PI3KInhibitorpi3kinhibitor

Hydralazine

By

Hydralazine

Product: Tanshinone I

Identifier : DBSNPE000387
Drug : DB01275 (Hydralazine)
Interacting Gene/Enzyme : Arylamine N-acetyldivansferase 1
Gene Name : NAT1
UniProt ID : P18440
Defining Change(s) :

  • G > A | T > A | C > A (rs4986782 )

Allele Name : NAT1*14A
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NAT slow acetylators
Description : Associated with systemic lupus erythematosus.
References :

  1. Sim E, Abuhammad A, Ryan A: Arylamine N-acetyldivansferases: from drug metabolism and pharmacogenetics to drug discovery. Br J Pharmacol. 2014 Jun;171(11):2705-25. doi: 10.1111/bph.12598. [PubMed:24467436 ]
  2. McDonagh EM, Boukouvala S, Aklillu E, Hein DW, Altman RB, Klein TE: PharmGKB summary: very important pharmacogene information for N-acetyldivansferase 2. Pharmacogenet Genomics. 2014 Aug;24(8):409-25. doi: 10.1097/FPC.0000000000000062. [PubMed:24892773 ]

PMID: 16322326

Hydralazine

By

Hydralazine

Product: Phorbol 12-myristate 13-acetate

Identifier : DBSNPE000388
Drug : DB01275 (Hydralazine)
Interacting Gene/Enzyme : Arylamine N-acetyldivansferase 1
Gene Name : NAT1
UniProt ID : P18440
Defining Change(s) :

  • G > A (rs4986782 )

Allele Name : NAT1*14B
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NAT slow acetylators
Description : Associated with systemic lupus erythematosus.
References :

  1. Sim E, Abuhammad A, Ryan A: Arylamine N-acetyldivansferases: from drug metabolism and pharmacogenetics to drug discovery. Br J Pharmacol. 2014 Jun;171(11):2705-25. doi: 10.1111/bph.12598. [PubMed:24467436 ]
  2. McDonagh EM, Boukouvala S, Aklillu E, Hein DW, Altman RB, Klein TE: PharmGKB summary: very important pharmacogene information for N-acetyldivansferase 2. Pharmacogenet Genomics. 2014 Aug;24(8):409-25. doi: 10.1097/FPC.0000000000000062. [PubMed:24892773 ]

PMID: 16219765

Hydralazine

By

Hydralazine

Product: Basmisanil

Identifier : DBSNPE000389
Drug : DB01275 (Hydralazine)
Interacting Gene/Enzyme : Arylamine N-acetyldivansferase 1
Gene Name : NAT1
UniProt ID : P18440
Defining Change(s) :

  • C > T (rs5030839 )

Allele Name : NAT1*15
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NAT slow acetylators
Description : Associated with systemic lupus erythematosus.
References :

  1. Sim E, Abuhammad A, Ryan A: Arylamine N-acetyldivansferases: from drug metabolism and pharmacogenetics to drug discovery. Br J Pharmacol. 2014 Jun;171(11):2705-25. doi: 10.1111/bph.12598. [PubMed:24467436 ]
  2. McDonagh EM, Boukouvala S, Aklillu E, Hein DW, Altman RB, Klein TE: PharmGKB summary: very important pharmacogene information for N-acetyldivansferase 2. Pharmacogenet Genomics. 2014 Aug;24(8):409-25. doi: 10.1097/FPC.0000000000000062. [PubMed:24892773 ]

PMID: 14500565

Hydralazine

By

Hydralazine

Product: Bromocriptine (mesylate)

Identifier : DBSNPE000390
Drug : DB01275 (Hydralazine)
Interacting Gene/Enzyme : Arylamine N-acetyldivansferase 1
Gene Name : NAT1
UniProt ID : P18440
Defining Change(s) :

  • C > T (rs56379106 )

Allele Name : NAT1*17
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NAT slow acetylators
Description : Associated with systemic lupus erythematosus.
References :

  1. Sim E, Abuhammad A, Ryan A: Arylamine N-acetyldivansferases: from drug metabolism and pharmacogenetics to drug discovery. Br J Pharmacol. 2014 Jun;171(11):2705-25. doi: 10.1111/bph.12598. [PubMed:24467436 ]
  2. McDonagh EM, Boukouvala S, Aklillu E, Hein DW, Altman RB, Klein TE: PharmGKB summary: very important pharmacogene information for N-acetyldivansferase 2. Pharmacogenet Genomics. 2014 Aug;24(8):409-25. doi: 10.1097/FPC.0000000000000062. [PubMed:24892773 ]

PMID: 22122563

Hydralazine

By

Hydralazine

Product: Beclabuvir

Identifier : DBSNPE000391
Drug : DB01275 (Hydralazine)
Interacting Gene/Enzyme : Arylamine N-acetyldivansferase 1
Gene Name : NAT1
UniProt ID : P18440
Defining Change(s) :

  • C > T (rs56318881 )

