Belinostat
Identifier : DBSNPE000258
Drug : DB05015 (Belinostat)
Interacting Gene/Enzyme : UDP-glucuronosyldivansferase 1-1
Gene Name : UGT1A1
UniProt ID : P22309
Defining Change(s) :
- exdiva TA in promoter (rs8175347 )
Allele Name : UGT1A1*28
Genotype(s) : Not Available
Type(s) : ADR Directly Studied
Groups : Not Available
Description : Hematological toxicities.
References :
- Goey AK, Sissung TM, Peer CJ, Trepel JB, Lee MJ, Tomita Y, Ehrlich S, Bryla C, Balasubramaniam S, Piekarz R, Steinberg SM, Bates SE, Figg WD: Effects of UGT1A1 genotype on the pharmacokinetics, pharmacodynamics, and toxicities of belinostat administered by 48-hour continuous infusion in patients with cancer. J Clin Pharmacol. 2016 Apr;56(4):461-73. doi: 10.1002/jcph.625. Epub 2015 Nov 9. [PubMed:26313268 ]