

Product: Tipiracil

Identifier : DBSNPE000558
Drug : DB00883 (Isosorbide Dinidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 6 c.535G>A

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Diladivate®-SR(isosorbide dinidivate) [package insert]. Chesterbrook, Pennsylvania: Auxilium Pharmaceuticals, Inc.; 2014. [Link]

PMID: 16393666

Isosorbide Dinitrate

By

Isosorbide Dinitrate

Product: PRIMA-1

Identifier : DBSNPE000559
Drug : DB00883 (Isosorbide Dinidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 6 c.535G>A

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Diladivate®-SR(isosorbide dinidivate) [package insert]. Chesterbrook, Pennsylvania: Auxilium Pharmaceuticals, Inc.; 2014. [Link]

PMID: 16474171

Isosorbide Dinitrate

By

Isosorbide Dinitrate

Product: RIP2 kinase inhibitor 2

Identifier : DBSNPE000560
Drug : DB00883 (Isosorbide Dinidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 6 c.535G>A

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Diladivate®-SR(isosorbide dinidivate) [package insert]. Chesterbrook, Pennsylvania: Auxilium Pharmaceuticals, Inc.; 2014. [Link]

PMID: 16415910

Isosorbide Dinitrate

By

Isosorbide Dinitrate

Product: FGFR4-IN-1

Identifier : DBSNPE000561
Drug : DB00883 (Isosorbide Dinidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 7 c.610T>C

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Diladivate®-SR(isosorbide dinidivate) [package insert]. Chesterbrook, Pennsylvania: Auxilium Pharmaceuticals, Inc.; 2014. [Link]

PMID: 17029634

Isosorbide Dinitrate

By

Isosorbide Dinitrate

Product: APS-2-79

Identifier : DBSNPE000562
Drug : DB00883 (Isosorbide Dinidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 7 c.610T>C

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Diladivate®-SR(isosorbide dinidivate) [package insert]. Chesterbrook, Pennsylvania: Auxilium Pharmaceuticals, Inc.; 2014. [Link]

PMID: 16457696

Isosorbide Dinitrate

By

Isosorbide Dinitrate

Product: IC87201

Identifier : DBSNPE000563
Drug : DB00883 (Isosorbide Dinidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 7 c.611G>A

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Diladivate®-SR(isosorbide dinidivate) [package insert]. Chesterbrook, Pennsylvania: Auxilium Pharmaceuticals, Inc.; 2014. [Link]

PMID: 16417650

Isosorbide Dinitrate

By

Isosorbide Dinitrate

Product: Beclometasone

Identifier : DBSNPE000564
Drug : DB00883 (Isosorbide Dinidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 8 c.637G>A

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Diladivate®-SR(isosorbide dinidivate) [package insert]. Chesterbrook, Pennsylvania: Auxilium Pharmaceuticals, Inc.; 2014. [Link]

PMID: 16780365

Isosorbide Dinitrate

By

Isosorbide Dinitrate

Product: Sulconazole (nitrate)

Identifier : DBSNPE000565
Drug : DB00883 (Isosorbide Dinidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 8 c.647T>C

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Diladivate®-SR(isosorbide dinidivate) [package insert]. Chesterbrook, Pennsylvania: Auxilium Pharmaceuticals, Inc.; 2014. [Link]

PMID: 17043237

Isosorbide Dinitrate

By

Isosorbide Dinitrate

Product: ZL006

Identifier : DBSNPE000566
Drug : DB00883 (Isosorbide Dinidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 8 c.650T>C

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Diladivate®-SR(isosorbide dinidivate) [package insert]. Chesterbrook, Pennsylvania: Auxilium Pharmaceuticals, Inc.; 2014. [Link]

PMID: 17053178

Isosorbide Dinitrate

By

Isosorbide Dinitrate

Product: Pymetrozine

Identifier : DBSNPE000567
Drug : DB00883 (Isosorbide Dinidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 8 c.655C>T

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Diladivate®-SR(isosorbide dinidivate) [package insert]. Chesterbrook, Pennsylvania: Auxilium Pharmaceuticals, Inc.; 2014. [Link]

PMID: 16835357

Isosorbide Dinitrate

By

Isosorbide Dinitrate

Product: Fondaparinux (sodium)

Identifier : DBSNPE000568
Drug : DB00883 (Isosorbide Dinidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 8 c.716T>G

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Diladivate®-SR(isosorbide dinidivate) [package insert]. Chesterbrook, Pennsylvania: Auxilium Pharmaceuticals, Inc.; 2014. [Link]

PMID: 17157789

Isosorbide Dinitrate

By

Isosorbide Dinitrate

Product: RIP2 kinase inhibitor 1

Identifier : DBSNPE000569
Drug : DB00883 (Isosorbide Dinidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 8 c.719A>G