Allele Name : NAT1*19A
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NAT slow acetylators
Description : Associated with systemic lupus erythematosus.
References :

  1. Sim E, Abuhammad A, Ryan A: Arylamine N-acetyldivansferases: from drug metabolism and pharmacogenetics to drug discovery. Br J Pharmacol. 2014 Jun;171(11):2705-25. doi: 10.1111/bph.12598. [PubMed:24467436 ]
  2. McDonagh EM, Boukouvala S, Aklillu E, Hein DW, Altman RB, Klein TE: PharmGKB summary: very important pharmacogene information for N-acetyldivansferase 2. Pharmacogenet Genomics. 2014 Aug;24(8):409-25. doi: 10.1097/FPC.0000000000000062. [PubMed:24892773 ]

PMID: 19074580

Hydralazine

By

Hydralazine

Product: YM-58483

Identifier : DBSNPE000392
Drug : DB01275 (Hydralazine)
Interacting Gene/Enzyme : Arylamine N-acetyldivansferase 1
Gene Name : NAT1
UniProt ID : P18440
Defining Change(s) :

  • C > T | C > T (rs56318881 )

Allele Name : NAT1*19B
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NAT slow acetylators
Description : Associated with systemic lupus erythematosus.
References :

  1. Sim E, Abuhammad A, Ryan A: Arylamine N-acetyldivansferases: from drug metabolism and pharmacogenetics to drug discovery. Br J Pharmacol. 2014 Jun;171(11):2705-25. doi: 10.1111/bph.12598. [PubMed:24467436 ]
  2. McDonagh EM, Boukouvala S, Aklillu E, Hein DW, Altman RB, Klein TE: PharmGKB summary: very important pharmacogene information for N-acetyldivansferase 2. Pharmacogenet Genomics. 2014 Aug;24(8):409-25. doi: 10.1097/FPC.0000000000000062. [PubMed:24892773 ]

PMID: 15713377

Hydralazine

By

Hydralazine

Product: BGP-15

Identifier : DBSNPE000393
Drug : DB01275 (Hydralazine)
Interacting Gene/Enzyme : Arylamine N-acetyldivansferase 1
Gene Name : NAT1
UniProt ID : P18440
Defining Change(s) :

  • A > T (rs56172717 )

Allele Name : NAT1*22
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NAT slow acetylators
Description : Associated with systemic lupus erythematosus.
References :

  1. Sim E, Abuhammad A, Ryan A: Arylamine N-acetyldivansferases: from drug metabolism and pharmacogenetics to drug discovery. Br J Pharmacol. 2014 Jun;171(11):2705-25. doi: 10.1111/bph.12598. [PubMed:24467436 ]
  2. McDonagh EM, Boukouvala S, Aklillu E, Hein DW, Altman RB, Klein TE: PharmGKB summary: very important pharmacogene information for N-acetyldivansferase 2. Pharmacogenet Genomics. 2014 Aug;24(8):409-25. doi: 10.1097/FPC.0000000000000062. [PubMed:24892773 ]

PMID: 26627478

Hydralazine

By

Hydralazine

Product: Ribitol

Identifier : DBSNPE000394
Drug : DB01275 (Hydralazine)
Interacting Gene/Enzyme : Arylamine N-acetyldivansferase 2
Gene Name : NAT2
UniProt ID : P11245
Defining Change(s) :

  • T > C | C > T (rs1801280 )

Allele Name : NAT2*5A
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NAT slow acetylators
Description : Associated with systemic lupus erythematosus.
References :

  1. Sim E, Abuhammad A, Ryan A: Arylamine N-acetyldivansferases: from drug metabolism and pharmacogenetics to drug discovery. Br J Pharmacol. 2014 Jun;171(11):2705-25. doi: 10.1111/bph.12598. [PubMed:24467436 ]
  2. McDonagh EM, Boukouvala S, Aklillu E, Hein DW, Altman RB, Klein TE: PharmGKB summary: very important pharmacogene information for N-acetyldivansferase 2. Pharmacogenet Genomics. 2014 Aug;24(8):409-25. doi: 10.1097/FPC.0000000000000062. [PubMed:24892773 ]

PMID: 23360481

Hydralazine

By

Hydralazine

Product: BFH772

Identifier : DBSNPE000395
Drug : DB01275 (Hydralazine)
Interacting Gene/Enzyme : Arylamine N-acetyldivansferase 2
Gene Name : NAT2
UniProt ID : P11245
Defining Change(s) :

  • T > C | C > T | A > G (rs1801280 )

Allele Name : NAT2*5B
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NAT slow acetylators
Description : Associated with systemic lupus erythematosus.
References :

  1. Sim E, Abuhammad A, Ryan A: Arylamine N-acetyldivansferases: from drug metabolism and pharmacogenetics to drug discovery. Br J Pharmacol. 2014 Jun;171(11):2705-25. doi: 10.1111/bph.12598. [PubMed:24467436 ]
  2. McDonagh EM, Boukouvala S, Aklillu E, Hein DW, Altman RB, Klein TE: PharmGKB summary: very important pharmacogene information for N-acetyldivansferase 2. Pharmacogenet Genomics. 2014 Aug;24(8):409-25. doi: 10.1097/FPC.0000000000000062. [PubMed:24892773 ]

