Isoflurane

Product: JK184

Identifier : DBSNPE000350
Drug : DB00753 (Isoflurane)
Interacting Gene/Enzyme : Voltage-dependent L-type calcium channel subunit alpha-1S
Gene Name : CACNA1S
UniProt ID : Q13698
Defining Change(s) :

  • c.3257G>A (rs1800559 )

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Forane® (isoflurane, USP) [package insert]. Deerfield, Illinois: Baxter Healthcare Corporation; 2010. [Link]

PMID: 22209345

Isoflurane

Product: Ensartinib

Identifier : DBSNPE000351
Drug : DB00753 (Isoflurane)
Interacting Gene/Enzyme : Voltage-dependent L-type calcium channel subunit alpha-1S
Gene Name : CACNA1S
UniProt ID : Q13698
Defining Change(s) :

  • c.520C>T (rs772226819 )

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Forane® (isoflurane, USP) [package insert]. Deerfield, Illinois: Baxter Healthcare Corporation; 2010. [Link]

PMID: 22908233

Isoflurane

Product: Dehydroisoandrosterone 3-acetate

Identifier : DBSNPE000352
Drug : DB00753 (Isoflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.103T>C (rs193922747 )

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Forane® (isoflurane, USP) [package insert]. Deerfield, Illinois: Baxter Healthcare Corporation; 2010. [Link]

PMID: 21536586

Isoflurane

Product: Pemafibrate

Identifier : DBSNPE000353
Drug : DB00753 (Isoflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.487C>T (rs118192161 )

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Forane® (isoflurane, USP) [package insert]. Deerfield, Illinois: Baxter Healthcare Corporation; 2010. [Link]

PMID: 21182085

Isoflurane

Product: PF06650833

Identifier : DBSNPE000354
Drug : DB00753 (Isoflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.488G>T (rs193922753 )

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Forane® (isoflurane, USP) [package insert]. Deerfield, Illinois: Baxter Healthcare Corporation; 2010. [Link]

PMID: 21518785

Isoflurane

Product: Erythromycin Cyclocarbonate

Identifier : DBSNPE000355
Drug : DB00753 (Isoflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.742G>A (rs1801086 )

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Forane® (isoflurane, USP) [package insert]. Deerfield, Illinois: Baxter Healthcare Corporation; 2010. [Link]

PMID: 21356374

Isoflurane

Product: E7820

Identifier : DBSNPE000356
Drug : DB00753 (Isoflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.742G>C (rs1801086 )

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Forane® (isoflurane, USP) [package insert]. Deerfield, Illinois: Baxter Healthcare Corporation; 2010. [Link]

PMID: 21492444

Isoflurane

Product: BX517

Identifier : DBSNPE000357
Drug : DB00753 (Isoflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.1021G>A (rs121918592 )

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Forane® (isoflurane, USP) [package insert]. Deerfield, Illinois: Baxter Healthcare Corporation; 2010. [Link]

PMID: 21803942

Isoflurane

Product: Leonurine

Identifier : DBSNPE000358
Drug : DB00753 (Isoflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.1209C>G (rs118192116 )

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Forane® (isoflurane, USP) [package insert]. Deerfield, Illinois: Baxter Healthcare Corporation; 2010. [Link]

PMID: 21533185

Isoflurane

Product: Ketanserin (tartrate)

Identifier : DBSNPE000359
Drug : DB00753 (Isoflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.1565A>C (rs118192162 )

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Forane® (isoflurane, USP) [package insert]. Deerfield, Illinois: Baxter Healthcare Corporation; 2010. [Link]

PMID: 21818323

Isoflurane

Product: Rotenone

Identifier : DBSNPE000360
Drug : DB00753 (Isoflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.1589G>A

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Forane® (isoflurane, USP) [package insert]. Deerfield, Illinois: Baxter Healthcare Corporation; 2010. [Link]

PMID: 20733032

Isoflurane

Product: BAPTA

Identifier : DBSNPE000361
Drug : DB00753 (Isoflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.1654C>T (rs193922770 )

