End that PrEP adherence counselors explore with women the most appropriate external cues and reminders that will facilitate adherence. Nevertheless, for participants in the moderate adherence group, adherence counseling and other motivations described here appear to have been only marginally or temporarily effective at motivating these participants to adhere; in these cases, the barriers participants faced in FEM-PrEP [11] may have challenged s11606-015-3271-0 their motivations and ability to adhere. Women’s perceptions that many participants were taking the study pill immediately prior to a study visit in order to appear adherent were not supported by drug concentration data [7]. However, the misreporting of adherence was common in FEM-PrEP. We have described elsewhere that participants over-reported their adherence during the trial [12]; the AZD0865 web primary reason for over-reporting was an incorrect assumption that they 1471-2474-14-48 would be terminated from the trial for non-adherence [14]. Our study had several limitations. First, we did not design the study to compare reasons for adherence between the adherence groups; the ACASI data could not be aggregated by adherence group (due to procedures in place to reduce socially-desirable responses), and different questions and probes were asked to participants in each SSI adherence group based on factors we believed might be relevant to their specific levels of adherence. We were, however, able to identify the Saroglitazar Magnesium web overall facilitators of adherence among participants who took the pill most or some of the time. From the SSI findings, these factors were similar between the moderate and high groups. Therefore, the differences between these two groups may have lied instead on participants’ abilities to overcome any barriers to adherence they may have faced. Second, because of the large gap in time between the closure of FEM-PrEP and the implementation of the followup study, recruiting former FEM-PrEP participants with the most specimens available and reaching our sample size (particularly in the high adherence group in Pretoria) were purchase SCR7 difficult because many participants’ contact information had changed. We therefore enrolled some participants who had only a few specimens available. Yet, a strength of our study was that we explored adherence over multiple time points for many participants rather than using drug concentration data from a single cross-sectional visit. Third, our findings may not be, and were not expected to be, representative of all FEM-PrEP participants who took the study pills given our sampling and recruitment strategies. Fourth, participants in the placebo arm did not participate in SSIs before they completed ACASI as part of this study. These participants might have responded differently if they had previously discussed adherence-related issues face-toface with an interviewer. In moving forward, participants’ mistrust of their partners’ ability to remain HIV-negative provides further evidence that women want and need novel HIV prevention strategies. Our study’s findings can help inform both future ARV-based HIV prevention trials and the rollout of effective ARV-based HIV prevention technologies for women. Future trials should continue to describe, during community engagement, the importance of clinical research to appeal to individuals who may be interested in participating in clinical trials for altruistic reasons or out of a Varlitinib price general interest in finding new HIV prevention products. Counseling in such trials should ex.End that PrEP adherence counselors explore with women the most appropriate external cues and reminders that will facilitate adherence. Nevertheless, for participants in the moderate adherence group, adherence counseling and other motivations described here appear to have been only marginally or temporarily effective at motivating these participants to adhere; in these cases, the barriers participants faced in FEM-PrEP [11] may have challenged s11606-015-3271-0 their motivations and ability to adhere. Women’s perceptions that many participants were taking the study pill immediately prior to a study visit in order to appear adherent were not supported by drug concentration data [7]. However, the misreporting of adherence was common in FEM-PrEP. We have described elsewhere that participants over-reported their adherence during the trial [12]; the primary reason for over-reporting was an incorrect assumption that they 1471-2474-14-48 would be terminated from the trial for non-adherence [14]. Our study had several limitations. First, we did not design the study to compare reasons for adherence between the adherence groups; the ACASI data could not be aggregated by adherence group (due to procedures in place to reduce socially-desirable responses), and different questions and probes were asked to participants in each SSI adherence group based on factors we believed might be relevant to their specific levels of adherence. We were, however, able to identify the overall facilitators of adherence among participants who took the pill most or some of the time. From the SSI findings, these factors were similar between the moderate and high groups. Therefore, the differences between these two groups may have lied instead on participants’ abilities to overcome any barriers to adherence they may have faced. Second, because of the large gap in time between the closure of FEM-PrEP and the implementation of the followup study, recruiting former FEM-PrEP participants with the most specimens available and reaching our sample size (particularly in the high adherence group in Pretoria) were difficult because many participants’ contact information had changed. We therefore enrolled some participants who had only a few specimens available. Yet, a strength of our study was that we explored adherence over multiple time points for many participants rather than using drug concentration data from a single cross-sectional visit. Third, our findings may not be, and were not expected to be, representative of all FEM-PrEP participants who took the study pills given our sampling and recruitment strategies. Fourth, participants in the placebo arm did not participate in SSIs before they completed ACASI as part of this study. These participants might have responded differently if they had previously discussed adherence-related issues face-toface with an interviewer. In moving forward, participants’ mistrust of their partners’ ability to remain HIV-negative provides further evidence that women want and need novel HIV prevention strategies. Our study’s findings can help inform both future ARV-based HIV prevention trials and the rollout of effective ARV-based HIV prevention technologies for women. Future trials should continue to describe, during community engagement, the importance of clinical research to appeal to individuals who may be interested in participating in clinical trials for altruistic reasons or out of a general interest in finding new HIV prevention products. Counseling