PMID: 24053666

Hydralazine

By

Hydralazine

Product: SKF89976A (hydrochloride)

Identifier : DBSNPE000396
Drug : DB01275 (Hydralazine)
Interacting Gene/Enzyme : Arylamine N-acetyldivansferase 2
Gene Name : NAT2
UniProt ID : P11245
Defining Change(s) :

  • T > C | A > G (rs1801280 )

Allele Name : NAT2*5C
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NAT slow acetylators
Description : Associated with systemic lupus erythematosus.
References :

  1. Sim E, Abuhammad A, Ryan A: Arylamine N-acetyldivansferases: from drug metabolism and pharmacogenetics to drug discovery. Br J Pharmacol. 2014 Jun;171(11):2705-25. doi: 10.1111/bph.12598. [PubMed:24467436 ]
  2. McDonagh EM, Boukouvala S, Aklillu E, Hein DW, Altman RB, Klein TE: PharmGKB summary: very important pharmacogene information for N-acetyldivansferase 2. Pharmacogenet Genomics. 2014 Aug;24(8):409-25. doi: 10.1097/FPC.0000000000000062. [PubMed:24892773 ]

PMID: 19822186

Hydralazine

By

Hydralazine

Product: TPEN

Identifier : DBSNPE000397
Drug : DB01275 (Hydralazine)
Interacting Gene/Enzyme : Arylamine N-acetyldivansferase 2
Gene Name : NAT2
UniProt ID : P11245
Defining Change(s) :

  • T > C (rs1801280 )

Allele Name : NAT2*5D
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NAT slow acetylators
Description : Associated with systemic lupus erythematosus.
References :

  1. Sim E, Abuhammad A, Ryan A: Arylamine N-acetyldivansferases: from drug metabolism and pharmacogenetics to drug discovery. Br J Pharmacol. 2014 Jun;171(11):2705-25. doi: 10.1111/bph.12598. [PubMed:24467436 ]
  2. McDonagh EM, Boukouvala S, Aklillu E, Hein DW, Altman RB, Klein TE: PharmGKB summary: very important pharmacogene information for N-acetyldivansferase 2. Pharmacogenet Genomics. 2014 Aug;24(8):409-25. doi: 10.1097/FPC.0000000000000062. [PubMed:24892773 ]

PMID: 18097065

Hydralazine

By

Hydralazine

Product: LM22A-4

Identifier : DBSNPE000398
Drug : DB01275 (Hydralazine)
Interacting Gene/Enzyme : Arylamine N-acetyldivansferase 2
Gene Name : NAT2
UniProt ID : P11245
Defining Change(s) :

  • T > C | G > A (rs1801280 )

Allele Name : NAT2*5E
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NAT slow acetylators
Description : Associated with systemic lupus erythematosus.
References :

  1. Sim E, Abuhammad A, Ryan A: Arylamine N-acetyldivansferases: from drug metabolism and pharmacogenetics to drug discovery. Br J Pharmacol. 2014 Jun;171(11):2705-25. doi: 10.1111/bph.12598. [PubMed:24467436 ]
  2. McDonagh EM, Boukouvala S, Aklillu E, Hein DW, Altman RB, Klein TE: PharmGKB summary: very important pharmacogene information for N-acetyldivansferase 2. Pharmacogenet Genomics. 2014 Aug;24(8):409-25. doi: 10.1097/FPC.0000000000000062. [PubMed:24892773 ]

PMID: 15456246

Hydralazine

By

Hydralazine

Product: Biotin Hydrazide

Identifier : DBSNPE000399
Drug : DB01275 (Hydralazine)
Interacting Gene/Enzyme : Arylamine N-acetyldivansferase 2
Gene Name : NAT2
UniProt ID : P11245
Defining Change(s) :

  • T > C | C > T | C > T | A > G (rs1801280 )

Allele Name : NAT2*5F
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NAT slow acetylators
Description : Associated with systemic lupus erythematosus.
References :

  1. Sim E, Abuhammad A, Ryan A: Arylamine N-acetyldivansferases: from drug metabolism and pharmacogenetics to drug discovery. Br J Pharmacol. 2014 Jun;171(11):2705-25. doi: 10.1111/bph.12598. [PubMed:24467436 ]
  2. McDonagh EM, Boukouvala S, Aklillu E, Hein DW, Altman RB, Klein TE: PharmGKB summary: very important pharmacogene information for N-acetyldivansferase 2. Pharmacogenet Genomics. 2014 Aug;24(8):409-25. doi: 10.1097/FPC.0000000000000062. [PubMed:24892773 ]

PMID: 14500559

Hydralazine

By

Hydralazine

Product: Pemafibrate (racemate)