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Forane® (isoflurane, USP) [package insert]. Deerfield, Illinois: Baxter Healthcare Corporation; 2010. [Link]

PMID: 20448060

Isoflurane

Product: AM-2394

Identifier : DBSNPE000362
Drug : DB00753 (Isoflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.1840C>T (rs118192172 )

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Forane® (isoflurane, USP) [package insert]. Deerfield, Illinois: Baxter Healthcare Corporation; 2010. [Link]

PMID: 20696772

Isoflurane

Product: GSK2256098

Identifier : DBSNPE000363
Drug : DB00753 (Isoflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.1841G>T (rs193922772 )

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Forane® (isoflurane, USP) [package insert]. Deerfield, Illinois: Baxter Healthcare Corporation; 2010. [Link]

PMID: 19897485

Isoflurane

Product: RAF709

Identifier : DBSNPE000364
Drug : DB00753 (Isoflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.6487C>T (rs118192175 )

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Forane® (isoflurane, USP) [package insert]. Deerfield, Illinois: Baxter Healthcare Corporation; 2010. [Link]

PMID: 19008331

Isoflurane

Product: VU0364770

Identifier : DBSNPE000365
Drug : DB00753 (Isoflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.6488G>A (rs118192163 )

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Forane® (isoflurane, USP) [package insert]. Deerfield, Illinois: Baxter Healthcare Corporation; 2010. [Link]

PMID: 18950659

Isoflurane

Product: Rbin-1

Identifier : DBSNPE000366
Drug : DB00753 (Isoflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.6502G>A (rs118192176 )

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Forane® (isoflurane, USP) [package insert]. Deerfield, Illinois: Baxter Healthcare Corporation; 2010. [Link]

PMID: 19477925

Isoflurane

Product: Piperoxan (hydrochloride)

Identifier : DBSNPE000367
Drug : DB00753 (Isoflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.6617C>G (rs118192177 )

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Forane® (isoflurane, USP) [package insert]. Deerfield, Illinois: Baxter Healthcare Corporation; 2010. [Link]

PMID: 19211805

Isoflurane

Product: Leonurine (hydrochloride)

Identifier : DBSNPE000368
Drug : DB00753 (Isoflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.6617C>T (rs118192177 )

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Forane® (isoflurane, USP) [package insert]. Deerfield, Illinois: Baxter Healthcare Corporation; 2010. [Link]

PMID: 18974111

Isoflurane

Product: Impurity of Doxercalciferol

Identifier : DBSNPE000369
Drug : DB00753 (Isoflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.7007G>A

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Forane® (isoflurane, USP) [package insert]. Deerfield, Illinois: Baxter Healthcare Corporation; 2010. [Link]

PMID: 18317592

Isoflurane

Product: Dehydrocorydaline (chloride)

Identifier : DBSNPE000370
Drug : DB00753 (Isoflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.7048G>A (rs193922802 )

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Forane® (isoflurane, USP) [package insert]. Deerfield, Illinois: Baxter Healthcare Corporation; 2010. [Link]

PMID: 18177995

Isoflurane

Product: Epiberberine (chloride)

Identifier : DBSNPE000371
Drug : DB00753 (Isoflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.7124G>C (rs193922807 )

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Forane® (isoflurane, USP) [package insert]. Deerfield, Illinois: Baxter Healthcare Corporation; 2010. [Link]

PMID: 18354059

Isoflurane

Product: Menadione bisulfite (sodium)

Identifier : DBSNPE000372
Drug : DB00753 (Isoflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.7282G>A (rs193922809 )

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Forane® (isoflurane, USP) [package insert]. Deerfield, Illinois: Baxter Healthcare Corporation; 2010. [Link]

PMID: 18505969

Isoflurane

Product: L-Ascorbic acid (sodium)

Identifier : DBSNPE000373
Drug : DB00753 (Isoflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.7300G>A (rs121918593 )

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Forane® (isoflurane, USP) [package insert]. Deerfield, Illinois: Baxter Healthcare Corporation; 2010. [Link]

