Desflurane

Product: Tanshinone IIA

Identifier : DBSNPE000313
Drug : DB01189 (Desflurane)
Interacting Gene/Enzyme : Voltage-dependent L-type calcium channel subunit alpha-1S
Gene Name : CACNA1S
UniProt ID : Q13698
Defining Change(s) :

  • c.3257G>A (rs1800559 )

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Suprane® (desflurane, USP) liquid[package insert]. Deerfield, Illinois: Baxter Healthcare Corporation; 2016. [Link]

PMID: 3756133

Desflurane

Product: Nuciferine

Identifier : DBSNPE000314
Drug : DB01189 (Desflurane)
Interacting Gene/Enzyme : Voltage-dependent L-type calcium channel subunit alpha-1S
Gene Name : CACNA1S
UniProt ID : Q13698
Defining Change(s) :

  • c.520C>T (rs772226819 )

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Suprane® (desflurane, USP) liquid[package insert]. Deerfield, Illinois: Baxter Healthcare Corporation; 2016. [Link]

PMID: 3778949

Desflurane

Product: Chrysophanol

Identifier : DBSNPE000315
Drug : DB01189 (Desflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.103T>C (rs193922747 )

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Suprane® (desflurane, USP) liquid[package insert]. Deerfield, Illinois: Baxter Healthcare Corporation; 2016. [Link]

PMID: 24658113

Desflurane

Product: Dihydrotanshinone I

Identifier : DBSNPE000316
Drug : DB01189 (Desflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.487C>T (rs118192161 )

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Suprane® (desflurane, USP) liquid[package insert]. Deerfield, Illinois: Baxter Healthcare Corporation; 2016. [Link]

PMID: 22489865

Desflurane

Product: Astragaloside IV

Identifier : DBSNPE000317
Drug : DB01189 (Desflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.488G>T (rs193922753 )

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Suprane® (desflurane, USP) liquid[package insert]. Deerfield, Illinois: Baxter Healthcare Corporation; 2016. [Link]

PMID: 22398409

Desflurane

Product: SF1670

Identifier : DBSNPE000318
Drug : DB01189 (Desflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.742G>A (rs1801086 )

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Suprane® (desflurane, USP) liquid[package insert]. Deerfield, Illinois: Baxter Healthcare Corporation; 2016. [Link]

PMID: 20803239

Desflurane

Product: Scutellarin

Identifier : DBSNPE000319
Drug : DB01189 (Desflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.742G>C (rs1801086 )

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Suprane® (desflurane, USP) liquid[package insert]. Deerfield, Illinois: Baxter Healthcare Corporation; 2016. [Link]

PMID: 19596275

Desflurane

Product: Tanshinone IIA sulfonate (sodium)

Identifier : DBSNPE000320
Drug : DB01189 (Desflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.1021G>A (rs121918592 )

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Suprane® (desflurane, USP) liquid[package insert]. Deerfield, Illinois: Baxter Healthcare Corporation; 2016. [Link]

PMID: 12943986

Desflurane

Product: GS-7340 (hemifumarate)

Identifier : DBSNPE000321
Drug : DB01189 (Desflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.1209C>G (rs118192116 )

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Suprane® (desflurane, USP) liquid[package insert]. Deerfield, Illinois: Baxter Healthcare Corporation; 2016. [Link]

PMID: 12890703

Desflurane

Product: Podocarpic acid

Identifier : DBSNPE000322
Drug : DB01189 (Desflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.1565A>C (rs118192162 )

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Suprane® (desflurane, USP) liquid[package insert]. Deerfield, Illinois: Baxter Healthcare Corporation; 2016. [Link]

PMID: 11708925

Desflurane

Product: IDE1

Identifier : DBSNPE000323
Drug : DB01189 (Desflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.1589G>A

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Suprane® (desflurane, USP) liquid[package insert]. Deerfield, Illinois: Baxter Healthcare Corporation; 2016. [Link]

PMID: 26397183

Desflurane

Product: SYP-5

Identifier : DBSNPE000324
Drug : DB01189 (Desflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.1654C>T (rs193922770 )

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Suprane® (desflurane, USP) liquid[package insert]. Deerfield, Illinois: Baxter Healthcare Corporation; 2016. [Link]