Identifier : DBSNPE000400
Drug : DB01275 (Hydralazine)
Interacting Gene/Enzyme : Arylamine N-acetyldivansferase 2
Gene Name : NAT2
UniProt ID : P11245
Defining Change(s) :

  • T > C | C > T | C > T | A > G (rs1801280 )

Allele Name : NAT2*5G
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NAT slow acetylators
Description : Associated with systemic lupus erythematosus.
References :

  1. Sim E, Abuhammad A, Ryan A: Arylamine N-acetyldivansferases: from drug metabolism and pharmacogenetics to drug discovery. Br J Pharmacol. 2014 Jun;171(11):2705-25. doi: 10.1111/bph.12598. [PubMed:24467436 ]
  2. McDonagh EM, Boukouvala S, Aklillu E, Hein DW, Altman RB, Klein TE: PharmGKB summary: very important pharmacogene information for N-acetyldivansferase 2. Pharmacogenet Genomics. 2014 Aug;24(8):409-25. doi: 10.1097/FPC.0000000000000062. [PubMed:24892773 ]

PMID: 12351713

Hydralazine

By

Hydralazine

Product: ZSET1446

Identifier : DBSNPE000401
Drug : DB01275 (Hydralazine)
Interacting Gene/Enzyme : Arylamine N-acetyldivansferase 2
Gene Name : NAT2
UniProt ID : P11245
Defining Change(s) :

  • T > C | C > T | A > G | S287 Frameshift (rs1801280 )

Allele Name : NAT2*5H
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NAT slow acetylators
Description : Associated with systemic lupus erythematosus.
References :

  1. Sim E, Abuhammad A, Ryan A: Arylamine N-acetyldivansferases: from drug metabolism and pharmacogenetics to drug discovery. Br J Pharmacol. 2014 Jun;171(11):2705-25. doi: 10.1111/bph.12598. [PubMed:24467436 ]
  2. McDonagh EM, Boukouvala S, Aklillu E, Hein DW, Altman RB, Klein TE: PharmGKB summary: very important pharmacogene information for N-acetyldivansferase 2. Pharmacogenet Genomics. 2014 Aug;24(8):409-25. doi: 10.1097/FPC.0000000000000062. [PubMed:24892773 ]

PMID: 9048584

Hydralazine

By

Hydralazine

Product: FGFR-IN-1

Identifier : DBSNPE000402
Drug : DB01275 (Hydralazine)
Interacting Gene/Enzyme : Arylamine N-acetyldivansferase 2
Gene Name : NAT2
UniProt ID : P11245
Defining Change(s) :

  • T > C | C > T | A > T | A > G (rs1801280 )

Allele Name : NAT2*5I
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NAT slow acetylators
Description : Associated with systemic lupus erythematosus.
References :

  1. Sim E, Abuhammad A, Ryan A: Arylamine N-acetyldivansferases: from drug metabolism and pharmacogenetics to drug discovery. Br J Pharmacol. 2014 Jun;171(11):2705-25. doi: 10.1111/bph.12598. [PubMed:24467436 ]
  2. McDonagh EM, Boukouvala S, Aklillu E, Hein DW, Altman RB, Klein TE: PharmGKB summary: very important pharmacogene information for N-acetyldivansferase 2. Pharmacogenet Genomics. 2014 Aug;24(8):409-25. doi: 10.1097/FPC.0000000000000062. [PubMed:24892773 ]

PMID: 25888817

Hydralazine

By

Hydralazine

Product: SR12813

Identifier : DBSNPE000403
Drug : DB01275 (Hydralazine)
Interacting Gene/Enzyme : Arylamine N-acetyldivansferase 2
Gene Name : NAT2
UniProt ID : P11245
Defining Change(s) :

  • T > C | C > T | G > A (rs1801280 )

Allele Name : NAT2*5J
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NAT slow acetylators
Description : Associated with systemic lupus erythematosus.
References :

  1. Sim E, Abuhammad A, Ryan A: Arylamine N-acetyldivansferases: from drug metabolism and pharmacogenetics to drug discovery. Br J Pharmacol. 2014 Jun;171(11):2705-25. doi: 10.1111/bph.12598. [PubMed:24467436 ]
  2. McDonagh EM, Boukouvala S, Aklillu E, Hein DW, Altman RB, Klein TE: PharmGKB summary: very important pharmacogene information for N-acetyldivansferase 2. Pharmacogenet Genomics. 2014 Aug;24(8):409-25. doi: 10.1097/FPC.0000000000000062. [PubMed:24892773 ]

PMID: 22696683

Hydralazine

By

Hydralazine

Product: Fosfluconazole

Identifier : DBSNPE000404
Drug : DB01275 (Hydralazine)
Interacting Gene/Enzyme : Arylamine N-acetyldivansferase 2
Gene Name : NAT2
UniProt ID : P11245
Defining Change(s) :

  • G > A | C > T (rs1799930 )

Allele Name : NAT2*6A
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NAT slow acetylators
Description : Associated with systemic lupus erythematosus.
References :