in such trials should ex.End that PrEP adherence counselors explore with women the most appropriate external cues and reminders that will facilitate adherence. Nevertheless, for participants in the moderate adherence group, adherence counseling and other motivations described here appear to have been only marginally or temporarily effective at motivating these participants to adhere; in these cases, the barriers participants faced in FEM-PrEP [11] may have challenged s11606-015-3271-0 their motivations and ability to adhere. Women’s perceptions that many participants were taking the study pill immediately prior to a study visit in order to appear adherent were not supported by drug concentration data [7]. However, the misreporting of adherence was common in FEM-PrEP. We have described elsewhere that participants over-reported their adherence during the trial [12]; the primary reason for over-reporting was an incorrect assumption that they 1471-2474-14-48 would be terminated from the trial for non-adherence [14]. Our study had several limitations. First, we did not design the study to compare reasons for adherence between the adherence groups; the ACASI data could not be aggregated by adherence group (due to procedures in place to reduce socially-desirable responses), and different questions and probes were asked to participants in each SSI adherence group based on factors we believed might be relevant to their specific levels of adherence. We were, however, able to identify the overall facilitators of adherence among participants who took the pill most or some of the time. From the SSI findings, these factors were similar between the moderate and high groups. Therefore, the differences between these two groups may have lied instead on participants’ abilities to overcome any barriers to adherence they may have faced. Second, because of the large gap in time between the closure of FEM-PrEP and the implementation of the followup study, recruiting former FEM-PrEP participants with the most specimens available and reaching our sample size (particularly in the high adherence group in Pretoria) were difficult because many participants’ contact information had changed. We therefore enrolled some participants who had only a few specimens available. Yet, a strength of our study was that we explored adherence over multiple time points for many participants rather than using drug concentration data from a single cross-sectional visit. Third, our findings may not be, and were not expected to be, representative of all FEM-PrEP participants who took the study pills given our sampling and recruitment strategies. Fourth, participants in the placebo arm did not participate in SSIs before they completed ACASI as part of this study. These participants might have responded differently if they had previously discussed adherence-related issues face-toface with an interviewer. In moving forward, participants’ mistrust of their partners’ ability to remain HIV-negative provides further evidence that women want and need novel HIV prevention strategies. Our study’s findings can help inform both future ARV-based HIV prevention trials and the rollout of effective ARV-based HIV prevention technologies for women. Future trials should continue to describe, during community engagement, the importance of clinical research to appeal to individuals who may be interested in participating in clinical trials for altruistic reasons or out of a general interest in finding new HIV prevention products. Counseling in such trials should ex.End that PrEP adherence counselors explore with women the most appropriate external cues and reminders that will facilitate adherence. Nevertheless, for participants in the moderate adherence group, adherence counseling and other motivations described here appear to have been only marginally or temporarily effective at motivating these participants to adhere; in these cases, the barriers participants faced in FEM-PrEP [11] may have challenged s11606-015-3271-0 their motivations and ability to adhere. Women’s perceptions that many participants were taking the study pill immediately prior to a study visit in order to appear adherent were not supported by drug concentration data [7]. However, the misreporting of adherence was common in FEM-PrEP. We have described elsewhere that participants over-reported their adherence during the trial [12]; the primary reason for over-reporting was an incorrect assumption that they 1471-2474-14-48 would be terminated from the trial for non-adherence [14]. Our study had several limitations. First, we did not design the study to compare reasons for adherence between the adherence groups; the ACASI data could not be aggregated by adherence group (due to procedures in place to reduce socially-desirable responses), and different questions and probes were asked to participants in each SSI adherence group based on factors we believed might be relevant to their specific levels of adherence. We were, however, able to identify the overall facilitators of adherence among participants who took the pill most or some of the time. From the SSI findings, these factors were similar between the moderate and high groups. Therefore, the differences between these two groups may have lied instead on participants’ abilities to overcome any barriers to adherence they may have faced. Second, because of the large gap in time between the closure of FEM-PrEP and the implementation of the followup study, recruiting former FEM-PrEP participants with the most specimens available and reaching our sample size (particularly in the high adherence group in Pretoria) were difficult because many participants’ contact information had changed. We therefore enrolled some participants who had only a few specimens available. Yet, a strength of our study was that we explored adherence over multiple time points for many participants rather than using drug concentration data from a single cross-sectional visit. Third, our findings may not be, and were not expected to be, representative of all FEM-PrEP participants who took the study pills given our sampling and recruitment strategies. Fourth, participants in the placebo arm did not participate in SSIs before they completed ACASI as part of this study. These participants might have responded differently if they had previously discussed adherence-related issues face-toface with an interviewer. In moving forward, participants’ mistrust of their partners’ ability to remain HIV-negative provides further evidence that women want and need novel HIV prevention strategies. Our study’s findings can help inform both future ARV-based HIV prevention trials and the rollout of effective ARV-based HIV prevention technologies for women. Future trials should continue to describe, during community engagement, the importance of clinical research to appeal to individuals who may be interested in participating in clinical trials for altruistic reasons or out of a general interest in finding new HIV prevention products. Counseling in such trials should ex.