Ier: NCT01126268). This study was approved by the institutional review board at The University of Texas Health Science Center at Houston, also known as the Committee for the Protection of Human Subjects. Patients were recruited from The University of Texas Health Science Center at Houston outpatient dermatology clinic. The study was conducted in accordance with Good Clinical Practice and the guiding principles of the Declaration of Helsinki.Table 1 Baseline demographic and clinical characteristics. Characteristic Age, years, mean (SD) Age, n ( ) Sex, n ( ) Race, n ( ) All patients b 18 18 Female Male Eastern European descent African American Hispanic Asian Other All pathogens Staphylococcus aureus MRSA MSSA Streptococcus pyogenes Other Streptococcus species Coagulase negative Staphylococcus No growth Retapamulin ointment 1 (n = 38) 18.5 (25.66) 28 (73.7 ) 10 (26.3 ) 27 (71.1 ) 11 (28.9 ) 18 (47.4 ) 10 (26.3 ) 5 (13.2 ) 4 (10.5 ) 1 (2.6 ) n = 36 26 (72.2 ) (7, 19.4 ) (19, 52.8 ) 2 (5.5 ) 1 (2.8 ) 7 (19.4 ) n=Participants Male or female patients aged 9 months to 98 years, diagnosed with impetigo, folliculitis, or minor soft tissue infection (including secondarily infected eczema presumed to be caused by S. aureus) suitable for PD168393 molecular weight Treatment with a topical antibiotic, were eligible for inclusion. If the patient was a female of childbearing potential, a negative urine pregnancy test before performing any study-related procedures was required. Exclusion criteria were as follows: use of topical antibacterial medication to the area being treated within the last 48 hours; enrollment in another clinical trial within the last 30 days; signs of systemic infection (such as fever) or evidence of abscess or cellulitis at the site to be treated; presence of a bacterial skin infection that, in the opinion of the investigator, would not be appropriately treated by a topical antibiotic; oral antibiotic use within the last 7 days; known sensitivity to the study medication; and current pregnancy or breastfeeding.Baseline pathogen, n ( )The seven patients with MRSA include six pediatric (aged b 18 years) patients and one adult (aged 18 years) patient. Three patients were male and four were female.Interventions Patients attended up to 2 study clinic visits over a period of 5 to 7 days (Fig. 1). Treatment was started at the first clinic visit. The infected area was first cleaned with a sterile nonantibacterial wipe. Study Torin 1 chemical information personnel then provided the patient (or parent/guardian if applicable) with a 10 g tube of topical retapamulin ointment 1 (10 mg retapamulin per 1 gm of ointment), a study diary to document study drug applications, and instructions for basic wound care and application of study drug. Patients were instructed to apply a thin layer of retapamulin ointment 1 to the infected lesion(s) twice daily for 5 days, for a total of 10 doses, regardless of clinical improvement. Study personnel delivered treatment at visit 1. The maximum area to be treated was 100 cm 2 in adults, and 2 of the total body surface area for pediatric patients, corresponding with a maximum retapamulin ointment 1 dose of approximately 1 g. Sterile bandage or gauze use to cover the treatment area was allowed for all patients and required for children who could have potentially put the treated lesion(s) in their mouth. Patients were allowed to withdraw themselves from the study at any time. The investigator could withdraw a patient due to failure of therapy or worsening signs of.Ier: NCT01126268). This study was approved by the institutional review board at The University of Texas Health Science Center at Houston, also known as the Committee for the Protection of Human Subjects. Patients were recruited from The University of Texas Health Science Center at Houston outpatient dermatology clinic. The study was conducted in accordance with Good Clinical Practice and the guiding principles of the Declaration of Helsinki.Table 1 Baseline demographic and clinical characteristics. Characteristic Age, years, mean (SD) Age, n ( ) Sex, n ( ) Race, n ( ) All patients b 18 18 Female Male Eastern European descent African American Hispanic Asian Other All pathogens Staphylococcus aureus MRSA MSSA Streptococcus pyogenes Other Streptococcus species Coagulase negative Staphylococcus No growth Retapamulin ointment 1 (n = 38) 18.5 (25.66) 28 (73.7 ) 10 (26.3 ) 27 (71.1 ) 11 (28.9 ) 18 (47.4 ) 10 (26.3 ) 5 (13.2 ) 4 (10.5 ) 1 (2.6 ) n = 36 26 (72.2 ) (7, 19.4 ) (19, 52.8 ) 2 (5.5 ) 1 (2.8 ) 7 (19.4 ) n=Participants Male or female patients aged 9 months to 98 years, diagnosed with impetigo, folliculitis, or minor soft tissue infection (including secondarily infected eczema presumed to be caused by S. aureus) suitable for treatment with a topical antibiotic, were eligible for inclusion. If the patient was a female of childbearing potential, a negative urine pregnancy test before performing any study-related procedures was required. Exclusion criteria were as follows: use of topical antibacterial medication to the area being treated within the last 48 hours; enrollment in another clinical trial within the last 30 days; signs of systemic infection (such as fever) or evidence of abscess or cellulitis at the site to be treated; presence of a bacterial skin infection that, in the opinion of the investigator, would not be appropriately treated by a topical antibiotic; oral antibiotic use within the last 7 days; known sensitivity to the study medication; and current pregnancy or breastfeeding.Baseline pathogen, n ( )The seven patients with MRSA include six pediatric (aged b 18 years) patients and one adult (aged 18 years) patient. Three patients were male and four were female.Interventions Patients attended up to 2 study clinic visits over a period of 5 to 7 days (Fig. 1). Treatment was started at the first clinic visit. The infected area was first cleaned with a sterile nonantibacterial wipe. Study personnel then provided the patient (or parent/guardian if applicable) with a 10 g tube of topical retapamulin ointment 1 (10 mg retapamulin per 1 gm of ointment), a study diary to document study drug applications, and instructions for basic wound care and application of study drug. Patients were instructed to apply a thin layer of retapamulin ointment 1 to the infected lesion(s) twice daily for 5 days, for a total of 10 doses, regardless of clinical improvement. Study personnel delivered treatment at visit 1. The maximum area to be treated was 100 cm 2 in adults, and 2 of the total body surface area for pediatric patients, corresponding with a maximum retapamulin ointment 1 dose of approximately 1 g. Sterile bandage or gauze use to cover the treatment area was allowed for all patients and required for children who could have potentially put the treated lesion(s) in their mouth. Patients were allowed to withdraw themselves from the study at any time. The investigator could withdraw a patient due to failure of therapy or worsening signs of.