  1. Sim E, Abuhammad A, Ryan A: Arylamine N-acetyldivansferases: from drug metabolism and pharmacogenetics to drug discovery. Br J Pharmacol. 2014 Jun;171(11):2705-25. doi: 10.1111/bph.12598. [PubMed:24467436 ]
  2. McDonagh EM, Boukouvala S, Aklillu E, Hein DW, Altman RB, Klein TE: PharmGKB summary: very important pharmacogene information for N-acetyldivansferase 2. Pharmacogenet Genomics. 2014 Aug;24(8):409-25. doi: 10.1097/FPC.0000000000000062. [PubMed:24892773 ]

PMID: 15539556

Hydralazine

By

Hydralazine

Product: D-Glutamine

Identifier : DBSNPE000405
Drug : DB01275 (Hydralazine)
Interacting Gene/Enzyme : Arylamine N-acetyldivansferase 2
Gene Name : NAT2
UniProt ID : P11245
Defining Change(s) :

  • G > A (rs1799930 )

Allele Name : NAT2*6B
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NAT slow acetylators
Description : Associated with systemic lupus erythematosus.
References :

  1. Sim E, Abuhammad A, Ryan A: Arylamine N-acetyldivansferases: from drug metabolism and pharmacogenetics to drug discovery. Br J Pharmacol. 2014 Jun;171(11):2705-25. doi: 10.1111/bph.12598. [PubMed:24467436 ]
  2. McDonagh EM, Boukouvala S, Aklillu E, Hein DW, Altman RB, Klein TE: PharmGKB summary: very important pharmacogene information for N-acetyldivansferase 2. Pharmacogenet Genomics. 2014 Aug;24(8):409-25. doi: 10.1097/FPC.0000000000000062. [PubMed:24892773 ]

PMID: 23239970

Hydralazine

By

Hydralazine

Product: Asarylaldehyde

Identifier : DBSNPE000406
Drug : DB01275 (Hydralazine)
Interacting Gene/Enzyme : Arylamine N-acetyldivansferase 2
Gene Name : NAT2
UniProt ID : P11245
Defining Change(s) :

  • G > A | C > T | A > G (rs1799930 )

Allele Name : NAT2*6C
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NAT slow acetylators
Description : Associated with systemic lupus erythematosus.
References :

  1. Sim E, Abuhammad A, Ryan A: Arylamine N-acetyldivansferases: from drug metabolism and pharmacogenetics to drug discovery. Br J Pharmacol. 2014 Jun;171(11):2705-25. doi: 10.1111/bph.12598. [PubMed:24467436 ]
  2. McDonagh EM, Boukouvala S, Aklillu E, Hein DW, Altman RB, Klein TE: PharmGKB summary: very important pharmacogene information for N-acetyldivansferase 2. Pharmacogenet Genomics. 2014 Aug;24(8):409-25. doi: 10.1097/FPC.0000000000000062. [PubMed:24892773 ]

PMID: 19128016

Hydralazine

By

Hydralazine

Product: Tempol

Identifier : DBSNPE000407
Drug : DB01275 (Hydralazine)
Interacting Gene/Enzyme : Arylamine N-acetyldivansferase 2
Gene Name : NAT2
UniProt ID : P11245
Defining Change(s) :

  • G > A | C > T | T > C (rs1799930 )

Allele Name : NAT2*6D
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NAT slow acetylators
Description : Associated with systemic lupus erythematosus.
References :

  1. Sim E, Abuhammad A, Ryan A: Arylamine N-acetyldivansferases: from drug metabolism and pharmacogenetics to drug discovery. Br J Pharmacol. 2014 Jun;171(11):2705-25. doi: 10.1111/bph.12598. [PubMed:24467436 ]
  2. McDonagh EM, Boukouvala S, Aklillu E, Hein DW, Altman RB, Klein TE: PharmGKB summary: very important pharmacogene information for N-acetyldivansferase 2. Pharmacogenet Genomics. 2014 Aug;24(8):409-25. doi: 10.1097/FPC.0000000000000062. [PubMed:24892773 ]

PMID: 16515477

Hydralazine

By

Hydralazine

Product: D-alpha-Hydroxyglutaric acid (disodium salt)

Identifier : DBSNPE000408
Drug : DB01275 (Hydralazine)
Interacting Gene/Enzyme : Arylamine N-acetyldivansferase 2
Gene Name : NAT2
UniProt ID : P11245
Defining Change(s) :

  • G > A | C > T (rs1799930 )

Allele Name : NAT2*6E
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NAT slow acetylators
Description : Associated with systemic lupus erythematosus.
References :

  1. Sim E, Abuhammad A, Ryan A: Arylamine N-acetyldivansferases: from drug metabolism and pharmacogenetics to drug discovery. Br J Pharmacol. 2014 Jun;171(11):2705-25. doi: 10.1111/bph.12598. [PubMed:24467436 ]
  2. McDonagh EM, Boukouvala S, Aklillu E, Hein DW, Altman RB, Klein TE: PharmGKB summary: very important pharmacogene information for N-acetyldivansferase 2. Pharmacogenet Genomics. 2014 Aug;24(8):409-25. doi: 10.1097/FPC.0000000000000062. [PubMed:24892773 ]