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Diladivate®-SR(isosorbide dinidivate) [package insert]. Chesterbrook, Pennsylvania: Auxilium Pharmaceuticals, Inc.; 2014. [Link]

PMID: 16908847

Isosorbide Dinitrate

By

Isosorbide Dinitrate

Product: JNJ16259685

Identifier : DBSNPE000570
Drug : DB00883 (Isosorbide Dinidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 8 c.719A>G

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Diladivate®-SR(isosorbide dinidivate) [package insert]. Chesterbrook, Pennsylvania: Auxilium Pharmaceuticals, Inc.; 2014. [Link]

PMID: 16682622

Isosorbide Dinitrate

By

Isosorbide Dinitrate

Product: PSI-697

Identifier : DBSNPE000571
Drug : DB00883 (Isosorbide Dinidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 8 Not reported

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Diladivate®-SR(isosorbide dinidivate) [package insert]. Chesterbrook, Pennsylvania: Auxilium Pharmaceuticals, Inc.; 2014. [Link]

PMID: 15976055

Isosorbide Dinitrate

By

Isosorbide Dinitrate

Product: SCD inhibitor 1

Identifier : DBSNPE000572
Drug : DB00883 (Isosorbide Dinidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 9 c.757G>A

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Diladivate®-SR(isosorbide dinidivate) [package insert]. Chesterbrook, Pennsylvania: Auxilium Pharmaceuticals, Inc.; 2014. [Link]

PMID: 15496458

Isosorbide Dinitrate

By

Isosorbide Dinitrate

Product: trans-ACPD

Identifier : DBSNPE000573
Drug : DB00883 (Isosorbide Dinidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 9 c.757G>A

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Diladivate®-SR(isosorbide dinidivate) [package insert]. Chesterbrook, Pennsylvania: Auxilium Pharmaceuticals, Inc.; 2014. [Link]

PMID: 15528300

Isosorbide Dinitrate

By

Isosorbide Dinitrate

Product: Hemin

Identifier : DBSNPE000574
Drug : DB00883 (Isosorbide Dinidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 9 c.757G>A

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Diladivate®-SR(isosorbide dinidivate) [package insert]. Chesterbrook, Pennsylvania: Auxilium Pharmaceuticals, Inc.; 2014. [Link]

PMID: 15972514

Isosorbide Dinitrate

By

Isosorbide Dinitrate

Product: CCG215022

Identifier : DBSNPE000575
Drug : DB00883 (Isosorbide Dinidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 9 c.757G>A

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Diladivate®-SR(isosorbide dinidivate) [package insert]. Chesterbrook, Pennsylvania: Auxilium Pharmaceuticals, Inc.; 2014. [Link]

PMID: 16285913

Isosorbide Dinitrate

By

Isosorbide Dinitrate

Product: Endoxifen (E-isomer)

Identifier : DBSNPE000576
Drug : DB00883 (Isosorbide Dinidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 9 c.766_768del

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Diladivate®-SR(isosorbide dinidivate) [package insert]. Chesterbrook, Pennsylvania: Auxilium Pharmaceuticals, Inc.; 2014. [Link]

PMID: 15735050

Isosorbide Dinitrate

By

Isosorbide Dinitrate

Product: Endoxifen (hydrochloride)

Identifier : DBSNPE000577
Drug : DB00883 (Isosorbide Dinidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 9 c.775C>T

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Diladivate®-SR(isosorbide dinidivate) [package insert]. Chesterbrook, Pennsylvania: Auxilium Pharmaceuticals, Inc.; 2014. [Link]

PMID: 16011795

Isosorbide Dinitrate

By

Isosorbide Dinitrate

Product: BI-9564

Identifier : DBSNPE000578
Drug : DB00883 (Isosorbide Dinidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 9 c.815_817del

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Diladivate®-SR(isosorbide dinidivate) [package insert]. Chesterbrook, Pennsylvania: Auxilium Pharmaceuticals, Inc.; 2014. [Link]

PMID: 15677324

Isosorbide Dinitrate

By

Isosorbide Dinitrate

Product: BI-7273

Identifier : DBSNPE000579
Drug : DB00883 (Isosorbide Dinidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 9 c.827C>T

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Diladivate®-SR(isosorbide dinidivate) [package insert]. Chesterbrook, Pennsylvania: Auxilium Pharmaceuticals, Inc.; 2014. [Link]

PMID: 15808510

Isosorbide Dinitrate

By

Isosorbide Dinitrate

Product: AZD0156

Identifier : DBSNPE000580
Drug : DB00883 (Isosorbide Dinidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 9 c.875G>A

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Diladivate®-SR(isosorbide dinidivate) [package insert]. Chesterbrook, Pennsylvania: Auxilium Pharmaceuticals, Inc.; 2014. [Link]

PMID: 15994367

Isosorbide Dinitrate

By

Isosorbide Dinitrate

Product: Delamanid

Identifier : DBSNPE000581
Drug : DB00883 (Isosorbide Dinidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 9 c.875G>A