PMID: 18339713

Isoflurane

Product: ARS-853

Identifier : DBSNPE000374
Drug : DB00753 (Isoflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.7304G>A (rs28933396 )

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Forane® (isoflurane, USP) [package insert]. Deerfield, Illinois: Baxter Healthcare Corporation; 2010. [Link]

PMID: 18566133

Isoflurane

Product: Monepantel

Identifier : DBSNPE000375
Drug : DB00753 (Isoflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.7360C>T (rs193922816 )

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Forane® (isoflurane, USP) [package insert]. Deerfield, Illinois: Baxter Healthcare Corporation; 2010. [Link]

PMID: 18644836

Isoflurane

Product: Ketanserin

Identifier : DBSNPE000376
Drug : DB00753 (Isoflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.7361G>A (rs118192122 )

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Forane® (isoflurane, USP) [package insert]. Deerfield, Illinois: Baxter Healthcare Corporation; 2010. [Link]

PMID: 18310301

Isoflurane

Product: (R)-Flurbiprofen

Identifier : DBSNPE000377
Drug : DB00753 (Isoflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.7372C>T (rs28933397 )

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Forane® (isoflurane, USP) [package insert]. Deerfield, Illinois: Baxter Healthcare Corporation; 2010. [Link]

PMID: 17320868

Isoflurane

Product: JPH203

Identifier : DBSNPE000378
Drug : DB00753 (Isoflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.7373G>A (rs121918594 )

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Forane® (isoflurane, USP) [package insert]. Deerfield, Illinois: Baxter Healthcare Corporation; 2010. [Link]

PMID: 17272673

Isoflurane

Product: ASK1-IN-1

Identifier : DBSNPE000379
Drug : DB00753 (Isoflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.7522C>T (rs118192178 )

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Forane® (isoflurane, USP) [package insert]. Deerfield, Illinois: Baxter Healthcare Corporation; 2010. [Link]

PMID: 17493623

Isoflurane

Product: URB602

Identifier : DBSNPE000380
Drug : DB00753 (Isoflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.7523G>A

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Forane® (isoflurane, USP) [package insert]. Deerfield, Illinois: Baxter Healthcare Corporation; 2010. [Link]

PMID: 17785421

Isoflurane

Product: NSC23005 (sodium)

Identifier : DBSNPE000381
Drug : DB00753 (Isoflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.14387A>G (rs118192167 )

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Forane® (isoflurane, USP) [package insert]. Deerfield, Illinois: Baxter Healthcare Corporation; 2010. [Link]

PMID: 17332286

Isoflurane

Product: Sophoflavescenol

Identifier : DBSNPE000382
Drug : DB00753 (Isoflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.14477C>T (rs121918595 )

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Forane® (isoflurane, USP) [package insert]. Deerfield, Illinois: Baxter Healthcare Corporation; 2010. [Link]

PMID: 16627587

Isoflurane

Product: Phorbol

Identifier : DBSNPE000383
Drug : DB00753 (Isoflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.14497C>T

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Forane® (isoflurane, USP) [package insert]. Deerfield, Illinois: Baxter Healthcare Corporation; 2010. [Link]

PMID: 17062671

Isoflurane

Product: Epoxymicheliolide

Identifier : DBSNPE000384
Drug : DB00753 (Isoflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.14512C>G (rs193922878 )

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Forane® (isoflurane, USP) [package insert]. Deerfield, Illinois: Baxter Healthcare Corporation; 2010. [Link]

PMID: 16965620

Isoflurane

Product: Protodioscin

Identifier : DBSNPE000385
Drug : DB00753 (Isoflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.14582G>A (rs63749869 )

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Forane® (isoflurane, USP) [package insert]. Deerfield, Illinois: Baxter Healthcare Corporation; 2010. [Link]

PMID: 16223864

Isoflurane

Product: Hederacoside D

Identifier : DBSNPE000386
Drug : DB00753 (Isoflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.14693T>C (rs118192170 )

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Forane® (isoflurane, USP) [package insert]. Deerfield, Illinois: Baxter Healthcare Corporation; 2010. [Link]

PMID: 16007178

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