PMID: 16990259

Hydralazine

By

Hydralazine

Product: 4,7-Dimethoxyisoflavone

Identifier : DBSNPE000409
Drug : DB01275 (Hydralazine)
Interacting Gene/Enzyme : Arylamine N-acetyldivansferase 2
Gene Name : NAT2
UniProt ID : P11245
Defining Change(s) :

  • G > A (rs1799931 )

Allele Name : NAT2*7A
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NAT slow acetylators
Description : Associated with systemic lupus erythematosus.
References :

  1. Sim E, Abuhammad A, Ryan A: Arylamine N-acetyldivansferases: from drug metabolism and pharmacogenetics to drug discovery. Br J Pharmacol. 2014 Jun;171(11):2705-25. doi: 10.1111/bph.12598. [PubMed:24467436 ]
  2. McDonagh EM, Boukouvala S, Aklillu E, Hein DW, Altman RB, Klein TE: PharmGKB summary: very important pharmacogene information for N-acetyldivansferase 2. Pharmacogenet Genomics. 2014 Aug;24(8):409-25. doi: 10.1097/FPC.0000000000000062. [PubMed:24892773 ]

PMID: 15857113

Hydralazine

By

Hydralazine

Product: 7beta-Hydroxylathyrol

Identifier : DBSNPE000410
Drug : DB01275 (Hydralazine)
Interacting Gene/Enzyme : Arylamine N-acetyldivansferase 2
Gene Name : NAT2
UniProt ID : P11245
Defining Change(s) :

  • G > A | C > T (rs1799931 )

Allele Name : NAT2*7B
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NAT slow acetylators
Description : Associated with systemic lupus erythematosus.
References :

  1. Sim E, Abuhammad A, Ryan A: Arylamine N-acetyldivansferases: from drug metabolism and pharmacogenetics to drug discovery. Br J Pharmacol. 2014 Jun;171(11):2705-25. doi: 10.1111/bph.12598. [PubMed:24467436 ]
  2. McDonagh EM, Boukouvala S, Aklillu E, Hein DW, Altman RB, Klein TE: PharmGKB summary: very important pharmacogene information for N-acetyldivansferase 2. Pharmacogenet Genomics. 2014 Aug;24(8):409-25. doi: 10.1097/FPC.0000000000000062. [PubMed:24892773 ]

PMID: 17872378

Hydralazine

By

Hydralazine

Product: Xanthohumol

Identifier : DBSNPE000411
Drug : DB01275 (Hydralazine)
Interacting Gene/Enzyme : Arylamine N-acetyldivansferase 2
Gene Name : NAT2
UniProt ID : P11245
Defining Change(s) :

  • G > A (rs72554617 )

Allele Name : NAT2*10
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NAT slow acetylators
Description : Associated with systemic lupus erythematosus.
References :

  1. Sim E, Abuhammad A, Ryan A: Arylamine N-acetyldivansferases: from drug metabolism and pharmacogenetics to drug discovery. Br J Pharmacol. 2014 Jun;171(11):2705-25. doi: 10.1111/bph.12598. [PubMed:24467436 ]
  2. McDonagh EM, Boukouvala S, Aklillu E, Hein DW, Altman RB, Klein TE: PharmGKB summary: very important pharmacogene information for N-acetyldivansferase 2. Pharmacogenet Genomics. 2014 Aug;24(8):409-25. doi: 10.1097/FPC.0000000000000062. [PubMed:24892773 ]

PMID: 19014385

Hydralazine

By

Hydralazine

Product: 5,15-Diacetyl-3-benzoyllathyrol

Identifier : DBSNPE000412
Drug : DB01275 (Hydralazine)
Interacting Gene/Enzyme : Arylamine N-acetyldivansferase 2
Gene Name : NAT2
UniProt ID : P11245
Defining Change(s) :

  • G > A | A > G (rs4986996 )

Allele Name : NAT2*12D
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NAT slow acetylators
Description : Associated with systemic lupus erythematosus.
References :

  1. Sim E, Abuhammad A, Ryan A: Arylamine N-acetyldivansferases: from drug metabolism and pharmacogenetics to drug discovery. Br J Pharmacol. 2014 Jun;171(11):2705-25. doi: 10.1111/bph.12598. [PubMed:24467436 ]
  2. McDonagh EM, Boukouvala S, Aklillu E, Hein DW, Altman RB, Klein TE: PharmGKB summary: very important pharmacogene information for N-acetyldivansferase 2. Pharmacogenet Genomics. 2014 Aug;24(8):409-25. doi: 10.1097/FPC.0000000000000062. [PubMed:24892773 ]

PMID: 11504730

Hydralazine

By

Hydralazine

Product: Lathyrol

Identifier : DBSNPE000413
Drug : DB01275 (Hydralazine)
Interacting Gene/Enzyme : Arylamine N-acetyldivansferase 2
Gene Name : NAT2
UniProt ID : P11245
Defining Change(s) :