PMID: 26453052

Desflurane

Product: IPI549

Identifier : DBSNPE000325
Drug : DB01189 (Desflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.1840C>T (rs118192172 )

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Suprane® (desflurane, USP) liquid[package insert]. Deerfield, Illinois: Baxter Healthcare Corporation; 2016. [Link]

PMID: 25723814

Desflurane

Product: Antibiotic-5d

Identifier : DBSNPE000326
Drug : DB01189 (Desflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.1841G>T (rs193922772 )

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Suprane® (desflurane, USP) liquid[package insert]. Deerfield, Illinois: Baxter Healthcare Corporation; 2016. [Link]

PMID: 25874233

Desflurane

Product: KRIBB11

Identifier : DBSNPE000327
Drug : DB01189 (Desflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.6487C>T (rs118192175 )

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Suprane® (desflurane, USP) liquid[package insert]. Deerfield, Illinois: Baxter Healthcare Corporation; 2016. [Link]

PMID: 25549949

Desflurane

Product: MX69

Identifier : DBSNPE000328
Drug : DB01189 (Desflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.6488G>A (rs118192163 )

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Suprane® (desflurane, USP) liquid[package insert]. Deerfield, Illinois: Baxter Healthcare Corporation; 2016. [Link]

PMID: 25730107

Desflurane

Product: Conduritol B epoxide

Identifier : DBSNPE000329
Drug : DB01189 (Desflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.6502G>A (rs118192176 )

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Suprane® (desflurane, USP) liquid[package insert]. Deerfield, Illinois: Baxter Healthcare Corporation; 2016. [Link]

PMID: 25663821

Desflurane

Product: BBT594

Identifier : DBSNPE000330
Drug : DB01189 (Desflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.6617C>G (rs118192177 )

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Suprane® (desflurane, USP) liquid[package insert]. Deerfield, Illinois: Baxter Healthcare Corporation; 2016. [Link]

PMID: 25000562

Desflurane

Product: GGTI298

Identifier : DBSNPE000331
Drug : DB01189 (Desflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.6617C>T (rs118192177 )

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Suprane® (desflurane, USP) liquid[package insert]. Deerfield, Illinois: Baxter Healthcare Corporation; 2016. [Link]

PMID: 24877132

Desflurane

Product: UNC3866

Identifier : DBSNPE000332
Drug : DB01189 (Desflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.7007G>A

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Suprane® (desflurane, USP) liquid[package insert]. Deerfield, Illinois: Baxter Healthcare Corporation; 2016. [Link]

PMID: 24621993

Desflurane

Product: MRE-269

Identifier : DBSNPE000333
Drug : DB01189 (Desflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.7048G>A (rs193922802 )

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Suprane® (desflurane, USP) liquid[package insert]. Deerfield, Illinois: Baxter Healthcare Corporation; 2016. [Link]

PMID: 24334513

Desflurane

Product: N-Desmethylclozapine

Identifier : DBSNPE000334
Drug : DB01189 (Desflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.7124G>C (rs193922807 )

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Suprane® (desflurane, USP) liquid[package insert]. Deerfield, Illinois: Baxter Healthcare Corporation; 2016. [Link]

PMID: 24613724

Desflurane

Product: AS1517499

Identifier : DBSNPE000335
Drug : DB01189 (Desflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.7282G>A (rs193922809 )

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Suprane® (desflurane, USP) liquid[package insert]. Deerfield, Illinois: Baxter Healthcare Corporation; 2016. [Link]

PMID: 24670778

Desflurane

Product: DREADD agonist 21

Identifier : DBSNPE000336
Drug : DB01189 (Desflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.7300G>A (rs121918593 )

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Suprane® (desflurane, USP) liquid[package insert]. Deerfield, Illinois: Baxter Healthcare Corporation; 2016. [Link]

PMID: 26417324

Desflurane

Product: ONO-7300243

Identifier : DBSNPE000337
Drug : DB01189 (Desflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.7304G>A (rs28933396 )

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Suprane® (desflurane, USP) liquid[package insert]. Deerfield, Illinois: Baxter Healthcare Corporation; 2016. [Link]