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Diladivate®-SR(isosorbide dinidivate) [package insert]. Chesterbrook, Pennsylvania: Auxilium Pharmaceuticals, Inc.; 2014. [Link]

PMID: 15642162

Isosorbide Dinitrate

By

Isosorbide Dinitrate

Product: o-Dianisidine (dihydrochloride)

Identifier : DBSNPE000583
Drug : DB00883 (Isosorbide Dinidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 9 c.882_884delinsAA

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Diladivate®-SR(isosorbide dinidivate) [package insert]. Chesterbrook, Pennsylvania: Auxilium Pharmaceuticals, Inc.; 2014. [Link]

PMID: 15531431

Isosorbide Dinitrate

By

Isosorbide Dinitrate

Product: Triethanolamine

Identifier : DBSNPE000584
Drug : DB00883 (Isosorbide Dinidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Exon 9 c.895_897del

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Diladivate®-SR(isosorbide dinidivate) [package insert]. Chesterbrook, Pennsylvania: Auxilium Pharmaceuticals, Inc.; 2014. [Link]

PMID: 15467735

Isosorbide Dinitrate

By

Isosorbide Dinitrate

Product: CCT245737

Identifier : DBSNPE000585
Drug : DB00883 (Isosorbide Dinidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Indivon 4 c.418-2A>G

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Diladivate®-SR(isosorbide dinidivate) [package insert]. Chesterbrook, Pennsylvania: Auxilium Pharmaceuticals, Inc.; 2014. [Link]

PMID: 15477866

Isosorbide Dinitrate

By

Isosorbide Dinitrate

Product: BRD9539

Identifier : DBSNPE000586
Drug : DB00883 (Isosorbide Dinidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Indivon 4 c.418-1G>A

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Diladivate®-SR(isosorbide dinidivate) [package insert]. Chesterbrook, Pennsylvania: Auxilium Pharmaceuticals, Inc.; 2014. [Link]

PMID: 15304487

Isosorbide Dinitrate

By

Isosorbide Dinitrate

Product: R1487 (Hydrochloride)

Identifier : DBSNPE000587
Drug : DB00883 (Isosorbide Dinidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Indivon 5 c.548

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Diladivate®-SR(isosorbide dinidivate) [package insert]. Chesterbrook, Pennsylvania: Auxilium Pharmaceuticals, Inc.; 2014. [Link]

PMID: 15310397

Isosorbide Dinitrate

By

Isosorbide Dinitrate

Product: Neferine

Identifier : DBSNPE000588
Drug : DB00883 (Isosorbide Dinidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Indivon 5 c.548

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Diladivate®-SR(isosorbide dinidivate) [package insert]. Chesterbrook, Pennsylvania: Auxilium Pharmaceuticals, Inc.; 2014. [Link]

PMID: 15318176

Isosorbide Dinitrate

By

Isosorbide Dinitrate

Product: Pristinamycin IA

Identifier : DBSNPE000589
Drug : DB00883 (Isosorbide Dinidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Indivon 5 c.547+2T>C

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Diladivate®-SR(isosorbide dinidivate) [package insert]. Chesterbrook, Pennsylvania: Auxilium Pharmaceuticals, Inc.; 2014. [Link]

PMID: 14699001

Isosorbide Dinitrate

By

Isosorbide Dinitrate

Product: GNE-3511

Identifier : DBSNPE000590
Drug : DB00883 (Isosorbide Dinidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Indivon 5 c.547+8G>C

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Diladivate®-SR(isosorbide dinidivate) [package insert]. Chesterbrook, Pennsylvania: Auxilium Pharmaceuticals, Inc.; 2014. [Link]

PMID: 15173068

Isosorbide Dinitrate

By

Isosorbide Dinitrate

Product: R 80123

Identifier : DBSNPE000591
Drug : DB00883 (Isosorbide Dinidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Indivon 6 c.631+1G>A

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Diladivate®-SR(isosorbide dinidivate) [package insert]. Chesterbrook, Pennsylvania: Auxilium Pharmaceuticals, Inc.; 2014. [Link]

PMID: 12676604

Isosorbide Dinitrate

By

Isosorbide Dinitrate

Product: Revizinone

Identifier : DBSNPE000592
Drug : DB00883 (Isosorbide Dinidivate)
Interacting Gene/Enzyme : NADH-cytochrome b5 reductase 3
Gene Name : CYB5R3
UniProt ID : P00387
Defining Change(s) :

  • Indivon 8 c.818-1G>T

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NADH methemoglobin reductase deficiency
Description : Risk of methemglobinemia.
References :

  1. Diladivate®-SR(isosorbide dinidivate) [package insert]. Chesterbrook, Pennsylvania: Auxilium Pharmaceuticals, Inc.; 2014. [Link]

PMID: 12700139

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