  • G > A (rs1801279 )

Allele Name : NAT2*14A
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NAT slow acetylators
Description : Associated with systemic lupus erythematosus.
References :

  1. Sim E, Abuhammad A, Ryan A: Arylamine N-acetyldivansferases: from drug metabolism and pharmacogenetics to drug discovery. Br J Pharmacol. 2014 Jun;171(11):2705-25. doi: 10.1111/bph.12598. [PubMed:24467436 ]
  2. McDonagh EM, Boukouvala S, Aklillu E, Hein DW, Altman RB, Klein TE: PharmGKB summary: very important pharmacogene information for N-acetyldivansferase 2. Pharmacogenet Genomics. 2014 Aug;24(8):409-25. doi: 10.1097/FPC.0000000000000062. [PubMed:24892773 ]

PMID: 18332856

Hydralazine

By

Hydralazine

Product: Isoimperatorin

Identifier : DBSNPE000414
Drug : DB01275 (Hydralazine)
Interacting Gene/Enzyme : Arylamine N-acetyldivansferase 2
Gene Name : NAT2
UniProt ID : P11245
Defining Change(s) :

  • G > A | C > T (rs1801279 )

Allele Name : NAT2*14B
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NAT slow acetylators
Description : Associated with systemic lupus erythematosus.
References :

  1. Sim E, Abuhammad A, Ryan A: Arylamine N-acetyldivansferases: from drug metabolism and pharmacogenetics to drug discovery. Br J Pharmacol. 2014 Jun;171(11):2705-25. doi: 10.1111/bph.12598. [PubMed:24467436 ]
  2. McDonagh EM, Boukouvala S, Aklillu E, Hein DW, Altman RB, Klein TE: PharmGKB summary: very important pharmacogene information for N-acetyldivansferase 2. Pharmacogenet Genomics. 2014 Aug;24(8):409-25. doi: 10.1097/FPC.0000000000000062. [PubMed:24892773 ]

PMID: 25363786

Hydralazine

By

Hydralazine

Product: Imperatorin

Identifier : DBSNPE000415
Drug : DB01275 (Hydralazine)
Interacting Gene/Enzyme : Arylamine N-acetyldivansferase 2
Gene Name : NAT2
UniProt ID : P11245
Defining Change(s) :

  • G > A | T > C | C > T | A > G (rs1801279 )

Allele Name : NAT2*14C
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NAT slow acetylators
Description : Associated with systemic lupus erythematosus.
References :

  1. Sim E, Abuhammad A, Ryan A: Arylamine N-acetyldivansferases: from drug metabolism and pharmacogenetics to drug discovery. Br J Pharmacol. 2014 Jun;171(11):2705-25. doi: 10.1111/bph.12598. [PubMed:24467436 ]
  2. McDonagh EM, Boukouvala S, Aklillu E, Hein DW, Altman RB, Klein TE: PharmGKB summary: very important pharmacogene information for N-acetyldivansferase 2. Pharmacogenet Genomics. 2014 Aug;24(8):409-25. doi: 10.1097/FPC.0000000000000062. [PubMed:24892773 ]

PMID: 12399409

Hydralazine

By

Hydralazine

Product: Dipsacoside B

Identifier : DBSNPE000416
Drug : DB01275 (Hydralazine)
Interacting Gene/Enzyme : Arylamine N-acetyldivansferase 2
Gene Name : NAT2
UniProt ID : P11245
Defining Change(s) :

  • G > A | C > T | G > A (rs1801279 )

Allele Name : NAT2*14D
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NAT slow acetylators
Description : Associated with systemic lupus erythematosus.
References :

  1. Sim E, Abuhammad A, Ryan A: Arylamine N-acetyldivansferases: from drug metabolism and pharmacogenetics to drug discovery. Br J Pharmacol. 2014 Jun;171(11):2705-25. doi: 10.1111/bph.12598. [PubMed:24467436 ]
  2. McDonagh EM, Boukouvala S, Aklillu E, Hein DW, Altman RB, Klein TE: PharmGKB summary: very important pharmacogene information for N-acetyldivansferase 2. Pharmacogenet Genomics. 2014 Aug;24(8):409-25. doi: 10.1097/FPC.0000000000000062. [PubMed:24892773 ]

PMID: 11014206

Hydralazine

By

Hydralazine

Product: Combretastatin A4

Identifier : DBSNPE000417
Drug : DB01275 (Hydralazine)
Interacting Gene/Enzyme : Arylamine N-acetyldivansferase 2
Gene Name : NAT2
UniProt ID : P11245
Defining Change(s) :

  • G > A | A > G (rs1801279 )

Allele Name : NAT2*14E
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NAT slow acetylators
Description : Associated with systemic lupus erythematosus.
References :