PMID: 24048848

Desflurane

Product: DG051

Identifier : DBSNPE000338
Drug : DB01189 (Desflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.7360C>T (rs193922816 )

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Suprane® (desflurane, USP) liquid[package insert]. Deerfield, Illinois: Baxter Healthcare Corporation; 2016. [Link]

PMID: 24222765

Desflurane

Product: Oleanolic acid derivative 1

Identifier : DBSNPE000339
Drug : DB01189 (Desflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.7361G>A (rs118192122 )

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Suprane® (desflurane, USP) liquid[package insert]. Deerfield, Illinois: Baxter Healthcare Corporation; 2016. [Link]

PMID: 23756706

Desflurane

Product: Oleanolic acid derivative 2

Identifier : DBSNPE000340
Drug : DB01189 (Desflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.7372C>T (rs28933397 )

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Suprane® (desflurane, USP) liquid[package insert]. Deerfield, Illinois: Baxter Healthcare Corporation; 2016. [Link]

PMID: 24191028

Desflurane

Product: Protocatechuic acid

Identifier : DBSNPE000341
Drug : DB01189 (Desflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.7373G>A (rs121918594 )

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Suprane® (desflurane, USP) liquid[package insert]. Deerfield, Illinois: Baxter Healthcare Corporation; 2016. [Link]

PMID: 23804112

Desflurane

Product: PF-06282999

Identifier : DBSNPE000342
Drug : DB01189 (Desflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.7522C>T (rs118192178 )

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Suprane® (desflurane, USP) liquid[package insert]. Deerfield, Illinois: Baxter Healthcare Corporation; 2016. [Link]

PMID: 23718638

Desflurane

Product: L-Praziquanamine

Identifier : DBSNPE000343
Drug : DB01189 (Desflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.7523G>A

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Suprane® (desflurane, USP) liquid[package insert]. Deerfield, Illinois: Baxter Healthcare Corporation; 2016. [Link]

PMID: 21884022

Desflurane

Product: CA-074 methyl ester

Identifier : DBSNPE000344
Drug : DB01189 (Desflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.14387A>G (rs118192167 )

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Suprane® (desflurane, USP) liquid[package insert]. Deerfield, Illinois: Baxter Healthcare Corporation; 2016. [Link]

PMID: 24068106

Desflurane

Product: Nicainoprol

Identifier : DBSNPE000345
Drug : DB01189 (Desflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.14477C>T (rs121918595 )

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Suprane® (desflurane, USP) liquid[package insert]. Deerfield, Illinois: Baxter Healthcare Corporation; 2016. [Link]

PMID: 22142990

Desflurane

Product: HT-2157

Identifier : DBSNPE000346
Drug : DB01189 (Desflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.14497C>T

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Suprane® (desflurane, USP) liquid[package insert]. Deerfield, Illinois: Baxter Healthcare Corporation; 2016. [Link]

PMID: 22810004

Desflurane

Product: Niraparib metabolite M1

Identifier : DBSNPE000347
Drug : DB01189 (Desflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.14512C>G (rs193922878 )

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Suprane® (desflurane, USP) liquid[package insert]. Deerfield, Illinois: Baxter Healthcare Corporation; 2016. [Link]

PMID: 22509330

Desflurane

Product: PF-1355

Identifier : DBSNPE000348
Drug : DB01189 (Desflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.14582G>A (rs63749869 )

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Suprane® (desflurane, USP) liquid[package insert]. Deerfield, Illinois: Baxter Healthcare Corporation; 2016. [Link]

PMID: 22896656

Desflurane

Product: ML RR-S2 CDA (ammonium salt)

Identifier : DBSNPE000349
Drug : DB01189 (Desflurane)
Interacting Gene/Enzyme : Ryanodine receptor 1
Gene Name : RYR1
UniProt ID : P21817
Defining Change(s) :

  • c.14693T>C (rs118192170 )

Allele Name : Not Available
Genotype(s) : Not Available
Type(s) : ADR Inferred
Groups : Malignant hyperthermia vulnerability
Description : Malignant hyperthermia.
References :

  1. Suprane® (desflurane, USP) liquid[package insert]. Deerfield, Illinois: Baxter Healthcare Corporation; 2016. [Link]

PMID: 23071688

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