  1. Sim E, Abuhammad A, Ryan A: Arylamine N-acetyldivansferases: from drug metabolism and pharmacogenetics to drug discovery. Br J Pharmacol. 2014 Jun;171(11):2705-25. doi: 10.1111/bph.12598. [PubMed:24467436 ]
  2. McDonagh EM, Boukouvala S, Aklillu E, Hein DW, Altman RB, Klein TE: PharmGKB summary: very important pharmacogene information for N-acetyldivansferase 2. Pharmacogenet Genomics. 2014 Aug;24(8):409-25. doi: 10.1097/FPC.0000000000000062. [PubMed:24892773 ]

PMID: 11150164

Hydralazine

By

Hydralazine

Product: MQAE

Identifier : DBSNPE000418
Drug : DB01275 (Hydralazine)
Interacting Gene/Enzyme : Arylamine N-acetyldivansferase 2
Gene Name : NAT2
UniProt ID : P11245
Defining Change(s) :

  • G > A | T > C | A > G (rs1801279 )

Allele Name : NAT2*14F
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NAT slow acetylators
Description : Associated with systemic lupus erythematosus.
References :

  1. Sim E, Abuhammad A, Ryan A: Arylamine N-acetyldivansferases: from drug metabolism and pharmacogenetics to drug discovery. Br J Pharmacol. 2014 Jun;171(11):2705-25. doi: 10.1111/bph.12598. [PubMed:24467436 ]
  2. McDonagh EM, Boukouvala S, Aklillu E, Hein DW, Altman RB, Klein TE: PharmGKB summary: very important pharmacogene information for N-acetyldivansferase 2. Pharmacogenet Genomics. 2014 Aug;24(8):409-25. doi: 10.1097/FPC.0000000000000062. [PubMed:24892773 ]

PMID: 26374855

Hydralazine

By

Hydralazine

Product: Sugammadex (sodium)

Identifier : DBSNPE000419
Drug : DB01275 (Hydralazine)
Interacting Gene/Enzyme : Arylamine N-acetyldivansferase 2
Gene Name : NAT2
UniProt ID : P11245
Defining Change(s) :

  • G > A | C > T | A > G (rs1801279 )

Allele Name : NAT2*14G
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NAT slow acetylators
Description : Associated with systemic lupus erythematosus.
References :

  1. Sim E, Abuhammad A, Ryan A: Arylamine N-acetyldivansferases: from drug metabolism and pharmacogenetics to drug discovery. Br J Pharmacol. 2014 Jun;171(11):2705-25. doi: 10.1111/bph.12598. [PubMed:24467436 ]
  2. McDonagh EM, Boukouvala S, Aklillu E, Hein DW, Altman RB, Klein TE: PharmGKB summary: very important pharmacogene information for N-acetyldivansferase 2. Pharmacogenet Genomics. 2014 Aug;24(8):409-25. doi: 10.1097/FPC.0000000000000062. [PubMed:24892773 ]

PMID: 25926772

Hydralazine

By

Hydralazine

Product: MMAF-OMe

Identifier : DBSNPE000420
Drug : DB01275 (Hydralazine)
Interacting Gene/Enzyme : Arylamine N-acetyldivansferase 2
Gene Name : NAT2
UniProt ID : P11245
Defining Change(s) :

  • A > C (rs72554616 )

Allele Name : NAT2*17
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NAT slow acetylators
Description : Associated with systemic lupus erythematosus.
References :

  1. Sim E, Abuhammad A, Ryan A: Arylamine N-acetyldivansferases: from drug metabolism and pharmacogenetics to drug discovery. Br J Pharmacol. 2014 Jun;171(11):2705-25. doi: 10.1111/bph.12598. [PubMed:24467436 ]
  2. McDonagh EM, Boukouvala S, Aklillu E, Hein DW, Altman RB, Klein TE: PharmGKB summary: very important pharmacogene information for N-acetyldivansferase 2. Pharmacogenet Genomics. 2014 Aug;24(8):409-25. doi: 10.1097/FPC.0000000000000062. [PubMed:24892773 ]

PMID: 25795708

Hydralazine

By

Hydralazine

Product: BMS 299897

Identifier : DBSNPE000421
Drug : DB01275 (Hydralazine)
Interacting Gene/Enzyme : Arylamine N-acetyldivansferase 2
Gene Name : NAT2
UniProt ID : P11245
Defining Change(s) :

  • C > T (rs1805158 )

Allele Name : NAT2*19
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : NAT slow acetylators
Description : Associated with systemic lupus erythematosus.
References :

  1. Sim E, Abuhammad A, Ryan A: Arylamine N-acetyldivansferases: from drug metabolism and pharmacogenetics to drug discovery. Br J Pharmacol. 2014 Jun;171(11):2705-25. doi: 10.1111/bph.12598. [PubMed:24467436 ]
  2. McDonagh EM, Boukouvala S, Aklillu E, Hein DW, Altman RB, Klein TE: PharmGKB summary: very important pharmacogene information for N-acetyldivansferase 2. Pharmacogenet Genomics. 2014 Aug;24(8):409-25. doi: 10.1097/FPC.0000000000000062. [PubMed:24892773 ]

PMID: 25256868

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